Clone wars - The emergence of neoplastic blood-cell clones with aging

New England Journal of Medicine

Volumn 371, Issue 26, 2014, Pages 2523-2525

  Abkowitz, Janis L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

AGE; AGING; ASXL1 GENE; BLOOD CELL; CELL CLONE; CELL RENEWAL; CLONAL HEMATOPOIESIS; DNA REPLICATION; DNMT3A GENE; EDITORIAL; GENE; GENE MUTATION; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; PPM1D GENE; RISK FACTOR; STEM CELL EXPANSION; TELOMERE HOMEOSTASIS; TET2 GENE; TUMOR CELL; BLOOD; CELL TRANSFORMATION; GENETICS; HEMATOLOGIC DISEASE; MUTATION; PHYSIOLOGY;

BLOOD; CELL TRANSFORMATION, NEOPLASTIC; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MUTATION;

EID: 84920000947     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1412902     Document Type: Editorial

References (10)

1. Abkowitz JL, Catlin SN, McCallie MT, Guttorp P. Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. Blood 2002; 100: 2665-7.
2. Catlin SN, Busque L, Gale RE, Guttorp P, Abkowitz JL. The replication rate of human hematopoietic stem cells in vivo. Blood 2011; 117: 4460-6.
3. Walter MJ, Shen D, Ding L, et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med 2012; 366: 1090-8.
4. The Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-74.
5. Cazzola M, Della Porta MG, Malcovati L. The genetic basis of myelodysplasia and its clinical relevance. Blood 2013; 122: 4021-34.
6. Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014; 371: 2488-98.
7. Genovese G, Kähler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med 2014; 371: 2477-87.
8. Xie M, Lu C, Wang J, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med 2014 October 19 (Epub ahead of print).
9. Yoshizoto T, Dumitriu B, Hosokawa K, et al. Chronological analysis of clonal evolution in acquired aplastic anemia. Blood 2014; 123: 253. abstract.
10. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64: 9-29.