Clinical features and management of cytomegalovirus corneal endotheliitis: Analysis of 106 cases from the Japan corneal endotheliitis study

British Journal of Ophthalmology

Volumn 99, Issue 1, 2015, Pages 54-58

  Koizumi, Noriko ^a,b   Inatomi, Tsutomu ^a   Suzuki, Takashi ^c   Shiraishi, Atsushi ^c   Ohashi, Yuichi ^c   Kandori, Michiko ^d   Miyazaki, Dai ^d   Inoue, Yoshitsugu ^d   Soma, Takeshi ^e   Nishida, Kohji ^e   Takase, Hiroshi ^f   Sugita, Sunao ^f   Mochizuki, Manabu ^f   Kinoshita, Shigeru ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIGLAUCOMA AGENT; GANCICLOVIR; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IMMUNOSUPPRESSIVE AGENT; STEROID; VALACICLOVIR; VALGANCICLOVIR; ANTIVIRUS AGENT; VIRUS DNA;

ADULT; AGED; ARTICLE; CATARACT; CORNEA EDEMA; CORNEA ENDOTHELIUM; CORNEA TRANSPLANTATION; CORNEAL ENDOTHELIAL CELL LOSS; CYTOMEGALOVIRUS CORNEAL ENDOTHELIITIS; CYTOMEGALOVIRUS INFECTION; EYE DISEASE; EYE SYNECHIA; FEMALE; GLAUCOMA SURGERY; GRAFT REJECTION; HUMAN; INTRAOCULAR HYPERTENSION; IRIDOCYCLITIS; JAPAN; KERATITIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PATIENT HISTORY OF CATARACT SURGERY; PATIENT HISTORY OF TRANSPLANTATION; POLYMERASE CHAIN REACTION; SYSTEMIC DISEASE; VISUAL ACUITY; AGE DISTRIBUTION; ANALOGS AND DERIVATIVES; AQUEOUS HUMOR; CELL COUNT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EYE INFECTIONS, VIRAL; GENETICS; INTRAOCULAR PRESSURE; ISOLATION AND PURIFICATION; OCULAR HYPERTENSION; PATHOLOGY; SEX RATIO; UVEITIS, ANTERIOR; VERY ELDERLY; VIROLOGY;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; AQUEOUS HUMOR; CELL COUNT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; ENDOTHELIUM, CORNEAL; EYE INFECTIONS, VIRAL; FEMALE; GANCICLOVIR; HUMANS; INTRAOCULAR PRESSURE; JAPAN; KERATITIS; MALE; MIDDLE AGED; OCULAR HYPERTENSION; POLYMERASE CHAIN REACTION; SEX DISTRIBUTION; UVEITIS, ANTERIOR; VISUAL ACUITY;

EID: 84918785908     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2013-304625     Document Type: Article

References (25)

1. Khodadoust AA, Attarzadeh A. Presumed autoimmune corneal endotheliopathy. Am J Ophthalmol 1982;93: 718-22.
2. Suzuki T, Ohashi Y. Corneal endotheliitis. Semin Ophthalmol 2008;23: 235-40.
3. Ohashi Y, Kinoshita S, Mano T, et al. Idiopathic corneal endotheliopathy. A report of two cases. Arch Ophthalmol 1985;103: 1666-8.
4. Robin JB, Steigner JB, Kaufman HE. Progressive herpetic corneal endotheliitis. Am J Ophthalmol 1985;100: 336-7.
5. Ohashi Y, Yamamoto S, Nishida K, et al. Demonstration of herpes simplex virus DNA in idiopathic corneal endotheliopathy. Am J Ophthalmol 1991;112: 419-23.
6. Maudgal PC, Missotten L, De Clercq E, et al. Varicella-zoster virus in the human corneal endothelium: A case report. Bull Soc Belge Ophtalmol 1980;190: 71-86.
7. Singh K, Sodhi PK. Mumps-induced corneal endotheliitis. Cornea 2004;23: 400-2.
8. Koizumi N, Yamasaki K, Kawasaki S, et al. Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis. Am J Ophthalmol 2006;141: 564-5.
9. Chee SP, Bacsal K, Jap A, et al. Corneal endotheliitis associated with evidence of cytomegalovirus infection. Ophthalmology 2007;114: 798-803.
10. Shiraishi A, Hara Y, Takahashi M, et al. Demonstration of "owl's eye" morphology by confocal microscopy in a patient with presumed cytomegalovirus corneal endotheliitis. Am J Ophthalmol 2007;143: 715-17.
11. Suzuki T, Hara Y, Uno T, et al. DNA of cytomegalovirus detected by PCR in aqueous of patient with corneal endotheliitis after penetrating keratoplasty. Cornea 2007;26: 370-2.
12. Yamauchi Y, Suzuki J, Sakai J, et al. A case of hypertensive keratouveitis with endotheliitis associated with cytomegalovirus. Ocul Immunol Inflamm 2007;15: 399-401.
13. Koizumi N, Suzuki T, Uno T, et al. Cytomegalovirus as an etiologic factor in corneal endotheliitis. Ophthalmology 2008;115: 292-7.
14. Anshu A, Chee SP, Mehta JS, et al. Cytomegalovirus endotheliitis in Descemet's stripping endothelial keratoplasty. Ophthalmology 2009;116: 624-30.
15. Kandori M, Inoue T, Takamatsu F, et al. Prevalence and features of keratitis with quantitative polymerase chain reaction positive for cytomegalovirus. Ophthalmology 2010;117: 216-22.
16. Miyanaga M, Sugita S, Shimizu N, et al. A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. Br J Ophthalmol 2010;94: 336-40.
17. Kandori M, Miyazaki D, Yakura K, et al. Relationship between the number of cytomegalovirus in anterior chamber and severity of anterior segment inflammation. Jpn J Ophthalmol 2013;57: 497-502.
18. Shimazaki J, Harashima A, Tanaka Y. Corneal endotheliitis with cytomegalovirus infection of corneal stroma. Eye (Lond) 2010;24: 1105-7.
19. Chee SP, Jap A. Immune ring formation associated with cytomegalovirus endotheliitis. Am J Ophthalmol 2011;152: 449-53.
20. Hwang YS, Shen CR, Chang SH, et al. The validity of clinical feature profiles for cytomegaloviral anterior segment infection. Graefes Arch Clin Exp Ophthalmol 2011;249: 103-10.
21. Lusthaus JA, Kim P, Steller AK, et al. Successful corneal autograft after clearance of anterior chamber cytomegalovirus with oral valganciclovir in a patient with multiple failed corneal allografts. Cornea 2011;30: 1054-7.
22. Chee SP, Jap A. Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis. Graefes Arch Clin Exp Ophthalmol 2012;250: 383-9.
23. Chu HY, Sun CC, Chuang WY, et al. Cytomegalovirus associated corneal endotheliitis after penetrating keratoplasty in a patient with Fuchs corneal endothelial dystrophy. Br J Ophthalmol 2012;96: 300-1.
24. Kobayashi A, Yokogawa H, Higashide T, et al. Clinical significance of owl eye morphologic features by in vivo laser confocal microscopy in patients with cytomegalovirus corneal endotheliitis. Am J Ophthalmol 2012;153: 445-53.
25. Zheng X, Yamaguchi M, Goto T, et al. Experimental corneal endotheliitis in rabbit. Invest Ophthalmol Vis Sci 2000;41: 377-85.