Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 11, Issue 1, 2015, Pages 47-55

  Orel, Valerii ^a   Shevchenko, Anatoliy ^b   Romanov, Andriy ^a   Tselepi, Marina ^c,d   Mitrelias, Thanos ^c,d   Barnes, Crispin H W ^c   Burlaka, Anatoliy ^e   Lukin, Sergey ^e   Shchepotin, Igor ^a  

^a NATIONAL CANCER INSTITUTE   (Ukraine)

^b INSTITUTE OF METAL PHYSICS   (Ukraine)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d Cavendish NanoTherapeutics   (United Kingdom)

^e R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

Author keywords

Doxorubicin; Free radicals; Lewis lung carcinoma; Magnetic nanoparticles; Magneto mechano chemical synthesis

Indexed keywords

BIOLOGICAL ORGANS; ELECTRON TRANSPORT PROPERTIES; FERROMAGNETIC MATERIALS; FERROMAGNETISM; FREE RADICALS; HISTOLOGY; HYSTERESIS; HYSTERESIS LOOPS; IRON COMPOUNDS; MAGNETIC FIELD EFFECTS; MAGNETIC PROPERTIES; MAGNETS; MECHANICAL ALLOYING; MILLING (MACHINING); NANOPARTICLES; NITRIC OXIDE; PARAMAGNETIC RESONANCE; RADIO WAVES; SUPERCONDUCTING MATERIALS; SYNTHESIS (CHEMICAL); TISSUE;

CONSTANT MAGNETIC FIELDS; DOXORUBICIN; ELECTRON TRANSPORT CHAIN; LEWIS LUNG CARCINOMATA; MAGNETIC NANO-PARTICLES; MECHANOCHEMICAL SYNTHESIS; SOFT FERROMAGNETIC MATERIALS; VIBRATING MAGNETOMETERS;

NANOMAGNETICS;

DOXORUBICIN; FERROMAGNETIC MATERIAL; IRON OXIDE; MAGNETIC NANOPARTICLE; ANTINEOPLASTIC AGENT; DRUG CARRIER; FERRIC ION; FERRIC OXIDE; FREE RADICAL; MAGNETITE NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; HYSTERESIS; IN VIVO STUDY; LEWIS CARCINOMA; MAGNETIC FIELD; MAGNETO MECHANO CHEMICAL SYNTHESIS; MAGNETOMETRY; METASTASIS INHIBITION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; ANIMAL; C57BL MOUSE; CHEMISTRY; HYPERTHERMIC THERAPY; MAGNETISM; MALE; METABOLISM; MITOCHONDRION; NANOTECHNOLOGY; PROCEDURES; TEMPERATURE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERRIC COMPOUNDS; FREE RADICALS; HYPERTHERMIA, INDUCED; MAGNETICS; MAGNETITE NANOPARTICLES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NANOTECHNOLOGY; TEMPERATURE;

EID: 84919635829     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2014.07.007     Document Type: Article

References (44)

