The efficacy of trimetazidine on stable angina pectoris: A meta-analysis of randomized clinical trials

International Journal of Cardiology

Volumn 177, Issue 3, 2014, Pages 780-785

  Peng, Song ^a   Zhao, Min ^b   Wan, Jing ^a   Fang, Qi ^a   Fang, Dong ^a   Li, Kaiyong ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Antianginal agents; Meta analysis; Randomized controlled trials; Stable angina pectoris; Trimetazidine

Indexed keywords

ANTIANGINA PECTORIS AGENT; GLYCERYL TRINITRATE; TRIMETAZIDINE; VASODILATOR AGENT;

DRUG EFFICACY; ERGOMETRY; EXERCISE; HUMAN; JADAD SCORE; META ANALYSIS (TOPIC); OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCORING SYSTEM; SENSITIVITY ANALYSIS; ST SEGMENT DEPRESSION; STABLE ANGINA PECTORIS; TREATMENT DURATION; ANGINA PECTORIS; META ANALYSIS; PROCEDURES; TREATMENT OUTCOME;

ANGINA PECTORIS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 84920107276     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.10.149     Document Type: Review

References (34)

1. S.D. Fihn, J.M. Gardin, J. Abrams, K. Berra, J.C. Blankenship, and A.P. Dallas 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons J. Am. Coll. Cardiol. 60 2012 e44 e164
2. M. Schmidt, H.E. Botker, L. Pedersen, and H.T. Sorensen Young adulthood obesity and risk of acute coronary syndromes, stable angina pectoris, and congestive heart failure: a 36-year cohort study Ann. Epidemiol. 24 2014 356 361 (e351)
3. P.A. Heidenreich, K.M. McDonald, T. Hastie, B. Fadel, V. Hagan, and B.K. Lee Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina JAMA 281 1999 1927 1936
4. C. Held, P. Hjemdahl, S.V. Eriksson, I. Bjorkander, L. Forslund, and N. Rehnqvist Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris Eur. Heart J. 22 2001 62 72
5. M. Marzilli, and W.W. Klein Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomized, double-blind, controlled trials Coron. Artery Dis. 14 2003 171 179
6. R.J. Gibbons, K. Chatterjee, J. Daley, J.S. Douglas, S.D. Fihn, and J.M. Gardin ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina) J. Am. Coll. Cardiol. 33 1999 2092 2197
7. Management of stable angina pectoris. Recommendations of the Task Force of the European Society of Cardiology Eur. Heart J. 18 1997 394 413
8. X. Xu, W. Zhang, Y. Zhou, Y. Zhao, Y. Liu, and D. Shi Effect of trimetazidine on recurrent angina pectoris and left ventricular structure in elderly multivessel coronary heart disease patients with diabetes mellitus after drug-eluting stent implantation: a single-centre, prospective, randomized, double-blind study at 2-year follow-up Clin. Drug Investig. 34 2014 251 258
9. P.F. Kantor, A. Lucien, R. Kozak, and G.D. Lopaschuk The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase Circ. Res. 86 2000 580 588
10. A. Desideri, and L. Celegon Metabolic management of ischemic heart disease: clinical data with trimetazidine Am. J. Cardiol. 82 1998 50K 53K
11. J.D. Parker, and J.O. Parker Stable angina pectoris: the medical management of symptomatic myocardial ischemia Can. J. Cardiol. 28 2012 S70 S80
12. N. Danchin, M. Marzilli, A. Parkhomenko, and J.P. Ribeiro Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysis Cardiology 120 2011 59 72
13. H.R. Cross Trimetazidine for stable angina pectoris Expert. Opin. Pharmacother. 2 2001 857 875
14. D.F. Stroup, J.A. Berlin, S.C. Morton, I. Olkin, G.D. Williamson, and D. Rennie Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group JAMA 283 2000 2008 2012
15. D. Moher, D.J. Cook, S. Eastwood, I. Olkin, D. Rennie, and D.F. Stroup Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses Lancet 354 1999 1896 1900
16. A.R. Jadad, R.A. Moore, D. Carroll, C. Jenkinson, D.J. Reynolds, and D.J. Gavaghan Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control. Clin. Trials 17 1996 1 12
17. H. Szwed, Z. Sadowski, W. Elikowski, A. Koronkiewicz, A. Mamcarz, and W. Orszulak Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand Eur. Heart J. 22 2001 2267 2274
18. C. Vitale, I. Spoletini, W. Malorni, P. Perrone-Filardi, M. Volterrani, and G.M. Rosano Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina - the VASCO-angina study Int. J. Cardiol. 168 2013 1078 1081
19. L.W. Ribeiro, J.P. Ribeiro, R. Stein, C. Leitao, and C.A. Polanczyk Trimetazidine added to combined hemodynamic antianginal therapy in patients with type 2 diabetes: a randomized crossover trial Am. Heart J. 154 2007 78 (e71-77)
20. S.C. Manchanda, and S. Krishnaswami Combination treatment with trimetazidine and diltiazem in stable angina pectoris Heart 78 1997 353 357
21. C.X. Zhang Gang, Cui Yingkai, Huang Xiong, Mao Jikang, and Wong Yulong A clinical study of the efficacy of trimetazidine combined with metoprolol in the treatment of stable angina pectoris Mod. J. Integr. Tradit. Chin. West. Med. 15 2006 2926 2927
22. C.Y. Lin Haiyun, and Xiong Bin The clinical efficacy of trimetazidine in the treatment of stable angina pectoris Pract. J. Card. Cereb. Vasc. Dis. 7 2013 61 62
23. Z. Yun Efficacy of trimetazidine on 50 cases of stable angina pectoris Med. Inf. 6 2010 1858 1859
24. W.H.Xu. Jianhua Clinical assessment of trimetazidine in the treatment of stable angina pectoris J. Jining Med. Coll. 28 2005 59
25. L. Jiang Efficacy of the trimetazidine on 258 cases with stable angina pectoris J. Hainan Med. Univ. 19 2013 908 910
26. Z. Guangrong Clinical analysis of trimetazidine in patients with stable angina pectoris Chin. J. Mod. Drug Appl. 4 2010 20 21
27. R. Lixin Effect of trimetazidine in patients with stable angina pectoris China Pract. Med. 3 2008 70 71
28. G.Y. Liang Changqing Observation of efficacy of trimetazidine and metoprolol on stable angina pectoris J. Sl'mnxi Med. Univ. 35 2004 580 581
29. Y. Dengyun Clinical observation of trimetazidine in treatment of 92 cases with heart failure Chin. J. Mod. Drug Appl. 5 2011 102 103
30. J.H. Jennings, B. Digiovine, D. Obeid, and C. Frank The association between depressive symptoms and acute exacerbations of COPD Lung 187 2009 128 135
31. J.D. Ferguson, O. Ormerod, and A.J. Lenox-Smith Bisoprolol alone and in combination with amlodipine or nifedipine in the treatment of chronic stable angina Int. J. Clin. Pract. 54 2000 360 363
32. A. Michaelides, K. Spiropoulos, K. Dimopoulos, D. Athanasiades, and P. Toutouzas Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitrate-propranolol in patients with stable angina Clin. Drug Investig. 13 1997 8 14
33. G. Jackson Combination therapy in angina: a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents Int. J. Clin. Pract. 55 2001 256 261
34. W.W. Klein, G. Jackson, and L. Tavazzi Efficacy of monotherapy compared with combined antianginal drugs in the treatment of chronic stable angina pectoris: a meta-analysis Coron. Artery Dis. 13 2002 427 436