Pathophysiology, management, and outcome of persistent pulmonary hypertension of the newborn: A clinical review

Frontiers in Pediatrics

Volumn 1, Issue SEP, 2013, Pages

  Puthiyachirakkal, Mohammed ^a   Mhanna, Maroun J ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Newborn; Outcome; Pathophysiology; Persistent pulmonary hypertension; Treatment

Indexed keywords

EID: 84919679906     PISSN: None     EISSN: 22962360     Source Type: Journal    
DOI: 10.3389/fped.2013.00023     Document Type: Review

References (44)

1. Gao Y, Raj JU. Regulation of the pulmonary circulation in the fetus and newborn. Physiol Rev (2010) 90:1291-335. doi:10.1152/physrev.00032.2009
2. Konduri GG, Kim UO. Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am (2009) 56:579-600. doi:10.1016/j.pcl.2009.04.004
3. Soll RF. Inhaled nitric oxide in the neonate. J Perinatol (2009) 29(Suppl 2):S63-7. doi:10.1038/jp.2009.40
4. Guyatt G, Gutterman D, Baumann M, Addrizzo-Harris D, Hylek E, Phillips B, et al. Grading strength of recommendations and quality of evidence in clinical guidelines. Chest (2006) 129:174-181
5. Rudolph AM. Distribution and regulation of blood flow in the fetal and neonatal lamb. Circ Res (1985) 57(6):811-21. doi:10.1161/01.RES.57.6.811
6. Steinhorn RH, Farrow KN. Pulmonary hypertension in the neonate. Neoreviews (2007) 8:e14-21. doi:10.1542/neo.8-1-e14
7. Ostrea EM, Villanueva ET, Natarajan G, Herbert G. Persistent pulmonary hypertension of the newborn: pathogenesis, etiology, and management. Pediatr Drugs (2006) 8(3):179-88. doi:10.2165/00148581-200608030-00004
8. Roofthooft MTR, Elema A, Bergman KA, Berger RMF. Patient characteristics in persistent pulmonary hypertension of the newborn. Pulm Med (2011) 2011:858154
9. Swarnam K, Soraisham AS, Sindhu S. Advances in the management of meconium aspiration syndrome. Int J Pediatr (2012) 2012:359571. doi:10.1155/2012/359571
10. Hsieh TK, Su BH, Chen AC, Lin TW, Tsai CH, Lin HC. Risk factors of meconium aspiration syndrome developing into persistent pulmonary hypertension of newborn. Acta Paediatr Taiwan (2004) 45(4):203-7
11. Abman SH. Abnormal vasoreactivity in the pathophysiology of persistent pulmonary hypertension of the newborn. Pediatr Rev (1999) 20:e103-10
12. Hernández-Díaz S, van Marter LJ, Werler MM, Louik C, Mitchell AA. Risk factors for persistent pulmonary hypertension of the newborn. Pediatrics (2007) 120(2):e272-82. doi:10.1542/peds.2006-3037
13. Winovitch KC, Padilla L, Ghamsary M, Lagrew DC, Wing DA. Persistent pulmonary hypertension of the newborn following elective cesarean delivery at term. J Matern Fetal Neonatal Med (2011) 24(11):1398-402. doi:10.3109/14767058.2010.551681
14. Woldesenbet M, Perlman JM. Histologic chorioamnionitis: an occult marker of severe pulmonary hypertension in the term newborn. J Perinatol (2005) 25(3):189-92. doi:10.1038/sj.jp.7211240
15. Koren G, Nordeng H. Antidepressant use during pregnancy: the benefit-risk ratio. Am J Obstet Gynecol (2012) 207(3):157-63. doi:10.1016/j.ajog.2012.02.009
16. Jong GW, Einarson T, Koren G, Einarson A. Antidepressant use in pregnancy and persistent pulmonary hypertension of the newborn (PPHN): a systematic review. Reprod Toxicol (2012) 34(3):293-7. doi:10.1016/j.reprotox.2012.04.015
17. Lim K, Sanders A, Brain U, Riggs W, Oberlander TF, Rurak D. Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure. Early Hum Dev (2012) 88(8):609-15. doi:10.1016/j.earlhumdev.2012.01.004
18. van Marter LJ, Hernandez-Diaz S, Werler MM, Louik C, Mitchell AA. Nonsteroidal anti-inflammatory drugs in late pregnancy and persistent pulmonary hypertension of the newborn. Pediatrics (2013) 131(1):79-87. doi:10.1542/peds.2012-0496
19. Alano MA, Ngougmna E, Ostrea EM Jr., Konduri GG. Analysis of nonsteroidal anti-inflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. Pediatrics (2001) 107(3):519-23. doi:10.1542/peds.107.3.519
20. Curtis J, Kim G, Wehr NB, Levine RL. Group B Streptococcus, phospholipids and pulmonary hypertension. J Perinatol (2011) 31(Suppl 1):S24-8. doi:10.1038/jp.2010.168
21. Waites KB, Crouse DT, Philips JB III, Canupp KC, Cassell GH. Ureaplasma pneumonia and sepsis associated with persistent pulmonary hypertension of the newborn. Pediatrics (1989) 83(1):79-85
