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Volumn , Issue , 2005, Pages 53-71

20 years of DNA damage signaling to p53

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EID: 84919683624     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-2922-6_3     Document Type: Chapter
Times cited : (1)

References (137)
  • 1
    • 0034326802 scopus 로고    scopus 로고
    • Threonine 68 phosphorylation by ATM is required for efficient activation of Chk2 in response to ionizing radiation
    • Ahn, J.-Y., Schwarz, J. K., Piwnica-Worms, H., and Canman, C. E. (2000). Threonine 68 phosphorylation by ATM is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Research 60, 5934-5936.
    • (2000) Cancer Research , vol.60 , pp. 5934-5936
    • Ahn, J.-Y.1    Schwarz, J.K.2    Piwnica-Worms, H.3    Canman, C.E.4
  • 2
    • 0022773059 scopus 로고
    • Immunologically distinct p53 molecules generated by alternative splicing
    • Arai, N., Nomura, D., Yokota, K., Wolf, D., Brill, E., Shohat, O., and Rotter, V. (1986). Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol 6, 3232-3239.
    • (1986) Mol Cell Biol , vol.6 , pp. 3232-3239
    • Arai, N.1    Nomura, D.2    Yokota, K.3    Wolf, D.4    Brill, E.5    Shohat, O.6    Rotter, V.7
  • 4
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J. and Kastan, M. B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 7
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest vs. apoptosis
    • Canman, C. E., Gilmer, T., Coutts, S., and Kastan, M. B. (1995). Growth factor modulation of p53-mediated growth arrest vs. apoptosis. Genes Dev. 9, 600-611.
    • (1995) Genes Dev , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.2    Coutts, S.3    Kastan, M.B.4
  • 9
    • 0028171182 scopus 로고
    • The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia
    • Canman, C. E., Wolff, A. C., Chen, C., Fornace, A. J., and Kastan, M. B. (1994). The p53-dependent G1 Cell Cycle Checkpoint Pathway and Ataxia-Telangiectasia. Cancer Res 54, 5054-5058.
    • (1994) Cancer Res , vol.54 , pp. 5054-5058
    • Canman, C.E.1    Wolff, A.C.2    Chen, C.3    Fornace, A.J.4    Kastan, M.B.5
  • 10
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    • Cao, L., Li, W., Kim, S., Brodie, S. G., and Deng, C. X. (2003). Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev. 17, 201-213.
    • (2003) Genes Dev , vol.17 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.X.5
  • 11
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
    • Chao, C., Saito, S., Anderson, C. W., Appella, E., and Xu, Y. (2000). Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci USA 97, 11936-11941.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 12
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab, N. H., Malikzay, A., Stavridi, E. S., and Halazonetis, T. D. (1999). Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96, 13777-13782.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 13
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho, Y., Gorina, S., Jeffery, P. D., and Pavletich, N. P. (1994). Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 265, 346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffery, P.D.3    Pavletich, N.P.4
  • 16
    • 0033603494 scopus 로고    scopus 로고
    • P73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    • Davison, T. S., Vagner, C., Kaghad, M., Ayed, A., Caput, D., and Arrowsmith, C. H. (1999). p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274, 18709-18714.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18709-18714
    • Davison, T.S.1    Vagner, C.2    Kaghad, M.3    Ayed, A.4    Caput, D.5    Arrowsmith, C.H.6
  • 17
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transfromed cells of the mouse
    • Deleo, A. B., Jay, G., Appells, E., Dubois, G. C., Law, L. W., and Old, L. J. (1979). Detection of a transformation-related antigen in chemically induced sarcomas and other transfromed cells of the mouse. Proc Natl Acad Sci USA 76, 2420-2424.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 2420-2424
    • Deleo, A.B.1    Jay, G.2    Appells, E.3    Dubois, G.C.4    Law, L.W.5    Old, L.J.6
  • 18
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., Linke, S. P., Clarkin, K., and Wahl, G. M. (1994). DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551.
    • (1994) Genes Dev , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 19
    • 0035092598 scopus 로고    scopus 로고
    • Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300
    • Dornan, D. and Hupp, T. R. (2001). Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300. EMBO Rep 2, 139-144.
