-
1
-
-
0141567459
-
Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation
-
E. Y. Chi, S. Krishnan, T. W. Randolph, and J. F. Carpenter, Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation, Pharm. Res. 20(9), 1325-1336 (2003).
-
(2003)
Pharm. Res.
, vol.20
, Issue.9
, pp. 1325-1336
-
-
Chi, E.Y.1
Krishnan, S.2
Randolph, T.W.3
Carpenter, J.F.4
-
2
-
-
0027729733
-
The development of stable protein formulations: A close look at protein aggregation, deamidation and oxidation
-
J. L. Cleland, M. F. Powell, and S. J. Shire, The development of stable protein formulations: a close look at protein aggregation, deamidation and oxidation, Crit. Rev. Ther. Drug Carrier Sys. 10(4), 307-377 (1993).
-
(1993)
Crit. Rev. Ther. Drug Carrier Sys.
, vol.10
, Issue.4
, pp. 307-377
-
-
Cleland, J.L.1
Powell, M.F.2
Shire, S.J.3
-
3
-
-
0036111474
-
Inverse relationship of protein concentration and aggregation
-
M. J. Treuheit, A. A. Kosky, and D. N. Brems, Inverse relationship of protein concentration and aggregation, Pharm. Res. 19(4), 511-516 (2002).
-
(2002)
Pharm. Res.
, vol.19
, Issue.4
, pp. 511-516
-
-
Treuheit, M.J.1
Kosky, A.A.2
Brems, D.N.3
-
4
-
-
0030856842
-
Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice
-
A. Braun, L. Kwee, M. A. Labow, and J. Alsenz, Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice, Pharm. Res. 14(10), 1472-1478 (1997).
-
(1997)
Pharm. Res.
, vol.14
, Issue.10
, pp. 1472-1478
-
-
Braun, A.1
Kwee, L.2
Labow, M.A.3
Alsenz, J.4
-
5
-
-
0026730739
-
Confinement as a determinant of macromolecular structure and reactivity
-
A. P. Minton, Confinement as a determinant of macromolecular structure and reactivity, Biophys. J. 63(4), 1090-1100 (1992).
-
(1992)
Biophys. J.
, vol.63
, Issue.4
, pp. 1090-1100
-
-
Minton, A.P.1
-
6
-
-
0019890347
-
Evidence for protein self-association induced by excluded volume. Myoglobin in the presence of globular proteins
-
J. Wilf and A. P. Minton, Evidence for protein self-association induced by excluded volume. Myoglobin in the presence of globular proteins, Biochim. Biophys. Acta 670(3), 316-322 (1981).
-
(1981)
Biochim. Biophys. Acta
, vol.670
, Issue.3
, pp. 316-322
-
-
Wilf, J.1
Minton, A.P.2
-
7
-
-
0027318513
-
Macromolecular crowding: Biochemical, biophysical, and physiological consequences
-
S. B. Zimmerman and A. P. Minton, Macromolecular crowding: biochemical, biophysical, and physiological consequences, Annu. Rev. Biophys. Biomol. Struct. 22, 27-65 (1993).
-
(1993)
Annu. Rev. Biophys. Biomol. Struct.
, vol.22
, pp. 27-65
-
-
Zimmerman, S.B.1
Minton, A.P.2
-
8
-
-
0036707991
-
Modern analytical ultracentrifugation in protein science: A tutorial review
-
J. Lebowitz, M. S. Lewis, and P. Schuck, Modern analytical ultracentrifugation in protein science: a tutorial review, Prot. Sci. 11(9), 2067-2079 (2002).
-
(2002)
Prot. Sci.
, vol.11
, Issue.9
, pp. 2067-2079
-
-
Lebowitz, J.1
Lewis, M.S.2
Schuck, P.3
-
9
-
-
0001052424
-
Analytical ultracentrifugation and its use in biotechnology
-
T. M. Schuster and T. M. Laue, Boston: Birkhauser
-
S. J. Shire, Analytical ultracentrifugation and its use in biotechnology, in Modern Analytical Ultracentrifugation, eds. T. M. Schuster and T. M. Laue, (Boston: Birkhauser, 1992, 261-297).
