Porokeratoses: An update of clinical, aetiopathogenic and therapeutic features

European Journal of Dermatology

Volumn 24, Issue 5, 2014, Pages 533-544

  Kanitakis, Jean ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Cornoid lamella; Genodermatoses; Immunosuppression; Keratinisation; Porokeratoses

Indexed keywords

CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTRAST ENHANCED PHOTOTRICHOGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CUTANEOUS PARAMETERS; HAIR ANALYSIS; HAIR FOLLICLE; HAIR GROWTH; HAIR LENGTH; HAIR LOSS; HAIR THICKNESS; HUMAN; MALE; MALE PATTERN HAIR LOSS; MALE TYPE ALOPECIA; QUALITY CONTROL; REVIEW; SCALP HAIR; CELL TRANSFORMATION; PATHOLOGY; POROKERATOSIS; PROGNOSIS; SKIN TUMOR; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; POROKERATOSIS; PROGNOSIS; SKIN NEOPLASMS;

EID: 84919387564     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2014.2402     Document Type: Review

References (206)

1. Allegra F. The man behind the eponym: Vittorio Mibelli and the tale of porokeratosis. Am J Dermatopathol1986; 11: 79-83.
2. Redondo P, Sola M, Lloret P. Porokeratosis and povidone-iodine: a new clinical diagnostic sign. Br J Dermatol2002; 147: 383.
3. Katugampola RP, Finlay AY. Fake sun tan diagnosis of porokeratosis. J Eur Acad Dermatol Venereol2006; 20: 224-5.
4. Sertznig P, von Felbert V, Megahed M. Porokeratosis: present concepts. J Eur Acad Dermatol Venereol2012; 26: 404-12.
5. Kanitakis C, Ktenides M, Tsoitis G. Porokératose de Mibelli des lèvres bilatérale et symétrique. Dermatologica1981; 163: 1-4.
6. Zhou C, Jin Y, Zang D, Zhang J. Disseminated bilateral hyperkeratotic variant of porokeratosis Mibelli with pruritus. Eur J Dermatol2011; 21: 1007-9.
7. Vergara G, Banuls J, Botella R, Silvestre JF, Belinchon I, Betlloch I. Porokeratosis of the lower lip. Eur J Dermatol2002; 12: 500-2.
8. Gotz A, Kopera D, Wach F, Hohenleutner U, Landthaler M. Porokeratosis Mibelli gigantea: case report and literature review. Hautarzt1999; 50: 435-8.
9. Sidwell RU, Seet JE, Francis N, Bunker CB. Giant actinic porokeratosis of the scalp. Br J Dermatol2003; 149: 654.
10. Gutierrez E, Galarza C, Ramos W, et al. Facial porokeratosis: a series of six patients. Australas J Dermatol2010; 51: 191-4.
11. Porter W, Du Menage H, Philip G, Bunker C. Porokeratosis of the penis.Br J Dermatol2001; 144: 643-4.
12. Robinson J, Im D, Jockle G, Rosenshein N. Vulvar porokeratosis: case report and review of the literature. Int J Gynecol Pathol1999; 18: 169-73.
13. Laino L, Pala S, Innocenzi D, Accappaticcio G, Van Steensel MA. Genital porokeratosis. Eur J Dermatol2004; 14: 190-2.
14. Mikhail G, Wertheimer F. Clinical variants of porokeratosis (Mibelli).Acta Derm Venereol1968; 98: 124-31.
15. Kim DS, Roh MR, Lee JH, Lee KH. Pterygium unguis formation in porokeratosis of Mibelli. Br J Dermatol2007; 156: 1384-5.
16. Handjani F, Shahbaz S, Aslani FS, Gheisari F, Mozaffarian K, Kasraee B. Porokeratosis of Mibelli with mutilation: a case report. Cutis2010; 86: 77-80.
17. Patrizi A, D’Acunto C, Passarini B, Neri I. Porokeratosis in the elderly: a new subtype of disseminated superficial actinic porokeratosis. Acta Derm Venereol2000; 80: 302-4.
18. Chernosky M, Freeman R. Disseminated superficial actinic porokeratosis (DSAP): clinical studies and experimental production of lesions. Arch Dermatol1967; 96: 611-24.
19. Allen AL, Glaser DA. Disseminated superficial actinic porokeratosis associated with topical PUVA. J Am Acad Dermatol2000; 43: 720-2.
20. Chernosky M, Anderson D. Disseminated superficial actinic porokeratosis. Clinical studies and experimental production of lesions. Arch Dermatol1969; 99: 401-7.
21. Cockerell C. Induction of disseminated superficial actinic porokeratosis by phototherapy for psoriasis. J Am Acad Dermatol1991; 24: 301-2.
22. Neumann R, Knobler R, Metze D, Jurecka W, Gebhart W. Disseminated superficial actinic porokeratosis: experimental induction and exacerbation of skin lesions. J Am Acad Dermatol1989; 21: 1182-8.
23. Roson E, Garcia-Doval I, De La Torre C, et al. Disseminated superficial porokeratosis with mucosal involvement. Acta Derm Venereol2001; 81: 64-5.