    • (2001) EMBO Rep , vol.2 , pp. 139-144
    • Dornan, D.1    Hupp, T.R.2
  • 20
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., Kaufmann, W. K., Wilson, S. J., Tlsty, T. D., Lees, E., Harper, W., Elledge, S. J., and Reed, S. I. (1994). p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76, 1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, W.6    Elledge, S.J.7    Reed, S.I.8
  • 21
    • 0033572746 scopus 로고    scopus 로고
    • Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
    • Dumaz, N. and Meek, D. W. (1999). Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J 18, 7002-7010.
    • (1999) EMBO J , vol.18 , pp. 7002-7010
    • Dumaz, N.1    Meek, D.W.2
  • 22
    • 0033429271 scopus 로고    scopus 로고
    • Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15
    • Dumaz, N., Milne, D. M., and Meek, D. W. (1999). Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Letters 463, 312-316.
    • (1999) FEBS Letters , vol.463 , pp. 312-316
    • Dumaz, N.1    Milne, D.M.2    Meek, D.W.3
  • 26
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa, J. M. and Emerson, B. M. (2001). Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell 8, 57-69.
    • (2001) Mol Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 27
    • 0037115539 scopus 로고    scopus 로고
    • Tissue-specific induction of p53 targets in vivo
    • Fei, P., Bernhard, E. J., and El-Deiry, W. S. (2002). Tissue-specific induction of p53 targets in vivo. Cancer Res. 62, 7316-7327.
    • (2002) Cancer Res , vol.62 , pp. 7316-7327
    • Fei, P.1    Bernhard, E.J.2    El-Deiry, W.S.3
  • 28
    • 0037041392 scopus 로고    scopus 로고
    • P63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • Flores, E. R., Tsai, K. Y., Crowley, D., Sengupta, S., Yang, A., McKeon, F., and Jacks, T. (2002). p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416, 560-564.
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3    Sengupta, S.4    Yang, A.5    McKeon, F.6    Jacks, T.7
  • 29
    • 85015066476 scopus 로고    scopus 로고
    • DNA damage and repair
    • Friedberg, E. C. (2003). DNA damage and repair. Nature 421, 436-440.
    • (2003) Nature , vol.421 , pp. 436-440
    • Friedberg, E.C.1
  • 30
    • 0030983331 scopus 로고    scopus 로고
    • Participation of the human p53 3'UTR in translational repression and activation following y-irradiation
    • Fu, L. and Benchimol, S. (1997). Participation of the human p53 3'UTR in translational repression and activation following y-irradiation. EMBO J 16, 4117-4125.
    • (1997) EMBO J , vol.16 , pp. 4117-4125
    • Fu, L.1    Benchimol, S.2
  • 31
    • 0026650531 scopus 로고
    • A transcriptionally active DNA-binding site for human p53 protein complexes
    • Funk, W. D., Pak, D. T., Karas, R. H., Wright, W. E., and Shay, J. W. (1992). A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12, 2866-2871.
    • (1992) Mol Cell Biol , vol.12 , pp. 2866-2871
    • Funk, W.D.1    Pak, D.T.2    Karas, R.H.3    Wright, W.E.4    Shay, J.W.5
  • 33
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A. J. and Kastan, M. B. (1998). The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12, 2973-2983.
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 34
    • 0030575866 scopus 로고    scopus 로고
    • Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
    • Gorina, S. and Pavletich, N. P. (1996). Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science 274, 1001-1005.
    • (1996) Science , vol.274 , pp. 1001-1005
    • Gorina, S.1    Pavletich, N.P.2
  • 37
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu, W. and Roeder, R. G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 38
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo, Z., Kumagai, A., Wang, S. X., and Dunphy, W. G. (2000). Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 14, 2745-2756.
    • (2000) Genes Dev , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 39
    • 0030879102 scopus 로고    scopus 로고
    • Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells
    • Gupta, M., Fan, S., Zhan, Q., Kohn, K. W., O'Connor, P. M., and Pommier, Y. (1997). Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells. Clinical Cancer Research 3, 1653-1660.
    • (1997) Clinical Cancer Research , vol.3 , pp. 1653-1660
    • Gupta, M.1    Fan, S.2    Zhan, Q.3    Kohn, K.W.4    O'Connor, P.M.5    Pommier, Y.6
  • 40
    • 0027521114 scopus 로고
    • Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants
    • Halazonetis, T. D. and Kandil, A. N. (1993). Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. EMBO J 12, 5057-5064.