-
(1992)
Modern Analytical Ultracentrifugation
, pp. 261-297
-
-
Shire, S.J.1
-
10
-
-
0030571043
-
Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions
-
J. Wen, T. Arakawa, and J. S. Philo, Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions, Anal. Biochem. 240(2), 155-166 (1996).
-
(1996)
Anal. Biochem.
, vol.240
, Issue.2
, pp. 155-166
-
-
Wen, J.1
Arakawa, T.2
Philo, J.S.3
-
11
-
-
0030836515
-
Recombinant human relaxin as a cervical ripening agent
-
J. E. Brennand, A. A. Calder, C. R. Leitch, I. A. Greer, M. M. Chou, and I. Z. MacKenzie, Recombinant human relaxin as a cervical ripening agent, Br. J. Obstet. Gynaecol. 104(7), 775-778 (1997).
-
(1997)
Br. J. Obstet. Gynaecol.
, vol.104
, Issue.7
, pp. 775-778
-
-
Brennand, J.E.1
Calder, A.A.2
Leitch, C.R.3
Greer, I.A.4
Chou, M.M.5
MacKenzie, I.Z.6
-
12
-
-
0027249542
-
A randomized, double-blind, placebo-controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening
-
R. J. Bell, M. Permezel, A. MacLennan, C. Hughes, D. Healy, and S. Brennecke, A randomized, double-blind, placebo-controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening, Obstet. Gynecol. 82(3), 328-333 (1993).
-
(1993)
Obstet. Gynecol.
, vol.82
, Issue.3
, pp. 328-333
-
-
Bell, R.J.1
Permezel, M.2
MacLennan, A.3
Hughes, C.4
Healy, D.5
Brennecke, S.6
-
13
-
-
0022454550
-
Ripening of the human cervix and induction of labor with intracervical purified porcine relaxin
-
A. H. MacLennan, R. C. Green, P. Grant, and R. Nicolson, Ripening of the human cervix and induction of labor with intracervical purified porcine relaxin, Obstet. Gynecol. 68(5), 598-601 (1986).
-
(1986)
Obstet. Gynecol.
, vol.68
, Issue.5
, pp. 598-601
-
-
MacLennan, A.H.1
Green, R.C.2
Grant, P.3
Nicolson, R.4
-
14
-
-
0020562507
-
Ripening of the human cervix with porcine ovarian relaxin
-
M. I. Evans, M. B. Dougan, A. H. Moawad, W. J. Evans, G. D. Bryant-Greenwood, and F. C. Greenwood, Ripening of the human cervix with porcine ovarian relaxin, Am. J. Obstet. Gynecol. 147(4), 410-414 (1983).
-
(1983)
Am. J. Obstet. Gynecol.
, vol.147
, Issue.4
, pp. 410-414
-
-
Evans, M.I.1
Dougan, M.B.2
Moawad, A.H.3
Evans, W.J.4
Bryant-Greenwood, G.D.5
Greenwood, F.C.6
-
15
-
-
6844266294
-
Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis
-
J. R. Seibold, P. J. Clements, D. E. Furst, M. D. Mayes, D. A. McCloskey, L. W. Moreland, B. White, F. M. Wigley, S. Rocco, M. Erikson, J. F. Hannigan, M. E. Sanders, and E. P. Amento, Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis, J. Rheumatol. 25(2), 302-307 (1998).
