Effects of intensive glycaemic control on ischaemic heart disease: Analysis of data from the randomised, controlled ACCORD trial

The Lancet

Volumn 384, Issue 9958, 2014, Pages 1936-1941

  Gerstein, Hertzel C ^a   Miller, Michael E ^b   Ismail Beigi, Faramarz ^c   Largay, Joe ^d   McDonald, Charlotte ^e   Lochnan, Heather A ^f   Booth, Gillian L ^g  

^a HAMILTON HEALTH SCIENCES   (Canada)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e WESTERN UNIVERSITY   (Canada)

^f OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^g ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ACETYLSALICYLIC ACID; FENOFIBRATE; GLUCOSE; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LONG ACTING INSULIN; METFORMIN; SULFONYLUREA DERIVATIVE; ANTIDIABETIC AGENT; GLYCOSYLATED HEMOGLOBIN;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CORONARY REVASCULARISATION; FEMALE; FOLLOW UP; GLYCEMIC CONTROL; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; HYPERGLYCEMIA; INTENSIVE CARE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; RISK FACTOR; UNSTABLE ANGINA PECTORIS; ANGINA, UNSTABLE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DRUG COMBINATION; METABOLISM; MULTICENTER STUDY; MYOCARDIAL INFARCTION; RANDOMIZED CONTROLLED TRIAL; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ADULT; AGED; ANGINA, UNSTABLE; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL REVASCULARIZATION; RISK FACTORS; TREATMENT OUTCOME;

EID: 84919428088     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)60611-5     Document Type: Article

References (18)

1. The Emerging Risk Factors Collaboration Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies Lancet 375 2010 2215 2222
2. SR Seshasai, S Kaptoge, A Thompson for the Emerging Risk Factors Collaboration Diabetes mellitus, fasting glucose, and risk of cause-specific death N Engl J Med 364 2011 829 841
3. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 36 suppl 1 2013 S67 S74
4. IM Stratton, AI Adler, HA Neil et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 321 2000 405 412
5. RR Holman, SK Paul, MA Bethel, DR Matthews, HA Neil 10-year follow-up of intensive glucose control in type 2 diabetes N Engl J Med 359 2008 1577 1589
6. FM Turnbull, C Abraira, RJ Anderson for the Control Group Intensive glucose control and macrovascular outcomes in type 2 diabetes Diabetologia 52 2009 2288 2298
7. MC Riddle, WT Ambrosius, DJ Brillon for the Action to Control Cardiovascular Risk in Diabetes Investigators Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial Diabetes Care 33 2010 983 990
8. DE Bonds, ME Miller, RM Bergenstal et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study BMJ 340 2010 b4909
9. MC Riddle Counterpoint: intensive glucose control and mortality in ACCORD - still looking for clues Diabetes Care 33 2010 2722 2724
10. R Pop-Busui, GW Evans, HC Gerstein for the Action to Control Cardiovascular Risk in Diabetes Study Group Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial Diabetes Care 33 2010 1578 1584
11. JM Lachin Point: Intensive glycemic control and mortality in ACCORD - a chance finding? Diabetes Care 33 2010 2719 2721
12. HC Gerstein, ME Miller, S Genuth the ACCORD Study Group Long-term effects of intensive glucose lowering on cardiovascular outcomes N Engl J Med 364 2011 818 828
13. HC Gerstein, ME Miller, RP Byington for the Action to Control Cardiovascular Risk in Diabetes Study Group Effects of intensive glucose lowering in type 2 diabetes N Engl J Med 358 2008 2545 2559
14. WC Cushman, GW Evans, RP Byington for the ACCORD Study Group Effects of intensive blood-pressure control in type 2 diabetes mellitus N Engl J Med 362 2010 1575 1585
15. HN Ginsberg, MB Elam, LC Lovato for the ACCORD Study Group Effects of combination lipid therapy in type 2 diabetes mellitus N Engl J Med 362 2010 1563 1574
16. H Putter, M Fiocco, RB Geskus Tutorial in biostatistics: competing risks and multi-state models Stat Med 26 2007 2389 2430
17. JP Fine, RJ Gray A proportional hazards model for the subdistribution of a competing risk J Am Stat Assoc 94 1999 496 509
18. M Benn, A Tybjaerg-Hansen, MI McCarthy, GB Jensen, P Grande, BG Nordestgaard Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study J Am Coll Cardiol 59 2012 2356 2365