Soluble MHC-II proteins promote suppressive activity in CD4+ T cells

Immunology

Volumn 144, Issue 1, 2015, Pages 158-169

  Bakela, Katerina ^a   Kountourakis, Nikos ^b   Aivaliotis, Michalis ^b   Athanassakis, Irene ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

Author keywords

Immunosuppression; Soluble MHCII proteins; T cells; Tolerance

Indexed keywords

ANTIGEN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN CLASS 2; IL10 PROTEIN, MOUSE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; LAT PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE ZAP 70; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ZAP70 PROTEIN, MOUSE;

ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MOUSE; SOLUBILITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CTLA-4 ANTIGEN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL; SOLUBILITY; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 84918812600     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12360     Document Type: Article

References (33)

1. Calne RY, White HJ, Yoffa DE et al. Prolonged survival of liver transplants in the pig. Br Med J 1967; 4:645-8.
2. van Rood JJ, van Leeuwen A, van Santen MCT. Anti-HL-A2 inhibitor in normal human serum. Nature 1970; 226:366-7.
3. Puppo F, Indiveri F, Scudeletti M, Femme S. Soluble HLA antigens: new roles and uses. Immunol Today 1997; 18:154-5.
4. Hagihara M, Shimura T, Yamamoto K, Takebe K, Munkhbat B, Tsuji K. Soluble HLA Class I and Class II in Japanese. Hum Immunol 1994; 40:171-3.
5. Pfeiffer KA, Rebmann V, Passler M, van der Ven K, van der Ven H, Krebs D, Grosse-Wilde H. Soluble HLA levels in early pregnancy after in vitro fertilization. Hum Immunol 2000; 61:559-64.
6. Aultman D, Adamashvili I, Yaturu K, Langford M, Gelder F, Gautreaux M, Ghali GE, McDonald J. Soluble HLA in human body fluids. Hum Immunol 1999; 60:239-44.
7. Dobbe LM, Stam NJ, Neefjes JJ, Giphart MJ. Biochemical complexity of serum HLA class I molecules. Immunogenetics 1988; 27:203-10.
8. Jendro M, Goronzy J, Weyand C. Structural and functional characterization of HLA-DR molecules circulating in the serum. Autoimmunity 1991; 8:289-96.
9. MacKay PA, Leibundgut LS, Koch N, Dunn AC, Reith W, Jack RW, McLellan AD. Circulating, soluble forms of major histocompatibility complex antigens are not exosome-associated. Eur J Immunol 2006; 36:3381.
10. Athanassakis I, Ranella A, Vassiliadis S. IFN-γ facilitates release of class II-loaded intracellular pools in trophoblast cells: a novel property in dependent of protein synthesis. J Interferon Cytokine Res 2000; 20:823-30.
11. Ranella A, Vassiliadis S, Mastora C, Dionyssopoulou E, Athanassakis I. Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells. Hum Immunol 2005; 66:43-55.
12. Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 2004; 21:401-13.
13. Fischer UB, Jacovetty EL, Medeiros RB et al. MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc Natl Acad Sci USA 2007; 104:7181-6.
14. Schwartz M, Ziv Y. Immunity to self and self-maintenance: a unified theory of brain pathologies. Trends Immunol 2008; 29:211-9.
15. Restrepo D, Lin W, Salcedo E, Yamazaki K, Beauchamp G. Odortypes and MHC peptides: complementary chemosignals of MHC haplotype? Trends Neurosci 2006; 29:604-9.
16. Vassiliadis MA, Theochari C, Georgiakakis P, Boura V, Athanassakis I, Kouzoupis S. Emotion transfer through transmission of vocal messages in mice. 4th International Conference on Bio-Acoustics 2007; 29 Pt.3.
17. Verbruggen LA, Versaen H, Rebmann V, Duquet W, De CS, Grosse-Wilde H, Demanet C. Soluble HLA-DR levels in serum are associated with therapy and genetic factors in rheumatoid arthritis. Hum Immunol 2002; 63:758-64.
18. Verbruggen LA, Dumarey N, van de Velde H, Rebmann V, Flament J, van Wayenberge C, Grosse-Wilde H, Demanet C. Soluble HLA-DR antigen levels in serum correlate with rheumatoid arthritis disease activity and the presence of disease-associated epitopes. Tissue Antigens 2000; 56:436-40.
19. Wolf RE, Adamashvili IM, Gelder FB, Hall VC, Fraser PA, McDonald JC. Soluble HLA-I in rheumatic diseases. Hum Immunol 1998; 59:644-9.
20. Steinborn A, Rebmann V, Scharf A, Sohn C, Grosse-Wilde H. Soluble HLA-DR levels in the maternal circulation of normal and pathologic pregnancy. Am J Obstet Gynecol 2003; 188:473-9.
21. Rizzo R, Mapp CE, Melchiorri L et al. Defective production of soluble HLA-G molecules by peripheral blood monocytes in patients with asthma. J Allergy Clin Immunol 2004; 115:508-13.
22. Heiligenhaus A, Rebmann V, Neubert A, Plewa S, Ferencik S, Vogeler U, Steuhl KP, Grosse-Wilde H. Soluble HLA class I and HLA-DR plasma levels in patients with anterior uveitis. Tissue Antigens 2004; 63:369-75.
23. Athanassakis I, Vassiliadis S. T-regulatory cells: are we re-discovering T suppressors? Immunol Lett 2002; 84:179-83.
24. Ostman S, Taube M, Telemo E. Tolerosome-induced oral tolerance is MHC dependent. Immunology 2005; 116:464-76.
25. Almqvist N, Lonnqvist A, Hultkrantz S, Rask C, Telemo E. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 2008; 125:21-7.
26. Sardis M, Miltiadou P, Bakela K, Athanassakis I. Serum-derived MHC class II molecules: potent regulators of the cellular and humoral immune response. Immunobiology 2010; 215:194-205.
27. Nag B, Kendrick T, Arimilli S, Yu SCT, Sriram S. Soluble MHC II-peptide complexes induce antigen-specific apoptosis in T cells. Cell Immunol 1996; 170:25-33.
28. + T cells through transfer of the peptide to T cell MHC molecules. Proc Natl Acad Sci USA 2002; 99:13729-34.
29. Webb BJ, Bochan MR, Montel A, Padilla LM, Brahmi Z. The lack of NK cytotoxicity associated with fresh HUCB may be due to the presence of soluble HLA in the serum. Cell Immunol 1994; 159:246-61.
30. Vevis K, Matheakakis A, Kyvelidou C, Bakela K, Athanassakis I. Characterization of antigen-binding and MHC class II-bearing T cells with suppressive activity in response to tolerogenic stimulus. Immunobiology 2012; 217:100-10.
31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 277:680-5.
32. Candiano G, Bruschi M, Musante L et al. Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis 2004; 25:1327-33.
33. Huynh ML, Russell P, Walsh B. Tryptic digestion of in-gel proteins for mass spectrometry analysis. Methods Mol Biol 2009; 519:507-13.