Algal chloroplast produced camelid VHH antitoxins are capable of neutralizing botulinum neurotoxin

Plant Biotechnology Journal

Volumn 13, Issue 1, 2015, Pages 117-124

  Barrera, Daniel J ^a   Rosenberg, Julian N ^b,c   Chiu, Joanna G ^a   Chang, Yung Nien ^c   Debatis, Michelle ^d   Ngoi, Soo Mun ^e   Chang, John T ^e   Shoemaker, Charles B ^d   Oyler, George A ^b,c   Mayfield, Stephen P ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Johns Hopkins University   (United States)

^c SYNAPTIC RESEARCH LLC   (United States)

^d TUFTS UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Algae; Biotechnology; Chloroplast; Neurotoxin; Recombinant protein

Indexed keywords

ALGAE; CAMELIDAE; CHLAMYDOMONAS REINHARDTII; CHLOROPHYTA; ESCHERICHIA COLI; MUS; RATTUS;

ANTIGEN; ANTITOXIN; BOTULINUM TOXIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION; NANOBODY; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL; CELL SURVIVAL; CHLAMYDOMONAS REINHARDTII; CHLOROPLAST; GENE VECTOR; GENETIC TRANSFORMATION; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOUSE; NEW WORLD CAMELID; POLYMERASE CHAIN REACTION; TRANSGENE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS; ANTITOXINS; BOTULINUM TOXINS; CAMELIDS, NEW WORLD; CELL SURVIVAL; CHLAMYDOMONAS REINHARDTII; CHLOROPLASTS; GENETIC VECTORS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SINGLE-DOMAIN ANTIBODIES; TRANSFORMATION, GENETIC; TRANSGENES;

EID: 84919716395     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12244     Document Type: Article

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