Dietary protein requirement of female adults >65 years determined by the indicator amino acid oxidation technique is higher than current recommendations

Journal of Nutrition

Volumn 145, Issue 1, 2015, Pages 18-24

  Rafii, Mahroukh ^a   Chapman, Karen ^a   Owens, Jillian ^a   Elango, Rajavel ^b,c   Campbell, Wayne W ^d   Ball, Ronald O ^e,f   Pencharz, Paul B ^a,e,f   Courtney Martin, Glenda ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BC CHILDREN S HOSPITAL   (Canada)

^d PURDUE UNIVERSITY   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Indicator amino acid oxidation; Older female adults; Phenylalanine oxidation; Protein requirement; Stable isotope

Indexed keywords

ALANINE; AMINO ACID; AMINO ACID MIXTURE; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; EGG PROTEIN; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRACER; TRYPTOPHAN; TYROSINE; VALINE; CARBON; FLUORINE; PROTEIN INTAKE;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CLINICAL TRIAL; DIETARY REFERENCE INTAKE; FEMALE; GROUPS BY AGE; HUMAN; LEAN BODY WEIGHT; NITROGEN BALANCE; NORMAL HUMAN; OXIDATION; PROTEIN INTAKE; RESTING ENERGY EXPENDITURE; YOUNG ADULT; ADMINISTRATION AND DOSAGE; AGE; CALORIC INTAKE; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC USE; ENERGY METABOLISM; ISOTOPE LABELING; NUTRITION; NUTRITIONAL REQUIREMENT; OXIDATION REDUCTION REACTION; RANDOMIZED CONTROLLED TRIAL; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AMINO ACIDS; CARBON ISOTOPES; DIETARY PROTEINS; ENERGY INTAKE; ENERGY METABOLISM; FEMALE; FLUORINE; HUMANS; ISOTOPE LABELING; NUTRITION PROCESSES; NUTRITIONAL REQUIREMENTS; OXIDATION-REDUCTION; PHENYLALANINE; TYROSINE;

EID: 84919754692     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.197517     Document Type: Article

References (57)

