MicroRNA-29s could target AKT2 to inhibit gastric cancer cells invasion ability

Medical Oncology

Volumn 32, Issue 1, 2015, Pages 1-7

  Zhang, Hongkai ^a   Cheng, Yin ^a   Jia, Congwei ^a   Yu, Shuangni ^a   Xiao, Yu ^a   Chen, Jie ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

AKT2; Cell line; Gastric cancer; MicroRNAs; siRNA

Indexed keywords

MICRORNA 29; MICRORNA 29A; MICRORNA 29B; MICRORNA 29C; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG; AKT2 PROTEIN, HUMAN; MICRORNA; MIRN29 MICRORNA, HUMAN; PROTEIN KINASE B; SMALL INTERFERING RNA;

ARTICLE; CELL INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR THERAPY; PROTEIN EXPRESSION; STOMACH CANCER; BIOSYNTHESIS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; STOMACH TUMOR; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICRORNAS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84919922583     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0342-8     Document Type: Article

References (19)

1. Piazuelo MB, Correa P. Gastric cáncer: overview. Colomb Med (Cali). 2013;44:192–201.
2. Chen W, Zheng R, Zhang S, et al. Annual report on status of cancer in China, 2010. Chin J Cancer Res. 2014;26:48–58.
3. Acunzo M, Romano G, Wernicke D et al. MicroRNA and cancer—a brief overview. Adv Biol Regul. 2014. pii:S2212-4926:00052-9.
4. Shrestha S, Hsu SD, Huang WY, et al. A systematic review of microRNA expression profiling studies in human gastric cancer. Cancer Med. 2014;3(4):878–88.
5. Shin VY, Chu KM. MiRNA as potential biomarkers and therapeutic targets for gastric cancer. World J Gastroenterol. 2014;20:10432–9.
6. Jiang H, Zhang G, Wu JH, et al. Diverse roles of miR-29 in cancer (review). Oncol Rep. 2014;3:1509–16.
7. Wu DW, Hsu NY, Wang YC et al. c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT. Oncogene. 2014. doi:10.1038/onc.2014.152.
8. Yu PN, Yan MD, Lai HC, et al. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer. 2014;134:542–51.
9. Xu XD, Wu XH, Fan YR, et al. Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1. Asian Pac J Cancer Prev. 2014;15:3471–6.
10. Rostas JW 3rd, Pruitt HC, Metge BJ, et al. microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer. Mol Cancer. 2014;13:200.
11. Chen L, Xiao H, Wang ZH, et al. miR-29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF-A. BMB Rep. 2014;47:39–44.
12. Gong J, Li J, Wang Y, et al. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014;35:497–506.
13. Matsuo M, Nakada C, Tsukamoto Y, et al. MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2. Mol Cancer. 2013;12:15.
14. Cui Y, Su WY, Xing J, et al. MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer. PLoS One. 2011;6:e25872.
15. Lang N, Liu M, Tang QL, et al. Effects of microRNA-29 family members on proliferation and invasion of gastric cancer cell lines. Chin J Cancer. 2010;29:603–10.
16. Romano G. The role of the dysfunctional Akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development. Scientifica (Cairo). 2013;2013:317186.
17. Liu LL, Lu SX, Li M, et al. FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget. 2014;5:5113–24.
18. Wang L, Yao J, Zhang X, et al. miRNA-302b suppresses human hepatocellular carcinoma by targeting AKT2. Mol Cancer Res. 2014;12(190–202):9.
19. Gong JN, Yu J, Lin HS, et al. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ. 2014;21:100–12.