24. Kohara Y, Takeo T, Oshima Y, Akita Y, Tamada Y, Watanabe D. Linear porokeratosis with nail dystrophy. Eur J Dermatol2011; 21: 625-6.
25. Robati RM, Rahmati-Roosdari M, Ayatollahi A, Hejazi S. Facial and bilateral acral porokeratosis with nail dystrophy: a case report. Dermatol Online J2011; 17: 5.
26. Tseng SS, Levit EK, Ilarda I, et al. Linear porokeratosis with underlying bony abnormalities. Cutis2002; 69: 309-12.
27. Wei B, Liu M, Qu L, Xiao T, Chen H, He C. Congenital linear porokeratosis with pseudoainhum. Eur J Dermatol2010; 20: 817-8.
28. Zhang ZH, Xiang LH, Chen LJ, et al. Congenital facial linear porokeratosis. Clin Exp Dermatol2005; 30: 361-2.
29. Freyschmidt-Paul P, Hoffmann R, Konig A, Happle R. Linear porokeratosis superimposed on disseminated superficial actinic porokeratosis: report of two cases exemplifying the concept of type 2 segmental manifestation of autosomal dominant skin disorders. J Am Acad Dermatol1999; 41: 644-7.
30. Murata Y, Kumano K, Takai T. Type 2 segmental manifestation of disseminated superficial porokeratosis showing a systematized pattern of involvement and pronounced cancer proneness. Eur J Dermatol2001; 11: 191-4.
31. Schwarz N, Stadie V, Kreft B, Happle R, Marsch W, Fiedler E. Systematized linear porokeratosis: concept of type 2 segmental manifestation implies an increased cancer risk. J Dermatol2012; 39: 953-4.
32. Lestringant G, Berge T. Porokeratosis punctata palmaris et plantaris. A new entity? Arch Dermatol1989; 125: 816-9.
33. Guss S, Osbourn R, Lutzner M. Porokeratosis palmaris, plantaris et disseminata: a third type of porokeratosis. Arch Dermatol1971; 104: 366-73.
34. Irisawa R, Yamazaki M, Yamamoto T, Tsuboi R. A case of porokeratosis plantaris palmaris et disseminata and literature review. Dermatol Online J2012; 18: 5.
35. Patrizi A, Passarini B, Minghetti G, Massina M. Porokeratosis palmaris, plantaris et disseminata: an unusual clinical presentation. J Am Acad Dermatol1989; 21: 415-8.
36. Lucke T, Fallowfield M, Kemmett D. A sporadic case of porokeratosis plantaris palmaris et disseminata. Br J Dermatol1998; 138: 556-7.
37. Marque M, Meunier L. Les porokératoses. Ann Dermatol Vénéréol2012; 139: 668-76.
38. Suarez-Amor O, Pereiro-Ferreiros M, Ginarte M, et al. Coexistence of linear porokeratosis and disseminated superficial actinic porokeratosis: a type 2 segmental manifestation. Acta Derm Venereol2007; 87: 363-4.
39. Cho K, Lee Y, Park H, Cho B. Coexistence of congenital linear porokeratosis and disseminated superficial porokeratosis. Australas J Dermatol2012; 53: e30-1.
40. Murase J, Gilliam A. Disseminated superficial actinic porokeratosis co-existing with linear and verrucous porokeratosis in an elderly woman: update on the genetics and clinical expression of porokeratosis. J Am Acad Dermatol2010; 63: 886-91.
41. Löhrer R, Neumann-Acikel A, Eming R, et al. A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis. Case Rep Dermatol2010; 2: 130-4.
42. Niimi Y, Kawana S. Type 2 segmental manifestation of disseminated superficial actinic porokeratosis in a 7-year-old girl. Eur J Dermatol2009; 19: 25-8.
43. Kaur S, Thami G, Mohan H, Kanwar A. Co-existence of variants of porokeratosis : a case report and a review of the literature. J Dermatol2002; 29: 305-9.
44. Commens C, Schumack S. Linear porokeratosis in two families with disseminated superficial actinic porokeratosis. Ped Dermatol1987; 4: 209-14.
45. Helfman R, Poulos E. Reticulated porokeratosis: a unique variant of porokeratosis. Arch Dermatol1985; 121: 1542-3.
46. McGuigan K, Shurman D, Campanelli C, Lee J. Porokeratosis ptychotropica: a clinicaly distinct variant of porokeratosis. J Am Acad Dermatol2009; 60: 501-3.
47. Yeo J, Winhoven S, Tallon B. Porokeratosis ptychotropica: a rare and evolving variant of porokeratosis. J Cutan Pathol2013; 40: 1042-7.
48. Takiguchi R, White K, White C, Simpson E. Verrucous porokeratosis of the gluteal cleft (porokeratosis ptychotropica): a rare disorder easily misdiagosed. J Cutan Pathol2010; 37: 802-7.
49. Stone N, Ratnavel R, Wilkinson JD. Bilateral perianal inflammatory verrucous porokeratosis (porokeratosis ptychotropica). Br J Dermatol1999; 140: 553-5.