    • (1993) EMBO J , vol.12 , pp. 5057-5064
    • Halazonetis, T.D.1    Kandil, A.N.2
  • 42
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle enents
    • Hartwell, L. H. and Weinert, T. A. (1989). Checkpoints: Controls that ensure the order of cell cycle enents. Science 246, 629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 43
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 46
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., Tanaka, H., and Yasuda, H. (1997). Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Letters 420, 25-27.
    • (1997) FEBS Letters , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 47
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp, T. R., Meek, D. W., Midgley, C. A., and Lane, D. P. (1992). Regulation of the specific DNA binding function of p53. Cell 71, 875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 48
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequencespecific DNA binding function of p53
    • Hupp, T. R., Sparks, A., and Lane, D. P. (1995). Small peptides activate the latent sequencespecific DNA binding function of p53. Cell 83, 237-245.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 50
    • 0035868964 scopus 로고    scopus 로고
    • P300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
    • Ito, A., Lai, C. H., Zhao, X., Saito, S., Hamilton, M. H., Appella, E., and Yao, T. P. (2001). p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J 20, 1331-1340.
    • (2001) EMBO J , vol.20 , pp. 1331-1340
    • Ito, A.1    Lai, C.H.2    Zhao, X.3    Saito, S.4    Hamilton, M.H.5    Appella, E.6    Yao, T.P.7
  • 51
  • 52
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
    • Jayaraman, L. and Prives, C. (1995). Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81, 1021-1029.
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, L.1    Prives, C.2
  • 54
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • Kaeser, M. D. and Iggo, R. D. (2002). Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci USA 99, 95-100.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2
  • 55
    • 0032539816 scopus 로고    scopus 로고
    • Functional activation of p53 via phosphorylation following DNA damage by UV but not y radiation
    • Kapoor, M. and Lozano, G. (1998). Functional activation of p53 via phosphorylation following DNA damage by UV but not y radiation. Pro Natl Acad Sci USA 95, 2834-2837.
    • (1998) Pro Natl Acad Sci USA , vol.95 , pp. 2834-2837
    • Kapoor, M.1    Lozano, G.2
  • 56
    • 0027865495 scopus 로고
    • Control of G1 arrest after DNA damage
    • Kastan, M. B. and Kuerbitz, S. J. (1993). Control of G1 arrest after DNA damage. Environ. Health Persp. 101(suppl 5), 55-58.
    • (1993) Environ. Health Persp. , vol.101 , pp. 55-58
    • Kastan, M.B.1    Kuerbitz, S.J.2
  • 57
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. (1991). Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51, 6304-6311.
    • (1991) Cancer Res , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3    Vogelstein, B.4    Craig, R.W.5
  • 60
    • 0032005132 scopus 로고    scopus 로고
    • P53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
    • Khan, S. H. and Wahl, G. M. (1998). p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res 58, 396-401.
    • (1998) Cancer Res , vol.58 , pp. 396-401
    • Khan, S.H.1    Wahl, G.M.2
  • 61
    • 0027486024 scopus 로고
    • Ionizing Radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
    • Khanna, K. K. and Lavin, M. F. (1993). Ionizing Radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8, 3307-3312.
    • (1993) Oncogene , vol.8 , pp. 3307-3312
    • Khanna, K.K.1    Lavin, M.F.2
  • 63
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M. H., Jones, S. N., and Vousden, K. H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 64
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. (1996). Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274, 948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6    Pavletich, N.P.7
  • 65
    • 0018348655 scopus 로고
    • T antigen is bound to host protein in SV40 transformed cells
    • Lane, D. P. and Crawford, L. V. (1979). T antigen is bound to host protein in SV40 transformed cells. Nature 278, 261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 66
    • 0037430041 scopus 로고    scopus 로고
    • P53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection
    • Lee, E. J., Gerhold, M., Palmer, M. W., and Christen, R. D. (2003). p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br. J. Cancer 88, 754-759.
    • (2003) Br. J. Cancer , vol.88 , pp. 754-759
    • Lee, E.J.1    Gerhold, M.2    Palmer, M.W.3    Christen, R.D.4
  • 67
    • 0029013273 scopus 로고
    • P53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee, S., Elenbaas, B., Levine, A., and Griffith, J. (1995). p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81, 1013-1020.
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levine, A.3    Griffith, J.4
  • 68
    • 0032497587 scopus 로고    scopus 로고
    • A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kB
    • Lee, S. J., Dimtchev, A., Lavin, M., Dritschilo, A., and Jung, M. (1998). A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kB. Oncogene 17, 1821-1826.
