Epidemiology of hepatitis b virus infection in china: Current status and challenges

Journal of Clinical and Translational Hepatology

Volumn 2, Issue 1, 2014, Pages 15-22

  Yan, Yong Ping ^a   Su, Hai Xia ^a   Ji, Zhao Hua ^a   Shao, Zhong Jun ^a   Pu, Zhong Shu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Challenges; Distribution; Epidemiology; Hepatitis B; Prophylaxis

Indexed keywords

EID: 84919825510     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2013.00030     Document Type: Review

References (86)

1. Xia GL, Liu CB, Cao HL, Bi SL, Zhan MY, Su CA, et al. Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992. Int Hepatol Comm 1996;5:62–73.
2. Liang XF, Bi SL, Yang WZ, Wang LD, Cui G, Cui FQ, et al. Epidemiological serosurvey of hepatitis B in China–declining HBV prevalence due to hepatitis B vaccination. Vaccine 2009;27:6550–6557.
3. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet 2009;373:582–592.
4. El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012;142:1264–1273.
5. Wang LP, Guo Q, Zhang CX, Guo Y, Zhao ZX, Ma JQ, et al. National investigation into and analysis of hepatitis B reporting quality in 2006. Chinese Journal of Disease Control and Prevention 2009;13 69–71.
6. Health CsMo. China Health Statistics Yearbook of 2005. Peking Union Medical College Press 2005.
7. Health CsMo. China Health Statistics Yearbook of 2006. Peking Union Medical College Press 2006:230–238.
8. Health CsMo. China Health Statistics Yearbook of 2007. Peking Union Medical College Press 2007:226–233.
9. Health CsMo. China Health Statistics Yearbook of 2008. Peking Union Medical College Press 2008:198–205.
10. Health CsMo. China Health Statistics Yearbook of 2009. Peking Union Medical College Press 2009:237–244.
11. Health CsMo. China Health Statistics Yearbook of 2010. Peking Union Medical College Press 2010.
12. Cui FQ, Wang FZ, Zheng W, Chen YS, Gong XH, Wang HQ, Liang XF. Analysis on Reported Cases of Hepatitis B in China in 2005–2007. Chinese Journal of Vaccines and Immunization 2008;14:413–417.
13. Hou MC, Wu JC, Kuo BI, Sheng WY, Chen TZ, Lee SD, Lo KJ. Heterosexual transmission as the most common route of acute hepatitis B virus infection among adults in Taiwan–the importance of extending vaccination to susceptible adults. J Infect Dis 1993;167:938–941.
14. Chen Y, Liu LF, Hu J, X., Wang Y, Fan G. The problems existed in the work of heaptitis B virus case report and its recommendations. Occupation and Health 2006;22:2247–2247.
15. Chen Y, Liu LF, Hu JL, Wang Y, Fan G. Analysis and investigation on case reporting quality of hepatitis B. J iangsu Prev Med 2006;17:9–11.
16. Wang FZ, Cui FQ, Lu Y, Chen YS, Zheng W, Liang XF. Analysis on reported hepatitis B cases on pilot surveillance in 18 counties of 8 provinces of China. Chinese Journal of Vaccines and Immunization 2007;13:309–312.
17. Wiseman E, Fraser MA, Holden S, Glass A, Kidson BL, Heron LG, Maley MW, Ayres A, Locarnini SA, Levy MT. Perinatal transmission of hepatitis B virus: an Australian experience. Med J Aust 2009;190:489–492.
18. Xu WM, Cui YT, Wang L, Yang H, Liang ZQ, Li XM, Zhang SL, Qiao FY, Campbell F, Chang CN, Gardner S, Atkins M. Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, rando-mized, double-blind, placebo-controlled study. J Viral Hepat 2009;16:94– 103.
19. Wang JS, Zhu QR. Interruption of the transmission of hepatitis B virus from mother to babies. Chinese journal of hepatology 2002;10:308–310.