-
(1998)
J. Rheumatol.
, vol.25
, Issue.2
, pp. 302-307
-
-
Seibold, J.R.1
Clements, P.J.2
Furst, D.E.3
Mayes, M.D.4
McCloskey, D.A.5
Moreland, L.W.6
White, B.7
Wigley, F.M.8
Rocco, S.9
Erikson, M.10
Hannigan, J.F.11
Sanders, M.E.12
Amento, E.P.13
-
16
-
-
0034612234
-
Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial
-
J. R. Seibold, J. H. Korn, R. Simms, P. J. Clements, L. W. Moreland, M. D. Mayes, D. E. Furst, N. Rothfield, V. Steen, M. Weisman, D. Collier, F. M. Wigley, P. A. Merkel, M. E. Csuka, V. Hsu, S. Rocco, M. Erikson, J. Hannigan, W. S. Harkonen, and M. E. Sanders, Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial, Ann. Intern. Med. 132(11), 871-879 (2000).
-
(2000)
Ann. Intern. Med.
, vol.132
, Issue.11
, pp. 871-879
-
-
Seibold, J.R.1
Korn, J.H.2
Simms, R.3
Clements, P.J.4
Moreland, L.W.5
Mayes, M.D.6
Furst, D.E.7
Rothfield, N.8
Steen, V.9
Weisman, M.10
Collier, D.11
Wigley, F.M.12
Merkel, P.A.13
Csuka, M.E.14
Hsu, V.15
Rocco, S.16
Erikson, M.17
Hannigan, J.18
Harkonen, W.S.19
Sanders, M.E.20
more..
-
17
-
-
0025375757
-
Characterization of chemically synthesized human relaxin by high-performance liquid chromatography
-
E. Canova-Davis, I. P. Baldonado, and G. M. Teshima, Characterization of chemically synthesized human relaxin by high-performance liquid chromatography, J. Chromat. A 508(1), 81-96 (1990).
-
(1990)
J. Chromat. A
, vol.508
, Issue.1
, pp. 81-96
-
-
Canova-Davis, E.1
Baldonado, I.P.2
Teshima, G.M.3
-
18
-
-
0026076199
-
Self-association of human and porcine relaxin as assessed by analytical ultracentrifugation and circular dichroism
-
S. J. Shire, L. A. Holladay, and E. Rinderknecht, Self-association of human and porcine relaxin as assessed by analytical ultracentrifugation and circular dichroism, Biochemistry 30(31), 7703-7711 (1991).
-
(1991)
Biochemistry
, vol.30
, Issue.31
, pp. 7703-7711
-
-
Shire, S.J.1
Holladay, L.A.2
Rinderknecht, E.3
-
19
-
-
84913938374
-
Spectroscopic and hydrodynamic characterization of synthetic human and porcine relaxin
-
S. J. Shire, D. L. Foster, and E. Rinderknecht, Spectroscopic and hydrodynamic characterization of synthetic human and porcine relaxin, Biophys. Chem. 53, 72a (1988).
-
(1988)
Biophys. Chem.
, vol.53
, pp. 72a
-
-
Shire, S.J.1
Foster, D.L.2
Rinderknecht, E.3
-
20
-
-
0027218994
-
The application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates
-
T. W. Patapoff, R. J. Mrsny, and W. A. Lee, The application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates, Anal. Biochem. 212(1), 71-78 (1993).
-
(1993)
Anal. Biochem.
, vol.212
, Issue.1
, pp. 71-78
-
-
Patapoff, T.W.1
Mrsny, R.J.2
Lee, W.A.3
-
21
-
-
0025812626
-
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants
-
C. Eigenbrot, M. Randal, C. Quan, J. Burnier, L. O'Connell, E. Rinderknecht, and A. A. Kossiakoff, X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants, J. Mol. Biol. 221(1), 15-21 (1991).
-
(1991)
J. Mol. Biol.
, vol.221
, Issue.1
, pp. 15-21
-
-
Eigenbrot, C.1
Randal, M.2
Quan, C.3
Burnier, J.4
O'Connell, L.5
Rinderknecht, E.6
Kossiakoff, A.A.7
-
22
-
-
0038514919
-
Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer
-
N. H. Fernando and H. I. Hurwitz, Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer, Semin. Oncol. 30(3 Suppl 6), 39-50 (2003).
