Molecular characterization of carbapenemase and cephalosporinase genes among clinical isolates of acinetobacter baumannii in a tertiary medical centre in Malaysia

Journal of Medical Microbiology

Volumn 64, Issue 1, 2015, Pages 53-58

  Biglari, Shirin ^a   Alfizah, Hanafiah ^a   Ramliza, Ramli ^a   Rahman, Md Mostafizur ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CARBAPENEMASE; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN; CEPHALOSPORINASE; IMIPENEM; MEROPENEM; RNA 16S; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; DNA DIRECTED RNA POLYMERASE; RIBOSOME DNA; RNA POLYMERASE BETA SUBUNIT;

ACINETOBACTER BAUMANNII; ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLA ADC GENE; BLA OXA 23 GENE; BLA OXA 51 GENE; CHILD; FEMALE; GENETIC ANALYSIS; HUMAN; INFANT; ISABA1 GENE; MALAYSIA; MALE; MINIMUM INHIBITORY CONCENTRATION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RNA SEQUENCE; RPOB GENE; TERTIARY HEALTH CARE; ACINETOBACTER INFECTION; CHEMISTRY; DNA SEQUENCE; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; TERTIARY CARE CENTER; VERY ELDERLY; YOUNG ADULT;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CEPHALOSPORINASE; CEPHALOSPORINS; CHILD; CHILD, PRESCHOOL; DNA, BACTERIAL; DNA, RIBOSOMAL; DNA-DIRECTED RNA POLYMERASES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALAYSIA; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; TERTIARY CARE CENTERS; YOUNG ADULT;

EID: 84919724024     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.082263-0     Document Type: Article

References (27)

1. Bou, G. & Martínez-Beltrán, J. (2000). Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC beta-lactamase in Acinetobacter baumannii. Antimicrob Agents Chemother 44, 428-432.
2. Bratu, S., Landman, D., Martin, D. A., Georgescu, C. & Quale, J. (2008). Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. Antimicrob Agents Chemother 52, 2999-3005.
3. Brown, S. & Amyes, S. (2006). OXA b-lactamases in Acinetobacter: the story so far. J Antimicrob Chemother 57, 1-3.
4. CLSI (2013). Performance Standards for Antimicrobial Susceptibility Testing; 23rd Informational Supplement M100-S23. Wayne, PA: Clinical and Laboratory Standards Institute.
5. Corvec, S., Caroff, N., Espaze, E., Giraudeau, C., Drugeon, H. & Reynaud, A. (2003). AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains. J Antimicrob Chemother 52, 629-635.
6. Corvec, S., Poirel, L., Naas, T., Drugeon, H. & Nordmann, P. (2007). Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii. Antimicrob Agents Chemother 51, 1530-1533.
7. Danes, C., Navia, M. M., Ruiz, J., Marco, F., Jurado, A., Jimenez de Anta, M. T. & Vila, J. (2002). Distribution of b-lactamases in Acinetobacter baumannii clinical isolates and the effect of Syn 2190 (AmpC inhibitor) on the MICs of different b-lactam antibiotics. J Antimicrob Chemother 50, 261-264.
8. Dijkshoorn, L., Nemec, A. & Seifert, H. (2007). An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 5, 939-951.
9. Héritier, C., Poirel, L., Fournier, P. E., Claverie, J. M., Raoult, D. & Nordmann, P. (2005). Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob Agents Chemother 49, 4174-4179.
10. Hujer, K. M., Hujer, A. M., Hulten, E. A., Bajaksouzian, S., Adams, J. M., Donskey, C. J., Ecker, D. J., Massire, C., Eshoo, M. W. & other authors (2006). Analysis of antibiotic resistance genes in multidrugresistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother 50, 4114-4123.
11. Kong, B. H., Mohd Yusof, M. Y. & Thong, K. L. (2012). Persistence of ISAba1-blaOXA-23 Acinetobacter baumannii in Intensive Care Unit, University Hospital. In Proceedings of National Postgraduate Seminar, pp. 67-68, 00004462_83150.
12. Koshy, P., Wuen, Y. T., Sekaran, M. & Hashim, Y. (2008). Identification of major cultivable aerobic bacteria in the oral cavity of Malaysian subjects. Am J Biochem Biotech 4, 367-370.
13. La Scola, B., Gundi, V. A. K. B., Khamis, A. & Raoult, D. (2006). Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species. J Clin Microbiol 44, 827-832.
14. Lean, S. S., Suhaili, Z., Ismail, S., Rahman, N. I. A., Othman, N., Abdullah, F. H., Jusoh, Z., Yeo, C. C. & Thong, K. L. (2014). Prevalence and genetic characterization of carbapenem-and polymyxin-resistant Acinetobacter baumannii isolated from a tertiary hospital in Terengganu, Malaysia. ISRN Microbiology 2014, 953417.
15. Lin, Y. C., Hsia, K. C., Chen, Y. C., Sheng, W. H., Chang, S. C., Liao, M. H. & Li, S. Y. (2010). Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. Antimicrob Agents Chemother 54, 2078-2084.
16. Lopes, B. S., Hamouda, A., Findlay, J. & Amyes, S. G. B. (2011). Effect of frameshift mutagen acriflavine on control of resistance genes in Acinetobacter baumannii. J Med Microbiol 60, 211-215.
17. Mahillon, J. & Chandler, M. (1998). Insertion sequences. Microbiol Mol Biol Rev 62, 725-774.
18. Mendes, R.E., Kiyota, K. A., Monteiro, J., Castanheira, M., Andrade, S.S., Gales, A. C., Pignatari, A. C. C. & Tufik, S. (2007). Rapid detection and identification of metallo-b-lactamase-encoding genes by multiplex realtime PCR assay and melt curve analysis. J Clin Microbiol 45, 544-547.
19. Munoz-Price, L. S. & Weinstein, R. A. (2008). Acinetobacter infection. N Engl J Med 358, 1271-1281.
20. Opazo, A., Domínguez, M., Bello, H., Amyes, S. G. & González-Rocha, G. (2012). OXA-type carbapenemases in Acinetobacter baumannii in South America. J Infect Dev Ctries 6, 311-316.
21. Peleg, A. Y., Seifert, H. & Paterson, D. L. (2008). Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21, 538-582.
22. Perez, F., Hujer, A. M., Hujer, K. M., Decker, B. K., Rather, P. N. & Bonomo, R. A. (2007). Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 51, 3471-3484.
23. Towner, K. J. (2000). Acinetobacter in intensive care units. CPD Infect 1, 99-102.
24. Turton, J. F., Ward, M. E., Woodford, N., Kaufmann, M. E., Pike, R., Livermore, D. M. & Pitt, T. L. (2006a). The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 258, 72-77.
25. Turton, J. F., Woodford, N., Glover, J., Yarde, S., Kaufmann, M. E. & Pitt, T. L. (2006b). Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. J Clin Microbiol 44, 2974-2976.
26. Wang, D., Yan, D., Hou, W., Zeng, X., Qi, Y. & Chen, J. (2014). Characterization of blaOXA-23 gene in isolates of Acinetobacter baumannii. J Microbiol Immunol Infect doi:10.1016/j.jmii.2014.01.007 [Epub ahead of print].
27. Woodford, N., Ellington, M. J., Coelho, J. M., Turton, J. F., Ward, M. E., Brown, S., Amyes, S. G. B. & Livermore, D. M. (2006). Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 27, 351-353.