1. Bales CW, Ritchie CS. Sarcopenia, weight loss, and nutritional frailty in the elderly. Annu Rev Nutr 2002;22:309-23.
2. Morais JA, Gougeon R, Pencharz PB, Jones PJ, Ross R, Marliss EB. Wholebody protein turnover in the healthy elderly. Am J Clin Nutr 1997;66:880-9.
3. Uauy R, Winterer JC, Bilmazes C, Haverberg LN, Scrimshaw NS, Munro HN, Young VR. The changing pattern of whole body protein metabolism in aging humans. J Gerontol 1978;33:663-71.
4. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 2008;87:1562S-6S.
5. Evans W. Functional and metabolic consequences of sarcopenia. J Nutr 1997;127(Suppl):998S-1003S.
6. Fujita S, Volpi E. Amino acids and muscle loss with aging. J Nutr 2006;136(Suppl):277S-80S.
7. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the health, aging, and body composition (Health ABC Study). Am J Clin Nutr 2008;87:150-5.
8. Castaneda C, Charnley JM, Evans WJ, Crim MC. Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response. Am J Clin Nutr 1995;62:30-9.
9. Castaneda C, Dolnikowski GG, Dallal GE, Evans WJ, Crim MC. Protein turnover and energy metabolism of elderly women fed a lowprotein diet. Am J Clin Nutr 1995;62:40-8.
10. Berner LA, Becker G, Wise M, Doi J. Characterization of dietary protein among older adults in the United States: amount, animal sources, and meal patterns. J Acad Nutr Diet 2013;113:809-15.
11. Fulgoni VL III. Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008;87:1554S-7S.
12. Gregorio L, Brindisi J, Kleppinger A, Sullivan R, Mangano KM, Bihuniak JD, Kenny AM, Kerstetter JE, Insogna KL. Adequate dietary protein is associated with better physical performance among postmenopausal women 60-90 years. J Nutr Health Aging 2014;18:155-60.
13. Donald G, Fowles SG. A profile of older Americans. Administration on Aging, U.S. Department of Health and Human Services; 2011. http://www.ada.gov/ADArootAging.
14. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes: energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. Washington: The National Academies Press; 2005.
15. Rand WM, Pellett PL, Young VR. Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr 2003;77:109-27.
16. Fuller MF, Garlick PJ. Human amino acid requirements: can the controversy be resolved? Annu Rev Nutr 1994;14:217-41.
17. Young VR. Nutritional balance studies: indicators of human requirements or of adaptive mechanisms? J Nutr 1986;116:700-3.
18. Humayun MA, Elango R, Ball RO, Pencharz PB. Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Clin Nutr 2007;86:995-1002.
19. Campbell WW, Crim MC, Dallal GE, Young VR, Evans WJ. Increased protein requirements in elderly people: new data and retrospective reassessments. Am J Clin Nutr 1994;60:501-9.
20. Cheng AH, Gomez A, Bergan JG, Lee TC, Monckeberg F, Chichester CO. Comparative nitrogen balance study between young and aged adults using three levels of protein intake from a combination wheatsoy-milk mixture. Am J Clin Nutr 1978;31:12-22.
21. Zanni E, Calloway DH, Zezulka AY. Protein requirements of elderly men. J Nutr 1979;109:513-24.
22. Uauy R, Scrimshaw NS, Young VR. Human protein requirements: nitrogen balance response to graded levels of egg protein in elderly men and women. Am J Clin Nutr 1978;31:779-85.
23. Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 2013;14:542-59.
24. Tang M, McCabe GP, Elango R, Pencharz PB, Ball RO, Campbell WW. Assessment of protein requirement in octogenarian women with use of the indicator amino acid oxidation technique. Am J Clin Nutr 2014;99:891-8.
25. Bross R, Ball RO, Pencharz PB. Development of a minimally invasive protocol for the determination of phenylalanine and lysine kinetics in humans during the fed state. J Nutr 1998;128:1913-9.
26. Reilly JJ, Murray LA, Wilson J, Durnin JV. Measuring the body composition of elderly subjects: a comparison of methods. Br J Nutr 1994;72:33-44.
27. Durnin JV, Rahaman MM. The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr 1967;21:681-9.
28. Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986;60:1327-32.
29. Roubenoff R, Baumgartner RN, Harris TB, Dallal GE, Hannan MT, Economos CD, Stauber PM, Wilson PW, Kiel DP. Application of bioelectrical impedance analysis to elderly populations. J Gerontol A Biol Sci Med Sci 1997;52:M129-36.
30. Elango R, Humayun MA, Ball RO, Pencharz PB. Indicator amino acid oxidation is not affected by period of adaptation to a wide range of lysine intake in healthy young men. J Nutr 2009;139:1082-7.
