Human papillomavirus transcription

The Papillomaviruses

Volumn , Issue , 2007, Pages 109-144

  Chowand, Louise T ^a   Broker, Thomas R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84919845342     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-36523-7_7     Document Type: Chapter

References (215)

1. Ai, W., Narahari, J., and Roman, A. (2000). Yin yang 1 negatively regulates the differentiation-specific E1 promoter of human papillomavirus type 6. J. Virol. 74:5198-5205.
2. Ai, W., Toussaint, E., and Roman, A. (1999). CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters. J. Virol. 73:4220-4229.
3. Alloul, N., and Sherman, L. (1999). The E2 protein of human papillomavirus type 16 is translated from a variety of differentially spliced polycistronic mRNAs. J. Gen. Virol. 80:29-37.
4. Asselineau, D., and Prunieras, M. (1984). Reconstruction of 'simplified' skin: control of fabrication. Br. J. Dermatol. 111(27 Suppl.):219-222.
5. Badal, S., Badal, V., Calleja-Macias, I. E., Kalantari, M., Chuang, L. S., Li, B. F., and Bernard, H.-U. (2004). The human papillomavirus-18 genome is efficiently targeted by cellular DNA methylation. Virology 324:483-492.
6. Badal, V., Chuang, L. S., Tan, E. H., Badal, S., Villa, L. L., Wheeler, C. M., Li, B. F., and Bernard, H.-U. (2003). CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J. Virol. 77:6227-6234.
7. Baker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gond, M. A., and Howley, P. M. (1987). Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol. 61:962-971.
8. Banks, L., Pim, D., and Thomas, M. (2003). Viruses and the 26S proteasome: hacking into destruction. Trends Biochem. Sci. 28:452-459.
9. Baxter, M. K., McPhillips, M. G., Ozato, K., and McBride, A. A. (2005). The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J. Virol. 79:4806-4818.
10. Bechtold, V., Beard, P., and Raj, K. (2003). Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA. J. Virol. 77:2021-2128.
11. Belaguli, N. S., Pater, M. M., and Pater, A. (1992). Nucleotide 880 splice donor site required for efficient transformation and RNA accumulation by human papillomavirus type 16 E7 gene. J. Virol. 66:2724-2730.
12. Bernard, B. A., Bailly, C., Lenoir, M. C., Darmo, M., Thierry, F., and Yaniv, M. (1989). The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. J. Virol. 63:4317-4324.
13. Bernard, H.-U. (2002). Gene expression of genital human papillomaviruses and considerations on potential antiviral approaches. Antivir. Ther. 7:219-237.
14. Blanton, R. A., Coltrera, M. D., Gown, A. M., Halbert, C. L., and McDougall, J. K. (1992). Expression of the HPV16 E7 gene generates proliferation in stratified squamous cell cultures which is independent of endogenous p53 levels. Cell Growth Differ. 3:791-802.
15. Bodily, J. M., and Meyers, C. (2005). Genetic analysis of the human papillomavirus type 31 differentiation-dependent late promoter. J. Virol. 79:3309-3321.
16. Bohm, S., Wilczynski, S. P., Pfister, H., and Iftner, T. (1993). The predominant mRNA class in HPV16-infected genital neoplasias does not encode the E6 or the E7 protein. Int. J. Cancer 55:791-798.
17. Bouallaga, I., Teissier, S., Yaniv, M., and Thierry, F. (2003). HMG-I (Y) and the CBP/p300 coactivator are essential for human papillomavirus type 18 enhanceosome transcriptional activity. Mol. Cell. Biol. 23:2329-2340.
18. Broker, T. R., and Botchan, M. (1986). Papillomaviruses: Retrospectives and prospectives. Cancer Cells 4:17-36.
19. Bromberg-White, J. L., Sen, E., Alam, S., Bodily, J. M., and Meyers, C. (2003). Induction of the upstream regulatory region of human papillomavirus type 31 by dexamethasone is differentiation dependent. J. Virol. 77:10975-10983.
20. Brown, D. R., Chin, M. T., and Strike, D. G. (1988). Identification of human papillomavirus type 11 E4 gene products in human tissue implants from athymic mice. Virology 165:262-267.
21. Brown, D. R., McClowry, T. L., Sidner, R. A., Fife, K. H., and Bryan, J. T. (1998). Expression of the human papillomavirus type 11 E5A protein from the E1E4, E5 transcript. Intervirology 41:47-54.
22. Brown, D. R., Pratt, L., Bryan, J. T., Fife, K. H., and Jansen, K. (1996). Viruslike particles and E1E4 protein expressed from the human papillomavirus type 11 bicistronic E1E4L1 transcript. Virology 222:43-50.
23. Bryan, J. T., and Brown, D. R. (2001). Transmission of human papillomavirus type 11 infection by desquamated cornified cells. Virology 281:35-42.
24. Butel, J. S. (1972). Studies with human papilloma virus modeled after known papovavirus systems. J. Natl. Cancer Inst. 48:285-299.
25. Cheng, S., Schmidt-Grimminger, D.-C, Murant, T., Broker, T. R., and Chow, L. T. (1995). Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev. 9:2335-2349.
26. Chiang, C.-M., Broker, T. R., and Chow, L. T. (1991). An E1MAE2C fusion protein encoded by human papillomavirus type 11 is a sequence specific transcription repressor. J. Virol. 65:3317-3329.