20. Zhu QR, Duan SC. Transmission from mother to baby of the hepatitis B virus. Chinese Journal of Infectious Diseases 1989;7:159–161.
21. Shao ZJ, Xu DZ, Xu JQ, Li JH, Yan YP, Men K, Wang XP, Zhang ZY, Jiang QW, Zhang L. Maternal hepatitis B virus (HBV) DNA positivity and sexual intercourse are associated with HBV intrauterine transmission in China: a prospective case-control study. J Gastroenterol Hepatol 2007;22:165–170.
22. Cui HC, Yan YP, Shao ZJ, Xu DZ, Men K, Xu JQ, Li J. Follow?up study on relationship between hepatitis B e antigens an d intrauterine HBV infection after imm unoprophylaxis. Chinese Journal of Public Health 2006;22:824– 826.
23. Yi W, Pan CQ, Hao J, Hu Y, Liu M, Li L, Liang D. Risk of vertical transmission of hepatitis B after amniocentesis in HBs antigen-positive mothers. J Hepatol 2014;60:523–529.
24. Wang ST, Weng XZ. Five cases of the same serum heaptitis caused by blood transfusion. Journal of Peking University (Health Sciences) 1960;1:014.
25. Lu FM, Li T, Liu S, Zhuang H. Epidemiology and prevention of hepatitis B virus infection in China. J Viral Hepat 2010;17 (Suppl 1)::4–9.
26. Zhang HW, Yin JH, Li YT, Li CZ, Ren H, Gu CY, Wu HY, Liang XS, Zhang P, Zhao JF, Tan XJ, Lu W, Schaefer S, Cao GW. Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut 2008;57:1713– 1720.
27. Jia JD, Li LJ. The guideline of prevention and treatment for chronic hepatitis B (2010 version) . Chinese Journal of Clinical Hepatology 2011;27:113–128.
28. Shang G, Seed CR, Wang F, Nie D, Farrugia A. Residual risk of transfusion-transmitted viral infections in Shenzhen, China, 2001 through 2004. Transfusion 2007;47:529–539.
29. Velati C, Fomiatti L, Baruffi L, Romano L, Zanetti A. Impact of nucleic acid amplification technology (NAT) in Italy in the three years following implementation (2001–2003). Euro Surveill 2005;10:12–14.
30. Alvarez do Barrio M, Gonzalez Diez R, Hernandez Sanchez JM, Oyonarte Gomez S. Residual risk of transfusion-transmitted viral infections in Spain, 1997–2002, and impact of nucleic acid testing. Euro Surveill 2005;10:20– 22.
31. Chiavetta JA, Escobar M, Newman A, He Y, Driezen P, Deeks S, Hone DE, O’Brien SF, Sher G. Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990–2000. CMAJ 2003;169:767–773.
32. Su Y, Yan R, Duan Z, Norris JL, Wang L, Jiang Y, Xing W, Chen Y, Xiao Y, Li L. Prevalence and risk factors of hepatitis C and B virus infections in hemodialysis patients and their spouses: A multicenter study in Beijing, China. J Med Virol 2013;85:425–432.
33. Alter MJ, Margolis HS. The emergence of hepatitis B as a sexually transmitted disease. Med Clin North Am 1990;74:1529–1541.
34. Daniels D, Grytdal S, Wasley A. Surveillance for acute viral hepatitis-United States, 2007. MMWR Surveill Summ 2009;58:1–27.
35. Zou S, Zhang J, Tepper M, Giulivi A, Baptiste B, Predy G, Poliquin D, Morin M, Jones D, Lowewen J, Ogonowski M, Moses S, Elliott L. Enhanced surveillance of acute hepatitis B and C in four health regions in Canada, 1998 to 1999. Can J Infect Dis 2001;12:357–363.
36. Hahne S, Ramsay M, Balogun K, Edmunds WJ, Mortimer P. Incidence and routes of transmission of hepatitis B virus in England and Wales, 1995–2000: implications for immunisation policy. J Clin Virol 2004;29:211–220.