50. Corradin MT, Giulioni E, Forcione M, et al. Porokeratosis ptychotropica. Eur J Dermatol2011; 21: 416-7.
51. Kanzaki T, Miwa N, Kobayashi T, Ogawa S. Eruptive pruritic papular porokeratosis. J Dermatol1992; 19: 109-12.
52. Kang B, Kye Y, Kim S. Disseminated superficial actinic porokeratosis with both typical and prurigo nodularis-like lesions. J Dermatol2001; 28: 81-5.
53. Watanabe T, Murakami T, Okochi H, Kikuchi K, Furue M. Ulcerative porokeratosis. Dermatology1998; 196: 256-9.
54. Ricci C, Rosset A, Panizzon R. Bullous and pruritic variant of disseminated superficial actinic porokeratosis: successful treatment with grenz rays. Dermatology1999; 199: 328-31.
55. Miller DD, Ruben BS. Pustular porokeratosis. J Cutan Pathol2009; 36: 1191-3.
56. Chen H, Chou Y, Chen C, Kuo T, Hong H. Genital porokeratosis: a series of 10 patients and review of the literature. Br J Dermatol2006; 155: 325-9.
57. Wang NS, Gruson LM, Kamino H. Facial follicular porokeratosis: a case report. Am J Dermatopathol2010; 32: 720-2.
58. Asawanonda P, Noppakun N, Huiprasert P. Seborrheic keratosislike porokeratosis: A case report. Dermatol Online J2005; 11: 18.
59. Walsh S, Hurt M, Santa Cruz D.Porokeratoma. Am J Surg Pathol2007; 31: 1897-901.
60. Kanitakis J, Rival-Tringali AL, Chouvet B, Vignot E, Claudy A, Faure M. Porokeratoma (porokeratotic acanthoma): immunohistological study of a new case. J Cutan Pathol2009; 36: 804-7.
61. Batalla A, Roson E, De la Torre C. Porokeratoma: a different entity or a variant of verrucous (hyperkeratotic) porokeratosis? Indian J Dermatol2013; 58: 158.
62. Du-Thanh A, Frouin E, Vignon-Pennamen MD, Debu A, Guillot B, Dereure O. Solitary plaque of the labial commissure with contiguous mucosal involvement: a distinct subset of porokeratosis? Eur J Dermatol2013; 23: 722-3.
63. Shumack S, Commens C, Kossard S. Disseminated superficial actinic porokeratosis. A histological review of 61 cases with particular reference to lymphocytic infiltration. Am J Dermatopathol1991; 23: 26-31.
64. Ginarte M, Leon A, Toribio J. Disseminated superficial porokeratosis with amyloid deposits. Eur J Dermatol2005; 15: 298-300.
65. Inamoto N, Watanabe T, Nakamura K. Porokeratosis of Mibelli: benzochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis. J Am Acad Dermatol1984; 11: 357-61.
66. Park BS, Moon SE, Kim JA. Disseminated superficial porokeratosis in a patient with chronic liver disease. J Dermatol1997; 24: 485-7.
67. Raychaudhuri S, Smoller B. Porokeratosis in immunosuppressed and non-immunosuppressed patients. Int J Dermatol1992; 31: 781-2.
68. Kanitakis J, Miséry L, Nicolas JF, et al. Disseminated superficial porokeratosis in a patient with AIDS. Br J Dermatol1994; 131: 284-9.
69. Sato A, Anton-Lamprecht I, Schnyder U. Ultrastructure of inborn errors of keratinization: Porokeratosis Mibelli and disseminated superficial actinic porokeratosis. Arch Dermatol Res1976; 255: 271-84.
70. Gray M, Smoller B, McNutt N. Carcinogenesis in porokeratosis: evidence for a role relating to chronic growth activation of keratinocytes. Am J Dermatopathol1991; 13: 438-44.
71. Ito M, Fujiwara H, Maruyama T, Oguro K, Ishihara O, Sato Y. Morphogenesis of the cornoid lamella: histochemical, immunohistochemical and ultrastructural study of porokeratosis. J Cutan Pathol1991; 18: 247-56.
72. Manganoni A, Faccheti F, Gavazzoni R. Involvement of epidermal Langerhans cells in porokeratosis of immunosuppressed renal transplant patients. J Am Acad Dermatol1989; 21: 799-801.
73. Wade T, Ackerman B. Cornoid lamellation: a histologic reaction pattern. Am J Dermatopathol1980; 2: 5-15.
74. Biswas A. Cornoid lamellation revisited: apropos of porokeratosis with emphasis on unusual clinicopathologic variants. Am J Dermatopathol(published online Jan 13, 2014).
75. Oiso N, Kawada A. Dermoscopic features in disseminated superficial actinic porokeratosis. Eur J Dermatol2011; 21: 439-40.
76. Moscarella E, Longo C, Zalaudek I, Argenziano G, Piana S, Lallas A. Dermoscopy and confocal microscopy clues in the diagnosis of psoriasis and porokeratosis. J Am Acad Dermatol2013; 69: e231-3.
77. Ulrich M, Forschner T, Röwert-Hüber J, et al. Differentiation between actinic keratoses and disseminated superficial actinic porokeratoses with reflectance confocal micrscopy.Br J Dermatol2007; 156(suppl. 3): 47-52.
