A simple LC-MS/MS method using HILIC chromatography for the determination of fosfomycin in plasma and urine: Application to a pilot pharmacokinetic study in humans

Journal of Pharmaceutical and Biomedical Analysis

Volumn 105, Issue , 2015, Pages 39-45

  Parker, Suzanne L ^a   Lipman, Jeffrey ^a,b   Roberts, Jason A ^a,b   Wallis, Steven C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Antibiotic; Fosfomycin; HILIC; LC MS MS; Pharmacokinetic

Indexed keywords

FOSFOMYCIN; ANTIINFECTIVE AGENT;

AQUEOUS SOLUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; GOOD CLINICAL PRACTICE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIC STRENGTH; KIDNEY CONCENTRATING CAPACITY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPH; MASS SPECTROMETER; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; MINIMUM PLASMA CONCENTRATION; PH; PRACTICE GUIDELINE; QUALITY CONTROL; SIGNAL NOISE RATIO; STANDARD; TANDEM MASS SPECTROMETRY; URINALYSIS; BLOOD; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CRITICAL ILLNESS; DRUG ADMINISTRATION; DRUG MONITORING; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; PILOT STUDY; PROCEDURES; REPRODUCIBILITY; URINE;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRITICAL ILLNESS; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; DRUG STABILITY; FOSFOMYCIN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IN VITRO TECHNIQUES; INJECTIONS, INTRAVENOUS; LIMIT OF DETECTION; MOLECULAR STRUCTURE; PILOT PROJECTS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84919791212     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.11.042     Document Type: Article

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