Skin under the sun: When melanin pigment meets vitamin D

Endocrinology

Volumn 156, Issue 1, 2015, Pages 1-4

  Slominski, Andrzej ^a,b   Postlethwaite, Arnold E ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; MELANIN; VITAMIN D; DOPACHROME ISOMERASE; EXOC2 PROTEIN, HUMAN; ISOMERASE; MEMBRANE PROTEIN; MONOPHENOL MONOOXYGENASE; OXIDOREDUCTASE; TYRP1 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

GENETIC LINKAGE; HUMAN; NONHUMAN; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN PIGMENTATION; SUN EXPOSURE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; GENETICS; METABOLISM;

HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MEMBRANE GLYCOPROTEINS; MONOPHENOL MONOOXYGENASE; OXIDOREDUCTASES; POLYMORPHISM, SINGLE NUCLEOTIDE; SKIN PIGMENTATION; VESICULAR TRANSPORT PROTEINS;

EID: 84919733759     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1918     Document Type: Review

References (20)

1. Saternus R, Pilz S, Gräber S, et al.Acloser look at evolution: variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1 and DCT, are associated with 25(OH)D serum concentration. Endocrinology. 2015;156:39-47
2. Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: Regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol. 2012;212:v, vii, 1-115
3. Desotelle JA, Wilking MJ, Ahmad N. The circadian control of skin and cutaneous photodamage. Photochem Photobiol. 2012;88(5): 1037-1047
4. Kripke ML. Ultraviolet radiation and immunology: Something new under the sun-presidential address. Cancer Res. 1994;54(23):6102-6105
5. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004;84(4):1155-1228
6. Costin GE, Hearing VJ. Human skin pigmentation: Melanocytes modulate skin color in response to stress. FASEB J. 2007;21(4): 976-994
7. WoodJM, Jimbow K, Boissy RE, S et al. What's the use of generating melanin? Exp Dermatol. 1999;8(2):153-164
8. Slominski A, Zmijewski MA, Pawelek J. L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res. 2012;25(1):14-27
9. Slominski A, Paus R, Schadendorf D. Melanocytes as "sensory" and regulatory cells in the epidermis. J Theor Biol. 1993;164(1):103-120
10. Takeuchi S, Zhang W, Wakamatsu K, et al. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci USA. 2004;101(42):15076-15081
11. Mitra D, Luo X, Morgan A, et al. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012;491(7424):449-453
12. Olivares C, Solano F. New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins. Pigment Cell Melanoma Res. 2009;22(6):750-760
13. Liu JJ, Fisher DE. Lighting a path to pigmentation: Mechanisms of MITF induction by UV. Pigment Cell Melanoma Res. 2010;23(6): 741-745
14. Holick MF. VitaminDdeficiency.NEngl J Med. 2007;357(3):266-281.
15. Holick MF. Vitamin D: A millennium perspective. J Cell Biochem. 2003;88(2):296-307
16. Bikle DD. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011;347(1-2):80-89
17. Slominski AT, Kim TK, Shehabi HZ, et al. In vivo evidence for a novel pathway of vitamin D metabolism initiated by P450scc and modified by CYP27B1. FASEB J. 2012;26(9):3901-3915
18. Elias PM, Menon G, Wetzel BK, Williams JJ. Evidence that stress to the epidermal barrier influenced the development of pigmentation in humans. Pigment Cell Melanoma Res. 2009;22(4):420-434
19. Slominski A. Neuroendocrine activity of the melanocyte. Exp Dermatol. 2009;18(9):760-763
20. Han J, Kraft P, Nan H, et al. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet. 2008;4(5):e1000074.