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Volumn , Issue , 2013, Pages 221-239

Case study: An antibody-drug conjugate targeting MUC16 for ovarian cancer

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EID: 84918784455     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-5456-4_13     Document Type: Chapter
Times cited : (4)

References (57)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 49449119098 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Carter PJ, Senter PD (2008) Antibody-drug conjugates for cancer therapy. Cancer J 14(3): 154-169
    • (2008) Cancer J , vol.14 , Issue.3 , pp. 154-169
    • Carter, P.J.1    Senter, P.D.2
  • 3
    • 67649886201 scopus 로고    scopus 로고
    • Potent antibody drug conjugates for cancer therapy
    • Senter PD (2009) Potent antibody drug conjugates for cancer therapy. Curr Opin Chem Biol 13(3):235-244
    • (2009) Curr Opin Chem Biol , vol.13 , Issue.3 , pp. 235-244
    • Senter, P.D.1
  • 4
    • 74849092615 scopus 로고    scopus 로고
    • Antibody-drug conjugate targets
    • Teicher BA (2009) Antibody-drug conjugate targets. Curr Cancer Drug Targets 9(8):982-1004
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.8 , pp. 982-1004
    • Teicher, B.A.1
  • 5
    • 0141920354 scopus 로고    scopus 로고
    • Comparing protein abundance and mRNA expression levels on a genomic scale
    • Greenbaum D, Colangelo C, Williams K et al (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 4(9):117
    • (2003) Genome Biol , vol.4 , Issue.9 , pp. 117
    • Greenbaum, D.1    Colangelo, C.2    Williams, K.3
  • 6
    • 0019790278 scopus 로고
    • Reactivity of a monoclonal antibody with human ovarian carcinoma
    • Bast RC Jr, Feeney M, Lazarua H et al (1981) Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68:1331-1337
    • (1981) J Clin Invest , vol.68 , pp. 1331-1337
    • Bast, R.C.1    Feeney, M.2    Lazarua, H.3
  • 7
    • 33846897016 scopus 로고    scopus 로고
    • CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients
    • Høgdall EVS, Christensen L, Kjaer SK et al (2007) CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. Gynecol Oncol 104(3):508-515
    • (2007) Gynecol Oncol , vol.104 , Issue.3 , pp. 508-515
    • Høgdall, E.V.S.1    Christensen, L.2    Kjaer, S.K.3
  • 8
    • 0020682587 scopus 로고
    • Immunopathologic characterization of a monoclo- nal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types
    • Kabawat SE, Bast RC, Welch WR et al (1983) Immunopathologic characterization of a monoclo- nal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types. Am J Clin Pathol 79:98-104
    • (1983) Am J Clin Pathol , vol.79 , pp. 98-104
    • Kabawat, S.E.1    Bast, R.C.2    Welch, W.R.3
  • 9
    • 27144489497 scopus 로고    scopus 로고
    • Potential markers that complement expression of CA125 in epithelial ovarian cancer
    • Rosen DG, Wang L, Atkinson JN et al (2005) Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol 99(2):267-277
    • (2005) Gynecol Oncol , vol.99 , Issue.2 , pp. 267-277
    • Rosen, D.G.1    Wang, L.2    Atkinson, J.N.3
  • 11
    • 0036560755 scopus 로고    scopus 로고
    • The CA 125 gene: A newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure
    • O'Brien TJ, Beard JB, Underwood LJ et al (2002) The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumor Biol 23:154-169
    • (2002) Tumor Biol , vol.23 , pp. 154-169
    • O'Brien, T.J.1    Beard, J.B.2    Underwood, L.J.3
  • 12
    • 0035920171 scopus 로고    scopus 로고
    • Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16
    • Yin BWT, Lloyd KO (2001) Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J Biol Chem 276:27371-27375
    • (2001) J Biol Chem , vol.276 , pp. 27371-27375
    • Yin, B.W.T.1    Lloyd, K.O.2
  • 13
    • 0037051691 scopus 로고    scopus 로고
    • Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene
    • Yin BWT, Dnistrian A, Lloyd KO (2002) Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. Int J Cancer 98:737-740
    • (2002) Int J Cancer , vol.98 , pp. 737-740
    • Yin, B.W.T.1    Dnistrian, A.2    Lloyd, K.O.3
  • 14
    • 0025022576 scopus 로고
    • CA 125 in peritoneal fluid and serum from patients with benign gynecologic conditions and ovarian cancer
    • Hunter VJ, Weinberg JB, Haney AF et al (1990) CA 125 in peritoneal fluid and serum from patients with benign gynecologic conditions and ovarian cancer. Gynecol Oncol 36(2):161-165
    • (1990) Gynecol Oncol , vol.36 , Issue.2 , pp. 161-165
    • Hunter, V.J.1    Weinberg, J.B.2    Haney, A.F.3
  • 15
    • 0023771736 scopus 로고
    • Expression of CA125 in pancreatic carcinoma and chronic pancreatitis
    • Macdonald F, Downing R, Allum WH (1988) Expression of CA125 in pancreatic carcinoma and chronic pancreatitis. Br J Cancer 58(4):505-506
    • (1988) Br J Cancer , vol.58 , Issue.4 , pp. 505-506
    • Macdonald, F.1    Downing, R.2    Allum, W.H.3
  • 16
    • 35048884094 scopus 로고    scopus 로고
    • Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125)
    • Belisle JA, Gubbels JAA, Raphael CA et al (2007) Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125). Immunology 122(3):418-429
    • (2007) Immunology , vol.122 , Issue.3 , pp. 418-429
    • Belisle, J.A.1    Gubbels, J.A.A.2    Raphael, C.A.3
  • 17
    • 77952482466 scopus 로고    scopus 로고
    • Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes
    • Belisle JA, Horibata S, Gubbels JAA et al (2010) Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes. Mol Cancer 9(1):118
    • (2010) Mol Cancer , vol.9 , Issue.1 , pp. 118
    • Belisle, J.A.1    Horibata, S.2    Gubbels, J.A.A.3
  • 18
    • 33750998782 scopus 로고    scopus 로고
    • Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    • Gubbels JAA, Belisle J, Onda M et al (2006) Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer 5(1):50
    • (2006) Mol Cancer , vol.5 , Issue.1 , pp. 50
    • Gubbels, J.A.A.1    Belisle, J.2    Onda, M.3
  • 19
    • 76749085709 scopus 로고    scopus 로고
    • MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
    • Gubbels JA, Felder M, Horibata S et al (2010) MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells. Mol Cancer 9(1):11
    • (2010) Mol Cancer , vol.9 , Issue.1 , pp. 11
    • Gubbels, J.A.1    Felder, M.2    Horibata, S.3
  • 20
    • 28044467326 scopus 로고    scopus 로고
    • Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125
    • Patankar M, Jing Y, Morrison J et al (2005) Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125. Gynecol Oncol 99(3):704-713
    • (2005) Gynecol Oncol , vol.99 , Issue.3 , pp. 704-713
    • Patankar, M.1    Jing, Y.2    Morrison, J.3
  • 21
    • 1542365125 scopus 로고    scopus 로고
    • Binding of ovarian cancer antigen CA125/ MUC16 to mesothelin mediates cell adhesion
    • Rump A, Morikawa Y, Tanaka M et al (2004) Binding of ovarian cancer antigen CA125/ MUC16 to mesothelin mediates cell adhesion. J Biol Chem 279(10):9190-9198
    • (2004) J Biol Chem , vol.279 , Issue.10 , pp. 9190-9198
    • Rump, A.1    Morikawa, Y.2    Tanaka, M.3
  • 22
    • 4444383336 scopus 로고    scopus 로고
    • Randomized, placebo-controlled study of oregov- omab for consolidation of clinical remission in patients with advanced ovarian cancer
    • Berek JS, Taylor PT, Gordon A et al (2004) Randomized, placebo-controlled study of oregov- omab for consolidation of clinical remission in patients with advanced ovarian cancer. J Clin Oncol 22:3507-3516
    • (2004) J Clin Oncol , vol.22 , pp. 3507-3516
    • Berek, J.S.1    Taylor, P.T.2    Gordon, A.3
  • 23
    • 58549088720 scopus 로고    scopus 로고
    • Oregovomab maintenance monoimmunotherapy does not improve outcomes in advanced ovarian cancer
