Antimicrobial Distribution From Local Delivery Depends on Dose: A Pilot Study With MRI

Clinical Orthopaedics and Related Research

Volumn 472, Issue 11, 2014, Pages 3324-3329

  McLaren, Alex ^a   Giers, Morgan B ^b   Fraser, James ^a   Hosack, Luke ^a   Caplan, Michael R ^b   McLemore, Ryan ^a  

^a BANNER GOOD SAMARITAN MEDICAL CENTER   (United States)

^b Arizona State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BONE CEMENT; GADOLINIUM PENTETATE; GENTAMICIN; CONTRAST MEDIUM; DRUG IMPLANT; METHACRYLIC ACID METHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MEGADOSE; LOADING DRUG DOSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PILOT STUDY; POSTOPERATIVE PAIN; QUADRICEPS FEMORIS MUSCLE; RABBIT MODEL; SOFT TISSUE; TIME; TISSUE DISTRIBUTION; TREATMENT DURATION; VOLUME OF DISTRIBUTION; ADMINISTRATION AND DOSAGE; ANALYSIS OF VARIANCE; ANIMAL; CHEMISTRY; DEBRIDEMENT; DEVICES; DIAGNOSTIC USE; DOSE RESPONSE; DRUG IMPLANT; PATHOLOGY; PHARMACOKINETICS; PROCEDURES; RABBIT; SURGERY; THIGH;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFECTIVE AGENTS; CONTRAST MEDIA; DEBRIDEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; METHYLMETHACRYLATE; MODELS, ANIMAL; PILOT PROJECTS; RABBITS; THIGH; TISSUE DISTRIBUTION;

EID: 84919871182     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-014-3493-1     Document Type: Article

References (24)

1. Adams K, Couch L, Cierny G, Calhoun J, Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop Relat Res. 1992;278:244–252.
2. Aime S, Delli Castelli D, Fedeli F, Terreno E. A paramagnetic MRI-CEST agent responsive to lactate concentration. J Am Chem Soc. 2002;124:9364–9365.
3. Altman DG. Practical Statistics for Medical Research. 2nd ed. Boca Raton, FL: Chapman & Hall/CRC; 2006.
4. Buchholz HW, Elson RA, Engelbrecht E, Lodenkämper H, Röttger J, Siegel A. Management of deep infection of total hip replacement. J Bone Joint Surg Br. 1981;63:342–353.
5. Butterfield JM, Patel N, Pai MP, Rosano TG, Drusano GL, Lodise TP. Refining vancomycin protein binding estimates: identification of clinical factors that influence protein binding. Antimicrob Agents Chemother. 2011;55:4277–4282.
6. Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003;414:7–24.
7. Coyle MB. Manual of Antimicrobial Susceptibility Testing. Washington, DC: American Society for Microbiology; 2005.
8. Cunningham B, McLaren A, Pauken C, McLemore R. Liposomal formulation increases local delivery of amphotericin from bone cement: a pilot study. Clin Orthop Relat Res. 2012;470:2671–2676.
9. De Kievit TR, Parkins MD, Gillis RJ, Srikumar R, Ceri H, Poole K, Iglewski BH, Storey DG. Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2001;45:1761–1770.
10. Diefenbeck M, Mückley T, Hofmann GO. Prophylaxis and treatment of implant-related infections by local application of antibiotics. Injury. 2006;37(suppl 2):S95–S104.
11. DiResta GR, Manoso MW, Naqvi A, Zanzonico P, Smith-Jones P, Tyler W, Morris C, Healey JH. Bisphosphonate delivery to tubular bone allografts. Clin Orthop Relat Res. 2008;466:1871–1879.
12. Dufour P, Gillet Y, Bes M, Lina G, Vandenesch F, Floret D, Etienne J, Richet H. Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis. 2002;35:819–824.
13. Giers MB, Estes CS, McLaren AC, Caplan MR, McLemore R. Jeannette Wilkins Award. Can locally delivered gadolinium be visualized on MRI? A pilot study. Clin Orthop Relat Res. 2012;470:2654–2662.
14. Giers MB, McLaren AC, Plasencia JD, Frakes D, McLemore R, Caplan MR. Spatiotemporal quantification of local drug delivery using MRI. Comput Math Methods Med. 2013;2013:149608.
15. Hanssen AD. Local antibiotic delivery vehicles in the treatment of musculoskeletal infection. Clin Orthop Relat Res. 2005;437:91–96.
16. Hanssen AD, Spangehl MJ. Practical applications of antibiotic-loaded bone cement for treatment of infected joint replacements. Clin Orthop Relat Res. 2004;427:79–85.
17. Iarikov D, Demian H, Rubin D, Alexander J, Nambiar S. Choice and doses of antibacterial agents for cement spacers in treatment of prosthetic joint infections: review of published studies. Clin Infect Dis. 2012;55:1474–1480.
18. Kweon C, McLaren AC, Leon C, McLemore R. Amphotericin B delivery from bone cement increases with porosity but strength decreases. Clin Orthop Relat Res. 2011;469:3002–3007.
19. Lewis G, Bhattaram A. Influence of a pre-blended antibiotic (gentamicin sulfate powder) on various mechanical, thermal, and physical properties of three acrylic bone cements. J Biomater Appl. 2006;20:377–408.
20. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57:6–14.
21. McLaren A, Nugent M, Economopoulos K, Kaul H, Vernon B, McLemore R. Hand-mixed and premixed antibiotic-loaded bone cement have similar homogeneity. Clin Orthop Relat Res. 2009;467:1693–1698.
22. Miller R, McLaren A, Leon C, McLemore R. Mixing method affects elution and strength of high-dose ALBC: a pilot study. Clin Orthop Relat Res. 2012;470:2677–2683.
23. Nugent M, McLaren A, Vernon B, McLemore R. Strength of antimicrobial bone cement decreases with increased poragen fraction. Clin Orthop Relat Res. 2010;468:2101–2106.
24. Odgers R, Jarbo K, McLaren A, McLemore R. Distribution of locally delivered antimicrobials is limited by cortical bone: a pilot study. Clin Orthop Relat Res. 2013;471:3141–3146.