    • (1998) Oncogene , vol.17 , pp. 1821-1826
    • Lee, S.J.1    Dimtchev, A.2    Lavin, M.3    Dritschilo, A.4    Jung, M.5
  • 69
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E., and Anderson, C. W. (1992). Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12, 5041-5049.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 70
    • 0035860784 scopus 로고    scopus 로고
    • Inhibition of p53 transcriptional activity by the S100B calcium-binding protein
    • Lin. J., Blake, M., Tang, C., Zimmer, D., Rustandi, R. R., Weber, D. J., and Carrier, F. (2001). Inhibition of p53 transcriptional activity by the S100B calcium-binding protein. J. Biol. Chem. 276, 35037-35041.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35037-35041
    • Lin, J.1    Blake, M.2    Tang, C.3    Zimmer, D.4    Rustandi, R.R.5    Weber, D.J.6    Carrier, F.7
  • 71
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer, D. I. and Levine, A. J. (1979). Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17, 43-52.
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 73
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., and Tlsty, T. D. (1992). Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70, 923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 74
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S. W., Schmitt, S. W., Smith, S. W., Osborne, B. A., and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, S.W.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 75
    • 0032568633 scopus 로고    scopus 로고
    • Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
    • Lu, H., Taya, Y., Ikeda, M., and Levine, A. J. (1998). Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389. Proc Natl Acad Sci USA 95, 6399-6402.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6399-6402
    • Lu, H.1    Taya, Y.2    Ikeda, M.3    Levine, A.J.4
  • 77
    • 0031015044 scopus 로고    scopus 로고
    • Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
    • Maki, C. G. and Howley, P. M. (1997). Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol 17, 355-363.
    • (1997) Mol Cell Biol , vol.17 , pp. 355-363
    • Maki, C.G.1    Howley, P.M.2
  • 78
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman, W. and Czyzyk, L. (1984). UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol 4(9), 1689-1694.
    • (1984) Mol Cell Biol , vol.4 , Issue.9 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 82
    • 0032526426 scopus 로고    scopus 로고
    • How p53 binds DNA as a tetramer
    • McLure, K. G. and Lee, P. W. K. (1998). How p53 binds DNA as a tetramer. EMBO J 17, 3342-3350.
    • (1998) EMBO J , vol.17 , pp. 3342-3350
    • McLure, K.G.1    Lee, P.W.K.2
  • 83
    • 0034306332 scopus 로고    scopus 로고
    • Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
    • Melchionna, R., Chen, X.-B., Blasina, A., and McGowan, C. H. (2000). Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nature Cell Biol 2, 762-765.
    • (2000) Nature Cell Biol , vol.2 , pp. 762-765
    • Melchionna, R.1    Chen, X.-B.2    Blasina, A.3    McGowan, C.H.4
  • 84
    • 0030935858 scopus 로고    scopus 로고
    • The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited
    • Middeler, G., Zerf, K., Jenovai, S., Thulig, A., Tschodrichrotter, M., Kubitscheck, U., and Peters, R. (1997). The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene 14, 1407-1417.
    • (1997) Oncogene , vol.14 , pp. 1407-1417
    • Middeler, G.1    Zerf, K.2    Jenovai, S.3    Thulig, A.4    Tschodrichrotter, M.5    Kubitscheck, U.6    Peters, R.7
  • 85
    • 0030825813 scopus 로고    scopus 로고
    • P53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley, C. A. and Lane, D. P. (1997). p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15, 1179-1189.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 87
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., Zambetti, G. P., Olson, D. C., George, D. L., and Levine, A. J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.L.4    Levine, A.J.5
  • 88
    • 0028286463 scopus 로고
    • DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
    • Morozov, V. E., Falzon, M., Anderson, C. W., and Kuff, E. L. (1994). DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269, 16684-16688.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16684-16688
    • Morozov, V.E.1    Falzon, M.2    Anderson, C.W.3    Kuff, E.L.4
  • 89
    • 0037066755 scopus 로고    scopus 로고
    • Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect
    • Nicholls, C. D., McLure, K. G., Shields, M. A., and Lee, P. W. (2002). Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect. J. Biol. Chem. 277, 12937-12945.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12937-12945
    • Nicholls, C.D.1    McLure, K.G.2    Shields, M.A.3    Lee, P.W.4
  • 90
    • 0037039445 scopus 로고    scopus 로고
    • Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability
    • Nichols, N. M. and Matthews, K. S. (2002). Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability. Biochemistry 41, 170-178.
