Protective effects of royal jelly against testicular damage in streptozotocin-induced diabetic rats

Turkish Journal of Medical Sciences

Volumn 45, Issue 1, 2015, Pages 27-32

  Karaca, Turan ^a   Demirtaş, Selim ^a   Karaboğa, İhsan ^a   Ayvaz, Süleyman ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Diabetes; Proliferation; Royal jelly; Testes

Indexed keywords

CASPASE 3; KI 67 ANTIGEN; ROYAL JELLY; TESTOSTERONE; FATTY ACID; PROTECTIVE AGENT; STREPTOZOCIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; HISTOPATHOLOGY; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; RAT; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; ANIMAL; BLOOD; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; PATHOLOGY; TESTIS;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; FATTY ACIDS; MALE; PROTECTIVE AGENTS; RATS; SEMINIFEROUS TUBULES; STREPTOZOCIN; TESTIS; TESTOSTERONE;

EID: 84920000752     PISSN: 13000144     EISSN: None     Source Type: Journal    
DOI: 10.3906/sag-1311-103     Document Type: Article

References (25)

1. Kim NN, Stankovic M, Cushman TT, Goldstein I, Munarriz R, Traish AM. Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers. BMC Physiol 2006; 6; 1-9.
2. Amaral S, Mota PC, Lacerda B, Alves M, Pereira Mde L, Oliveira PJ, Ramalho-Santos. J. Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats. Mitochondrion 2009; 9: 41-50.
3. Armagan A, Uz E, Yilmaz HR, Soyupek S, Oksay T, Ozcelik N. Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. Asian J Androl 2006; 8: 595-600.
4. Amaral S, Oliveira PJ, Ramalho-Santos J. Diabetes and the impairment of reproductive function: Possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev 2008; 4: 46-54.
5. Annunziata L, Domenico F, Pietro T. Glyco-oxidation in diabetes and related diseases. Clin Chim Acta 2005; 2: 236-250.
6. Kanter M, Aktas C, Erboga M. Curcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic rats. Mol Nutr Food Res 2012; 56: 1-8.
7. Seethalakshmi L, Menon M, Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J Urol 1987; 138: 190-194.
8. Cameron DF, Murray FT, Drylie DD. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. Anat Rec 1985; 213: 53-62.
9. Sadik NAH, El-Seweidy MM, Shaker OG. The antiapoptotic effects of sulphurous mineral water and sodium hydrosulphide on diabetic rat testes. Cell Physiol Biochem 2011; 28: 887-898.
10. Koh PO. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes. J Vet Med Sci 2007; 69: 969-971.
11. Cai L, Hales BF, Robaire B. Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide. Biol Reprod 1997; 56: 1490-1497.
12. Karaca T, Bayiroglu F, Yoruk M, Kaya MS, Uslu S, Comba B, Mis L. Effect of royal jelly on experimental colitis induced by acetic acid and alteration of mast cell distribution in the colon of rats. Eur J Histochem 2010; 21: 54: e35.
13. Elnagar SA. Royal jelly counteracts bucks’ “summer infertility”. Anim Reprod Sci 2010; 121: 174-180.
14. Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi ST, Yamaguchi M. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid-Based Compl Alt Med 2006; 3: 339-348.
15. Johnsen SG. Testicular biopsy score count - a method for registration of spermatogenesis in human testes. Normal values and results of 335 hypogonadal males. Hormones 1970; 1: 2-25.
16. Cameron DF, Rountree J, Schultz RE, Repetta D, Murray FT. Sustained hyperglycemia results in testicular dysfunction and reduced fertility potential in BBWOR diabetic rats. Am J Physiol 1990; 259: E881-E889.
17. Kushwaha S, Jena GB. Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms. Mut Res 2013; 755: 11-23.
18. Hakim LS, Goldstein I. Diabetic sexual dysfunction. Endocrinol Metab Clin N Am 1996; 25; 379-400.
19. Fujihara N, Koga O, Nishiyama H. Secretory function of the ductus deferens of male chickens. Poultry Sci 1983; 62: 557-560.
20. Karacal F, Aral F. Effect of the royal jelly on sperm quality in mice. Indian Vet J 2008; 85: 331-332.
21. Kohguchi M, Inoue S, Ushio S, Iwaki K, Ikeda M, Kurimoto M. Effect of royal jelly diet on the testicular function of hamsters. Food Sci Technol Res 2004; 10: 420-423.
22. Yang A, Zhou M, Zhang L, Xie G, Chen H, Liu Z, Ma W. Influence of royal jelly on the reproductive function of puberty male rats. Food Chem Toxicol 2012; 50: 1834-1840.
23. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-322.
24. Tsounapi P, Saito M, Dimitriadis F, Koukos S, Shimizu S, Satoh K, Takenaka A, Sofikitis N. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Mol Cell Biochem 2012; 369: 195-204.
25. Cai L, Chen S, Evans T, Deng DX, Mukherjee K, Chakrabarti S. Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism. Urol Res 2000; 28: 342-347.