-
(2003)
Semin. Oncol.
, vol.30
, Issue.3
, pp. 39-50
-
-
Fernando, N.H.1
Hurwitz, H.I.2
-
23
-
-
0345426282
-
Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor
-
J. M. R. Moore, T. W. Patapoff, and M. E. M. Cromwell, Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor, Biochemistry 38(42), 13960-13967 (1999).
-
(1999)
Biochemistry
, vol.38
, Issue.42
, pp. 13960-13967
-
-
Moore, J.M.R.1
Patapoff, T.W.2
Cromwell, M.E.M.3
-
24
-
-
0034142219
-
A unique zinc binding site revealed by a high-resolution x-ray structure of homotrimeric Apo2L/TRAIL
-
S. G. Hymowitz, M. P. O'Connell, M. A. Ultsch, A. Hurst, K. Totpal, A. Ashkenazi, B. De Vos, and R. F. Kelley, A unique zinc binding site revealed by a high-resolution x-ray structure of homotrimeric Apo2L/TRAIL, Biochemistry 39(4), 633-640 (2000).
-
(2000)
Biochemistry
, vol.39
, Issue.4
, pp. 633-640
-
-
Hymowitz, S.G.1
O'Connell, M.P.2
Ultsch, M.A.3
Hurst, A.4
Totpal, K.5
Ashkenazi, A.6
De Vos, B.7
Kelley, R.F.8
-
25
-
-
0032575714
-
Death receptors: Signaling and modulation
-
A. Ashkenazi and V. M. Dixit, Death receptors: signaling and modulation, Science 281, 1305-1308 (1998).
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
26
-
-
0032713075
-
Safety and anti-tumor activity of recombinant soluble Apo2 ligand
-
A. Ashkenazi, R. C. Pai, S. Fong, S. Leung, D. A. Lawrence, S. A. Marsters, C. Blackie, L. Chang, A. E. McMurtrey, A. Hebert, L. De Forge, I. L. Koumenis, D. Lewis, J. Bussiere, H. Koeppen, Z. Shahrokh, and R. H. Schwall, Safety and anti-tumor activity of recombinant soluble Apo2 ligand, J. Clin. Inv. 104(2), 155-162 (1999).
-
(1999)
J. Clin. Inv.
, vol.104
, Issue.2
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
Blackie, C.7
Chang, L.8
McMurtrey, A.E.9
Hebert, A.10
De Forge, L.11
Koumenis, I.L.12
Lewis, D.13
Bussiere, J.14
Koeppen, H.15
Shahrokh, Z.16
Schwall, R.H.17
-
27
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor apoptosis-inducing ligand in vivo
-
H. Walczak, R. E. Miller, K. Ariail, B. Gliniak, T. S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, C. Smith, P. Smolak, R. G. Goodwin, C. T. Rauch, J. C. Schuh, and D. H. Lynch, Tumoricidal activity of tumor necrosis factor apoptosis-inducing ligand in vivo, Nature Med. 5(2), 157-163 (1999).
-
(1999)
Nature Med.
, vol.5
, Issue.2
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
Chin, W.7
Jones, J.8
Woodward, A.9
Le, T.10
Smith, C.11
Smolak, P.12
Goodwin, R.G.13
Rauch, C.T.14
Schuh, J.C.15
Lynch, D.H.16
-
28
-
-
2642550862
-
Challenges in the development of high protein concentration formulations
-
S. J. Shire, Z. Shahrokh, and J. Liu, Challenges in the development of high protein concentration formulations, J. Pharm. Sci. 93(6), 1390-1402 (2004).