1. Maier-Hauff K., Rothe R., Scholz R., Gneveckow U., Wust P., Thiesen B., et al. Intracranial thermometry using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme. J Neurooncol 2007, 81:53-60.
2. Johannsen M., Gneveckow U., Thiesen B., Taymoorian K., Cho C.H., Waldöfner N., et al. Thermotherapy of prostate cancer using magnetic nanoparticles: Feasibility, imaging and three-dimensional temperature distribution. Eur Urol 2007, 55:1653-1661.
3. Thiesen B., Jordan A. Clinical applications of magnetic nanoparticles for hyperthermia. Int J Hyperthermia 2008, 24:467-474.
4. Song C.W. Effect of local hyperthermia on blood flow and microenvironment: A review. Cancer Res 1984, 44:4721s-4730s.
5. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:1-40.
6. McCarty M.F., Barroso-Aranda J., Contreras F. Oxidative stress therapy for solid tumors-a proposal. Med Hypotheses 2010, 74:1052.
7. Fang J., Seki T., Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009, 61:290-302.
8. Roca A.G., Costa R., Rebolledo A.F., Veintemillas-Verdaguer S., Tarttaj P., Gonzalez-Carreno T., et al. Progress in preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2009, 42:1-11.
9. Arruebo M., Fernández-Pacheco R., Irusta S., Arbiol J., Ibarra M.R., Santamaria J. Sustained release of doxorubicin from zeolite-magnetite nanocomposites prepared by mechanical activation. J Nanotechnol 2006, 17:4057-4064.
10. Orel V.E., Romanov A.V., Dzyatkovska I.I., Nikolov M.O., Mel'nik Y.G., Dzyatkovska N.M., et al. The effect of mechano- and magnetochemically synthesized magnetosensitive nanocomplex and electromagnetic irradiation on animal tumor. IFMBE Proceedings 2010 2010, vol. 29:510-512. Springer, Berlin.
11. Avvakumov E.G., Senna M., Kosova N. Soft mechanochemical synthesis: a basis for new chemical technologies 2001, Springer.
12. Kuramitz H. Magnetic microbead-based electrochemical immunoassays. Anal Bioanal Chem 2009, 394:61-69.
13. Baláž P. Mechanochemistry in nanoscience and minerals engineering 2008, Springer-Verlag, Berlin.
14. Timmel C.R., Till U., Brocklehurst B., Mclauchlan K.A., Hore P.J. Effects of weak magnetic fields on free radical recombination reactions. Mol Phys: Int J Interface Between Chem Phys 1998, 95:71-89.
15. Orel V., Kudryavets Y., Bezdenezhnih N., Danko M., Khranovskaya N., Romanov A., et al. Mechanochemically activated doxorubicin nanoparticles in combination with 40MHz frequency irradiation on A-549 lung carcinoma cells. Drug Deliv 2005, 12:171-178.
16. Cohen A.E. Nanomagnetic control of intersystem crossing. J Phys Chem 2009, 113:11084-11092.
17. Buchachenko A.L., Kuznetsov D.A. Magnetic field affects enzymatic ATP synthesis. J Am Chem Soc 2008, 130:12868-12869.
18. Kirschvink J., Tabrah F., Batkin S. Ferromagnetism in two mouse tumours. J Exp Biol 1982, 101:321-326.
19. Mittra R. International series of monographs in electrical engineering. Computer techniques for electromagnetics 1973, Pergamon Press, Oxford & New York.
20. Matsuzaki T., Yokokura T. Inhibition of tumor metastasis of Lewis lung carcinoma in C57BL/6 mice by intrapleural administration of Lactobacillus casei. Cancer Immunol Immunother 1987, 25:100-104.
21. Nikolov N., Orel V., Smolanka I., Dzyatkovskaya N., Romanov A., Mel'nik Y., et al. Apparatus for short-wave inductothermy magnetotherm. Proceedings of NBC 2008 2008, 294-298. Springer-Verlag, Berlin, Heidelberg. A. Katushev, Y. Dekhtyar, J. Spigulis (Eds.).
22. Orel V.E., Shchepotin I.B., Smolanka I.I., Korovin S.I., Palivets A.Y., Tsip N.P., et al. Radiofrequency hyperthermia of malignant neoplasm, nanotechnology and dynamic chaos 2012, Ternopol, Ukrmedbook, (in Russian).