31. Elango R, Humayun MA, Ball RO, Pencharz PB. Protein requirement of healthy school-age children determined by the indicator amino acid oxidation method. Am J Clin Nutr 2011;94:1545-52.
32. Zello GA, Pencharz PB, Ball RO. Phenylalanine flux, oxidation, and conversion to tyrosine in humans studied with L-[1-13C]phenylalanine. Am J Physiol 1990;259:E835-43.
33. Shiman R, Gray DW. Formation and fate of tyrosine. Intracellular partitioning of newly synthesized tyrosine in mammalian liver. J Biol Chem 1998;273:34760-9.
34. Kriengsinyos W, Wykes LJ, Ball RO, Pencharz PB. Oral and intravenous tracer protocols of the indicator amino acid oxidation method provide the same estimate of the lysine requirement in healthy men. J Nutr 2002;132:2251-7.
35. Matthews DE, Motil KJ, Rohrbaugh DK, Burke JF, Young VR, Bier DM. Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-3C]leucine. Am J Physiol 1980;238: E473-9.
36. Hoerr RA, Yu YM, Wagner DA, Burke JF, Young VR. Recovery of 13C in breath from NaH13CO3 infused by gut and vein: effect of feeding. Am J Physiol 1989;257:E426-38.
37. Kriengsinyos W, Wykes LJ, Goonewardene LA, Ball RO, Pencharz PB. Phase of menstrual cycle affects lysine requirement in healthy women. Am J Physiol Endocrinol Metab 2004;287:E489-96.
38. Elango R, Humayun MA, Ball RO, Pencharz PB. Lysine requirement of healthy school-age children determined by the indicator amino acid oxidation method. Am J Clin Nutr 2007;86:360-5.
39. Di Buono M, Wykes LJ, Ball RO, Pencharz PB. Total sulfur amino acid requirement in young men as determined by indicator amino acid oxidation with L-[1-13C]phenylalanine. Am J Clin Nutr 2001;74:756-60.
40. Courtney-Martin G, Chapman KP, Moore AM, Kim JH, Ball RO, Pencharz PB. Total sulfur amino acid requirement and metabolism in parenterally fed postsurgical human neonates. Am J Clin Nutr 2008;88:115-24.
41. Chapman KP, Courtney-Martin G, Moore AM, Ball RO, Pencharz PB. Threonine requirement of parenterally fed postsurgical human neonates. Am J Clin Nutr 2009;89:134-41.
42. Chapman KP, Courtney-Martin G, Moore AM, Langer JC, Tomlinson C, Ball RO, Pencharz PB. Lysine requirement in parenterally fed postsurgical human neonates. Am J Clin Nutr 2010;91:958-65.
43. Seber GAF. Linear regression analysis. New York: Wiley; 1977.
44. Zello GA, Pencharz PB, Ball RO. Dietary lysine requirement of young adult males determined by oxidation of L-[1-13C]phenylalanine. Am J Physiol 1993;264:E677-85.
45. Kato M, Hattori S, Kohsuke H. Estimation of amino acid requirement adjusting for carry-over effect based on approximate change-point regression model. Biomedical Research India 2013;24:216-22.
46. Hayamizu K, KatoM, Hattori S. Determining amino acid requirements from repeated observations on indicator amino acid oxidation method by mixedeffect change-point regression models. J Clin Biochem Nutr 2011;49:115-20.
47. Millward DJ. Optimal intakes of protein in the human diet. Proc Nutr Soc 1999;58:403-13.
48. Gaffney-Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc 2009;57:1073-9.
49. Young VR, Bier DM. Amino acid requirements in the adult human: how well do we know them? J Nutr 1987;117:1484-7.
50. Reeds PJ, Hutchens TW. Protein requirements: from nitrogen balance to functional impact. J Nutr 1994;124(Suppl):1754S-64S.
51. Jackson AA, Gibson NR, Lu Y, Jahoor F. Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary protein. Am J Clin Nutr 2004;80:101-7.
52. CampbellWW, Trappe TA, Jozsi AC, Kruskall LJ,Wolfe RR, Evans WJ. Dietary protein adequacy and lower body versus whole body resistive training in older humans. J Physiol 2002;542:631-42.
53. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucoseinduced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 2000;85:4481-90.
54. Symons TB, Schutzler SE, Cocke TL, Chinkes DL, Wolfe RR, Paddon-Jones D. Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr 2007;86:451-6.
55. Arnal MA, Mosoni L, Boirie Y, Houlier ML, Morin L, Verdier E, Ritz P, Antoine JM, Prugnaud J. Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr 1999;69:1202-8.
56. Millward DJ, Jackson AA. Protein requirements and the indicator amino acid oxidation method. Am J Clin Nutr 2012;95:1498-501; author reply 501-2.
57. Fukagawa NK. Protein requirements: methodologic controversy amid a call for change. Am J Clin Nutr 2014;99:761-2.