Packaging interventions to increase medication adherence: Systematic review and meta-Analysis

Current Medical Research and Opinion

Volumn 31, Issue 1, 2015, Pages 145-160

  Conn, Vicki S ^a   Ruppar, Todd M ^a   Chan, Keith C ^a   Dunbar Jacob, Jacqueline ^b   Pepper, Ginette A ^c   De Geest, Sabina ^d  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Intervention; Medication adherence; Medication compliance; Meta Analysis

Indexed keywords

BLISTER PACK; COGNITIVE DEFECT; CONTAINER; DRUG PACKAGING; EFFECT SIZE; HUMAN; MEDICATION COMPLIANCE; META ANALYSIS; OUTCOME ASSESSMENT; PHARMACY; PILL; PUBLISHING; REGISTER; RESEARCH; REVIEW; SELF REPORT; SYSTEMATIC REVIEW;

DRUG PACKAGING; HUMANS; MEDICATION ADHERENCE;

EID: 84918831469     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2014.978939     Document Type: Review

References (95)

1. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva, Switzerland: World Health Organization, 2003
2. Chaudhry HJ, McDermott B. Recognizing and improving patient nonadherence to statin therapy. Curr Atheroscler Rep 2008;10:19-24
3. DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes: a meta-Analysis. Med Care 2002;40:794-811
4. Starner T. The price of noncompliance: hospitalization rates and other medical costs go down when employees take their medication regularly. Human Resources Executive Online 2006. Accessed at http://www.hreonline.com/ HRE/view/story.jhtml?id=5059249
5. European Policymakers Debate. Summary of Policymakers' Debate - Just What the Doctor Ordered: An EU Response To Medication Non-Adherence. Brussels, Belgium, 2010. Accessed at http://archive.friendsofeurope.org/ Contentnavigation/Events/Eventsoverview/tabid/1187/EventType/EventView/ EventId/841/EventDateID/845/PageID/5043/JustwhatthedoctororderedAnEU responsetomedicationnonadherence.aspx
6. Bosworth HB. Medication treatment adherence. In: Bosworth HB, Oddone EZ, eds. Patient treatment adherence: concepts, intervention, and measurement. Psychology Press; 2006;147-94
7. McDonald HP, Garg AX, Haynes R. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA 2002;288:2868-79
8. Haynes RB, Ackloo E, Sahota N, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008;(2):CD000011
9. Christensen AJ. Patient Adherence to Medical Treatment Regimens. New Haven: Yale University Press, 2004
10. Frishman WH. Importance of medication adherence in cardiovascular disease and the value of once-daily treatment regimens. Cardiol Rev 2007;15:257-63
11. Urquhart J. Pharmionics: research on what patients do with prescription drugs. Pharmacoepidemiol Drug Saf 2004;13:587-90
12. Rivers PH. Compliance aids - do they work? Drugs Aging 1992;2:103-11
13. Connor J, Rafter N, Rodgers A. Do fixed-dose combination pills or unit-of-use packaging improve adherence? A systematic review. Bull World Health Organ 2004;82:935-9
14. Zedler BK, Kakad P, Colilla S, et al. Does packaging with a calendar feature improve adherence to self-Administered medication for long-term use? A systematic review. Clin Ther 2011;33:62-73
15. Orton LC, Barnish G. Unit-dose packaged drugs for treating malaria. Cochrane Database Syst Rev 2009;1:1
16. Mahtani KR, Heneghan CJ, Glasziou PP, Perera R. Reminder packaging for improving adherence to self-Administered long-term medications. Cochrane Database Syst Rev 2011;(9):CD005025
17. Rudd P. Medication packaging: simple solutions to nonadherence problems? Clin Pharmacol Ther 1979;25:257-65
18. Morrison A, Wertheimer AI, Berger ML. Interventions to improve antihypertensive drug adherence: a quantitative review of trials. Formulary 2000;35:234-6
19. Cooper H, Hedges LV, Valentine JC, eds. The Handbook of Research Synthesis and Meta-Analysis, 2nd edn. New York: Russell Sage Foundation, 2009
20. White H. Scientific communication and literature retrieval. In: Cooper H, Hedges L, Valentine J, eds. The Handbook of Research Synthesis and Meta-Analysis, 2nd edn. New York: Russell Sage Foundation, 2009:51-71
21. Rothstein HR, Hopewell S. Grey literature. In: Cooper H, Hedges L, Valentine J, eds. The Handbook of Research Synthesis and Meta-Analysis, 2nd edn. New York: Russell Sage Foundation, 2009:103-25
