Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 28, Issue 2, 2015, Pages 134-140

  Kacerovsky, Marian ^a,b   Musilova, Ivana ^b   Jacobsson, Bo ^c,d   Drahosova, Marcela ^b   Hornychova, Helena ^b   Janku, Petr ^e   Prochazka, Martin ^f   Simetka, Ondrej ^g   Andrys, Ctirad ^b  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF OSLO   (Norway)

^e UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^f UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

^g UNIVERSITY OF OSTRAVA   (Czech Republic)

Author keywords

Chorioamnionitis; Inflammatory response; Non invasive sample

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6; INTERLEUKIN 8; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN;

ADULT; AMNION FLUID ANALYSIS; AREA UNDER THE CURVE; ARTICLE; BODY FLUID; CERVICAL FLUID; CONTROLLED STUDY; DACRON POLYESTER SWAB; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUNISITIS; GESTATIONAL AGE; HISTOLOGICAL CHORIOAMNIONITIS; HUMAN; MAJOR CLINICAL STUDY; MEMBRANE RUPTURE; MICROBIAL INVASION OF THE AMNIOTIC CAVITY; NONHUMAN; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PREGNANCY COMPLICATION; PREMATURE LABOR; PRETERM PRELABOR RUPTURE OF MEMBRANE; RECEIVER OPERATING CHARACTERISTIC; SAMPLER; SENSITIVITY AND SPECIFICITY; AMNION; AMNION FLUID; CHEMISTRY; CHORIOAMNIONITIS; METABOLISM; MICROBIOLOGY; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREMATURE FETUS MEMBRANE RUPTURE; UTERINE CERVIX; YOUNG ADULT;

ADULT; AMNION; AMNIOTIC FLUID; BODY FLUIDS; CERVIX UTERI; CHORIOAMNIONITIS; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; YOUNG ADULT;

EID: 84920025241     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2014.908179     Document Type: Article

References (30)

1. Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol 2003;101:178-93.
2. Mercer BM. Preterm premature rupture of the membranes: current approaches to evaluation and management. Obstet Gynecol Clin North Am 2005;32:411-28.
3. Caughey AB, Robinson JN, Norwitz ER. Contemporary diagnosis and management of preterm premature rupture of membranes. Rev Obstet Gynecol 2008;1:11-22.
4. DiGiulio DB, Romero R, Kusanovic JP, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38-57.
5. Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998;179:1254-60.
6. Romero R, Ghidini A, Mazor M, Behnke E. Microbial invasion of the amniotic cavity in premature rupture of membranes. Clin Obstet Gynecol 1991;34:769-78.
7. Tsiartas P, Kacerovsky M, Musilova I, et al. The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2013;26:1332-6.
8. Zanardo V, Vedovato S, Cosmi E, et al. Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome. BJOG 2010;117:94-8.
9. Matsuda Y, Kouno S, Nakano H. The significance of interleukin-6 concentrations in cervicovaginal fluid: its relation to umbilical cord plasma and the influence of antibiotic treatment. J Perinat Med 2000;28:129-32.
10. Jun JK, Yoon BH, Romero R, et al. Interleukin 6 determinations in cervical fluid have diagnostic and prognostic value in preterm premature rupture of membranes. Am J Obstet Gynecol 2000;183: 868-73.
11. Rizzo G, Capponi A, Vlachopoulou A, et al. Interleukin-6 concentrations in cervical secretions in the prediction of intrauter-ine infection in preterm premature rupture of the membranes. Gynecol Obstet Invest 1998;46:91-5.
12. Matsuda Y, Kouno S, Nakano H. Effects of antibiotic treatment on the concentrations of interleukin-6 and interleukin-8 in cervicova-ginal fluid. Fetal Diagn Ther 2002;17:228-32.
13. Ryu A, Park KH, Oh KJ, et al. Predictive value of combined cervicovaginal cytokines and gestational age at sampling for intra-amniotic infection in preterm premature rupture of membranes. Acta Obstet Gynecol Scand 2013;92:517-24.
14. Holst RM, Laurini R, Jacobsson B, et al. Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med 2007; 20:885-93.
15. Holst RM, Mattsby-Baltzer I, Wennerholm UB, et al. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand 2005;84:551-7.
16. Salafia CM, Weigl C, Silberman L. The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol 1989;73:383-9.
17. Romero R, Yoon BH, Mazor M, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1993; 169:839-51.
18. Jacobsson B, Mattsby-Baltzer I, Andersch B, et al. Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes. Acta Obstet Gynecol Scand 2003;82:423-31.
19. Romero R, Salafia CM, Athanassiadis AP, et al. The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology. Am J Obstet Gynecol 1992;166: 1382-8.
20. Romero R, Sepulveda W, Kenney JS, et al. Interleukin 6 determination in the detection of microbial invasion of the amniotic cavity. Ciba Found Symp 1992;167:205-20.
21. Kacerovsky M, Musilova I, Khatibi A, et al. Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid proteins in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2012;25:2014-19.
22. Roberts DJ, Celi AC, Riley LE, et al. Acute histologic chorioamnionitis at term: nearly always noninfectious. PLoS One 2012;7:e31819.
23. Menon R, Camagro C, Thorsen P, et al. Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans. Am J Obstet Gynecol 2008;198:77.e1-7.
24. Menon R, Williams SM, Fortunato SJ. Amniotic fluid interleukin-1 beta and interleukin-8 concentrations: racial disparity in preterm birth. Reprod Sci 2007;14:253-9.
25. Menon R, Thorsen P, Vogel I, et al. Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-alpha and soluble TNF receptors in spontaneous preterm birth. Am J Obstet Gynecol 2008;198:533.e1-10.
26. Fortunato SJ, Lombardi SJ, Menon R. Racial disparity in membrane response to infectious stimuli: a possible explanation for observed differences in the incidence of prematurity. Am J Obstet Gynecol 2004;190:1557-62.
27. Cobo T, Kacerovsky M, Palacio M, et al. Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes. PLoS One 2012;7:e43677.
28. Kacerovsky M, Cobo T, Andrys C, et al. The fetal inflammatory response in subgroups of women with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2013;26:795-801.
29. Tambor V, Kacerovsky M, Andrys C, et al. Amniotic fluid cathelicidin in PPROM pregnancies: from proteomic discovery to assessing its potential in inflammatory complications diagnosis. PLoS One 2012;7:e41164.
30. Andrys C, Kacerovsky M, Drahosova M, et al. Amniotic fluid soluble Toll-like receptor 2 in pregnancies complicated by preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2013; 26:520-7.