27. Chiang, C.-M., Ustav, M., Stenlund, A., Ho, T. F., Broker, T. R., and Chow, L. T. (1992b). Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins. Proc. Natl. Acad. Sci. USA 89:5799-5803.
28. Chien, W.-M., Noya, F., Benedict-Hamilton, H. M., Broker, T. R., and Chow, L. T. (2002). Alternative fates of keratinocytes transduced by human papillomavirus type 18 E7 during squamous differentiation. J. Virol. 76:2964-2972.
29. Chien, W.-M., Parker, J. N., Schmidt-Grimminger, D.-C, Broker, T. R., and Chow, L. T. (2000). Casein kinase II phosphorylation of the human papillomavirus-18 E7 protein is critical for promoting S phase entry. Cell Growth Differ. 11:425-435.
30. Chin, M. T., Hirochika, R., Hirochika, H., Broker, T. R., and Chow, L. T. (1988). Regulation of the human papillomavirus type 11 enhancer and E6 promoter by activating and repressing proteins from the E2 open reading frame: functional and biochemical studies. J. Virol. 62:2994-3002.
31. Chin, M. T., Broker, T. R., and Chow, L. T. (1989). Identification of a novel constitutive enhancer element and its associated binding protein: Implications for human papillomavirus type 11 enhancer regulation. J. Virol. 63:2967-2976.
32. Chow, L. T., and Broker, T. R. (1997a). Small DNA tumor viruses. In N. Nathanson (ed.): Viral Pathogenesis. Philadelphia, PA: Lippincott-Raven Publishers, pp. 267-302.
33. Chow, L. T., and Broker, T. R. (1997b). In vitro experimental systems for HPV: Epithelial raft cultures for viral reproduction and pathogenesis and for genetic analyses of viral proteins and regulatory sequences. Clin. Dermatol. 15:217-227.
34. Chow, L. T., and Broker, T. R. (2006a). Mechanisms and regulation of papillomavirus DNA replication. In M. S. Campo (ed.): Recent Advances in Papillomavirus Research. Caister Academic Press. pp. 53-71.
35. Chow, L. T., and Broker, T. R. (2006b). Human papillomavirus infections: warts or cancer? In M. DePamphilis (ed.): DNA Replication and Human Disease. pp. 609-625, chapter 30. Cold Spring Harbor Laboratory Press.
36. Chow, L. T., Nasseri, M., Wolinsky, S. M., and Broker, T. R. (1987a). Human papilloma virus type 6 and 11 mRNAs from genital condylomata acuminata. J. Virol. 61:2581-2588.
37. Chow, L. T., Reilly, S., Broker, T. R., and Taichman, L. (1987b). Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures. J. Virol. 61:1913-1918.
38. Collier, B., Oberg, D., Zhao, X., and Schwartz, S. (2002). Specific inactivation of inhibitory sequences in the 5' end of the human papillomavirus type 16 L1 open reading frame results in production of high levels of L1 protein in human epithelial cells. J. Virol. 76:2739-2752.
39. Crum, C. P, Nuovo, G., Friedman, D., and Silverstein, S. J. (1988). Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers. J. Virol. 62:84-90.
40. Cumming, S. A., Repellin, C. E., McPhillips, M., Radford, J. C., Clements, J. B., and Graham, S. V. (2002). The human papillomavirus type 31 late 3' untranslated region contains a complex regulatory element. J. Virol. 76:5993-6003.
41. De Filippis, R. A., Goodwin, E. C., Wu, L., and Di Maio, D. (2003). Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J. Virol. 77:1551-1563.
42. Del Mar Pena, L. M., and Laimins, L. A. (2001). Differentiation-dependent chromatin rearrangement coincides with activation of human papillomavirus type 31 late gene expression. J. Virol. 75:10005-10013.
43. Demeret, C, Garcia-Carranca, A., and Thierry, F. (2003). Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene 16:168-175.
44. Demers, G. W., Halbert, C. L., and Galloway, D. A. (1994). Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene. Virology 198:169-174.
45. Demeter, L. M., Stoler, M. H., Broker T. R., and Chow, L. T. (1994). Induction of proliferating cell nuclear antigen (PCNA) in differentiated epithelium in productively infected human papillomavirus-infected lesions. Hum. Pathol. 25:343-348.
46. Deng, W., Jin, G., Lin, B. Y., Van Tine, B. A., Broker, T. R., and Chow, L. T. (2003). mRNA splicing regulates human papillomavirus type 11 E1 protein production and DNA replication. J. Virol. 77:10213-10226.
47. Deng, W., Lin, B. Y., Jin, G., Wheeler, C, Ma, T., Harper, J. W., Broker, T. R., and Chow, L. T. (2004). Cyclin/CDK regulates the nucleo-cytoplasmic localization of the human papillomavirus E1 DNA helicase. J. Virol. 78:13954-13965.
48. Desaintes, C, Demeret, C, Goyat, S., Yaniv, M., and Thierry, F. (1997). Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J. 16:504-514.
49. De Villiers, E.-M., Fauquet, C, Broker, T. R., Bernard, H.-U., and Zur Hausen, H. (2004). Classification of papillomaviruses. Virology 324:17-27.
50. Di Lorenzo, T. P., and Steinberg, B. M. (1995). Differential regulation of human papillomavirus type 6 and 11 early promoters in cultured cells derived from laryngeal papillomas. J. Virol. 69:6865-6872.