22. Conn VS, Valentine JC, Cooper HM, Rantz MJ. Grey literature in meta-Analyses. Nurs Res 2003;52:256-61
23. Burdett S, Stewart LA, Tierney JF. Publication bias and meta-Analyses: a practical example. Int J Technol Assess Health Care 2003;19:129-34
24. Wilson D. Systematic coding. In: Cooper H, Hedges L, Valentine J, eds. The Handbook of Research Synthesis and Meta-Analysis, 2nd edn. New York: Russell Sage Foundation, 2009:159-76
25. Orwin R, Vevea J. Evaluating coding decisions. In: Cooper H, Hedges L, Valentine J, eds. The Handbook of Research Synthesis and Meta-Analysis, 2nd edn. New York: Russell Sage Foundation, 2009:177-203
26. Borenstein M, Hedges L, Higgins JPT, Rothstein H. Introduction to Meta- Analysis. West Sussex, England: John Wiley & Sons Ltd, 2009
27. Hedges L, Olkin I. Statistical Methods for Meta-Analysis. Orlando, FL: Academic Press, 1985
28. Conn VS, Hafdahl AR, Mehr DR, et al. Metabolic effects of interventions to increase exercise in adults with type 2 diabetes. Diabetologia 2007;50:913-21
29. Awofeso N, Lammers H, Verschuuren M. Effect of blister calendar packs in enhancing compliance with MDT: The Kaduna State (Nigeria) experience. Int J Lepr Other Mycobact Dis 1995;63:453-4
30. Becker LA, Glanz K, Sobel E, et al. A randomized trial of special packaging of antihypertensive medications. J Fam Pract 1986;22:357-61
31. Bosworth HB, Olsen MK, Neary A, et al. Take Control of Your Blood Pressure (TCYB) study: a multifactorial tailored behavioral and educational intervention for achieving blood pressure control. Patient Educ Couns 2008;70:338-47
32. Burrelle TN. Evaluation of an interdisciplinary compliance service for elderly hypertensives. J Geriatr Drug Ther 1986;1:23-51
33. Calvert SB, Kramer JM, Anstrom KJ, et al. Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial. Am Heart J 2012;163:657-65
34. Crome P, Curl B, Boswell M, et al. Assessment of a new calendar pack: the 'C-Pak'. Age Ageing 1982;11:275-79
35. Desborough JA, Sach T, Bhattacharya D, et al. A cost-consequences analysis of an adherence focused pharmacist-led medication review service. Int J Pharm Pract 2012;20:41-9
36. Eshelman FN, Fitzloff J. Effect of packaging on patient compliance with an antihypertensive medication. Curr Ther Res Clin Exp 1976;20:215-19
37. Goujard C, Bernard N, Sohier N, et al. Impact of a patient education program on adherence to HIV medication: a randomized clinical trial. J Acquir Immune Defic Syndr 2003;34:191-4
38. Griffiths R, Johnson M, Piper M, Langdon R. A nursing intervention for the quality use of medicines by elderly community clients. Int J Nurs Pract 2004;10:166-76
39. Henry A, Batey RG. Enhancing compliance not a prerequisite for effective eradication of Helicobacter pylori: the HelP Study. Am J Gastroenterol 1999;94:811-15
40. Hirsch JD, Gonzales M, Rosenquist A, et al. Antiretroviral therapy adherence, medication use, and health care costs during 3 years of a community pharmacy medication therapy management program for Medi-Cal beneficiaries with HIV/AIDS. J Managed Care Pharm 2011;17:213-23
41. Holzemer WL, Bakken S, Portillo CJ, et al. Testing a nurse-tailored HIV medication adherence intervention. Nurs Res 2006;55:189-97
42. Ingersoll KS, Farrell-Carnahan L, Cohen-Filipic J, et al. A pilot randomized clinical trial of two medication adherence and drug use interventions for HIV+ crack cocaine users. Drug Alcohol Depend 2011;116:177-87
43. Insel KC, Cole L. Individualizing memory strategies to improve medication adherence. Appl Nurs Res 2005;18:199-204
44. Kalichman SC, Cherry J, Cain D. Nurse-delivered antiretroviral treatment adherence intervention for people with low literacy skills and living with HIV/AIDS. J Assoc Nurses AIDS Care 2005;16:3-15
45. Kalichman SC, Kalichman MO, Cherry C, et al. Brief behavioral self-regulation counseling for HIV treatment adherence delivered by cell phone: an initial test of concept trial. AIDS Patient Care STDS 2011;25:303-10