    • (2002) Biochemistry , vol.41 , pp. 170-178
    • Nichols, N.M.1    Matthews, K.S.2
  • 91
    • 0033985661 scopus 로고    scopus 로고
    • Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization
    • Nie, Y., Li, H.-H., Bula, C. M., and Liu, X. (2000). Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization. Mol Cell Biol 20, 741-748.
    • (2000) Mol Cell Biol , vol.20 , pp. 741-748
    • Nie, Y.1    Li, H.-H.2    Bula, C.M.3    Liu, X.4
  • 92
    • 0032894008 scopus 로고    scopus 로고
    • Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery
    • Offer, H., Wolkowicz, R., Matas, D., Blumenstein, S., Livneh, A., and Rotter, V. (1999). Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery. FEBS Letters 450, 197-204.
    • (1999) FEBS Letters , vol.450 , pp. 197-204
    • Offer, H.1    Wolkowicz, R.2    Matas, D.3    Blumenstein, S.4    Livneh, A.5    Rotter, V.6
  • 93
    • 0030826733 scopus 로고    scopus 로고
    • Induced N- and C-terminal cleavage of p53: A core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53
    • Okorokov, A. L., Ponchel, F., and Milner, J. (1997). Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53. EMBO J 16, 6008-6017.
    • (1997) EMBO J , vol.16 , pp. 6008-6017
    • Okorokov, A.L.1    Ponchel, F.2    Milner, J.3
  • 95
    • 0035496922 scopus 로고    scopus 로고
    • Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis
    • Pestina, T. I., Cleveland, J. L., Yang, C., Zambetti, G. P., and Jackson, C. W. (2001). Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98, 2084-2090.
    • (2001) Blood , vol.98 , pp. 2084-2090
    • Pestina, T.I.1    Cleveland, J.L.2    Yang, C.3    Zambetti, G.P.4    Jackson, C.W.5
  • 96
    • 0037505736 scopus 로고    scopus 로고
    • P53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells
    • Phelps, M., Darley, M., Primrose, J. N., and Blaydes, J. P. (2003). p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res. 63, 2616-2623.
    • (2003) Cancer Res , vol.63 , pp. 2616-2623
    • Phelps, M.1    Darley, M.2    Primrose, J.N.3    Blaydes, J.P.4
  • 100
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse, J. and Jackson, S. P. (2002). Interfaces between the detection, signaling, and repair of DNA damage. Science 297, 547-551.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 101
    • 0344011603 scopus 로고    scopus 로고
    • Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
    • Rubbi, C. P. and Milner, J. (2003a). Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J 22, 6068-6077.
    • (2003) EMBO J , vol.22 , pp. 6068-6077
    • Rubbi, C.P.1    Milner, J.2
  • 102
    • 0037450761 scopus 로고    scopus 로고
    • P53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
    • Rubbi, C. P. and Milner, J. (2003b). p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J 22, 975-986.
    • (2003) EMBO J , vol.22 , pp. 975-986
    • Rubbi, C.P.1    Milner, J.2
  • 104
    • 0034737438 scopus 로고    scopus 로고
    • Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
    • Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S., Anderson, C. W., and Appella, E. (2000). Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem 275, 9278-9283.
    • (2000) J Biol Chem , vol.275 , pp. 9278-9283
    • Sakaguchi, K.1    Saito, S.2    Higashimoto, Y.3    Roy, S.4    Anderson, C.W.5    Appella, E.6
  • 107
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S.-Y., Ikeda, M., Taya, Y., and Prives, C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 108
    • 0033118933 scopus 로고    scopus 로고
    • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • Shieh, S.-Y., Taya, Y., and Prives, C. (1999). DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J 18, 1815-1823.
    • (1999) EMBO J , vol.18 , pp. 1815-1823
    • Shieh, S.-Y.1    Taya, Y.2    Prives, C.3
  • 110
    • 1642458412 scopus 로고    scopus 로고
    • Phosphorylation of serine 18 regulates distinct p53 functions in mice
    • Sluss, H. K., Armata, H., Gallant, J., and Jones, S. N. (2004). Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol 24, 976-984.