51. Dietrich-Goetz, W., Kennedy, I. M., Levins, B., Stanley, M. A., and Clements, J. B. (1997). A cellular 65-kDa protein recognizes the negative regulatory element of human papillomavirus late mRNA. Proc. Natl. Acad. Sci. USA 94:163-168.
52. Dilts, D. P., Broker, T. R., and Chow, L. T. (1990). The structures of human papillomavirus type 1 and type 16 messenger RNAs determined by polymerase chain reaction. In P. Howley, and T. Broker (eds): Papillomaviruses. UCLA Symp. Mol. Cell. Biol. 124:533-540. New York, NY: Alan R. Liss.
53. Dollard, S. C., Broker, T. R., and Chow L. T. (1993). Regulation of the human papillomavirus type-11 E6 promoter by viral and host transcription factors in primary human keratinocytes. J. Virol. 67:1721-1726.
54. Dollard, S. C., Wilson, J. L., Demeter, L. M., Bonnez, W., Reichman, R. C., Broker, T. R., and Chow, L. T. (1992). Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. Genes Dev. 6:1131-1142.
55. Dong, G., Broker, T. R., and Chow, L. T. (1994a). Human papillomavirus type-11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements. J. Virol. 68:1115-1127.
56. Dong, X. P., Stubenrauch, F., Beyer-Finkler, E., and Pfister, H. (1994b). Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers. Int. J. Cancer 58:803-808.
57. Doorbar, J., Parton, A., Hartley, K., Banks, L., Crook, T., Stanley, M., and Crawford, L. (1990). Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line. Virology 178:254-262.
58. Dostatni, N., Lambert, P. F., Sousa, R., Ham, J., Howley, P. M, and Yaniv, M. (1991). The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex. Genes Dev. 5:1657-1671.
59. Dowhanick, J. J., McBride, A. A., and Howley, P. M. (1995). Suppression of cellular proliferation by the papillomavirus E2 protein. J. Virol. 69:7791-7799.
60. Dürst, M., Gissmann, L., Ikenberg, H., and Zur Hausen, H. (1983). A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80:3812-3815.
61. Egawa, K., Iftner, A., Doorbar, J., Honda Y., and Iftner, T. (2000). Synthesis of viral DNA and late capsid protein L1 in parabasal spinous cell layers of naturally occurring benign warts infected with human papillomavirus type 1. Virology 268:281-293.
62. Eichten, A., Westfall, M., Pietenpol, J. A., and Münger, K. (2002). Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein. Virology 295:74-85.
63. Fang, L., Budgeon, L. R., Doorbar, J., Briggs, E. R., and Howett, M. K. (2006a). The human papillomavirus type 11 E1-E4 protein is not essential for viral genome amplification. Virology 351:271-279.
64. Fang, L., Meyers, C., Budgeon, and Howett, M. K. (2006b). Induction of productive human papillomavirus type 11 life cycle in epithelial cells grown in organotypic raft cultures. Virology 347:28-35.
65. Farr, A., Pattison, S., Youn, B. S., and Roman, A. (1995). Detection of silencer activity in the long control regions of human papillomavirus type 6 isolated from both benign and malignant lesions. J. Gen. Virol. 76:827-835.
66. Flores, E. R., Allen-Hoffmann, B. L., Lee, D., and Lambert, P. F. (2000). The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J. Virol. 74:6622-6631.
67. Flores, E. R., Allen-Hoffmann, B. L., Lee, D., Sattler, C. A., and Lambert, P. F. (1999). Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology 262:344-354.
68. Francis, D. A., Schmid, S. I., and Howley, P. M. (2000). Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J. Virol. 74:2679-2686.
69. Frattini, M. G., Hurst, S. D., Lim, H. B., Swaminathan, S., and Laimins, L. A. (1997a). Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein. EMBO J. 16:318-331.
70. Frattini, M. G., Lim, H. B., Doorbar, J., and Laimins, L. A. (1997b). Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates. J. Virol. 71:7068-7072.
71. Frattini, M. G., Lim, H. B., and Laimins, L. A. (1996). In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. Proc. Natl. Acad. Sci. USA 93:3062-3067.
72. Fuchs, E. (1993). Epidermal differentiation and keratin gene expression. J. Cell. Sci. Suppl. 17:197-208.
73. Garner-Hamrick, P. A., Fostel, J. M., Chien, W.-M., Banerjee, N. S., Chow, L. T., Broker, T. R., and Fisher, C. (2004). Global effects of human papillomavirus 18 (HPV-18) E6/E7 in an organotypic culture system. J. Virol. 78:9041-9050.
74. Glahder, J. A., Hansen, C. N., Vinther, J., Madsen, B. S., and Norrild, B. (2003). A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA. J. Gen. Virol. 84:3429-3441.
75. Goodwin, E. C., and Di Maio, D. (2000). Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. USA 97:12513-12518.
76. Goodwin, E. C, Naeger, L. K., Breiding, D. E., Androphy, E. J., and Di Maio, D. (1998). Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol. 72:3925-3934.
77. Grassmann, K., Rapp, B., Maschek, H., Petry, K. U., and Iftner, T. (1996). Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA. J. Virol. 70:2339-2349.
78. Guccione, E., Pim, D., and Banks, L. (2004). HPV-18 E6∗I modulates HPV-18 full-length E6 functions in a cell cycle dependent manner. Int. J. Cancer 110:928-933.
79. Halbert, C. L., Demers, G. W., and Galloway, D. A. (1992). The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J. Virol. 66:2125-2134.