    • Berek J, Taylor P, McGuire W, Smith L, Schultes B, Nicodemus C (2009) Oregovomab maintenance monoimmunotherapy does not improve outcomes in advanced ovarian cancer. J Clin Oncol 27:418-425
    • (2009) J Clin Oncol , vol.27 , pp. 418-425
    • Berek, J.1    Taylor, P.2    McGuire, W.3    Smith, L.4    Schultes, B.5    Nicodemus, C.6
  • 24
    • 14244250598 scopus 로고    scopus 로고
    • A pilot phase 2 study of oregovomab murine monoclonal antibody to CA125 as an immunotherapeutic agent for recurrent ovarian cancer
    • Ehlen TG, Hoskins PJ, Miller D et al (2005) A pilot phase 2 study of oregovomab murine monoclonal antibody to CA125 as an immunotherapeutic agent for recurrent ovarian cancer. Int J Gynecol Cancer 15(6):1023-1034
    • (2005) Int J Gynecol Cancer , vol.15 , Issue.6 , pp. 1023-1034
    • Ehlen, T.G.1    Hoskins, P.J.2    Miller, D.3
  • 25
    • 0031747870 scopus 로고    scopus 로고
    • Anti-idiotype induction therapy: Anti-CA125 antibodies (Ab3) mediated tumor killing in patients treated with Ovarex mAb B43.13 (Ab1)
    • Schultes BC, Baum RP, Niesen A et al (1998) Anti-idiotype induction therapy: anti-CA125 antibodies (Ab3) mediated tumor killing in patients treated with Ovarex mAb B43.13 (Ab1). Cancer Immunol Immunother 46(4):201-212
    • (1998) Cancer Immunol Immunother , vol.46 , Issue.4 , pp. 201-212
    • Schultes, B.C.1    Baum, R.P.2    Niesen, A.3
  • 26
    • 12144287745 scopus 로고    scopus 로고
    • Vaccina- tion of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: Immunological response and survival (phase Ib/II)
    • Reinartz S, Kohler S, Schlebusch H et al (2004) Vaccina- tion of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (phase Ib/II). Clin Cancer Res 10:1580-1587
    • (2004) Clin Cancer Res , vol.10 , pp. 1580-1587
    • Reinartz, S.1    Kohler, S.2    Schlebusch, H.3
  • 27
    • 33749316413 scopus 로고    scopus 로고
    • Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer
    • Sabbatini P, Dupont J, Aghajanian C et al (2006) Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer. Clin Cancer Res 12(18): 5503-5510
    • (2006) Clin Cancer Res , vol.12 , Issue.18 , pp. 5503-5510
    • Sabbatini, P.1    Dupont, J.2    Aghajanian, C.3
  • 28
    • 48149110374 scopus 로고    scopus 로고
    • The use of monoclonal antibodies for the treatment of epithelial ovarian cancer
    • Oei AL, Sweep FC, Thomas CMG et al (2008) The use of monoclonal antibodies for the treatment of epithelial ovarian cancer. Int J Oncol 32:1145-1157
    • (2008) Int J Oncol , vol.32 , pp. 1145-1157
    • Oei, A.L.1    Sweep, F.C.2    Thomas, C.M.G.3
  • 29
    • 17444447733 scopus 로고    scopus 로고
    • MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope
    • Argüeso P, Spurr-Michaud S, Russo CL, Tisdale A, Gipson IK (2003) MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci 44:2487-2495
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2487-2495
    • Argüeso, P.1    Spurr-Michaud, S.2    Russo, C.L.3    Tisdale, A.4    Gipson, I.K.5
  • 30
    • 0022638965 scopus 로고
    • Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung
    • Nouwen EJ, Pollet DE, Eerdekens MW et al (1986) Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung. Cancer Res 46(2):866-876
    • (1986) Cancer Res , vol.46 , Issue.2 , pp. 866-876
    • Nouwen, E.J.1    Pollet, D.E.2    Eerdekens, M.W.3
  • 31
    • 0023122575 scopus 로고
    • Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study
    • Nouwen EJ, Hendrix PG, Dauwe S, Eerdekens MW, De Broe ME (1987) Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study. Am J Pathol 126:230-242
    • (1987) Am J Pathol , vol.126 , pp. 230-242
    • Nouwen, E.J.1    Hendrix, P.G.2    Dauwe, S.3    Eerdekens, M.W.4    De Broe, M.E.5
  • 32
    • 0025616231 scopus 로고