37. Wu Q, Li Z, Fan J. A seroepidemiological study on sexually transmitted HBV infection. Zhonghua Liu Xing Bing Xue Za Zhi 1994;15:67–70.
38. Jia JD. Hepatitis B in China: from guideline to practice. Virol Sin 2008;23: 152–155.
39. Ma X, Zhang Q, He X, Sun W, Yue H, Chen S, Raymond HF, Li Y, Xu M, Du H, McFarland W. Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006. J Acquir Immune Defic Syndr 2007;45:581–587.
40. Hu Z, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nat Genet 2013;45:1499–503.
41. Chen XL, Sun DX, Zhang XL. Hepatitis B virus genotypes. World J Gastroenterol 2011(04):389–393.
42. Sun KX, LI J, Yan L, Sun MS, Ma JF, Chen J, Nie JJ, Zhuang H. Distribution of hepatitis B virus genotypes and subgenotypes in Chinese patients with chronic hepatitis B virus infection. Chinese Journal of Viral Diseases 2011; 03:177–182.
43. Gao JW, Li YJ, Zhuang H, Li J, Wang J, Dong QM, Chen YJ, Niu JQ, Ma WM, Zhao W, Zhao BA, Zhong JQ. Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B virus infection among 12 cities in China. Zhonghua Liu Xing Bing Xue Za Zhi 2007;28:315–318.
44. Li X, Liu Y, Xu Z, Wan Z, Bai S, Mao P, Mao Y, Xin S, Xu D. A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations (pages 1698–1704). J Med Virol 2013;85:1698– 1704.
45. Zhao HP, Shen YY, Shen R, Li Q, Wang YY, Fu MY. Study on genotypes and subgenotypes of hepatitis B virus among Dai Nationality in Xishuangbanna, Yunnan Province. China Tropical Medicine 2009;9:211–213.
46. Cao ZL, Gao YT, Liu S, Jing L, Ji Z, Liu T, Liu CJ, Du Z. Detection of HBV genotypes in Lhasa by gene chip. World J Gastroenterol 2007:3500–3506.
47. Xu YQ, Zhou YD, Bi SL. Preliminary study on genotype of hepatitis B virus detected from Tibetans in China. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2005;19:118–120.
48. Xia G, Nainan OV, Jia Z. Characterization and distribution of hepatitis B virus genotypes and subtypes in 4 provinces of China. Zhonghua Liu Xing Bing Xue Za Zhi 2001;22:348–351.
49. Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 1994;198:489–503.
50. Huang WJ, Zhou C, Wang YC, ZHANG HY, Wu X, Liang ZL, Li HM. Cloning and sequence analysis of complete genome of hepatitis B virus isolates of genotypes B, C, D/C and A from Chinese patients with chronic hepatitis B. World J Gastroenterol 2009:2978–2983.
51. Lu XB, Wang XL, Deng GH, Kuang XM, Aman GL, Zhang YX, Zhang JL, Wang YM. Distribution and characteristics of hepatitis B virus genotypes in Uighur patients with chronic hepatitis B in Xinjiang province of China. Zhonghua Gan Zang Bing Za Zhi 2007;15:241–244.
52. Zhuang L, You J, Chen HY, Yu L, Kun L, Tang BZ, Huang JH, Yuan SM, Hutcha S, Virasakdi C. Distribution and clinical significance of hepatitis B virus genotypes in patients with chronic HBV infection in Yunnan province, China. World Chinese Journal of Digestology 2007;15:2120–2127.
53. Zhou B, Wang ZH, Wen SJ, Chen JJ, Sun J, Hou JL. Identification of two newly discovered subgenotypes of hepatitis B virus genotype C. Chinese Journal of Infectious Diseases 2008;26:358–361.
54. Chen X, Dai B, Liu Z, Gao J, Ji Z, Guo J, Chen G, Deng Z, Shao Z. A novel B/C inter-genotype recombinant of hepatitis B virus identified in north-west China. J Gen Virol 2014;95:153–155.
