Loss of tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

DMM Disease Models and Mechanisms

Volumn 7, Issue 12, 2014, Pages 1407-1415

  Berger, Joachim ^a   Tarakci, Hakan ^a   Berger, Silke ^a   Li, Mei ^b   Hall, Thomas E ^c   Arner, Anders ^b   Currie, Peter D ^a  

^a MONASH UNIVERSITY   (Australia)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Myofibrillogenesis; Nemaline myopathy; Neuromuscular disorder; Sarcomere assembly; Tmod; Tropomodulin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HUNTINGTIN; MUTANT PROTEIN; ACTIN; ACTININ; PHALLOIDIN; TMOD4 PROTEIN, ZEBRAFISH; TROPOMODULIN; ZEBRAFISH PROTEIN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; ENDOPLASMIC RETICULUM; FIBROBLAST; GENE MUTATION; GENE TARGETING; GOLGI COMPLEX; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; NERVE FIBER TRANSPORT; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; SECRETORY PATHWAY; TRANSPORT VESICLE; WILD TYPE; ALLELE; ANIMAL; CHEMISTRY; CYTOPLASM; DISEASE MODEL; GENETIC LINKAGE; GENETICS; MALE; METABOLISM; MUSCLE; MUSCLE DISEASE; MUSCLE FIBRIL; MUTATION; NEUROMUSCULAR DISEASE; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; SARCOMERE; TRANSGENIC ANIMAL; ZEBRA FISH;

DANIO RERIO;

ACTININ; ACTINS; ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYTOPLASM; DISEASE MODELS, ANIMAL; GENETIC LINKAGE; MALE; MUSCLES; MUSCULAR DISEASES; MUTATION; MYOFIBRILS; NEUROMUSCULAR DISEASES; PHALLOIDINE; PHENOTYPE; SARCOMERES; TROPOMODULIN; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84919690726     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.017376     Document Type: Article

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