23. Gorelik E., Segal S., Feldman M. Control of lung metastasis progression in mice: role of growth kinetics of 3LL Lewis lung carcinoma and host immune reactivity. J Natl Cancer Inst 1980, 65:1257-1264.
24. Bertotti G. Hysteresis in magnetism 1998, Academic Press, San Diego.
25. Mayo J.G. Biologic characterization of the subcutaneously implanted Lewis lung tumor. Cancer Chemother Rep 1972, 3:325-330.
26. Orel V.E., Shevchenko A.D., Romanov A.V., Burlaka A.P., Lukin S.N., Sidorik E.P., et al. Magnetic properties of Lewis lung carcinoma and antitumor magneto-sensitive complex. IFMBE Proceedings 2012 2013, vol. 38:86-89. [Riga, Latvia].
27. Blumenfeld L. Problems of biological physics 1981, Springer-Verlag, Berlin.
28. Xiong X.B., Ma Z., Lai R., Lavasanifar A. The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin. Biomaterials 2010, 31:757-768.
29. Valko M., Leibfritz D., Moncol J., Cronin M., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007, 39:44-84.
30. Nicholls D.G., Ferguson S.J. Bioenergetics 3 2002, Academic Press.
31. Burlaka A.P., Sidorik E.P., Ganusevich I.I., Osinsky S.P. Effects of radical oxygen species and no: formation of intracellular hypoxia and activation of matrix metalloproteinases in tumor tissues. Exp Oncol 2006, 28:49-53.
32. Orel V., Mitrelias T., Shevchenko A., Romanov A., Barnes C., Tselepi M., et al. Studies of complex magnetic nanoparticles with anticancer agents for cancer therapy. J Basic Appl Phys 2013, 2:8-12.
33. Beach G.S.D., Tsoi M., Erskine J.L. Current-induced domain wall motion. J Magn Mat 2008, 320:1272-1281.
34. Baibich M.N., Broto J.M., Fert A., Van Dau Nguyen F., Petroff F., Etienne P., et al. Giant megnetoresistance of (001)Fe/(001)Cr magnetic supperlattices. Phys Rev Lett 1988, 61:2472-2475.
35. Orel V.E., Grabovoy A.N., Romanov A.V., Harkevich N.A., Schepotin I.B. Mitochondria in Lewis lung carcinoma cells under the effect of magnetosensitive nanocomplex and radiofrequency hyperthermia. Bull Exp Biol Med 2013, 155:484-487.
36. Orel V.E., Romanov A.V. The effect of spatially inhomogeneous electromagnetic field and local inductive hyperthermia on nonlinear dynamics of the growth for transplanted animal tumors. Nonlinear dynamics 2010, 285-308. INTECH, shroatia. T. Evans (Ed.).
37. Minotti G., Menna P., Salvatorelli E., Cairo G., Gianni L. Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004, 56:185-229.
38. Uchikawa Y., Kobayashi K., Uchida Y., Sugiyama S., Miyashita O. Effect of a pulsed magnetic field on brain tumor cells (RGC-6), and eddy current analysis. J Magn Soc Jpn 1998, 22:813-816.
39. Liu H., Li X.Z., Leng Y.J., Wang C. Kinetic modeling of electro-Fenton reaction in aqueous solution. Water Res 2007, 41:161-167.
40. Orel V.E., Dzyatkovskaya N.N., Romanov A.V. Magnenic nanotherapeutics of cancer 2013, vol. 1. LAP Lambert Academic Publishing, Saarbrücken, Germany.
41. 4 nanoparticles in nanocomplex with doxorubicin during electromagnetic irradiation and modification of hepatocarcinoma HepG2 human cells with interferon-Alpha. Clin Oncol 2013, 9:140-144.
42. Scaiano J.C., Cozens F.L., McLean J. Model for the rationalization of magnetic field effects in vivo. application of the radical-pair mechanism to biological systems. Photochem Photobiol 1994, 59:585-589.
43. Orel V.E., Nikolov N.A., Rykhalskiy A.Y., Dzyatkovskya N.N., Romanov A.V., Yaroshenko O.Y., et al. Magnetic nanotherapeutics of Guerin carcinoma. Proc Electronics and Nanotechnology (ELNANO), 2013 IEEE XXXIII Int Sci Conf 2013, 241-245.
44. Brem F., Hirt A., Winklhofer M., Frei K., Yonekawa Y., Wieser H.-G., et al. Magnetic iron compounds in the human brain a comparison of tumor and hippocampal tissue. J Royal Soc Interf 2006, 3:833-841.