78. Von Felbert V, Neis M, Megahed M, Spöler F. Imaging of actinic porokeratosis by optical coherence tomography. Hautarzt2008; 59: 877-9.
79. Reed R, Leone P. Porokeratosis - a mutant clonal keratosis of the epidermis. Arch Dermatol1970; 101: 340-7.
80. Beers B, Jaszcz W, Sheetz K, Hogan D, Lynch P. Porokeratosis palmaris et plantaris disseminata. Report of a case with abnormal DNA ploidy in lesional epidermis. Arch Dermatol1992; 128: 236-9.
81. Otsuka F, Shima A, Ishibashi Y. Porokeratosis as a premalignant condition of the skin. Cytologic demonstration of abnormal DNA ploidy in cells of the epidermis. Cancer1989; 63: 891-6.
82. Otsuka F, Iwata M, Watanabe R, Chi H, Ishibashi Y. Porokeratosis: clinical and cellular characterization of its cancer-prone nature. J Dermatol1992; 19: 702-6.
83. Chang SE, Lim Y, Lee H, Choi J, Sung K. Expression of p53, pRb, p16 and proliferating cell nuclear antigen in squamous cell carcinomas arising on a giant porokeratosis. Br J Dermatol1999; 141: 575-6.
84. Arranz-Salas I, Sanz-Trelles A, Ojeda D. p53 alterations in porokeratosis. J Cutan Pathol2003; 7: 455-8.
85. Anderson D, Chernosky M. Disseminated superficial actinic porokeratosis. Genetic aspects. Arch Dermatol1969; 99: 408-12.
86. Sacppaticci S, Limbiase S, Orecchia G, Fraccaro M. Clonal chromosome abnormalities with preferential involvement of chromosome 3 in patients with porokeratosis of Mibelli. Cancer Genet Cytogenet1989; 43: 89-94.
87. Luan J, Niu Z, Zhang J, et al. A novel locus for disseminated superficial porokeratosis maps to chromosome 16q24.1-24.3. Hum Genet2011; 129: 329-34.
88. Cao H, Wang Z, Zhang G, et al. Identification of a locus (DSP2) for disseminated superficial porokeratosis at chromosome 12q21.2- 24.21. Clin Exp Dermatol2012; 37: 672-6.
89. Zhang SQ, Jiang T, Li M, et al. Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. Nat Genet2012; 44: 1156-60.
90. Zhou Y, Liu J, Fu X, et al. Identification of three novel frameshift mutations of the MVK gene in four Chinese families with disseminated superficial actinic porokeratosis. Br J Dermatol2013; 169: 193-5.
91. Occella C, Bleidl D, Nozza P, et al. Identification of an interstitial 18p11.32-p11.31 duplication including the EMILIN2 gene in a family with porokeratosis of Mibelli. PLoS One2013; 8: e61311
92. Kawara S, Oiso N, Kawada A. Disseminated superficial actinic porokeratosis in a patient undergoing treatment with longterm narrowband ultraviolet B for psoriasis. J Dermatol2011; 38: 585-7.
93. Romani J, Pujol R, Casanova J, de Moragas J. Disseminated superficial porokeratosis developing after electron beam total skin irradiation for mycosis fungoides. Clin Exp Dermatol1996; 21: 310-2.
94. Batchelor J, Fife K, Burrows N. Localized porokeratosis secondary to ionizing radiotherapy for prostate carcinoma. Arch Dermatol2010; 146: 1318-20.
95. James A, Clarke L, Elenitsas R, Katz K. Segmental porokeratosis after radiation therapy for follicular lymphoma. J Am Acad Dermatol2008; 58: S49-50.
96. D’Errico M, Teson M, Calcagnile A, et al. Characterization of the ultraviolet B and X-ray response of primary cultured epidermal cells from patients with disseminated superficial actinic porokeratosis. Br J Dermatol2004; 150: 47-55.
97. Schwartz T, Seiser A, Gschnait F. Disseminated superficial « actinic » porokeratosis. J Am Acad Dermatol1984; 11: 724-30.
98. Bencini PL, Tarantino A, Grimalt R, Ponticelli C, Caputo R. Porokeratosis and immunosuppression. Br J Dermatol1995; 132: 74-8.
99. Macmillan A, Roberts S. Porokeratosis of Mibelli after renal transplantation. Br J Dermatol1974; 90: 45-51.
100. Rodriguez E, Jakubowicz S, Chinchilla D, Carril A, Viglioglia P. Porokeratosis of Mibelli and HIV infection. Int J Dermatol1996; 35: 402-4.
101. Zenarola P, Melillo L, Lomuto M, Carotenuto M, Enzo Gomes V, Marzocchi W. Exacerbation of porokeratosis: a sign of immunodepression. J Am Acad Dermatol1993; 29: 1035-6.
102. Tsambaos D, Spiliopoulos T. Disseminated superficial porokeratosis: complete remission subsequent to discontinuation of immunosuppression. J Am Acad Dermatol1993; 28: 651-2.
103. Kroiss M, Stolz W, Hohenleutner U, Landthaler M. Disseminated superficial porokeratosis induced by furosemide. Acta Derm Venereol2000; 80: 52-3.