46. Kennedy LM. Effectiveness of a self-care medication education protocol on the home medication behaviors of recently hospitalized elderly. Austin: University of Texas, 1990
47. Kripalani S, Roumie CL, Dalal AK, et al. Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Ann Intern Med 2012;157:1-10
48. Laramee AS, Levinsky SK, Sargent J, et al. Case management in a heterogeneous congestive heart failure population: a randomized controlled trial. Arch Intern Med 2003;163:809-17
49. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA 2006;296: 2563-71
50. Lee M, Kemp JA, Canning A, et al. A randomized controlled trial of an enhanced patient compliance program for Helicobacter pylori therapy. Arch Intern Med 1999;159:2312-16
51. Lefante Jr JJ, Harmon GN, Roy W, et al. The effect of medication reviews in a rural community pharmacy assistance program: the Cenla Medication Access Program. J Pharm Pract 2005;18:486-92
52. Leung LB, Busch AM, Nottage SL, et al. Approach to antihypertensive adherence: a feasibility study on the use of student health coaches for uninsured hypertensive adults. Behav Med 2012;38:19-27
53. Levensky ER. Further development and evaluation of an individualized intervention for increasing adherence to HIV medications. Reno: University of Nevada, 2006
54. Linkewich JA, Catalano RB, Flack HL. The effect of packaging and instruction on outpatient compliance with medication regimens. Drug Intell Clin Pharm 1974;8:10-15
55. MacDonald E, MacDonald JB, Phoenix M. Improving drug compliance after hospital discharge. Br Med J 1977;2:618-21
56. MacIntosh P, Pond G, Pond B, et al. A comparison of patient adherence and preference of packaging method for oral anticancer agents using conventional pill bottles versus daily pill boxes. Eur J Cancer Care (Engl) 2007;16:380-86
57. McPherson-Baker S, Malow RM, Penedo F, et al. Enhancing adherence to combination antiretroviral therapy in non-Adherent HIV-positive men. AIDS Care 2000;12:399-404
58. Morales Suarez-Varela M, GEMECOR. Study on the use of a smart pillbox to improve treatment compliance. Atencion Primaria/Sociedad Espanola de Medicina de Familia y Comunitaria 2009;41:185-91
59. Moshkovska T, Stone MA, Smith RM, et al. Impact of a tailored patient preference intervention in adherence to 5-Aminosalicylic acid medication in ulcerative colitis: results from an exploratory randomized controlled trial. Inflamm Bowel Dis 2011;17:1874-81
60. Nazareth I, Burton A, Shulman S, et al. A pharmacy discharge plan for hospitalized elderly patients - a randomized controlled trial. Age Ageing 2001;30:33-40
61. Nochowitz B, Shapiro NL, Nutescu EA, Cavallari LH. Effect of a warfarin adherence aid on anticoagulation control in an inner-city anticoagulation clinic population. Ann Pharmacother 2009;43:1165-72
62. Park DC, Morrell RW, Frieske D, Kincaid D. Medication adherence behaviors in older adults: Effects of external cognitive supports. Psychol Aging 1992;7:252-6
63. Peterson GM, McLean S, Millingen KS. A randomised trial of strategies to improve patient compliance with anticonvulsant therapy. Epilepsia 1984;25:412-17
64. Qingjun L, Jihui D, Laiyi T, et al. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bull World Health Organ 1998;76:21-7
65. Revankar CR, Gupta N, Sorensen BH, Naik SS. Further observations on MDT blister-calendar packs in vertical leprosy eradication programmes - a multicentre study (phase II). Lepr Rev 1993;64:250-4
66. Robbins B, Rausch KJ, Garcia RI, Prestwood KM. Multicultural medication adherence: a comparative study. J Gerontol Nurs 2004;30:25-32
67. Safren SA, O'Cleirigh C, Reilly LC, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol 2009;28:1-10
68. Safren SA, Otto MW, Worth JL, et al. Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring. Behav Res Ther 2001;39:1151-62
69. Skaer TL, Sclar DA, Markowski DJ, Won JK. Effect of value-Added utilities on prescription refill compliance and health care expenditures for hypertension. J Hum Hypertens 1993;7:515-18
70. Skaer TL, Sclar DA, Markowski DJ, Won JK. Effect of value-Added utilities on prescription refill compliance and Medicaid health care expenditures - a study of patients with non-insulin-dependent diabetes mellitus. J Clin Pharm Ther 1993;18:295-9
