Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

ChemBioChem

Volumn 16, Issue 1, 2015, Pages 59-63

  Wilbek, Theis S ^a   Skovgaard, Tine ^b   Sorrell, Fiona J ^c   Knapp, Stefan ^c   Berthelsen, Jens ^d   Strømgaard, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Institute for International Health Immunology and Microbiology   (Denmark)

Author keywords

Drug discovery; Enzymes; Inhibitors phosphorylation; Protein structures

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 1; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PEPTIDE; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; DAPK1 PROTEIN, HUMAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2B NMDA RECEPTOR; PROTEIN BINDING; PYRIDAZINE DERIVATIVE;

ARTICLE; BINDING SITE; CAPILLARY ELECTROPHORESIS; CEREBROVASCULAR ACCIDENT; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETIC ASSAY; ENZYME PHOSPHORYLATION; HIGH THROUGHPUT SCREENING; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MICROFLUIDICS; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ASSAY; GENE EXPRESSION REGULATION; GENETICS; KINETICS; MICROFLUIDIC ANALYSIS; MOLECULAR GENETICS; PHOSPHORYLATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BENZAMIDES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEATH-ASSOCIATED PROTEIN KINASES; ENZYME ASSAYS; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; LIGANDS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIDAZINES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84919707906     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402512     Document Type: Article

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