104. Trcka J, Pettke-Rank CV, Brocker EB, Hamm H. Genitoanocrural porokeratosis following chronic exposure to benzene. Clin Exp Dermatol1998; 23: 28-31.
105. Yazkan F, Turk BG, Dereli T, Kazandi AC. Porokeratosis of Mibelli induced by topical corticosteroid. J Cutan Pathol2006; 33: 516-8.
106. Guarneri C, Cannavo S, Lentini M, Polimeni G. Adalimumabinduced disseminated superficial porokeratosis. Ann Pharmacother2011 (epub Feb 8).
107. Stewart L, Howat A, Coulson I. Disseminated superficial porokeratosis secondary to immunosuppression induced by etanercept for extensive psoriasis. Arch Dermatol2010; 146: 1193-4.
108. Goulding J, Teoh J, Carr R, Humphreys F, Gee B. Eruptive disseminated superficial porokeratosis with rapid resolution: a drug induced phenomenon? Clin Exp Dermatol2009; 34: 895-7.
109. Kanitakis J, Arbona-Vidal E, Faure M. Porokeratosis in patients with polycythemia rubra vera: a new side-effect of hydroxyurea? J Eur Acad Dermatol Venereol2012; 26: 1040-1.
110. Esser AC, Pittelkow MR, Randle HW. Human papillomavirus isolated from transplant-associated porokeratoses of Mibelli responsive to topical 5% imiquimod cream. Dermatol Surg2006; 32: 858-61.
111. Mizukawa Y, Shiohara T. Onset of porokeratosis of Mibelli in organ transplant recipients: lack of a search for transmissible agents in these patients. J Am Acad Dermatol2001; 44: 143-4.
112. Kono T, Kobayashi H, Ishii M, Nishiguchi S, Taniguchi S. Synchronous development of disseminated superficial porokeratosis and hepatitis C virus-related hepatocellular carcinoma. J Am Acad Dermatol2000; 43: 966-8.
113. Mizukawa Y, Shiohara T. Porokeratosis in patients with hepatitis C virus infection: does hepatitis C virus infection provide a link between porokeratosis and immunosuppression? Br J Dermatol1999; 141: 163-4.
114. Nova M, Goldberg L, Mattison T, Halperin A. Porokeratosis arising in a burn scar. J Am Acad Dermatol1991; 25: 354-6.
115. Nakazawa A, Matsuo I, Ohkido M. Porokeratosis localized to the access region for hemodialysis. J Am Acad Dermatol1991; 21: 338-40.
116. D’Errico M, Teson M, Calcagnile A, et al. Characterization of the ultraviolet B and X-ray response of primary cultured epidermal cells from patients with disseminated superficial actinic porokeratosis. Br J Dermatol2004; 150: 47-55.
117. Schena D, Papagrigoraki A, Frigo A, Girolomoni G. Eruptive disseminated porokeratosis associated with internal maignancies: a case report. Cutis2010; 85: 156-9.
118. Torres T, Velho G, Selores M. Disseminated superficial porokeratosis in a patient with cholangiocarcinoma: a paraneoplastic manifestation? An Bras Dermatol2010; 85: 229-31.
119. Cannavo M, Borgia F, Adamo B, Guarneri B. Simultaneous development and parallel course of disseminated superficial porokeratosis and ovarian cancer: coincidental association or true paraneplastic syndrome? J Am Acad Dermatol2008; 58: 657-60.
120. Lee WJ, Kim CH, Park GH, et al. Disseminated superficial porokeratosis in a patient with esophageal cancer. J Dermatol2010; 37: 747-8.
121. Diluvio L, Campione E, Paterno EJ, et al. Acute onset disseminated superficial porokeratosis heralding diffuse large B-cell lymphoma. Eur J Dermatol2008; 18: 349-50.
122. Breton AL, Pralong P, Trillet-Lenoir V, Balme B, Nicolas JF, Berard F. Disseminated porokeratosis transiently healed by cancer chemotherapy. Eur J Dermatol2014; 24: 261-2.
123. Flanagan N, Boyadjiev SA, Harper J, et al. Familial craniosynostosis, anal anomalies, and porokeratosis: CAP syndrome. J Med Genet1998; 35: 763-6.
124. Mendoza-Londono R, Lammer E, Watson R, et al. Characterization of a new syndrome that associates craniosynostosis, delayed fontanel closure, parietal foramina, imperforate anus, and skin eruption: CDAGS. Am J Hum Genet2005; 77: 161-8.
125. Chouery E, Guissart C, Mégarbané H, et al. Craniosynostosis, anal anomalies, and porokeratosis (CDAGS syndrome): case report and literature review. Eur J Med Genet2013; 56: 674-7.
126. Tanaka M, Terui T, Kudo K, Tagami H. Inflammatory disseminated superficial porokeratosis followed by regression. Br J Dermatol1995; 132: 153-5.
127. Gilead L, Guberman D, Zlotogorski A, Vardy D, Klaus S. Immunosuppression-induced porokeratosis of Mibelli: complete regression of lesions upon cessation of immunosuppressive therapy. J Eur Acad Dermatol Venereol1995; 5: 170-2.