80. Halbert, C. L., and Galloway, D. A. (1988). Identification of the E5 open reading frame of human papillomavirus type 16. J. Virol. 62:1071-1075.
81. Hawley-Nelson, P., Androphy, E. J., Lowy, D. R., and Schiller, J. T. (1988). The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer. EMBO J. 7:525-531.
82. Higgins, G. D., Uzelin, D. M., Phillips, G. E., and Burrell, C. J. (1991). Presence and distribution of human papillomavirus sense and antisense RNA transcripts in genital cancers. J. Gen. Virol. 72:885-895.
83. Higgins, G. D., Uzelin, D. M., Phillips, G. E., McEvoy, P., Marin, R., and Burrell, C. J. (1992). Transcription patterns of human papillomavirus type 16 in genital intraepithelial neoplasia: evidence for promoter usage within the E7 open reading frame during epithelial differentiation. J. Gen. Virol. 73:2047-2057.
84. Hirochika, H., Broker, T. R., and Chow, L. T. (1987). Enhancers and trans-acting E2 transcriptional factors of papilloma viruses. J. Virol. 61:2599-2606.
85. Hirochika, H., Hirochika, R., Broker, T. R., and Chow, L. T. (1988). Functional mapping of the human papillomavirus transcriptional enhancer and its complexes with the transacting E2 protein. Genes Dev. 2:54-67.
86. Hopman, A. H. N., Smedts, F., Dignef, W., Ummelen, M., Sonke, G., Mravunac, M., Vooijs, G. P., Speel, E. J., and Ramaekers, F. C. (2004). Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J. Pathol. 202:23-33.
87. Horner, S. M., De Filippis, R. A., Manuelidis, L., and Di Maio, D. (2004). Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. J. Virol. 78:4063-4073.
88. Hou, S. Y., Wu, S.-Y., and Chiang, C.-M. (2002). Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding. J. Biol. Chem. 277:45619-45629.
89. Hou, S. Y., Wu, S.-Y., Zhou, T., Thomas, M. C., and Chiang, C.-M. (2000). Alleviation of human papillomavirus E2-mediated transcriptional repression via formation of a TATA binding protein (or TFIID)-TFIIB-RNA polymerase II-TFIIF preinitiation complex. Mol. Cell Biol. 20:113-125.
90. Hubert, W. G., Kanaya, T., and Laimins, L. A. (1999). DNA replication of human papillomavirus type 31 is modulated by elements of the upstream regulatory region that lie 5' of the minimal origin. J. Virol. 73:1835-1845.
91. Hubert, W. G., and Laimins, L. A. (2002). Human papillomavirus type 31 replication modes during the early phases of the viral life cycle depend on transcriptional and posttranscriptional regulation of E1 and E2 expression. J. Virol. 76:2263-2273.
92. Hummel, M., Hudson, J. B., and Laimins, L. A. (1992). Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. J. Virol. 66:6070-6080.
93. Hwang, E. S., Riese, D. J. II, Settleman, J., Nilson, L. A., Honig, J., Flynn, S., and Di Maio, D. (1993). Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J. Virol. 67:3720-3729.
94. Iftner, T., Oft, M., Bohm, S., Wilczynski, S. P., and Pfister, H. (1992). Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium. J. Virol. 66:4639-4646.
95. Ilves, I., Kivi, S., and Ustav, M. (1999). Long-term episomal maintenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which is mediated by the viral E2 protein and its binding sites. J. Virol. 73:4404-4412.
96. Inagaki, Y., Tsunokawa, Y., Takebe, N., Nawa, H., Nakanishi, S., Terada, M., and Sugimura, T. (1988). Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells. J. Virol. 62:1640-1646.
97. Jeon, S., Allen-Hoffmann, B. L., and Lambert, P. F. (1995). Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J. Virol. 69:2989-2997.
98. Jeon, S., and Lambert, P. F. (1995). Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl. Acad. Sci. USA 92:1654-1658.
99. Jian, Y., Schmidt-Grimminger, D.-C, Wu, X., Broker, T. R., and Chow, L. T. (1998). Post-transcriptional induction of p21cip1 protein by HPV E7 in differentiated epithelial cells inhibits reactivated unscheduled DNA synthesis. Oncogene 17:2027-2038.
100. Jian, Y., Van Tine, B. A., Chien, W.-M., Shaw, G. M., Broker, T. R., and Chow, L. T. (1999). Concordant induction of cyclin E and p21cip1 in differentiated keratinocytes by the HPV E7 protein inhibits cellular and viral DNA synthesis. Cell Growth Differ. 10:101-111.
101. Kalantari, M., Calleja-Macias, I. E., Tewari, D., Hagmar, B., Lie, K., Barrera-Saldana, H. A., Wiley, D. J., and Bernard, H.-U. (2004). Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia. J. Virol. 78:12762-12772.
102. Kanaya, T., Kyo, S., and Laimins, L. A. (1997). The 5' region of the human papillomavirus type 31 upstream regulatory region acts as an enhancer which augments viral early expression through the action of YY1. Virology 237:159-169.
103. Kim, K., Garner-Hamrick, P. A., Fisher, C, Lee, D., and Lambert, P. F. (2003). Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J. Virol. 77:12450-12459.
104. Klaes, R., Woerner, S. M., Ridder, R., Wentzensen, N., Dürst, M., Schneider, A., Lotz, B., Melsheimer, P., and Von Knebel Doeberitz, M. (1999). Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res. 59:6132-6136.
