Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats

Psychopharmacology

Volumn 231, Issue 21, 2014, Pages 4145-4155

  Morales Rivera, Amarilys ^a   Hernández Burgos, Mayté M ^b   Martínez Rivera, Arlene ^b   Pérez Colón, Jeremy ^b   Rivera, Raymond ^b   Montalvo, Janitza ^b   Rodríguez Borrero, Enrique ^b   Maldonado Vlaar, Carmen S ^b  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO RIO PIEDRAS   (Puerto Rico)

Author keywords

Anxiety; Cocaine; Drug seeking behavior; Intracerebroventricular injections; Oxytocin; Self administration

Indexed keywords

COCAINE; OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN DERIVATIVE; ANXIOLYTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; ASSOCIATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG SEEKING BEHAVIOR; ELEVATED PLUS MAZE TEST; INFUSION; LOCOMOTION; MALE; NONHUMAN; RAT; REWARD; TRANQUILIZING ACTIVITY; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; DRUG SELF ADMINISTRATION; DRUG THERAPY; REINFORCEMENT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; COCAINE; CUES; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; MALE; OXYTOCIN; RATS; RATS, SPRAGUE-DAWLEY; SELF ADMINISTRATION;

EID: 84919752729     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3553-y     Document Type: Article

References (43)