128. Seishima M, Izumi T, Oyama Z, Maeda M. Squamous cell carcinoma arising from lesions of porokeratosis palmaris et plantaris disseminata. Eur J Dermatol2000; 10: 478-80.
129. Maubec E, Duvillard P, Margulis A, Bachollet B, Degois G, Avril MF. Common skin cancers in porokeratosis.Br J Dermatol2005; 152: 1389-91.
130. Ehsani AH, Shakoei S, Ranjbar M. Giant porokeratosis of Mibelli with squamous cell carcinoma. Indian J Dermatol Venereol Leprol2014; 80: 96.
131. Guenova E, Hoetzenecker W, Metzler G, et al. Multicentric Bowen disease in linear porokeratosis. Eur J Dermatol2007; 17: 439-40.
132. Sasson M, Krain A. Porokeratosis and cutaneous malignancy. A review. Dermatol Surg1996; 22: 339-42.
133. Otsuka F, Someya T, Ishibashi Y. Porokeratosis and malignant skin tumors. J Cancer Res Clin Oncol1991; 117: 55-60.
134. Happle R. Cancer proneness of linear porokeratosis may be explained by allelic loss. Dermatology1997; 195: 20-5.
135. Shumack S, Commens C. Disseminated superficial actinic porokeratosis: a clinical study. J Am Acad Dermatol1989; 20: 1015-22.
136. Lee HR, Han TY, Son S, Lee JH. Squamous cell carcinoma developing within lesions of disseminated superficial actinic porokeratosis. Ann Dermatol2011; 23: 536-8.
137. Scola N, Skrygan M, Wieland U, Kreuter A, Gambichler T. Altered gene expression in squamous cell carcinoma arising from congenital unilateral linear porokeratosis. Clin Exp Dermatol2012; 37: 781-5.
138. Sawai T, Hayakawa H, Danno K. Squamous cell carcinoma arising from giant porokeratosis: a case with extensive metastasis and hypercalcemia. J Am Acad Dermatol1996; 34: 507-9.
139. Lozinski AZ, Fisher BK, Walter JB, Fitzpatrick PJ. Metastatic squamous cell carcinoma in linear porokeratosis of Mibelli. J Am Acad Dermatol1987; 16(2 Pt 2): 448-51.
140. Silver S, Crawford R. Fatal squamous cell carcinoma arising from transplant-associated porokeratosis. J Am Acad Dermatol2003; 49: 931-3.
141. Rongioletti F, Rebora A. Disseminated porokeratosis with fatal metastatic squamous cell carcinoma: an additional case of “malignant disseminated porokeratosis”. Am J Dermatopathol2002; 24: 144-8.
142. Kanitakis J, Euvrard S, Faure M, Claudy A. Porokeratosis and immunosuppression. Eur J Dermatol1998; 8: 459-65.
143. Herranz P, Pizarro A, De Lucas R, et al. High incidence of porokeratosis in renal transplant patients. Br J Dermatol1997; 136: 176-9.
144. Bouman T, van de Kerkhof P, Happle R. Disseminierte Porokeratosis nach Nierentransplantation. In: Gollnick H, Stadler R, eds. Dia-Klinik Fallvorstellungen anlässlich des 17. Weltkongresses für Dermatologie. Stuttgart: Schattauer, 1987; 49-50.
145. Hunt S, Sharra W, Abell E. Linear and punctate porokeratosis associated with end-stage liver disease. J Am Acad Dermatol1991; 25: 937-9.
146. Perez-Crespo M, Betlloch I, Lucas-Costa A, Bauls-Roca J, Niveiro de Jaime M, Mataix J. Unusual evolution of giant porokeratosis developing in two renal transplant recipients. Int J Dermatol2008; 47: 759-60.
147. Anzai S, Takeo N, Yamaguchi T, et al. Squamous cell carcinoma in a renal transplant recipient with linear porokeratosis. J Dermatol1999; 26: 244-7.
148. Skupsky H, Skupsky J, Goldenberg G. Disseminated superficial actinic porokeratosis: a treatment review. J Dermatol Treat2012; 23: 52-6.
149. Tan L, Chong W. Porokeratosis in Singapore: an Asian perspective. Australas J Dermatol2012; 53: e40-4.
150. Spencer J, Katz B. Successful treatment of porokeratosis of Mibelli with diamond fraise dermabrasion. Arch Dermatol1992; 128: 1187-8.
151. Scheiba N, Enk A, Proske S, Hartschuh W. Porokeratosis ptychotropica: successful treatment with the dermatome. Dermatol Surg2010; 36: 257-60.
152. Dereli T, Ozyurt S, Ozturk G. Porokeratosis of Mibelli : succesful treatment with cryosurgery. J Dermatol2004; 31: 223-7.
153. Bhushan M, Craven NM, Beck MH, Chalmers RJ. Linear porokeratosis of Mibelli: successful treatment with cryotherapy. Br J Dermatol1999; 141: 389.
154. Itoh M, Nakagawa H. Successful treatment of disseminated superficial actinic porokeratosis with Q-switched ruby laser. J Dermatol2007; 34: 816-20.