105. Klumpp, D. J., and Laimins, L. A. (1999). Differentiation-induced changes in promoter usage for transcripts encoding the human papillomavirus type 31 replication protein E1. Virology 257:239-246.
106. Klumpp, D. J., Stubenrauch, F., and Laimins, L. A. (1997). Differential effects of the splice acceptor at nucleotide 3295 of human papillomavirus type 31 on stable and transient viral replication. J. Virol. 71:8186-8194.
107. Koffa, M. D., Graham, S. V., Takagaki, Y., Manley, J. L., and Clements, J. B. (2000). The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels. Proc. Natl. Acad. Sci. USA 97:4677-4682.
108. Kyo, S., Klumpp, D. J., Inoue, M., Kanaya, T., and Laimins, L. A. (1997). Expression of AP1 during cellular differentiation determines human papillomavirus E6/E7 expression in stratified epithelial cells. J. Gen. Virol. 78:401-411.
109. Lee, J. H., Yi, S. M., Anderson, M. E., Berger, K. L, Welsh, M. J., Klingelhutz, A. J., and Ozbun, M. A. (2004). Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism. Proc. Natl. Acad. Sci. USA 101:2094-2099.
110. Lee, C. J., Suh, E. J., Kang, H. T., Im, J. S., Um, S. J., Park, J. S., and Hwang, E. S. (2002). Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA. Exp. Cell Res. 277:173-182.
111. Lehman, C. W., and Botchan, M. R. (1998). Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proc. Natl. Acad. Sci. USA 95:4338-4343.
112. Lehr, E., Jarnik, M., and Brown, D. R. (2002). Human papillomavirus type 11 alters the transcription and expression of loricrin, the major cell envelope protein. Virology 298:240-247.
113. Lehr, E. E, Qadadri, B, Brown, C. R., and Brown, D. R. (2003). Human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulation. Virology 314:562-571.
114. Lepik, D., Ilves, I., Kristjuhan, A., Maimets, T., and Ustav, M. (1998). p53 protein is a suppressor of papillomavirus DNA amplificational replication. J. Virol. 72:6822-6831.
115. Lim, D. A., Gossen, M., Lehman, C. W., and Botchan, M. R. (1998). Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control. J. Virol. 72:1931-1940.
116. Lin, B. Y., Ma, T., Liu, J.-S., Kuo, S.-R., Jin, G., Broker, T. R., Harper, J. W., and Chow, L. T. (2000). HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication. J. Biol. Chem. 275:6167-6174.
117. Liu, J.-S., Kuo, S.-R., Broker, T. R., and Chow, L. T. (1995). The functions of human papillomavirus type 11 E1, E2 and E2C proteins in cell-free DNA replication. J. Biol. Chem. 270:27283-27291.
118. Ma, T., Zou, N., Lin, B. Y., Chow, L. T., and Harper, J. W. (1999). Interaction between cyclin-dependent kinases and human papillomavirus replication initiation protein E1 is required for efficient viral replication. Proc. Natl. Acad. Sci. USA 96:382-387.
119. May, M., Dong, X. P., Beyer-Finkler, E., Stubenrauch, F., Fuchs, P. G., and Pfister, H. (1994). The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1. EMBO J. 13:1460-1466.
120. McCance, D. J., Kopan, R., Fuchs, E., and Laimins, L. A. (1988). Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc. Natl. Acad. Sci. USA 85:7169-7173.
121. McLaughlin-Drubin, M. E., Bromberg-White, J. L., and Meyers, C. (2005). The role of the human papillomavirus type 18 E7 oncoprotein during the complete viral life cycle. Virology 338:61-68.
122. McLaughlin-Drubin, M. E., Christensen, N. D., and Meyers, C. (2004). Propagation, infection, and neutralization of authentic HPV16 virus. Virology 322:213-219.
123. McLaughlin-Drubin, M. E., Wilson, S. Mullikin, B., Suzich, J., and Meyers, C. (2003). Human papillomavirus type 45 propagation, infection, and neutralization. Virology 312:1-7.
124. Melsheimer, P., Vinokurova, S., Wentzensen, N., Bastert, G., and Von Knebel Doeberitz, M. (2004). DNA aneuploidy and integration of human papillomavirus type 16 E6/E7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin. Cancer Res. 10:3059-3063.
125. Meyers, C., Frattini, M. G., Hudson, J. B., and Laimins, L. A. (1992). Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation. Science 257:971-973.
126. Meyers, C., Mayer, T. J., and Ozbun, M. A. (1997). Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA. J. Virol. 71:7381-7386.
127. Münger, K., Baldwin, A., Edwards, K. M., Hayakawa, H., Nguyen, C. L., Owens, M., Grace, M., and Huh, K. (2004). Mechanisms of human papillomavirus-induced oncogenesis. J. Virol. 78:11451-11460.
128. Nasseri, M., Hirochika, R., Broker, T. R., and Chow, L. T. (1987). A human papillomavirus type 11 transcript encoding an E1 E4 protein. Virology 159:433-439.
129. Nicholls, P. K., Doorbar, J., Moore, R. A., Peh, W., Anderson, D. M., and Stanley, M. A. (2001). Detection of viral DNA and E4 protein in basal keratinocytes of experimental canine oral papillomavirus lesions. Virology 284:82-98.
130. Nishimura, A., Ono, T., Ishimoto, A., Dowhanick, J. J., Frizzell, M. A., Howley, P. M., and Sakai, H. (2000). Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J. Virol. 74:3752-3760.