71. Skaer TL, Sclar DA, Markowski DJ, Won JKH. Effect of value-Added utilities in promoting prescription refill compliance among patients with hypertension. Curr Ther Res 1993;53:251-5
72. Spriet A, Beiler D, Dechorgnat J, Simon P. Adherence of elderly patients to treatment with pentoxifylline. Clin Pharmacol Ther 1980;27:1-8
73. Sweeney SJ, Dixon JS, Sutcliffe I. Impact of the clinical pharmacist on compliance in a geriatric population. Pharm J 1989;242:R4-6
74. Taylor CT, Byrd DC, Krueger K. Improving primary care in rural Alabama with a pharmacy initiative. Am J Health Syst Pharm 2003;60:1123-9
75. Traiger GL, Bui LL. A self-medication administration program for transplant recipients. Transplantation 1997;17:71-9
76. Tsuyuki RT, Fradette M, Johnson JA, et al. A multicenter disease management program for hospitalized patients with heart failure. J Card Fail 2004;10:473-80
77. Wang H, Zhou J, Huang L, et al. Effects of nurse-delivered home visits combined with telephone calls on medication adherence and quality of life in HIV-infected heroin users in Hunan of China. J Clin Nurs 2010;19:380-8
78. Wright JM, Htun Y, Leong MG, et al. Evaluation of the use of calendar blister packaging on patient compliance with STD syndromic treatment regimens. Sex Transm Dis 1999;26:556-63
79. Zillich AJ, Jaynes HAW, Snyder ME, et al. Evaluation of specialized medication packaging combined with medication therapy management: adherence, outcomes, and costs among Medicaid patients. Med Care 2012;50: 485-93
80. Zillich AJ, Sutherland JM, Kumbera PA, Carter BL. Hypertension outcomes through blood pressure monitoring and evaluation by pharmacists (HOME study). J Gen Intern Med 2005;20:1091-6
81. Bakken S, Holzemer WL, Portillo CJ, et al. Utility of a standardized nursing terminology to evaluate dosage and tailoring of an HIV/AIDS adherence intervention. J Nurs Scholarsh 2005;37:251-7
82. Bosworth HB, Olsen MK, Dudley T, et al. The Take Control of Your Blood pressure (TCYB) study: study design and methodology. Contemp Clin Trials 2007;28:33-47
83. Dunnell K, Cartwright A. Medicine Takers, Prescribers and Hoarders. Boston: Routledge and Kegan Paul, 1972:148-65
84. Hirsch JD, Rosenquist A, Best BM, et al. Evaluation of the first year of a pilot program in community pharmacy: HIV/AIDS medication therapy management for Medi-Cal beneficiaries. J Managed Care Pharm 2009;15:32-41
85. Holzemer WL, Henry SB, Portillo CJ, Miramontes H. The Client Adherence Profiling-Intervention Tailoring (CAP-IT) intervention for enhancing adherence to HIV/AIDS medications: a pilot study. J Assoc Nurses AIDS Care 2000;11:36-44
86. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986;24:67-74
87. Safren SA, Otto MW, Worth JL. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cogn Behav Pract 1999;6:332-41
88. Schnipper JL, Roumie CL, Cawthon C, et al. Rationale and design of the Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILLCVD) study. Circulation 2010;3:212-19
89. Food and Drug Administration. Container Closure Systems for Packaging Human Drugs and Biologics. Rockville, MD:US Department of Health and Human Services Food and Drug Administration; 1999
90. Food and Drug Administration. Changes to an Approved NDA or ANDA. 2004
91. European Medicines Agency. Guideline on Plastic Immediate Packaging Materials. London, UK: European Medicines Agency, 2005
92. Littenberg B, MacLean CD, Hurowitz L. The use of adherence aids by adults with diabetes: a cross-sectional survey. BMC Family Practice 2006;7:1
93. Morello C, Chynoweth M, Kim H, et al. Strategies to improve medication adherence reported by diabetes patients and caregivers: results of taking control of your diabetes study. Ann Pharmacother 2011;45:145-53
94. Demonceau J, Ruppar T, Kristanto P, et al. Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-Analysis. Drugs 2013;73:545-62
95. Santschi V, Wuerzner G, Schneider M-P, et al. Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring. Eur J Clin Pharmacol 2007;63:1179-84