1. Bale TL, Davis AM, Auger AP, Dorsa DM, McCarthy MM (2001) CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 21:2546-2552. doi: 10.1038/npp.2011.95
2. Basso AM, Spina M, Rivier J, Vale W, Koob GF (1999) Corticotropin-releasing factor antagonist attenuates the anxiogenic-like effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology 145:21-30. doi: 10.1007/2Fs002130051028
3. Blanchard DC, Blanchard RJ (1999) Cocaine potentiates defensive behaviors related to fear and anxiety. Neurosci Biobehav 23:981-991
4. Blume A, Bosch OJ, Miklos S, Torner L, Wales L, Waldherr M, Neumann ID (2008) Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat
5. Campbell A (2010) Oxytocin and human social behavior. Personality and Social Psychology Review. Off J Soc Pers Soc Psychol, Inc 14:281-295. doi: 10.1177/1088868310363594
6. Carson DS, Cornish JL, Guastella AJ, Hunt GE, McGregor IS (2010) Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats. Neuropharmacology 58:38-43. doi: 10.1016/j.neuropharm.2009.06.018
7. Demaria S Jr, Weinkauf JL (2011) Cocaine and the club drugs. Int Anesthesiol Clin Winter 49:79-101. doi: 10.1097/AIA.0b013e3181ffc0cb
8. Esposito RU, Motola AM, Kornetsky CK (1978) Cocaine: acute effects reinforcement thresholds for self self-stimulation behavior to the medial forebrain bundle. Pharmacol Biochem Behav Behav 8:437. doi: 10.1016/0091
9. Erb S (2010) Evaluation of the relationship between anxiety during withdrawal and stress induced reinstatement of cocaine seeking. Prog Neuropsychopharmacol Biol Psychiatry 34:798-807. doi: 10.1016/j.pnpbp.2009.11.025
10. Febo M, Numan M, Ferris CF (2005) Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling. J Neurosci 25:11637-11644. doi: 10.1523/JNEUROSCI.3604-05.2005
11. Goeders NE, Clampitt DM, Keller C, Sharma M, Guerin GF (2009) Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology 201(4):581-588. doi: 10.1007/s00213-008-1326-1
12. Grooppe SE, Gossen A, Rademacher L, Hahn A, Westphal L, Gründer G, Spreckelmeyer KN (2014) Oxytocin influences processing of sociality relevant cues in the ventral tegmental area of the human brain. Biol Psychiatry. doi: 10.1016/j.biopsych.2012.12.023
13. Haney M, Maccari S, Le Moal M, Simon H, Piazza PV (1995) Social stress increases the acquisition of cocaine self-administration in male and female rats. Brain Res 698:46-52. doi: 10.1016/0006-8993(95)00788-R
14. Huber D, Veinante P, Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308:245-248. doi: 10.1126/science.1105636
15. Insel TR, Gingrich BS, Young LJ (2001) Oxytocin: who needs it? Prog Brain Res 133:59-66. doi: 10.1016/S0079-6123(01)33005-4
16. Knobloch HS, Charlet A, Hoffmann LC, Eliava M, Khrulev S, Cetin AH, Osten P, Schwarz MK, Seeburg PH, Stoop R, Grinevich V (2012) Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73:553-566. doi: 10.1016/j.neuron.2011.11.030
17. Kovacs GL, Sarnyai Z, Barbarczi E, Szabo G, Telegdy G (1990) The role of oxytocin dopamine interactions in cocaine-induced locomotor hyperactivity. Neuropharmacology 29:365-368. doi: 10.1016/0028-3908(90)90095-9
18. Kovacs GL, Sarnyai Z, Szabo G (1998) Oxytocin and addiction: a review. Psychoneuroendocrinology 23:945-962. doi: 10.1016/S0306-4530(98)00064-X
19. Lee HJ, Macbeth AH, Pagani JH, Young WS 3rd (2009) Oxytocin: the great facilitator of life. Prog Neurobiol 88:127-151. doi: 10.1016/j.pneurobio.2009.04.001
20. Leng G, Meddle SL, Douglas AJ (2008) Oxytocin and the maternal brain. Curr Opin Pharmacol 8:731-734. doi: 10.1016/j.coph.2008.07.001
21. Manning M, Sawyer WH (1989) Discovery, development, and some uses of vasopressin and oxytocin antagonists. J Lab Clin Med 114:617-632
22. Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G (2008) Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res 170:473-512. doi: 10.1016/S0079-6123(08)00437-8
23. Mantsch JR, Baker DA, Francis DM, Katz ES, Hoks MA, Serge JP (2008) Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats. Psychopharmacology 195:591-603
24. Martínez-Rivera A, Rodríguez-Borrero E, Matías-Alemán M, Montalvo-Acevedo A, Guerrero-Figuereo K, Febo-Rodríguez LJ, Morales-Rivera A, Maldonado-Vlaar CS (2013) Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression. Pharmacol, Biochem Behav 110:154-160. doi: 10.1016/j.pbb.2013.06.01
25. McCarthy MM, McDonald CH, Brooks PJ, Goldman D (1996) An anxiolytic action of oxytocin is enhanced by estrogen in the mouse. Physiol Behav 60:1209-1215. doi: 10.1016/S0031-9384(96)00212-0
26. McGregor IS, Callaghan PD, Hunt GE (2008) From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? Br J Pharmacol 154:358-368. doi: 10.1038/bjp.2008.132
27. Meil WM, See RE (1996) Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse. Behav Pharmacol 7:754-763. doi: 10.1016/j.ddmod.2009.03.001
28. Neumann ID (2008) Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J Neuroendocrinol 20:858-865. doi: 10.1111/j.1365-2826.2008.01726.x
29. Neumann ID (2002) Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis. Prog Brain Res 139:147-162. doi: 10.1016/S0079-6123(02)39014-9
30. O'Brien CP, Childress AR, McLellan AT, Ehrman R (1992) Classical conditioning in drug-dependent humans. Ann N Y Acad Sci 28:400-415. doi: 10.1111/j.1749
31. Olff M, Langeland W, Witteveen A, Denys D (2010) A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder. CNS Spectr 15:522-530. doi: 10.1007/s00125-012-2803-y
32. Pedersen CA, Boccia ML (2003) Oxytocin antagonism alters rat dams oral grooming and upright posturing over pups. Physiol Behav 80:233-241. doi: 10.1016/j.physbeh.2003.07.011
33. Ramos-Ortolaza DL, Negrón A, Cruz D, Falcón E, Iturbe MC, Cajigas MH, Maldonado-Vlaar CS (2009) Intra-accumbens shell injections of SR48692 enhanced cocaine self-administration intake in rats exposed to an environmentally-elicited reinstatement paradigm. Brain Res 1280:124-136. doi: 10.1016/j.brainres.2009.05.006
34. Richard S, Zingg HH (1990) The human oxytocin gene promoter is regulated by estrogen. J Biol Chem 265:6098-6103
35. Rodríguez-Borrero E, Rivera-Escalera F, Candelas F, Montalvo J, Muñoz-Miranda WJ, Walker JR, Maldonado-Vlaar CS (2010) Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats. Neuropharmacology 58:88-101. doi: 10.1016/j.neuropharm.2009.06.040
36. Sánchez-Andrade G, Kendrick KM (2008) The main olfactory system and social estrogens. J Biol Chem 265:6098-6103
37. Sarnyai Z, Szabo G, Kovacs GL, Telegdy G (1992) Opposite actions of oxytocin and vasopressin in the development of cocaine-induced behavioral sensitization in mice. Pharmacol, Biochem Behav 43:491-494. doi: 10.1016/0091-3057(92)90182-F
38. Sinha R, Fuse T, Aubin LR, O'Malley SS (2000) Psychological stress, drug related cues and cocaine craving. Psychopharmacology 152:140-148. doi: 10.1007/s002130000499
39. Terenzi MG, Ingram CD (2005) Oxytocin-induced excitation of neurons in the rat central and medial amygdaloid nuclei. Neuroscience 134:345-354. doi: 10.1016/j.neuroscience.2005.04.004
40. Viviani D, Terrettaz T, Magara F, Stoop R (2010) Oxytocin enhances the inhibitory effects of diazepam in the rat central medial amygdala. Neuropharmacology 58:62-68. doi: 10.1016/j.neuropharm.2009.06.039
41. Windle RJ, Shanks N, Lightman SL, Ingram CD (1997) Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 138:2829-2834. doi: 10.1210/en.138.7.2829
42. Windle RJ, Kershaw YM, Shanks N, Wood SA, Lightman SL, Ingram CD (2004) Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J Neurosci 24:2974-2982. doi: 10.1523/JNEUROSCI.3432-03.2004
43. Winslow JT, Hearn EF, Ferguson J, Young LJ, Matzuk MM, Insel TR (2000) Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse. Horm Behav 37:145-155. doi: 10.1006/hbeh.1999.1566