131. Noya, F., Chien, W.-M., Broker, T. R., and Chow, L. T. (2001). p21cip1 degradation in differentiated keratinocytes is abrogated by co-stabilization with cyclin E induced by HPV E7. J. Virol. 75:6121-6134.
132. Oberg, D., Collier, B., Zhao, X., and Schwartz, S. (2003). Mutational inactivation of two distinct negative RNA elements in the human papillomavirus type 16 L2 coding region induces production of high levels of L2 in human cells. J. Virol. 77:11674-11684.
133. O'Connor, M. J., Stunkel, W., Koh, C. H., Zimmermann, H., and Bernard, H.-U. (2000). The differentiation-specific factor CDP/Cut represses transcription and replication of human papillomaviruses through a conserved silencing element. J. Virol. 74:401-410.
134. O'Connor, M. J., Tan, S. H., Tan, V. H. and Bernard, H.-U. (1996). Bernard. YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity. J. Virol. 70:6529-6539.
135. Oh, S. T., Longworth, M. S., and Laimins, L. A. (2004). Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11. J. Virol. 78:2620-2626.
136. Ohtsubo, M., and Roberts, J. M. (1993). Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259:908-1912.
137. Ozbun, M. A. (2002a). Human papillomavirus type 31b infection of human keratinocytes and the onset of early transcription. J. Virol. 76:11291-11300.
138. Ozbun, M. A. (2002b). Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line. J. Gen. Virol. 83:2753-2763.
139. Ozbun, M. A., and Meyers, C. (1997). Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b. J. Virol. 71:5161-5172.
140. Ozbun, M. A., and Meyers, C. (1998). Temporal usage of multiple promoters during the life cycle of human papillomavirus type 31b. J. Virol. 72:2715-2722.
141. Ozbun, M. A., and Meyers, C. (1999). Two novel promoters in the upstream regulatory region of human papillomavirus type 31b are negatively regulated by epithelial differentiation. J. Virol. 73:3505-3510.
142. Palermo-Dilts, D. A., Broker, T. R., and Chow, L. T. (1990). Human papillomavirus type 1 produces redundant as well as polycistronic messenger RNAs in plantar warts. J. Virol. 64:3144-3149.
143. Park, R. B., and Androphy, E. J. (2002). Genetic analysis of high-risk E6 in episomal maintenance of human papillomavirus genomes in primary human keratinocytes. J. Virol. 76:11359-11364.
144. Parker, J. N., Zhao, W., Askins, K. J., Broker, T. R., and Chow, L. T. (1997). Mutational analyses of differentiation-dependent human papillomavirus type-18 enhancer elements in epithelial raft cultures of neonatal foreskin keratinocytes. Cell Growth Differ. 8:751-762.
145. Pater, M. M., and Pater, A. (1988). Expression of human papillomavirus types 16 and 18 DNA sequences in cervical carcinoma cell lines. J. Med. Virol. 26:185-195.
146. Peh, W. L., Brandsma, J. L., Christensen, N. D., Cladel, N. M., Wu, X., and Doorbar, J. (2004). The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo. J. Virol. 78:2142-2151.
147. Peh, W. L., Middleton, K., Christensen, N., Nicholls, P., Egawa, K., Sotlar, K., Brandsma, J., Percival, A., Lewis, J., Liu, W. J., and Doorbar, J. (2002). Life cycle heterogeneity in animal models of human papillomavirus-associated disease. J. Virol. 76:10401-10416.
148. Phelps, W. C., and Howley, P. M. (1987). Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product. J. Virol. 61:1630-1638.
149. Pim, D., and Banks, L. (1999). HPV-18 E6∗I protein modulates the E6-directed degradation of p53 by binding to full-length HPV-18 E6. Oncogene 18:7403-7408.
150. Pim, D., Massimi, P., and Banks, L. (1997). Alternatively spliced HPV-18 E6∗ protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth. Oncogene 15:257-264.
151. Psyrri, A., De Filippis, R. A., Edwards, A. P., Yates, K. E., Manuelidis, L., and Di Maio, D. (2004). Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res. 64:3079-3086.
152. Rapp, B., Pawellek, A., Kraetzer, F., Schaefer, M., May, C., Purdie, K., Grassmann, K., and Iftner, T. (1997). Cell-type-specific separate regulation of the E6 and E7 promoters of human papillomavirus type 6a by the viral transcription factor E2. J. Virol. 71:6956-6966.
153. Remm, M., Remm, A., and Ustav, M. (1999). Human papillomavirus type 18 E1 protein is translated from polycistronic mRNA by a discontinuous scanning mechanism. J. Virol. 73:3062-3070.
154. Rohlfs, M., Winkenbach, S., Meyer, S., Rupp, T., and Dürst, M. (1991). Viral transcription in human keratinocyte cell lines immortalized by human papillomavirus type-16. Virology 183:331-342.
155. Romanczuk, H., Thierry, F., and Howley, P. M. (1990). Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J. Virol. 64:2849-2859.
156. Rösl, F., Arab, A., Klevenz, B., and Zur Hausen, H. (1993). The effect of DNA methylation on gene regulation of human papillomaviruses. J. Gen. Virol. 74:791-801.
157. Rotenberg, M O., Chow, L. T., and Broker, T. R. (1989). Characterization of rare human papillomavirus type 11 mRNAs coding for regulatory and structural proteins using the polymerase chain reaction. Virology 172:489-497.
158. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75:495-505.
