Lyme disease: Diagnostic issues and controversies

Expert Review of Molecular Diagnostics

Volumn 15, Issue 1, 2015, Pages 1-4

  Aguero Rosenfeld, Maria E ^a   Wormser, Gary P ^b  

^a BELLEVUE HOSPITAL CENTER   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Controversy; diagnostic issues; Lyme disease; misdiagnosis; misinformation

Indexed keywords

DNA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; BACTERIUM ANTIBODY;

BORRELIA BURGDORFERI; DIAGNOSTIC PROCEDURE; DNA SEQUENCE; FALSE POSITIVE RESULT; FOOD AND DRUG ADMINISTRATION; HEALTH CARE FACILITY; HEALTH CARE PERSONNEL; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; IN VITRO STUDY; LYME DISEASE; REVIEW; UNITED STATES; ANIMAL; BLOOD; DIAGNOSTIC ERROR; IMMUNOLOGY; MICROBIOLOGY;

ANIMALS; ANTIBODIES, BACTERIAL; BORRELIA BURGDORFERI; DIAGNOSTIC ERRORS; HUMANS; LYME DISEASE;

EID: 84919926864     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.989837     Document Type: Review

References (18)

1. Steere AC, Grodzicki RL, Kornblatt AN, et al. The spirochetal etiology of Lyme disease. N Engl J Med 1983;308:733-40
2. Auwaerter PG, Bakken JS, Dattwyler RJ, et al. Antiscience and ethical concerns associated with advocacy of Lyme disease. Lancet Infect Dis 2011;11:713-19
3. Steere AC. Lyme disease. N Engl J Med 2001;345:115-25
4. Dressler F, Whalen JA, Reinhardt BN, Steere AC. Western blotting in the serodiagnosis of Lyme disease. J Infect Dis 1993;167:392-400
5. Aguero-Rosenfeld ME, Nowakowski J, Bittker S, et al. Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans. J Clin Microbiol 1996;34:1-9
6. Lawrenz MB, Hardham JM, Owens RT, et al. Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi. J Clin Microbiol 1999;37: 3997-4004
7. Centers for Disease Control and Prevention. Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease. Morb Mortal Wkly Rep 1995;44: 590-1
8. Bacon RM, Biggerstaff BJ, Schriefer ME, et al. Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J Infect Dis 2003;187:1187-99
9. Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment, treatment and prevention of Lyme disease, human granulocytic anaplasmosis and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006;43:1089-134
10. Hinckley AF, Connally NP, Meek JI, et al. Lyme disease testing by large commercial laboratories in the United States. Clin Infect Dis 2014;59:676-81
11. Brett ME, Hinckley AF, Zielinski-Gutierrez EC, Meade PS. U.S. healthcare providers' experience with Lyme and other tick-borne diseases. Ticks Tick Borne Dis 2014;5:404-8
12. Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. Diagnosis of Lyme borreliosis. Clin Microbiol Rev 2005;18:484-509
13. Wormser GP, Bittker S, Cooper D, et al. Yield of large-volume blood cultures in patients with early Lyme disease. J Infect Dis 2001;184:1070-2
14. Phillips SE, Mattman LH, Hulinska D, Moayad H. A proposal for the reliable culture of Borrelia burgdorferi from patients with chronic Lyme disease, even from those previously aggressively treated. Infection 1998;26:364-7
15. Sapi E, Pabbati N, Datar A, et al. Improved culture conditions for the growth and detection of Borrelia from human serum. Int J Med Sci 2013;10:362-76
16. Johnson BJB, Pilgard MA, Russell TM. Assessment of a new culture method to detect Borrelia species in serum of Lyme disease patients. J Clin Microbiol 2014;52: 721-4
17. Klempner MS, Schmid CH, Hu L, et al. Intralaboratory reliability of serologic and urine testing for Lyme disease. Am J Med 2001;110:217-19
18. Fallon BA, Pavlicova M, Coffino SW, Brenner C. A comparison of Lyme disease serologic test results from four laboratories in patients with persistent symptoms after antibiotic treatment. Clin Infect Dis 2014. [Epub ahead of print]