Epidemiological, clinical and histological characteristics of HBV/HDV co-infection:a retrospective cross-sectional study in Guangdong, China

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Liao, Baolin ^a   Zhang, Fuchun ^a   Lin, Siwei ^b   He, Haolan ^a   Liu, Yu ^c   Zhang, Jiansheng ^a   Xu, Ying ^c   Yi, Junqing ^a   Chen, Yunqing ^c   Liu, Huiyuan ^a   Wang, Zhanhui ^c   Cai, Weiping ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Yuexiu District Traditional Chinese Medicine Hospital   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; IMMUNOGLOBULIN M; VIRUS DNA; HEPATITIS ANTIBODY;

ADULT; AGE; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; CHEMILUMINESCENCE IMMUNOASSAY; CHEMILUMINESCENCE IMMUNOASSAY KIT; CHINA; CLINICAL FEATURE; CROSS-SECTIONAL STUDY; DELTA AGENT HEPATITIS; DISEASE COURSE; ELISA KIT; END STAGE LIVER DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS; HISTOPATHOLOGY; HOSPITAL PATIENT; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MIXED INFECTION; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; RISK FACTOR; VIRUS REACTIVATION; YOUNG ADULT; BLOOD; COINFECTION; FOLLOW UP; GENETICS; HEPATITIS D; ISOLATION AND PURIFICATION; LIVER FUNCTION TEST; PROGNOSIS; VIROLOGY; VIRUS LOAD;

HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS;

ADULT; AGED; CHINA; COINFECTION; CROSS-SECTIONAL STUDIES; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HEPATITIS ANTIBODIES; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS D; HEPATITIS DELTA VIRUS; HUMANS; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; VIRAL LOAD; YOUNG ADULT;

EID: 84919776424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115888     Document Type: Article

References (40)