-
(2004)
J. Pharm. Sci.
, vol.93
, Issue.6
, pp. 1390-1402
-
-
Shire, S.J.1
Shahrokh, Z.2
Liu, J.3
-
30
-
-
0019764210
-
Self-association in highly concentrated solutions of myoglobin: A novel analysis of sedimentation equilibrium of highly nonideal solutions
-
A. P. Minton and M. S. Lewis, Self-association in highly concentrated solutions of myoglobin: a novel analysis of sedimentation equilibrium of highly nonideal solutions, Biophys. Chem. 14(4), 317-324 (1981).
-
(1981)
Biophys. Chem.
, vol.14
, Issue.4
, pp. 317-324
-
-
Minton, A.P.1
Lewis, M.S.2
-
31
-
-
0024615169
-
Analytical centrifugation with preparative ultracentrifuges
-
A. P. Minton, Analytical centrifugation with preparative ultracentrifuges, Anal. Biochem. 176, 209-216 (1989).
-
(1989)
Anal. Biochem.
, vol.176
, pp. 209-216
-
-
Minton, A.P.1
-
32
-
-
0028284639
-
Quantitative characterization of macromolecular associations in solution via real-time and postcentrifugation measurements of sedimentation equilibrium: A comparison
-
S. Darawshe and A. P. Minton, Quantitative characterization of macromolecular associations in solution via real-time and postcentrifugation measurements of sedimentation equilibrium: a comparison, Anal. Biochem. 220, 1-4 (1994).
-
(1994)
Anal. Biochem.
, vol.220
, pp. 1-4
-
-
Darawshe, S.1
Minton, A.P.2
-
33
-
-
0027410312
-
Rapid and accurate microfractionation of the contents of small centrifuge tubes: Application in the measurement of molecular weight of proteins via sedimentation equilibrium
-
S. Darawshe, G. Rivas, and A. P. Minton, Rapid and accurate microfractionation of the contents of small centrifuge tubes: application in the measurement of molecular weight of proteins via sedimentation equilibrium, Anal. Biochem. 209, 130-135 (1993).
-
(1993)
Anal. Biochem.
, vol.209
, pp. 130-135
-
-
Darawshe, S.1
Rivas, G.2
Minton, A.P.3
-
34
-
-
0022665926
-
Technique and apparatus for automated fractionation of the contents of small centrifuge tubes: Application to analytical ultracentrifugation
-
A. K. Attri and A. P. Minton, Technique and apparatus for automated fractionation of the contents of small centrifuge tubes: application to analytical ultracentrifugation, Anal. Biochem. 152(2), 319-328 (1986).
-
(1986)
Anal. Biochem.
, vol.152
, Issue.2
, pp. 319-328
-
-
Attri, A.K.1
Minton, A.P.2
-
35
-
-
0015230398
-
Equilibrium centrifugation of nonideal systems. The Donnan effect in self-associating systems
-
D. E. Roark and D. A. Yphantis, Equilibrium centrifugation of nonideal systems. The Donnan effect in self-associating systems, Biochemistry 10(17), 3241-3249 (1971).
-
(1971)
Biochemistry
, vol.10
, Issue.17
, pp. 3241-3249
-
-
Roark, D.E.1
Yphantis, D.A.2
-
36
-
-
0020668187
-
The effect of volume occupancy upon the thermodynamic activity of proteins: Some biochemical consequences
-
A. P. Minton, The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences, Mol. Cell. Biochem. 55, 119-140 (1983).
-
(1983)
Mol. Cell. Biochem.
, vol.55
, pp. 119-140
-
-
Minton, A.P.1
-
37
-
-
0017397771
-
Hard quasispherical model for the viscosity of hemoglobin solutions
-
P. D. Ross and A. P. Minton, Hard quasispherical model for the viscosity of hemoglobin solutions, Biochem. Biophys. Res. Commun. 76(4), 971-976 (1977).
-
(1977)
Biochem. Biophys. Res. Commun.
, vol.76
, Issue.4
, pp. 971-976
-
-
Ross, P.D.1
Minton, A.P.2
|