155. Liu Y, Wang Y, Nie X, et al. Treatment of classic porokeratosis of Mibelli with Q-switched ruby laser. Eur J Dermatol2012; 22: 125-6.
156. Liu H. Treatment of lichen amyloidosis and disseminated superficial porokeratosis with frequency-doubled Q-switched Nd/Yag laser. Dermatol Surg2000; 26: 958-62.
157. Rosenblum J, Roenigk HH. Erbium laser for the treatment of disseminated superficial actinic porokeratosis : a case report. Dermatol Surg2013; 39: 1543-5.
158. Lolis M, Marmur E. Treatment of disseminated superficial actinic porokeratosis (DSAP) with the Q-switched ruby laser. J Cosmet Laser Ther2008; 10: 124-7.
159. Noborio R, Morita A. Split-face trial of CO2 laser-induced ring abrasion and high-dose tacalcitol in the treatment of disseminated superficial actinic porokeratosis. J Dermatol2012; 39: 879-80.
160. Alster T, Nanni C. Successful treatment of porokeratosis with 585 nm pulsed dye laser irradiation. Cutis1999; 63: 265-6.
161. Ashinoff R, Geronemus R. Porokeratosis of Mibelli with underlying hemangioma treated by the flashlamp-pumped pulsed dye laser. Cutis1990; 46: 410-2.
162. Rabbin P, Baldwin H. Treatment of porokeratosis of Mibelli with CO2 laser vaporization versus surgical excision with split-thickness skin graft. A comparison. J Dermatol Surg Oncol1993; 19: 199-202.
163. McCullough TL, Lesher JL. Porokeratosis of Mibelli : rapid recurrence of a large lesion after carbon dioxide laser treatment. Ped Dermatol1994; 11: 267-70.
164. Chrastil B, Glaich A, Goldberg L, Friedman P. Fractional photothermolysis : a novel treatment for disseminated superficial actinic porokeratosis. Arch Dermatol2007; 143: 1450-2.
165. Garcia-Navarro X, Garcès JR, Baselga E, Alomar A. Linear porokeratosis. Excellent response to photodynamic therapy. Arch Dermatol2009; 145: 526-7.
166. Curkova AK, Hegyi J, Kozub P, Szep Z, D’Erme AM, Simaljakova M. A case of linear porokeratosis treated with photodynamic therapy with confocal microscopy surveillance. Dermatol Ther2013 Oct 1. doi: 10.1111/dth.12097.
167. Giuliodori K, Campaati A, Ganzetti G, et al. The successful offlabel use of photodynamic therapy for classic porokeratosis of Mibelli: case report. Dermatol Ther2011; 24: 501-4.
168. Gutiérrez Paredes E, Bella Navarro R, Montesinos Villaescusa E, Jordá Cuevas E. Porokeratosis of Mibelli: A new indication for photodynamic therapy? Actas Dermosifilogr2013; 104: 259-61.
169. Cavicchini S, Tourlaki A. Successful treatment of disseminated superficial actinic porokeratosis with methyl aminolevulinatephotodynamic therapy. J Dermatol Treat2006; 17: 190-1.
170. Nayeemuddin FA, Wong M, Yell J, Rhodes LE. Topical photodynamic therapy in disseminated superficial actinic porokeratosis. Clin Exp Dermatol2002; 27: 703-6.
171. Fernández-Guarino M, Harto A, Pérez-Garcia B, Martin- González M, Urrutia S, Jaén P. Photodynamic therapy in disseminated superficial actinic porokeratosis. J Eur Acad Dermatol Venereol2009; 23: 176-7.
172. Boiy A, de Witte P, Roelandts R. Topical treatment of disseminated actinic porokeratosis with hypericin-photodynamic therapy: a case report. Photodiagnosis Photodyn Ther2010; 7: 123-5.
173. Böhm M, Luger TA, Bonsmann G. Disseminated superficial actinic porokeratosis: treatment with topical tacalcitol. J Am Acad Dermatol1999; 40: 479-80.
174. Harrison P, Stollery N. Disseminated superficial actinic porokeratosis responding to calcipotriol. Clin Exp Dermatol1994; 19: 95.
175. Abe M, Yokoyama Y, Ishikawa O. Successful treatment of disseminated superficial actinic porokeratosis with tacalcitol lotion. J Dermatol2010; 37: 913-5.
176. Bakardzhiev I, Kavaklieva S, Pehlivanov G. Successful treatment of disseminated superficial actinic porokeratosis with calcipotriol. Int J Dermatol2012; 51: 1139-42.
177. Almeida Gonc¸alves JC. Fluorouracil ointment treatment of porokeratosis of Mibelli. Arch Dermatol1973; 108: 131-2.
178. Rahman M, Ansari N, Hadiuzzaman M, Nipa N, Mumu S, Chowdhury I. A giant porokeratosis of Mibelli: successful treatment with topical 5 percent fluorouracil. Egypt Dermatol Online J2011; 7: 7.
179. McDonald SG, Peterka ES. Porokeratosis (Mibelli): treatment with topical 5-fluorouracil. J Am Acad Dermatol1983; 8: 107-10.