1. Rizzetto M, Canese MG, Arico S, Crivelli O, Trepo C, et al. (1977) Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut 18: 997-1003.
2. Fonseca JC (2002) [Hepatitis D]. Rev Soc Bras Med Trop 35: 181-190.
3. Pascarella S, Negro F (2011) Hepatitis D virus: An update. Liver Int 31: 7-21.
4. Sagnelli E, Sagnelli C, Pisaturo M, Macera M, Coppola N (2014) Epidemiology of acute and chronic hepatitis B and delta over the last 5 decades in Italy. World J Gastroenterol 20: 7635-7643.
5. Gaeta GB, Stroffolini T, Chiaramonte M, Ascione T, Stornaiuolo G, et al. (2000) Chronic hepatitis D:A vanishing Disease? An Italian multicenter study. Hepatology 32: 824-827.
6. Navascues CA, Rodriguez M, Sotorrio NG, Sala P, Linares A, et al. (1995) Epidemiology of hepatitis D virus infection: changes in the last 14 years. Am J Gastroenterol 90: 1981-1984.
7. Huo TI, Wu JC, Lin RY, Sheng WY, Chang FY, et al. (1997) Decreasing hepatitis D virus infection in Taiwan: an analysis of contributory factors. J Gastroenterol Hepatol 12: 747-751.
8. Degertekin H, Yalcin K, Yakut M (2006) The prevalence of hepatitis delta virus infection in acute and chronic liver diseases in Turkey: An analysis of clinical studies. Turk J Gastroenterol 17: 25-34.
9. Wedemeyer H, Heidrich B, Manns MP (2007) Hepatitis D virus infection-not a vanishing disease in Europe!. Hepatology 45: 1331-1332, 1332-1333.
10. Gaeta GB, Stroffolini T, Smedile A, Niro G, Mele A (2007) Hepatitis delta in Europe: vanishing or refreshing? Hepatology 46: 1312-1313.
11. Cross TJ, Rizzi P, Horner M, Jolly A, Hussain MJ, et al. (2008) The increasing prevalence of hepatitis delta virus (HDV) infection in South London. J Med Virol 80: 277-282.
12. Rizzetto M (2009) Hepatitis D: thirty years after. J Hepatol 50: 1043-1050.
13. Colombo M, Cambieri R, Rumi MG, Ronchi G, Del NE, et al. (1983) Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis.Gastroenterology 85: 235-239.
14. Sagnelli E, Coppola N, Scolastico C, Filippini P, Santantonio T, et al. (2000) Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis. Hepatology 32: 1106-1110.
15. Fattovich G, Giustina G, Christensen E, Pantalena M, Zagni I, et al. (2000) Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep). Gut 46: 420-426.
16. Mumtaz K, Ahmed US, Memon S, Khawaja A, Usmani MT, et al. (2011) Virological and clinical characteristics of hepatitis delta virus in South Asia. Virol J 8: 312.
17. Ji J, Sundquist K, Sundquist J (2012) A population-based study of hepatitis D virus as potential risk factor for hepatocellular carcinoma. J Natl Cancer Inst 104: 790-792.
18. Romeo R, Del NE, Rumi M, Russo A, Sangiovanni A, et al. (2009) A 28-year study of the course of hepatitis Delta infection: a risk factor for cirrhosis and hepatocellular carcinoma. Gastroenterology 136:1629-1638.
19. Hughes SA, Wedemeyer H, Harrison PM (2011) Hepatitis delta virus. Lancet 378: 73-85.
20. Wedemeyer H, Manns MP (2010) Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead. Nat Rev Gastroenterol Hepatol 7: 31-40.
21. Olivero A, Smedile A (2012) Hepatitis delta virus diagnosis. Semin Liver Dis 32: 220-227.
22. Calle SB, Grosshennig A, Homs M, Heidrich B, Erhardt A, et al. (2014) Development and evaluation of a baseline-event-anticipation score for hepatitis delta. J Viral Hepat 21: e154-e163.
23. Liao B, Wang Z, Lin S, Xu Y, Yi J, et al. (2013) Significant Fibrosis Is Not Rare in Chinese Chronic Hepatitis B Patients with Persistent Normal ALT. PLoS One 8: e78672.
24. Bedossa P, Poynard T (1996) An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 24: 289-293.
25. Abbas Z, Jafri W, Raza S (2010) Hepatitis D: Scenario in the Asia-Pacific region. World J Gastroenterol 16: 554-562.
26. Lu SN, Chen TM, Lee CM, Wang JH, Tung HD, et al. (2003) Molecular epidemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis viruses (B, C, D) endemic community in Taiwan. J Med Virol 70: 74-80.
27. Shen L, Gu Y, Sun L, Yang Y, Wang F, et al. (2012) Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China. J Med Virol 84: 445-449.
28. Chen GH, Zhang MD, Huang W (1990) Hepatitis delta virus superinfection in Guangzhou area. Chin Med J (Engl) 103: 451-454.
29. Schaper M, Rodriguez-Frias F, Jardi R, Tabernero D, Homs M, et al. (2010) Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D. J Hepatol 52: 658-664.
30. Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, et al. (2010) Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. Liver Int 30: 430-437.
31. Heidrich B, Deterding K, Tillmann HL, Raupach R, Manns MP, et al. (2009) Virological and clinical characteristics of delta hepatitis in Central Europe. J Viral Hepat 16: 883-894.
32. Williams V, Brichler S, Radjef N, Lebon P, Goffard A, et al. (2009) Hepatitis delta virus proteins repress hepatitis B virus enhancers and activate the alpha/beta interferon-inducible MxA gene. J Gen Virol 90: 2759-2767.
33. Wu JC, Chen TZ, Huang YS, Yen FS, Ting LT, et al. (1995) Natural history of hepatitis D viral superinfection: significance of viremia detected by polymerase chain reaction. Gastroenterology 108:796-802.
34. Wursthorn K, Manns MP, Wedemeyer H (2008) Natural history: the importance of viral load, liver damage and HCC. Best Pract Res Clin Gastroenterol 22: 1063-1079.
35. Chen CJ, Yang HI, Iloeje UH (2009) Hepatitis B virus DNA levels and outcomes in chronic hepatitis B. Hepatology 49: S72-S84.
36. Su CW, Huang YH, Huo TI, Shih HH, Sheen IJ, et al. (2006) Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients. Gastroenterology 130: 1625-1635.
37. Yurdaydin C, Idilman R, Bozkaya H, Bozdayi AM (2010) Natural history and treatment of chronic delta hepatitis. J Viral Hepat 17: 749-756.
38. Ho E, Deltenre P, Nkuize M, Delwaide J, Colle I, et al. (2013) Coinfection of hepatitis B and hepatitis delta virus in Belgium: A multicenter BASL study. Prospective epidemiology and comparison with HBV mono-infection. J Med Virol 85: 1513-1517.
39. Seto WK, Lai CL, IP PP, Fung J, Wong DK, et al. (2012) A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. PLoS One 7:e32622.
40. Mederacke I, Yurdaydin C, Dalekos GN, Bremer B, Erhardt A, et al. (2012) Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-alpha2a treatment. Antivir Ther 17: 305-312.