    • (2004) Mol Cell Biol , vol.24 , pp. 976-984
    • Sluss, H.K.1    Armata, H.2    Gallant, J.3    Jones, S.N.4
  • 111
    • 0032952584 scopus 로고    scopus 로고
    • P21 Waf1/Cip1 Inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
    • Stewart, Z. A., Leach, D. L., and Pietenpol, J. (1999a). p21 Waf1/Cip1 Inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol Cell Biol 19, 205-215.
    • (1999) Mol Cell Biol , vol.19 , pp. 205-215
    • Stewart, Z.A.1    Leach, D.L.2    Pietenpol, J.3
  • 112
    • 0033169231 scopus 로고    scopus 로고
    • Defective G 1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis
    • Stewart, Z. A., Mays, D., and Pietenpol, J. A. (1999b). Defective G 1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis. Cancer Research 59, 3831-3837.
    • (1999) Cancer Research , vol.59 , pp. 3831-3837
    • Stewart, Z.A.1    Mays, D.2    Pietenpol, J.A.3
  • 113
    • 0033559256 scopus 로고    scopus 로고
    • A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
    • Stommel, J. M., Marchenko, N. D., Jimenez, G. S., Moll, U. M., Hope, T. J., and Wahl, G. M. (1999). A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J 18, 1660-1672.
    • (1999) EMBO J , vol.18 , pp. 1660-1672
    • Stommel, J.M.1    Marchenko, N.D.2    Jimenez, G.S.3    Moll, U.M.4    Hope, T.J.5    Wahl, G.M.6
  • 114
    • 0026637484 scopus 로고
    • A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization
    • Sturzbecher, H. W., Brain, R., Addison, C., Rudge, K., Remm, M., Grimaldi, M., Keenan, E., and Jenkins, J. R. (1992). A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization. Oncogene 7, 1513-1523.
    • (1992) Oncogene , vol.7 , pp. 1513-1523
    • Sturzbecher, H.W.1    Brain, R.2    Addison, C.3    Rudge, K.4    Remm, M.5    Grimaldi, M.6    Keenan, E.7    Jenkins, J.R.8
  • 115
    • 0035028599 scopus 로고    scopus 로고
    • Kinetics of p53 binding to promoter sites in vivo
    • Szak, S. T., Mays, D., and Pietenpol, J. A. (2001). Kinetics of p53 binding to promoter sites in vivo. Mol Cell Biol 21, 3375-3386.
    • (2001) Mol Cell Biol , vol.21 , pp. 3375-3386
    • Szak, S.T.1    Mays, D.2    Pietenpol, J.A.3
  • 116
    • 0028966935 scopus 로고
    • Regulation of the sequencespecific DNA binding function of p53 by protein kinase C and protein phosphatases
    • Takenaka, I., Morin, F., Seizinger, B. R., and Kley, N. (1995). Regulation of the sequencespecific DNA binding function of p53 by protein kinase C and protein phosphatases. J. Biol. Chem. 270, 5405-5411.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5405-5411
    • Takenaka, I.1    Morin, F.2    Seizinger, B.R.3    Kley, N.4
  • 117
    • 0032980646 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
    • Tao, W. and Levine, A. J. (1999). Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc Natl Acad Sci USA 96, 3077-3080.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3077-3080
    • Tao, W.1    Levine, A.J.2
  • 119
    • 0027212267 scopus 로고
    • Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
    • Tishler, R. B., Calderwood, S. K., Coleman, C. N., and Price, B. D. (1993). Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res 53, 2212-2216.
    • (1993) Cancer Res , vol.53 , pp. 2212-2216
    • Tishler, R.B.1    Calderwood, S.K.2    Coleman, C.N.3    Price, B.D.4
  • 120
    • 0035939844 scopus 로고    scopus 로고
    • Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53
    • Turenne, G. A., Paul, P., Laflair, L., and Price, B. D. (2001). Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. Oncogene 20, 5100-5110.
    • (2001) Oncogene , vol.20 , pp. 5100-5110
    • Turenne, G.A.1    Paul, P.2    Laflair, L.3    Price, B.D.4
  • 122
    • 1642499359 scopus 로고    scopus 로고
    • Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
    • Unsal-Kacmaz, K. and Sancar, A. (2004). Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol Cell Biol 24, 1292-1300.