22. Thoresen M. Hypothermia after perinatal asphyxia: selection for treatment and cooling protocol. J Pediatr (2011) 2(Suppl):e45-9. doi:10.1016/j.jpeds.2010.11.013
23. Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol (2005) 32(1):18-24. doi:10.1016/j.pediatrneurol.2004.06.014
24. Fox WW, Duara S. Persistent pulmonary hypertension in the neonate: diagnosis and management. J Pediatr (1983) 103(4):505-14. doi:10.1016/S0022-3476(83)80573-3
25. Dhillon R. The management of neonatal pulmonary hypertension. Arch Dis Child Fetal Neonatal Ed (2012) 97(3):F223-8. doi:10.1136/adc.2009.180091
26. Reynolds EW, Ellington JG, Vranicar M, Bada HS. Brain-type natriuretic peptide in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatrics (2004) 114(5):1297-304. doi:10.1542/peds.2004-0525
27. Vijlbrief DC, Benders MJ, Kemperman H, van Bel F, de Vries WB. B-type natriuretic peptide and rebound during treatment for persistent pulmonary hypertension. J Pediatr (2012) 160(1):111-5.e1. doi:10.1016/j.jpeds.2011.06.038
28. Logan JW, Goldberg RN, Cotten CM. Congenital diaphragmatic hernia: a systematic review and summary of best-evidence practice strategies. J Perinatol (2007) 27(9):535-49. doi:10.1038/sj.jp.7211794
29. Lotze A, Mitchell BR, Bulas DI, Zola EM, Shalwitz RA, Gunkel JH. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group. J Pediatr (1998) 132(1):40-7. doi:10.1016/S0022-3476(98)70482-2
30. Gadzinowski J, Kowalska K, Vidyasagar D. Treatment of MAS with PPHN using combined therapy: SLL, bolus surfactant and iNO. J Perinatol (2008) 28(Suppl 3):S56-66. doi:10.1038/jp.2008.163
31. Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics (1998) 101(3 Pt 1):325-34. doi:10.1542/peds.101.3.325
32. Kinsella JP. Clinical trials of inhaled nitric oxide therapy in the newborn. Pediatr Rev (1999) 20:e110
33. Shivananda S, Ahliwahlia L, Kluckow M, Luc J, Jankov R, McNamara P. Variation in the management of persistent pulmonary hypertension of the newborn: a survey of physicians in Canada, Australia, and New Zealand. Am J Perinatol (2012) 29(7):519-26. doi:10.1055/s-0032-1310523
34. Shah PS, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev (2011) 10(8):CD005494
35. Steinhorn RH, Kinsella JP, Pierce C, Butrous G, Dilleen M, Oakes M, et al. Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension. J Pediatr (2009) 155(6):841-847.e1. doi:10.1016/j.jpeds.2009.06.012
36. Kehat R, Bonsall DJ, North R, Connors B. Ocular findings of oral sildenafil use in term and near-term neonates. J AAPOS (2010) 14(2):159-62. doi:10.1016/j.jaapos.2009.12.161
37. Bassler D, Kreutzer K, McNamara P, Kirpalani H. Milrinone for persistent pulmonary hypertension of the newborn. Cochrane Database Syst Rev (2010) 10(11):CD007802
38. Rao S, Bartle D, Patole S. Current and future therapeutic options for persistent pulmonary hypertension in the newborn. Expert Rev Cardiovasc Ther (2010) 8(6):845-62. doi:10.1586/erc.09.186
39. Nakwan N, Choksuchat D, Saksawad R, Thammachote P, Nakwan N. Successful treatment of persistent pulmonary hypertension of the newborn with bosentan. Acta Paediatr (2009) 98(10):1683-5. doi:10.1111/j.1651-2227.2009.01386.x
40. Mohamed WA, Ismail M. A randomized, double-blind, placebo-controlled, prospective study of bosentan for the treatment of persistent pulmonary hypertension of the newborn. J Perinatol (2012) 32(8):608-13. doi:10.1038/jp.2011.157
41. Lazar DA, Cass DL, Olutoye OO, Welty SE, Fernandes CJ, Rycus PT, et al. The use of ECMO for persistent pulmonary hypertension of the newborn: a decade of experience. J Surg Res (2012) 177(2):263-7. doi:10.1016/j.jss.2012.07.058
42. Rosenberg AA, Lee NR, Vaver KN, Werner D, Fashaw L, Hale K, et al. School-age outcomes of newborns treated for persistent pulmonary hypertension. J Perinatol (2010) 30(2):127-34. doi:10.1038/jp.2009.139
43. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in term and near-term infants: neurodevelopmental follow-up of the neonatal inhaled nitric oxide study group (NINOS). J Pediatr (2000) 136(5):611-7. doi:10.1067/mpd.2000.104826
44. Eriksen V, Nielsen LH, Klokker M, Greisen G. Follow-up of 5-to 11-year-old children treated for persistent pulmonary hypertension of the newborn. Acta Paediatr (2009) 98(2):304. doi:10.1111/j.1651-2227.2008.01065.x