159. Schneider-Gädicke, A., and Schwarz, E. (1986). Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J. 5:2285-2292.
160. Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., and Zur Hausen, H. (1985). Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111-114.
161. Seedorf, K., Krammer, G., Dürst, M., Suhai, S., and Rowekamp, W. G. (1985). Human papillomavirus type 16 DNA sequence. Virology 145:181-185.
162. Sen, E., Alam, S., and Meyers, C. (2004). Genetic and biochemical analysis of cis regulatory elements within the keratinocyte enhancer region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. J. Virol. 78:612-629.
163. Sen, E., Bromberg-White, J. L., and Meyers, C. (2002). Genetic analysis of cis regulatory elements within the 5/region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. J. Virol. 76:4798-4809.
164. Sengupta, S., and Harris, C. C. (2005). p53: traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell. Biol. 6:44-55.
165. Shally, M., Alloul, N., Jackman, A., Müller, M., Gissmann, L. and Sherman, L. (1996). The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53. Virus Res. 42:81-96.
166. Sherman, L., Alloul, H., Golan, I., Dürst, M., and Baram, A. (1992a). Expression and splicing patterns of human papillomavirus type-16 mRNAs in pre cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers. Int. J. Cancer 50:356-364.
167. Sherman, L., Golan, Y., Mitrani-Rosenbaum, S., and Baram, A. (1992b). Differential expression of HPV types 6 and 11 in condylomas and cervical preneoplastic lesions. Virus Res. 25:23-36.
168. Shirasawa, H., Tomita, Y., Kubota, K., Kasai, T., Sekiya, S., Takamizawa, H., and Simizu, B. (1988). Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas. J. Virol. 62:1022-1027.
169. Skiadopoulos, M. H., and McBride, A. A. (1998). Bovine papillomavirus type 1 genomes and the E2 transactivator protein are closely associated with mitotic chromatin. J. Virol. 72:2079-2088.
170. Smotkin, D., Prokoph, H., and Wettstein, F. O. (1989). Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J. Virol. 63:1441-1447.
171. Smotkin, D., and Wettstein, F. O. (1986). Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680-4684.
172. Spalholz, B. A., Yang, Y. C., and Howley, P. M. (1985). Transactivationof abovine papilloma virus transcriptional regulatory element by the E2 gene product. Cell 42:183-191.
173. Spink, K. M., and Laimins, L. A. (2005). Induction of the human papillomavirus type 31 late promoter requires differentiation but not DNA amplification. J. Virol. 79:4918-4926.
174. Stacey, S. N., Jordan, D., Snijders, P. J., Mackett, M., Walboomers, J. M., and Arrand, J. R. (1995). Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame. J. Virol. 69:7023-7031.
175. Stacey, S. N., Jordan, D., Williamson, A. J., Brown, M., Coote, J. H., and Arrand, J. R. (2000). Leaky scanning is the predominant mechanism for translation of human papillomavirus type 16 E7 oncoprotein from E6/E7 bicistronic mRNA. J. Virol. 74:7284-7297.
176. Stenlund, A. (2003). Initiation of DNA replication: lessons from viral initiator proteins. Nat. Rev. Mol. Cell. Biol. 4:777-785.
177. Stoler, M. H., and Broker, T. R. (1986). In situ hybridization detection of human papilloma virus DNAs and messenger RNAs in genital condylomas and a cervical carcinoma. Hum. Pathol. 17:1250-1257.
178. Stoler, M. H., Rhodes, C. R., Whitbeck, A., Wolinsky, S., Chow, L. T., and Broker, T. R. (1992). Gene expression of human papillomavirus type 16 and 18 in cervical neoplasias. Hum. Pathol. 23:117-128.
179. Stoler, M. H., Whitbeck, A., Wolinsky, S. M., Broker, T. R., Chow, L. T., Howett, M. K., and Kreider, J. W. (1990). Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice. J. Virol. 64:3310-3318.
180. Stoler, M. H., Wolinsky, S. M., Whitbeck, A., Broker, T. R., and Chow, L. T. (1989). Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology 172:331-340.
181. Stubenrauch, F., Colber, A. M., and Laimins, L. A. (1998). Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions. J. Virol. 72:8115-8123.
182. Stubenrauch, F., Hummel, M., Iftner, T., and Laimins, L. A. (2000). The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes. J. Virol. 74:1178-1186.
183. Stunkel, W., Huang, Z., Tan, S. H., O'Connor, M. J., and Bernard, H.-U. (2000). Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA. J. Virol. 74:2489-2501.
184. Tan, S. H., Baker, C. C., Stunkel, W., and Bernard, H.-U. (2003). A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16. Virology 305:486-501.
185. Tan, S. H., Bartsch, D., Schwarz, E., and Bernard, H.-U. (1998). Nuclear matrix attachment regions of human papillomavirus type 16 point toward conservation of these genomic elements in all genital papillomaviruses. J. Virol. 72:3610-3622.
186. Tan, S. H., Leong, L. E., Walker, P. A., and Bernard, H.-U. (1994). The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID. J. Virol. 68:6411-6420.
187. Terhune, S. S., Hubert, W. G., Thomas, J. T., and Laimins, L. A. (2001). Early polyadenylation signals of human papillomavirus type 31 negatively regulate capsid gene expression. J. Virol. 75:8147-8157.
188. Terhune, S. S., Milcarek, C., and Laimins, L. A. (1999). Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle. J. Virol. 73:7185-7192.
