Age-dependent reorganization of peri-infarct "premotor" cortex with task-specific rehabilitative training in mice

Neurorehabilitation and Neural Repair

Volumn 29, Issue 2, 2015, Pages 193-202

  Tennant, Kelly A ^a,b   Kerr, Abigail L ^c   Adkins, Deanna L ^d   Donlan, Nicole ^a   Thomas, Nagheme ^e   Kleim, Jeffrey A ^e   Jones, Theresa A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF VICTORIA   (Canada)

^c ILLINOIS WESLEYAN UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e Arizona State University   (United States)

Author keywords

Aging; Brain mapping; Forelimb; Motor skills disorders; Stroke

Indexed keywords

ENDOTHELIN 1;

AGE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FORELIMB; GROUP DYNAMICS; GROUPS BY AGE; INFANT; LEARNING; MALE; MOUSE; NONHUMAN; PREMOTOR CORTEX; PRIMARY MOTOR CORTEX; STATISTICAL SIGNIFICANCE; TASK PERFORMANCE; TASK POSITIVE NETWORK; TRAINING; AGING; ANIMAL; BRAIN ISCHEMIA; C57BL MOUSE; COMPARATIVE STUDY; CONVALESCENCE; DISEASE MODEL; ELECTROSTIMULATION; GROWTH, DEVELOPMENT AND AGING; KINESIOTHERAPY; MOTOR CORTEX; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; STROKE;

AGING; ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ENDOTHELIN-1; EXERCISE THERAPY; MALE; MICE, INBRED C57BL; MOTOR CORTEX; MOTOR SKILLS; NEURONAL PLASTICITY; RECOVERY OF FUNCTION; STROKE;

EID: 84920039894     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968314541329     Document Type: Article

References (29)

1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation. 2012 ; 125: e2 - e220
2. Soleman S, Yip P, Leasure JL, Moon L. Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats. Exp Neurol. 2010 ; 222: 13-24
3. Maldonado MA, Allred RP, Felthauser EL, Jones TA. Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats. Neurorehabil Neural Repair. 2008 ; 22: 250-261
4. Alaverdashvili M, Whishaw IQ. Compensation aids skilled reaching in aging and in recovery from forelimb motor cortex stroke in the rat. Neuroscience. 2010 ; 167: 21-30
5. Moore TL, Killiany RJ, Pessina MA, Moss MB, Finklestein SP, Rosene DL. Recovery from ischemia in the middle-aged brain: a nonhuman primate model. Neurobiol Aging. 2012 ; 33: 619.e9-619.e24
6. Nudo RJ, Milliken GW. Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol. 1996 ; 75: 2144-2149
7. Nudo RJ, Wise BM, SiFuentes F, Milliken GW. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 1996 ; 272: 1791-1794
8. Tennant KA, Adkins DL, Scalco MD, et al. Skill learning induced plasticity of motor cortical representations is time and age-dependent. Neurobiol Learn Mem. 2012 ; 98: 291-302
9. Tennant KA, Jones TA. Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in C57BL/6 mice. J Neurosci Methods. 2009 ; 181: 18-26
10. Rouiller EM, Moret V, Liang F. Comparison of the connectional properties of the two forelimb areas of the rat sensorimotor cortex: support for the presence of a premotor or supplementary motor cortical area. Somatosens Mot Res. 1993 ; 10: 269-289
11. Tennant KA, Adkins DL, Donlan NA, et al. The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. Cereb Cortex. 2011 ; 21: 865-876
12. Kleim JA, Barbay S, Nudo RJ. Functional reorganization of the rat motor cortex following motor skill learning. J Neurophysiol. 1998 ; 80: 3321-3325
13. Nishibe M, Barbay S, Guggenmos D, Nudo RJ. Reorganization of motor cortex after controlled cortical impact in rats and implications for functional recovery. J Neurotrauma. 2010 ; 27: 2221-2232
14. Henery CC, Mayhew TM. The cerebrum and cerebellum of the fixed human brain: efficient and unbiased estimates of volumes and cortical surface areas. J Anat. 1989 ; 167: 167-180
15. Smith CD, Umberger GH, Manning EL, et al. Critical decline in fine motor hand movements in human aging. Neurology. 1999 ; 53: 1458-1461
16. Whitall J, McCombe Waller S, Silver KH, Macko RF. Repetitive bilateral arm training with rhythmic auditory cueing improves motor function in chronic hemiparetic stroke. Stroke. 2000 ; 31: 2390-2395
17. Williams BK, Galea MP, Winter AT. What is the functional outcome for the upper limb after stroke?. Aust J Physiother. 2001 ; 47: 19-27
18. Wolf SL, Winstein CJ, Miller JP, et al. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA. 2006 ; 296: 2095-2104
19. Taub E, Uswatte G, King DK, Morris D, Crago JE, Chatterjee A. A placebo-controlled trial of constraint-induced movement therapy for upper extremity after stroke. Stroke. 2006 ; 37: 1045-1049
20. Lum PS, Mulroy S, Amdur RL, Requejo P, Prilutsky BI, Dromerick AW. Gains in upper extremity function after stroke via recovery or compensation: potential differential effects on amount of real-world limb use. Top Stroke Rehabil. 2009 ; 16: 237-253
21. Kleim JA, Bruneau R, VandenBerg P, MacDonald E, Mulrooney R, Pocock D. Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult. Neurol Res. 2003 ; 25: 789-793
22. Kleim JA, Jones TA, Schallert T. Motor enrichment and the induction of plasticity before or after brain injury. Neurochem Res. 2003 ; 28: 1757-1769
23. Frost SB, Barbay S, Friel KM, Plautz EJ, Nudo RJ. Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery. J Neurophysiol. 2003 ; 89: 3205-3214
24. Eisner-Janowicz I, Barbay S, Hoover E, et al. Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey. J Neurophysiol. 2008 ; 100: 1498-1512
25. Gharbawie OA, Karl JM, Whishaw IQ. Recovery of skilled reaching following motor cortex stroke: do residual corticofugal fibers mediate compensatory recovery?. Eur J Neurosci. 2007 ; 26: 3309-3327
26. Zeiler SR, Gibson EM, Hoesch RE, et al. Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke. Stroke. 2013 ; 44: 483-489
27. Kleim JA, Hogg TM, VandenBerg PM, Cooper NR, Bruneau R, Remple M. Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning. J Neurosci. 2004 ; 24: 628-633
28. Ramanathan D, Conner JM, Tuszynski MH. A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A. 2006 ; 103: 11370-11375
29. Heuninckx S, Wenderoth N, Swinnen SP. Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. J Neurosci. 2008 ; 28: 91-99