The effectiveness of an online e-health application compared to attention placebo or Sertraline in the treatment of Generalised Anxiety Disorder

Internet Interventions

Volumn 1, Issue 4, 2014, Pages 169-174

  Christensen, Helen ^a,b   Mackinnon, Andrew J ^c   Batterham, Philip J ^d   O'Dea, Bridianne ^a,b   Guastella, Adam J ^e   Griffiths, Kathleen M ^d   Eagleson, Claire ^e   Kalia Hehir, Kanupriya ^f   Kenardy, Justin ^g   Bennett, Kylie ^d   Hickie, Ian ^e  

^a BLACK DOG INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^g UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Anxiety disorders; Cognitive behavioural therapy; Early intervention; Internet; Intervention; Online systems

Indexed keywords

MONOAMINE OXIDASE INHIBITOR; PLACEBO; SERTRALINE;

ADULT; ARTICLE; ASSESSMENT OF HUMANS; ATTITUDE TO HEALTH; CLINICAL GLOBAL IMPRESSION SCALE; COGNITIVE THERAPY; COMPARATIVE STUDY; COMPUTER ASSISTED THERAPY; COMPUTER PROGRAM; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DRUG TOLERABILITY; DSM-IV; FEMALE; FOLLOW UP; GENERALIZED ANXIETY DISORDER; GENERALIZED ANXIETY DISORDER 7 SCALE; HUMAN; INTERNET; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MUSCLE RELAXATION; ONLINE E HEALTH APPLICATION; OUTCOME ASSESSMENT; PROGRAM EFFECTIVENESS; PSYCHOEDUCATION; RANDOMIZED CONTROLLED TRIAL;

EID: 84920138070     PISSN: 22147829     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.invent.2014.08.002     Document Type: Article

References (35)

