The identification of three novel biomarkers of major adverse kidney events

Biomarkers in Medicine

Volumn 8, Issue 10, 2014, Pages 1207-1217

  Haase, Michael ^a   Bellomo, Rinaldo ^b   Albert, Christian ^a   Vanpoucke, Gregoire ^c   Thomas, Griet ^c   Laroy, Wouter ^c   Verleysen, Katleen ^c   Kropf, Siegfried ^a   Kuppe, Hermann ^d   Hetzer, Roland ^d   Haase Fielitz, Anja ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b AUSTIN HOSPITAL   (Australia)

^c Pronota NV   (Belgium)

^d DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

C terminal fragment of perlecan; cathepsin L; creatinine; cystatin C; latent transforming growth factor binding protein 2; LG3; LTBP2; major adverse kidney event; MAKE; neutrophil gelatinase associated lipocalin; NGAL; urea; urine output

Indexed keywords

CATHEPSIN L; CREATININE; CYSTATIN C; LACTIC ACID; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 2; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PERLECAN; UNCLASSIFIED DRUG; UREA; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; LTBP2 PROTEIN, HUMAN; ONCOPROTEIN; PROTEOHEPARAN SULFATE;

ACUTE KIDNEY FAILURE; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD GAS ANALYZER; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CREATININE BLOOD LEVEL; DIAGNOSTIC TEST ACCURACY STUDY; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART VALVE SURGERY; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; OPEN HEART SURGERY; PHYSIOLOGICAL STRESS; POSTOPERATIVE PERIOD; PREDICTION; PREDICTIVE VALUE; PROGNOSIS; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECEIVER OPERATING CHARACTERISTIC; RENAL REPLACEMENT THERAPY; RISK ASSESSMENT; THORACIC AORTA SURGERY; UREA BLOOD LEVEL; URINALYSIS; URINE VOLUME; ACUTE KIDNEY INJURY; BLOOD; CLINICAL TRIAL; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; URINE; VERY ELDERLY;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CATHEPSIN L; CYSTATIN C; FEMALE; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; LATENT TGF-BETA BINDING PROTEINS; LIPOCALINS; MALE; PROTO-ONCOGENE PROTEINS;

EID: 84919817249     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.14.90     Document Type: Article

References (24)

1. Coppolino G, Presta P, Saturno L, Fuiano G. Acute kidney injury in patients undergoing cardiac surgery. J. Nephrol. 26(1), 32-40 (2013
2. Koyner JL, Garg AX, Coca SG., et al. Biomarkers predict progression of acute kidney injury after cardiac surgery. TRIBE-AKI Consortium. J. Am. Soc. Nephrol. 23(5), 905-914 (2012
3. KDIGO Clinical practice guideline for acute kidney injury. Kidney. Int. Suppl. doi:10.1038/kisup.2012 (2012) (Epub ahead of print
4. McCullough PA, Shaw AD, Haase M., et al. Diagnosis of acute kidney injury using functional and injury biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib. Nephrol. 182, 13-29 (2013
5. Haase M, Haase-Fielitz A, Plass M., et al. Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized controlled trial. PLoS Med. 10(4), e1001426 (2013
6. Bellomo R, Ronco C, Kellum JA., et al. Acute Dialysis Quality Initiative workgroup. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care. 8(4), R204-R212 (2004
7. von Elm E, Altman DG, Egger M., et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370(9596), 1453-1457 (2007
8. Levey AS, Stevens LA, Schmid CH., et al. CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150(9), 604-612 (2009
9. Lange V, Picotti P, Domon B., et al. Selected reaction monitoring for quantitative proteomics: a tutorial. Mol. Syst. Biol. 4(222)(2008
10. Swets JA. Measuring the accuracy of diagnostic systems. Science 3(240), 1285-1293 (1988
11. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44(3), 837-845 (1988
12. Pencina MJ, D'Agostino RB Sr, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat. Med. 30(1), 11-21 (2011
13. Soulez M, Pilon EA, Dieudé M., et al. The perlecan fragment LG3 is a novel regulator of obliterative remodeling associated with allograft vascular rejection. Circ. Res. 110(1), 94-104 (2012
14. Saini MG, Bix GJ. Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons. Brain Res. 15(1438), 65-74 (2012
15. Torres LS, Belini Júnior E, Silva DG., et al. Frequencies of -308G/A (TNFA) and -509C/T (TGFB1) polymorphisms in sickle cell anemia patients from Brazil. Genet. Mol. Res. 12(4), 6762-6766 (2013
16. Breidthardt T, Vanpoucke G, Potocki M., et al. The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea. Clin. Sci. (London) 123(9), 557-566 (2012
17. Kodama F1, Asanuma K, Takagi M., et al. Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy. Nephrol. Dial. Transplant. 28(7), 1762-1772 (2013
18. Urbich C, Heeschen C, Aicher A., et al. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat. Med. 11(2), 206-213 (2005
19. Bauer Y, Hess P, Qiu C., et al. Identification of cathepsin L as a potential sex-specific biomarker for renal damage. Hypertension 57(4), 795-801 (2011
20. Aregger F, Uehlinger DE, Witowski J., et al. Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury. Kidney. Int. 85(4), 909-919 (2013
21. Donadio C. Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients. Crit. Care. 18(1), R39 (2014
22. Bolignano D, Coppolino G. Biomarkers of cardio-renal damage in chronic kidney disease: one size cannot fit all - Crit. Care. 18(2), 134 (2014
23. Krawczeski CD, Goldstein SL, Woo JG., et al. Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J. Am. Coll. Cardiol. 58(22), 2301-2309 (2011
24. Star R, Kimmel P, Molitoris B. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Clinical trials in acute kidney injury: current opportunities and barriers (2011). http://archives.niddk.nih.gov