189. Thierry, F. and Yaniv, M. (1987). The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J. 6:3391-3397.
190. Thierry, F., Heard, J. M., Dartmann, K., and Yaniv, M. (1987). Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens. J. Virol. 61:134-142.
191. Thierry, F., and Howley, P. M. (1991). Functional analysis of E2-mediated repression of the HPV18 P105 promoter. New Biol. 3:90-100.
192. Thierry, F., Spyrou, G., Yaniv, M., and Howley, P. (1992). Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes. J. Virol. 66:3740-3748.
193. Thomas, J. T., Hubert, W. G., Ruesch, M. N., and Laimins, L. A. (1999). Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes. Proc. Natl. Acad. Sci. USA 96:8449-8454.
194. Thomas, J. T., Oh, S. T., Terhune, S. S., and Laimins, L. A. (2001). Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. J. Virol. 75:7564-7571.
195. Van Tine, B. A., Dao, L. D., Wu, S.-Y., Sonbuchner, T. M., Lin, B. Y., Zou, N., Chiang, C.-M., Broker, T. R., and Chow, L. T. (2004a). HPV origin binding protein associates with mitotic spindles to enable viral DNA partitioning. Proc. Natl. Acad. Sci. USA 101:4030-4035.
196. Van Tine, B. A, Kappes, J. C., Banerjee, N. S., Knops, J., Lai, L., Steenbergen, R. D. M., Meijer, C. L. J. M., Snijders, P. J. F., Chatis, P., Broker, T. R., Moen, Jr., P. T., and Chow, L. T. (2004b). Clonal selection for transcriptionally active viral oncogenes during progression to cancer by DNA methylation-mediated silencing. J. Virol. 78:11172-11186.
197. Walboomers, J. M., Jacobs, M. V., Manos, M. M., Bosch, F. X., Kummer, J. A., Shah, K. V., Snijders, P. J., Peto, J., Meijer, C. J., and Muñoz, N. (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Pathology 189:12-19.
198. Ward, P., and Mounts, P. (1989). Heterogeneity in mRNA of human papillomavirus type-6 subtypes in respiratory tract lesions. Virology 68:1-12.
199. Webster, K., Parish, J., Pandya, M., Stern, P. L., Clarke, A. R., and Gaston, K. (2000). The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J. Biol. Chem. 275:87-94.
200. Wells, S. I., Francis, D. A., Karpova, A. Y., Dowhanick, J. J., Benson, J. D., and Howley, P. M. (2000). Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21 (CIP)-dependent pathways. EMBO J. 19:5762-5771.
201. Wentzensen, N., Vinokurova, S., and Von Knebel Doeberitz, M. (2004). Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res. 64:3878-3884.
202. Wiklund, L., Sokolowski, M., Carlsson, A., Rush, M., and Schwartz, S. (2002). Inhibition of translation by UAUUUAU and UAUUUUUAU motifs of the AU-rich RNA instability element in the HPV-1 late 3' untranslated region. J. Biol. Chem. 277:40462-40471.
203. Wilson, J. L., Dollard, S. C., Chow, L. T., and Broker, T. R. (1992). Epithelial-specific gene expression during differentiation of stratified primary human keratinocyte cultures. Cell Growth Differ. 3:471-483.
204. Wilson, R., Fehrmann, F., and Laimins, L. A. (2005). Role of the E1AE4 protein in the differentiation-dependent life cycle of human papillomavirus type 31. J. Virol. 79:6732-6740.
205. Yee, C, Krishnan-Hewlett, I., Baker, C. C., Schlegel, R., and Howley, P. M. (1985). Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am. J. Pathol. 119:361-366.
206. You, J., Croyle, J. L., Nishimura, A., Ozato, K., and Howley, P. M. (2004). Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117:349-360.
207. Zhao, W., Broker, T. R., and Chow, L. T. (1997). Transcriptional activities of human papillomavirus type-11 promoter-proximal elements in raft and submerged cultures of foreskin keratinocytes. J. Virol. 71:8832-8840.
208. Zhao, W., Chow, L. T., and Broker, T. R. (1999a). A distal element in the HPV-11 upstream regulatory region contributes to promoter repression in basal keratinocytes of squamous epithelium. Virology 253:219-229.
209. Zhao, W., Noya, F., Chen, W. Y., Townes, T. M., Chow, L. T., and Broker, T. R. (1999b). Trichostatin A up-regulates HPV-11 URR-E6 promoter activity in undifferentiated primary human keratinocytes. J. Virol. 73:5026-5033.
210. Zhao, X., Oberg, D., Rush, M., Fay, J., Lambkin, H., and Schwartz, S. (2005). A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein. J. Virol. 79:4270-4288.
211. Zhao, X., Rush, M., and Schwartz, S. (2004). Identification of an hnRNP A1-dependent splicing silencer in the human papillomavirus type 16 L1 coding region that prevents premature expression of the late L1 gene. J. Virol. 78:10888-10905.
212. Zheng, Z. M. (2004). Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J. Biomed. Sci. 113:278-294.
213. Ziegert, C, Wentzensen, N., Vinokurova, S., Kisseljov, F., Einenkel, J., Hoeckel, M., and Von Knebel Doeberitz, M. (2003). A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques. Oncogene 22:3977-3984.
214. Zobel, T., Iftner, T., and Stubenrauch, F. (2003). The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins. Mol. Cell. Biol. 23:8352-8362.
215. Zur Hausen, H. (2002). Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2:342-350.