1. Allgulander C., Dahl A.A., Austin C., Morris P.L., Sogaard J.A., Fayyad R., Clary C.M. Efficacy of sertraline in a 12-week trial for generalized anxiety disorder. Am. J. Psychiatr. 2004, 161(9):1642-1649. 10.1176/appi.ajp.161.9.1642.
2. Andersson G., Cuijpers P. Internet-based and other computerized psychological treatments for adult depression: a meta-analysis. Cogn. Behav. Ther. 2009, 38(4):196-205. 10.1080/16506070903318960.
3. Andersson G., Paxling B., Roch-Norlund P., Östman G., Norgren A., Almlöv J., Cuijpers P. Internet-based psychodynamic versus cognitive behavioral guided self-help for generalized anxiety disorder: a randomized controlled trial. Psychother. Psychosom. 2012, 81(6):344-355. 10.1159/000339371.
4. Andrews G., Cuijpers P., Craske M.G., McEvoy P., Titov N. Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis. PLoS ONE 2010, 5(10):e13196. 10.1371/journal.pone.0013196.
5. Baldwin D.S., Polkinghorn C. Evidence-based pharmacotherapy of generalized anxiety disorder. Int. J. Neuropsychopharmacol. 2005, 8(02):293-302. 10.1017/S1461145704004870.
6. Brawman-Mintzer O., Knapp R.G., Rynn M., Carter R.E., Rickels K. Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry 2006, 67(6):874-881. 10.4088/JCP.v67n0603.
7. Brown T.A., DiNardo P., Barlow D.H. Anxiety disorders interview schedule for DSM-IV (ADIS-IV): client interview schedule 1994, Oxford University Press, San Antonio, TX.
8. Calear A.L., Christensen H., Mackinnon A., Griffiths K.M., O'Kearney R. The YouthMood Project: a cluster randomized controlled trial of an online cognitive behavioral program with adolescents. J. Consult. Clin. Psychol. 2009, 77(6):1021. 10.1037/a0017391.
9. Christensen H., Griffiths K.M., Jorm A.F. Delivering interventions for depression by using the internet: randomised controlled trial. BMJ 2004, 328(7434):265. 10.1136/bmj.37945.566632.EE.
10. Christensen H., Batterham P., Calear A. Online interventions for anxiety disorders. Curr. Opin. Psychiatry 2014, 27(1):7-13. 10.1097/YCO.0000000000000019.
11. Christensen H., Batterham P., Mackinnon A., Griffiths K.M., Kalia Hehir K., Kenardy J., Bennett K. The prevention of generalised anxiety disorder in those at risk using a Web intervention: I-chill, a randomised controlled trial. J. Med. Internet Res. 2014, 16(9):e:1999. 10.2196/jmir.3507.
12. Cuijpers P., Marks I.M., van Straten A., Cavanagh K., Gega L., Andersson G. Computer-aided psychotherapy for anxiety disorders: a meta-analytic review. Cogn. Behav. Ther. 2009, 38(2):66-82. 10.1080/16506070802694776.
13. Dear B.F., Titov N., Sunderland M., McMillan D., Anderson T., Lorian C., Robinson E. Psychometric comparison of the generalized anxiety disorder scale-7 and the Penn State Worry Questionnaire for measuring response during treatment of generalised anxiety disorder. Cogn. Behav. Ther. 2011, 40(3):216-227. 10.1080/16506073.2011.582138.
14. Griffiths K.M., Crisp D., Christensen H., Mackinnon A.J., Bennett K. The ANU WellBeing study: a protocol for a quasi-factorial randomised controlled trial of the effectiveness of an Internet support group and an automated Internet intervention for depression. BMC Psychiatry 2010, 10(1):20. 10.1186/1471-244X-10-20.
15. Griffiths K.M., Farrer L., Christensen H. The efficacy of internet interventions for depression and anxiety disorders: a review of randomised controlled trials. Med. J. Aust. 2010, 192(11):S4.
16. Griffiths K.M., Mackinnon A.J., Crisp D.A., Christensen H., Bennett K., Farrer L. The effectiveness of an online support group for members of the community with depression: a randomised controlled trial. PLoS ONE 2012, 7(12):e53244. 10.1371/journal.pone.0053244.
17. Guy W. Clinical global impression scale. The ECDEU Assessment Manual for Psychopharmacology 1976, 218-222. National Institute of Health, Rockville, MD.
18. Johansson R., Carlbring P., Heedman A., Paxling B., Andersson G. Depression, anxiety and their comorbidity in the Swedish general population: point prevalence and the effect on health-related quality of life. PeerJ 2013, 1:e98.
19. Kenardy J., McCafferty K., Rosa V. Internet-delivered indicated prevention for anxiety disorders: a randomized controlled trial. Behav. Cogn. Psychother. 2003, 31(3):279-289. 10.1017/S1352465803003047.
20. Kenardy J., McCafferty K., Rosa V. Internet-delivered indicated prevention for anxiety disorders: six-month follow-up. Clin. Psychol. 2006, 10(1):39-42. 10.1080/13284200500378746.
21. Lewis J.A. Statistical principles for clinical trials (ICH E9): an introductory note on an international guideline. Stat. Med. 1999, 18(15):1903-1942. 10.1002/(SICI)1097-0258(19990815)18:15%3C1903::AID-SIM188%3E3.3.CO;2-6.
22. Lewis C., Pearce J., Bisson J.I. Efficacy, cost-effectiveness and acceptability of self-help interventions for anxiety disorders: systematic review. Br. J. Psychiatry 2012, 200(1):15-21. 10.1192/bjp.bp.110.084756.
23. McIntosh A., Cohen A., Turnbull N., Esmonde L., Dennis P., Eatock J., Kelly J. Clinical Guidelines and Evidence Review for Panic Disorder and Generalised Anxiety Disorder 2004, University of Sheffield/London: National Collaborating Centre for Primary Care, Sheffield.
24. Mewton L., Wong N., Andrews G. The effectiveness of Internet cognitive behavioural therapy for generalized anxiety disorder in clinical practice. Depression Anxiety 2012, 29(10):843-849. 10.1002/da.21995.
25. Prochaska J.O., DiClemente C.C. Stages and processes of self-change of smoking: toward an integrative model of change. J. Consult. Clin. Psychol. 1983, 51(3):390. 10.1037//0022-006X.51.3.390.
26. Radloff L.S. The CES-D scale a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1977, 1(3):385-401. 10.1177/014662167700100306.
27. Robinson E., Titov N., Andrews G., McIntyre K., Schwencke G., Solley K. Internet treatment for generalized anxiety disorder: a randomized controlled trial comparing clinician vs. technician assistance. PLoS ONE 2010, 5(6):e10942. 10.1371/journal.pone.0010942.
28. Rozental A., Andersson G., Boettcher J., Ebert D.D., Cuijpers P., Knaevelsrud C., Carlbring P. Consensus statement on defining and measuring negative effects of Internet interventions. Internet Interv. 2014, 1(1):12-19.
29. Rynn M.A., Siqueland L., Rickels K. Placebo-controlled trial of sertraline in the treatment of children with generalized anxiety disorder. Am. J. Psychiatr. 2001, 158(12):2008-2014. 10.1176/appi.ajp.158.12.2008.
30. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 1998, 59:22-33.
31. Spence S.H., Donovan C.L., March S., Gamble A., Anderson R.E., Prosser S., Kenardy J. A randomized controlled trial of online versus clinic-based CBT for adolescent anxiety. J. Consult. Clin. Psychol. 2011, 79(5):629. 10.1037/a0024512.
32. Spitzer R.L., Kroenke K., Williams J.B., Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch. Intern. Med. 2006, 166(10):1092. 10.1001/archinte.166.10.1092.
33. Walkup J.T., Albano A.M., Piacentini J., Birmaher B., Compton S.N., Sherrill J.T., Waslick B. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N. Engl. J. Med. 2008, 359(26):2753-2766. 10.1056/NEJMoa0804633.
34. Wiles N., Thomas L., Abel A., Ridgway N., Turner N., Campbell J., Kessler D. Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial. Lancet 2013, 381(9864):375-384.
35. Wittchen H.-U. Met and unmet need for interventions in community cases with anxiety disorders. Unmet Need in Psychiatry: Problems, Resources, Responses 2000, 256-276. Cambridge University Press, Cambridge. G. Andrews, S. Henderson (Eds.).