55. Wang Z, Liu Z, Zeng G, Wen S, Qi Y, Ma S, Naoumov NV, Hou J. A new intertype recombinant between genotypes C and D of hepatitis B virus identified in China. J Gen Virol 2005;86:985–990.
56. Su HX, Zhang YH, Xu DZ, Wang B, Zhang L, Li D, Xiao D, Li F, Zhang JX, Yan YP. Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China. PloS one 2013 8:e70768.
57. Raimondo G, Caccamo G, Filomia R, Pollicino T. Occult HBV infection. Semin Immunopathol 2013;35:39–52.
58. Blackberg J, Kidd-Ljunggren K. Occult hepatitis B virus after acute self-limited infection persisting for 30 years without sequence variation. J Hepatol 2000;33:992–997.
59. van Hemert FJ, Zaaijer HL, Berkhout B, Lukashov VV. Occult hepatitis B infection: an evolutionary scenario. Virol J 2008;5:146.
60. Chen SJ, Zhao YX, Fang Y, Xu WZ, Ma YX, Song ZW, Teng X, Gu HX. Viral deletions among healthy young Chinese adults with occult hepatitis B virus infection. Virus Res 2012;163:197–201.
61. Xu L, Wei Y, Chen T, Lu J, Zhu CL, Ni Z, Huang F, Du J, Sun Z, Qu C. Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination. Vaccine 2010;28:5986–5992.
62. Dong XL, Yao QQ, Wang XC, Xu HT, Wang XL, Chen SY, Tang ZF, Zheng YJ. Prevalence of occult hepatitis B virus infection and its phylogenetic features among mother-teenager pairs. Zhonghua Liu Xing Bing Xue Za Zhi 2013;34: 210–213.
63. Kumar GT, Kazim SN, Kumar M, Hissar S, Chauhan R, Basir SF, Sarin SK. Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection. J Gastroenterol Hepatol 2009;24:588–598.
64. Fang Y, Shang QL, Liu JY, Li D, Xu WZ, Teng X, Zhao HW, Fu LJ, Zhang FM, Gu HX. Prevalence of occult hepatitis B virus infection among hepatopathy patients and healthy people in China. J Infect 2009;58:383–388.
65. Walz A, Wirth S, Hucke J, Gerner P. Vertical transmission of hepatitis B virus (HBV) from mothers negative for HBV surface antigen and positive for antibody to HBV core antigen. J Infect Dis 2009;200:1227–1231.
66. Luo Z, Li L, Ruan B. Impact of the implementation of a vaccination strategy on hepatitis B virus infections in China over a 20-year period. Int J Infect Dis 2012;16:e82–88.
67. Liang XF, Bi SL, Yang WZ, Wang LD, Cui G, Cui FQ, Zhang Y, Liu JH, Gong XH, Chen YS, Wang FZ, Zheng H, Wang F, Guo J, Jia ZY, Ma JC, Wang HQ, Luo HM, Li L, Jin SG, Hadler SC, Wang Y. Reprint of: Epidemiological serosurvey of Hepatitis B in China-Declining HBV prevalence due to Hepatitis B vaccination. Vaccine 2013;31:J21–J28.
68. Yao J, Yang JJ. Investigation on Immunization Coverage Rate and Immune Effect of Hepatitis B Vaccine among Newborns in Zhejiang Province. Chinese Journal of Vaccines and Immunization 2000;6:132–134.
69. Liu PB. Certain question discussion of hepatitis B vaccine inoculation. Chinese Journal of Public Health 2000;16:73–74.
70. Nelson JC, Bittner RC, Bounds L, Zhao S, Baggs J, Donahue JG, Hambidge SJ, Jacobsen SJ, Klein NP, Naleway AL, Zangwill KM, Jackson LA. Compliance with multiple-dose vaccine schedules among older children, adolescents, and adults: results from a vaccine safety datalink study. Am J Public Health 2009; 99 (Suppl 2)::S389–397.