180. Shelley WB, Shelley ED. Disseminated superficial porokeratosis: rapid therapeutic response to 5-fluorouracil. Cutis1983; 32: 139-40.
181. Balato N, Di Nardo G, Boccia L, Nappa P. [Linear Mibelli’s porokeratosis. Treatment with topical 5-fluorouracil]. G Ital Dermatol Venereol1986; 121: 147-8.
182. Teixeira S, Nascimento M, Bagatin E, Hassun K, Talarico S, Michalany N. The use of fluor-hydroxy pulse peel in actinic porokeratosis. Dermatol Surg2005; 31: 1145-8.
183. Levitt J, Emer JJ, Emanuel PO. Treatment of porokeratosis of Mibelli with combined use of photodynamic therapy and fluorouracil cream. Arch Dermatol2010; 146: 371-3.
184. Agarwal S, Berth-Jones J. Porokeratosis of Mibelli: successful treatment with 5% imiquimod cream. Br J Dermatol2002; 146: 338-9.
185. Harrison S, Sinclair R. Porokeratosis of Mibelli: successful treatment with topical 5% imiquimod cream. Australas J Dermatol2003; 44: 281-3.
186. Jain S. Successful treatment of porokeratosis of Mibelli with imiquimod 5% cream. Clin Exp Dermatol2006; 31: 302-3.
187. Gajic B, Tang K, Whitfeld M. Porokeratosis of Mibelli: Involution and resolution with 5% imiquimod cream. Australas J Dermatol2011; 52: 301-3.
188. Arun B, Pearson J, Chalmers R. Disseminated superficial actinic porokeratosis treated effectively with topical imiquimod 5% cream. Clin Exp Dermatol2011; 36: 509-11.
189. Riad H, Mansour K, Sada HA, Shaika SA, Ansari HA, Mohannadi HA. Disseminated superficial actinic porokeratosis on the face treated with imiquimod 5% cream. Case Rep Dermatol2013; 5: 283-9.
190. Ahn SJ, Lee HJ, Chang SE, et al. Case of linear porokeratosis: successful treatment with topical 5% imiquimod cream. J Dermatol2007; 34: 146-7.
191. Jensen JM, Egberts F, Proksch E, Hauschild A. Disseminated porokeratosis palmaris and plantaris treated with imiquimod cream to prevent malignancy. Acta Derm Venereol2005; 85: 550-1.
192. Venkatarajan S, LeLeux TM, Yang D, Rosen T, Orengo I. Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil. Dermatol Online J2010; 16: 10.
193. Vlachou C, Kanelleas AI, Martin-Clavijo A, Berth-Jones J. Treatment of disseminated superficial actinic porokeratosis with topical diclofenac gel: a case series. J Eur Acad Dermatol Venereol2008; 22: 1343-5.
194. Marks S, Varma R, Cantrell W, et al. Diclofenac sodium 3% gel as a potential treatment for disseminated superficial actinic porokeratosis. J Eur Acad Dermatol Venereol2009; 23: 42-5.
195. Kluger N, Dereure O, Guilhou JJ, Guillot B. Genital porokeratosis: treatment with diclofenac topical gel. J Dermatol Treat2007; 18: 188-90.
196. Naineni KK, Hohle R, Lucke T. Disseminated superficial actinic porokeratosis of the scalp. Clin Exp Dermatol2007; 32: 222-3.
197. Agrawal SK, Gandhi V, Madan V, Bhattacharya SN. Topical tretinoin in Indian male with zosteriform porokeratosis. Int J Dermatol2003; 42: 919-20.
198. Levitt JO, Keeley BR, Phelps RG. Treatment of porokeratosis of Mibelli with cantharidin. J Am Acad Dermatol2013; 69: e254-5.
199. Parks AC, Conner KJ, Armstrong CA. Long-term clearance of linear porokeratosis with tacrolimus 0.1% ointment. JAMA Dermatol2014; 150: 194-6.
200. Hong JB, Hsiao CH, Chu CY. Systematized linear porokeratosis: a rare variant of diffuse porokeratosis with good response to systemic acitretin. J Am Acad Dermatol2009; 60: 713-5.
201. Garg T, Ramchander T, Varghese B, Barara M, Nangia A. Generalized linear porokeratosis: a rare entity with excellent response to acitretin. Dermatol Online J2011; 17: 3.
202. Goldman G. Generalised linear porokeratosis treated with etretinate. Arch Dermatol1995; 131: 496-7.
203. Hacham-Zadeh S, Holubar K. Etretinate in the treatment of disseminated porokeratosis of Mibelli. Int J Dermatol1985; 24: 258-60.
204. Borroni G, Poddighe D, Zecca M, Brazzelli V. Efficacy of acitretin for porokeratosis in a child with chronic cutaneous graft versus host disease. Pediatr Dermatol2013; 30: 148-50.
205. Skroza N, Proietti I, Bernardini N, et al. Acitretin for treatment of familial porokeratosis palmaris et plantaris disseminate. Eur J Dermatol2012; 22: 699-700.
206. Knobler R, Neumann R. Exacerbation of porokeratosis during etretinate therapy. Acta Derm Venereol1990; 70: 319-22.