Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE

Journal of Neuroimmunology

Volumn 277, Issue 1-2, 2014, Pages 39-49

  Clarkson, Benjamin D ^a   Walker, Alec ^a   Harris, Melissa ^a   Rayasam, Aditya ^a   Sandor, Matyas ^a   Fabry, Zsuzsanna ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Choroid plexus; Dendritic cell; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Periventricular; Rostral migratory stream

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN VENTRICLE; CELL INTERACTION; CELLULAR DISTRIBUTION; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DENDRITIC CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HIPPOCAMPUS; MENINX; MESENCEPHALON; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLFACTORY BULB; SPINAL CORD; SUPERIOR COLLICULUS; T LYMPHOCYTE; ADOPTIVE TRANSFER; ANALYSIS OF VARIANCE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; CHEMICALLY INDUCED; DISEASE MODEL; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; PATHOLOGY; TIME FACTOR; TRANSGENIC MOUSE;

GLYCOPROTEIN P 15095; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT; PHOTOPROTEIN;

ADOPTIVE TRANSFER; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD11C; BONE MARROW CELLS; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FLOW CYTOMETRY; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; TIME FACTORS;

EID: 84919395291     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.09.016     Document Type: Article

References (32)

1. Bailey S.L., Schreiner B., McMahon E.J., Miller S.D. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat. Immunol. 2007, 8:172-180.
2. Bartholomaus I., Kawakami N., Odoardi F., Schlager C., Miljkovic D., Ellwart J.W., et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009, 462:94-98.
3. Brown D.A., Sawchenko P.E. Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis. J. Comp. Neurol. 2007, 502:236-260.
4. Bulloch K., Miller M.M., Gal-Toth J., Milner T.A., Gottfried-Blackmore A., Waters E.M., et al. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J. Comp. Neurol. 2008, 508:687-710.
5. Clarkson B.D., Heninger E., Harris M.G., Lee J., Sandor M., Fabry Z. Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS. Adv. Exp. Med. Biol. 2012, 946:309-333.
6. D'Agostino P.M., Kwak C., Vecchiarelli H.A., Toth J.G., Miller J.M., Masheeb Z., et al. Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:6175-6180.
7. Felger J.C., Abe T., Kaunzner U.W., Gottfried-Blackmore A., Gal-Toth J., McEwen B.S., et al. Brain dendritic cells in ischemic stroke: time course, activation state, and origin. Brain Behav. Immun. 2010, 24:724-737.
8. Fleming K.K., Bovaird J.A., Mosier M.C., Emerson M.R., LeVine S.M., Marquis J.G. Statistical analysis of data from studies on experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005, 170:71-84.
9. Gottfried-Blackmore A., Kaunzner U.W., Idoyaga J., Felger J.C., McEwen B.S., Bulloch K. Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:20918-20923.
10. Greter M., Heppner F.L., Lemos M.P., Odermatt B.M., Goebels N., Laufer T., et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 2005, 11:328-334.
11. Hatterer E., Touret M., Belin M.F., Honnorat J., Nataf S. Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions. PLoS One 2008, 3:e3321.
12. Karman J., Ling C., Sandor M., Fabry Z. Initiation of immune responses in brain is promoted by local dendritic cells. J. Immunol. 2004, 173:2353-2361.
13. Kaunzner U.W., Miller M.M., Gottfried-Blackmore A., Gal-Toth J., Felger J.C., McEwen B.S., et al. Accumulation of resident and peripheral dendritic cells in the aging CNS. Neurobiol. Aging 2012, 33:681-693. (e1).
14. Lee J., Ling C., Kosmalski M.M., Hulseberg P., Schreiber H.A., Sandor M., et al. Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNS. J. Neuroimmunol. 2009, 213:112-122.
15. Meeker R.B., Williams K., Killebrew D.A., Hudson L.C. Cell trafficking through the choroid plexus. Cell Adhes. Migr. 2012, 6:390-396.
16. Mohammad M.G., Tsai V.W., Ruitenberg M.J., Hassanpour M., Li H., Hart P.H., et al. Immune cell trafficking from the brain maintains CNS immune tolerance. J. Clin. Invest. 2014, 124:1228-1241.
17. Odoardi F., Kawakami N., Klinkert W.E., Wekerle H., Flugel A. Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:18625-18630.
18. Pesic M., Bartholomaus I., Kyratsous N.I., Heissmeyer V., Wekerle H., Kawakami N. 2-photon imaging of phagocyte-mediated T cell activation in the CNS. J. Clin. Invest. 2013, 123:1192-1201.
19. Pfueller C.F., Brandt A.U., Schubert F., Bock M., Walaszek B., Waiczies H., et al. Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PLoS One 2011, 6:e18019.
20. Prodinger C., Bunse J., Kruger M., Schiefenhovel F., Brandt C., Laman J.D., et al. CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol. 2011, 121:445-458.
21. Reboldi A., Coisne C., Baumjohann D., Benvenuto F., Bottinelli D., Lira S., et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat. Immunol. 2009, 10:514-523.
22. Reich D.S., Smith S.A., Gordon-Lipkin E.M., Ozturk A., Caffo B.S., Balcer L.J., et al. Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Arch. Neurol. 2009, 66:998-1006.
23. Rocca M.A., Mesaros S., Preziosa P., Pagani E., Stosic-Opincal T., Dujmovic-Basuroski I., et al. Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study. Mult. Scler. 2013, 19:1610-1617.
24. Schmitt C., Strazielle N., Ghersi-Egea J.F. Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain. J. Neuroinflammation 2012, 9:187.
25. Serafini B., Columba-Cabezas S., Di Rosa F., Aloisi F. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 2000, 157:1991-2002.
26. Shechter R., Miller O., Yovel G., Rosenzweig N., London A., Ruckh J., et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 2013, 38:555-569.
27. Tang S.K., Knobloch R.A., Maucksch C., Connor B. Redirection of doublecortin-positive cell migration by over-expression of the chemokines MCP-1, MIP-1alpha and GRO-alpha in the adult rat brain. Neuroscience 2014, 260:240-248.
28. Tepavcevic V., Lazarini F., Alfaro-Cervello C., Kerninon C., Yoshikawa K., Garcia-Verdugo J.M., et al. Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis. J. Clin. Invest. 2011, 121:4722-4734.
29. Ueno M., Tanaka S., Miyabe K., Kanenishi K., Onodera M., Yanghong W., et al. Dendritic cell-like immunoreactivity in the glomerulus of the olfactory bulb and olfactory nerves of mice. Neuroreport 2000, 11:3573-3576.
30. Wlodarczyk A., Lobner M., Cedile O., Owens T. Comparison of microglia and infiltrating CD11c(+) cells as antigen presenting cells for T cell proliferation and cytokine response. J. Neuroinflammation 2014, 11:57.
31. Zozulya A.L., Ortler S., Lee J., Weidenfeller C., Sandor M., Wiendl H., et al. Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS. J. Neurosci. 2009, 29:140-152.
32. Zozulya A.L., Clarkson B.D., Ortler S., Fabry Z., Wiendl H. The role of dendritic cells in CNS autoimmunity. J. Mol. Med. (Berl.) 2010, 88:535-544.