71. Li XM, Shi MF, Yang YB, Shi ZJ, Hou HY, Shen HM, Teng BQ. Effect of hepatitis B i mmunogl obul i n on i nterrupti on of HBV i ntrauteri ne i nfecti on. World J Gastroenterol 2004;10:3215–3217.
72. Zou H, Chen Y, Duan Z, Zhang H. Protective effect of hepatitis B vaccine combined with two-dose hepatitis B immunoglobulin on infants born to HBsAg-positive mothers. PloS one 2011;6:e26748.
73. Yuan J, Lin J, Xu A, Li H, Hu B, Chen J, Yao J, Dong H, Jiang M. Antepartum immunoprophylaxis of three doses of hepatitis B immunoglobulin is not effective: a single-centre randomized study. J Viral Hepat 2006;13:597–604.
74. Xie SS, Li WL. HBV serum markers pattern in 5824 workers. Chinese Journal of clinical medicine research 2005;144:15642–15643.
75. Zhu QX, Zhang YT, Gu WP, Wang Q. A survey of hepatitis B virus infection in migrant workers in Xianju county from 2005 to 2007. Zhejiang Journal of Preventive Medicine 2009;21:25–25.
76. Gong T, Gong Y, Deng D, Ye ML. A cross-sectional study on hepatitis B in migrant workers of Chongqing. Modern Preventive Medicine 2007;34:3842– 3844.
77. Zhang YB, Chen JQ, Hao YT, Chen WH, Ma ZC, Liao YX, Zhang R, Zhu QL. Comparisons and analysis of the hepatitis B infection status of transient population and registered residents in Shenzhen City. Chinese Journal of Disease Control and Prevention 2012;16:424–427.
78. Xu DZ, Yan YP, Zou S, Choi BC, Wang S, Liu P, Bai G, Wang X, Shi M, Wang X. Role of placental tissues in the intrauterine transmission of hepatitis B virus. Am J Obstet Gynecol 2001;185:981–987.
79. Bai GQ, Li SH, Yue YF, Shi L. The study on role of peripheral blood mononuclear cell in HBV intrauterine infection. Arch Gynecol Obstet 2011; 283:317–321.
80. Xu DZ, Yan YP, Choi BC, Xu JQ, Men K, Zhang JX, Liu ZH, Wang FS. Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study. J Med Virol 2002;67:20–26.
81. van Nunen AB, de Man RA, Heijtink RA, Niesters HG, Schalm SW. Lamivudine in the last 4 weeks of pregnancy to prevent perinatal transmission in highly viremic chronic hepatitis B patients. J Hepatol 2000;32:1040–1041.
82. van Zonneveld M, van Nunen AB, Niesters HG, de Man RA, Schalm SW, Janssen HL. Lamivudine treatment during pregnancy to prevent perinatal transmission of hepatitis B virus infection. J Viral Hepat 2003;10:294–297.
83. Shi Z, Yang Y, Ma L, Li X, Schreiber A. Lamivudine in late pregnancy to interrupt in utero transmission of hepatitis B virus: a systematic review and meta-analysis. Obstet Gynecol 2010;116:147–159.
84. MA QS, Zhou YH, Zhang SX, Liang S, Xiao HW, Xie X, Mei SJ, Jia WD, Zhang YF, Cui FQ, Wang FZ, Liang XF. Analysis on the direct economic burden and influence factors of HBV-related diseases in Guangzhou. China Preventive Medicine 2011;12:383–386.
85. Li XQ, Xu HX, Fan XM, Wu Z, Li YF, Zhang SX, Zhuang GH, Zhang LH. Analysis on economic burden and influencing factors of hepatitis B-related diseases patients. Modern Preventive Medicine 2012;39:1871– 1874.
86. Lu JJ, Li RP, Xu AQ, Zhang L, Song LZ, Yan BY, Ji F, Liu JY, Fang XQ, Wang Z, Zhu DW, Zhang GJ, Feng Y, Xiao ZK, Wang J. Economic burden and related factors on inpatients with HBV-related diseases in Shandong province. Zhonghua Liu Xing Bing Xue Za Zhi 2013;34:267–272.