    • (2004) Mol Cell Biol , vol.24 , pp. 1292-1300
    • Unsal-Kacmaz, K.1    Sancar, A.2
  • 123
    • 0036285034 scopus 로고    scopus 로고
    • C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., and Wahl, G. M. (2002). c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9, 1031-1044.
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6    Wahl, G.M.7
  • 125
    • 0344209296 scopus 로고    scopus 로고
    • Genomic instability and endoreduplication triggered by RAD17 deletion
    • Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S. J., and Li, L. (2003). Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 17, 965-970.
    • (2003) Genes Dev , vol.17 , pp. 965-970
    • Wang, X.1    Zou, L.2    Zheng, H.3    Wei, Q.4    Elledge, S.J.5    Li, L.6
  • 126
  • 127
    • 0028888020 scopus 로고
    • The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
    • Waterman, J. L., Shenk, J. L., and Halazonetis, T. D. (1995). The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J 14, 512-519.
    • (1995) EMBO J , vol.14 , pp. 512-519
    • Waterman, J.L.1    Shenk, J.L.2    Halazonetis, T.D.3
  • 128
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman, M. J., Stavridi, E. S., Waterman, J. L. F., and Halazonetis, T. D. (1998). ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nature Genetics 19, 175.
    • (1998) Nature Genetics , vol.19 , pp. 175
    • Waterman, M.J.1    Stavridi, E.S.2    Waterman, J.L.F.3    Halazonetis, T.D.4
  • 129
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in saccharomyces cerevisiae
    • Weinert, T. A. and Hartwell, L. H. (1988). The RAD9 gene controls the cell cycle response to DNA damage in saccharomyces cerevisiae. Science 241, 317-322.
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 130
    • 0028799060 scopus 로고
    • Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53
    • Will, K., Warnecke, G., Bergmann, S., and Deppert, W. (1995). Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53. Nucleic Acids Res 23, 4023-4028.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4023-4028
    • Will, K.1    Warnecke, G.2    Bergmann, S.3    Deppert, W.4
  • 131
    • 0037124322 scopus 로고    scopus 로고
    • DNA damageinduced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53
    • Woo, R. A., Jack, M. T., Xu, Y., Burma, S., Chen, D. J., and Lee, P. W. (2002). DNA damageinduced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J 21, 3000-3008.
    • (2002) EMBO J , vol.21 , pp. 3000-3008
    • Woo, R.A.1    Jack, M.T.2    Xu, Y.3    Burma, S.4    Chen, D.J.5    Lee, P.W.6
  • 132
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo, R. A., McLure, K. G., Lees-Miller, S. P., Rancourt, D. E., and Lee, P. W. K. (1998). DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394, 700-705.
    • (1998) Nature , vol.394 , pp. 700-705
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 133
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu, X., Bayle, H., Olson, D., and Levine, A. J. (1993). The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7, 1126-1132.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, H.2    Olson, D.3    Levine, A.J.4
  • 134
    • 0036205321 scopus 로고    scopus 로고
    • Mutation of mouse p53 Ser23 and the response to DNA damage
    • Wu, Z., Earle, J., Saito, S., Anderson, C. W., Appella, E., and Xu, Y. (2002). Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol. 22, 2441-2449.
    • (2002) Mol Cell Biol , vol.22 , pp. 2441-2449
    • Wu, Z.1    Earle, J.2    Saito, S.3    Anderson, C.W.4    Appella, E.5    Xu, Y.6
  • 135
    • 0026714672 scopus 로고
    • Redox activation of Fos-Jun. DNA binding activity is mediated by a DNA repair enzyme
    • Xanthoudakis, S., Miao, G., Wang, F., Pan, Y.-C. E., and Curran, T. (1992). Redox activation of Fos-Jun. DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11, 3323-3335.
    • (1992) EMBO J , vol.11 , pp. 3323-3335
    • Xanthoudakis, S.1    Miao, G.2    Wang, F.3    Pan, Y.-C.E.4    Curran, T.5
  • 136
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H. and Piwnica-Worms, H. (2001). ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21, 4129-4139.
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 137
    • 0035865399 scopus 로고    scopus 로고
    • A role for p53 in base excision repair
    • Zhou, J., Ahn, J., Wilson, S. H., and Prives, C. (2001). A role for p53 in base excision repair. EMBO J 20, 914-923.
    • (2001) EMBO J , vol.20 , pp. 914-923
    • Zhou, J.1    Ahn, J.2    Wilson, S.H.3    Prives, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.