    • Occurrence of the mucinous differentiation antigen CA125 in genital tract and conductive airway epithelia of diverse mammalian species (rabbit, dog, monkey)
    • Nouwen EJ, Dauwe S, De Broe ME (1990) Occurrence of the mucinous differentiation antigen CA125 in genital tract and conductive airway epithelia of diverse mammalian species (rabbit, dog, monkey). Differentiation 45:192-198
    • (1990) Differentiation , vol.45 , pp. 192-198
    • Nouwen, E.J.1    Dauwe, S.2    De Broe, M.E.3
  • 33
    • 34250379434 scopus 로고    scopus 로고
    • Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models
    • Chen Y, Clark S, Wong T et al (2007) Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models. Cancer Res 67(10):4924-4932
    • (2007) Cancer Res , vol.67 , Issue.10 , pp. 4924-4932
    • Chen, Y.1    Clark, S.2    Wong, T.3
  • 34
    • 65549151884 scopus 로고    scopus 로고
    • Antibody-drug conjugates for the treatment of non-hodgkin's lymphoma: Target and linker-drug selection
    • Polson AG, Calemine-Fenaux J, Chan P et al (2009) Antibody-drug conjugates for the treatment of non-hodgkin's lymphoma: target and linker-drug selection. Cancer Res 69(6):2358-2364
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2358-2364
    • Polson, A.G.1    Calemine-Fenaux, J.2    Chan, P.3
  • 35
    • 11144357605 scopus 로고    scopus 로고
    • Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16)
    • Maeda T, Inoue M, Koshiba S et al (2004) Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). J Biol Chem 279: 13174-13182
    • (2004) J Biol Chem , vol.279 , pp. 13174-13182
    • Maeda, T.1    Inoue, M.2    Koshiba, S.3
  • 36
    • 0021058774 scopus 로고
    • Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors
    • Hamilton TC, Young RC, McKoy WM et al (1983) Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors. Cancer Res 43(11):5379-5389
    • (1983) Cancer Res , vol.43 , Issue.11 , pp. 5379-5389
    • Hamilton, T.C.1    Young, R.C.2    McKoy, W.M.3
  • 38
    • 49449087300 scopus 로고    scopus 로고
    • Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
    • Junutula JR, Raab H, Clark S et al (2008) Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol 26(8):925-932
    • (2008) Nat Biotechnol , vol.26 , Issue.8 , pp. 925-932
    • Junutula, J.R.1    Raab, H.2    Clark, S.3
  • 39
    • 31544441685 scopus 로고    scopus 로고
    • Enhanced activity of monomethylau- ristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
    • Doronina SO, Mendelsohn BA, Bovee TD et al (2006) Enhanced activity of monomethylau- ristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem 17(1):114-124
    • (2006) Bioconjug Chem , vol.17 , Issue.1 , pp. 114-124
    • Doronina, S.O.1    Mendelsohn, B.A.2    Bovee, T.D.3
  • 40
    • 0347949497 scopus 로고    scopus 로고
    • Primary ovarian cancer chemotherapy: Current standards of care
    • McGuire WP, Markman M (2003) Primary ovarian cancer chemotherapy: current standards of care. Br J Cancer 89:S3-S8
    • (2003) Br J Cancer , vol.89 , pp. S3-S8
    • McGuire, W.P.1    Markman, M.2
  • 41
    • 20444448808 scopus 로고    scopus 로고
    • An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines
    • Smith JA, Ngo H, Martin MC, Wolf JK (2005) An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines. Gynecol Oncol 98(1):141-145
    • (2005) Gynecol Oncol , vol.98 , Issue.1 , pp. 141-145
    • Smith, J.A.1    Ngo, H.2    Martin, M.C.3    Wolf, J.K.4
  • 42
    • 10744222473 scopus 로고    scopus 로고
    • Development of potent monoclonal antibody auristatin conjugates for cancer therapy
    • Doronina SO, Toki BE, Torgov MY et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol 21(7):778-784
    • (2003) Nat Biotechnol , vol.21 , Issue.7 , pp. 778-784
    • Doronina, S.O.1    Toki, B.E.2    Torgov, M.Y.3
  • 43
    • 76049122850 scopus 로고    scopus 로고
    • Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate
    • Okeley NM, Miyamoto JB, Zhang X et al (2010) Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res 16(3):888-897
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 888-897
    • Okeley, N.M.1    Miyamoto, J.B.2    Zhang, X.3
  • 44
    • 78649530346 scopus 로고    scopus 로고
    • Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125
    • Pastuskovas CV, Mallet W, Clark S et al (2010) Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125. Drug Metab Dispos 38(12):2309-2319
    • (2010) Drug Metab Dispos , vol.38 , Issue.12 , pp. 2309-2319
    • Pastuskovas, C.V.1    Mallet, W.2    Clark, S.3
  • 45
    • 31544439933 scopus 로고    scopus 로고
    • Detection and quantitation of serum meso- thelin, a tumor marker for patients with mesothelioma and ovarian cancer
    • Hassan R, Remaley AT, Sampson ML et al (2006) Detection and quantitation of serum meso- thelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clin Cancer Res 12(2):447-453
    • (2006) Clin Cancer Res , vol.12 , Issue.2 , pp. 447-453
    • Hassan, R.1    Remaley, A.T.2    Sampson, M.L.3
  • 46
    • 0031804617 scopus 로고    scopus 로고
    • Plasma c-erbB-2 levels in breast cancer patients: Prognostic significance in predicting response to chemotherapy
    • Mehta RR, McDermott JH, Heiken TJ, Marler KC, Patel MK, Wild LD et al (1998) Plasma c-erbB-2 levels in breast cancer patients: prognostic significance in predicting response to chemotherapy. J Clin Oncol 16:2409-2416
    • (1998) J Clin Oncol , vol.16 , pp. 2409-2416
    • Mehta, R.R.1    McDermott, J.H.2    Heiken, T.J.3    Marler, K.C.4    Patel, M.K.5    Wild, L.D.6
  • 48
    • 70349083423 scopus 로고    scopus 로고
    • The pharmacologic basis for antibody-auristatin conjugate activity
    • Alley SC, Zhang X, Okeley NM et al (2009) The pharmacologic basis for antibody-auristatin conjugate activity. J Pharmacol Exp Ther 330(3):932-938
    • (2009) J Pharmacol Exp Ther , vol.330 , Issue.3 , pp. 932-938
    • Alley, S.C.1    Zhang, X.2    Okeley, N.M.3
  • 49
    • 41149160183 scopus 로고    scopus 로고
    • Contribution of linker stability to the activities of anticancer immunoconjugates
    • Alley SC, Benjamin DR, Jeffrey SC et al (2008) Contribution of linker stability to the activities of anticancer immunoconjugates. Bioconjug Chem 19(3):759-765
    • (2008) Bioconjug Chem , vol.19 , Issue.3 , pp. 759-765
    • Alley, S.C.1    Benjamin, D.R.2    Jeffrey, S.C.3
  • 50
    • 79960820705 scopus 로고    scopus 로고
    • Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components
    • Dosio F, Brusa P, Cattel L (2011) immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components. Toxins 3(7):848-883
    • (2011) Toxins , vol.3 , Issue.7 , pp. 848-883
    • Dosio, F.1    Brusa, P.2    Cattel, L.3
  • 51
    • 0023554984 scopus 로고
    • New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo
    • Thorpe PE, Wallace PM, Knowles PP et al (1987) New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo. Cancer Res 47(22):5924-5931
    • (1987) Cancer Res , vol.47 , Issue.22 , pp. 5924-5931
    • Thorpe, P.E.1    Wallace, P.M.2    Knowles, P.P.3
  • 52
    • 0042738861 scopus 로고    scopus 로고
    • CAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity
    • Francisco JA (2003) cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 102(4):1458-1465
    • (2003) Blood , vol.102 , Issue.4 , pp. 1458-1465
    • Francisco, J.A.1
  • 53
    • 12244295755 scopus 로고    scopus 로고
    • In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate
    • Sanderson RJ, Hering MA, James SF et al (2005) In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res 11(2 Pt 1):843-852
    • (2005) Clin Cancer Res , vol.11 , Issue.2 , pp. 843-852
    • Sanderson, R.J.1    Hering, M.A.2    James, S.F.3
  • 54
    • 0032859305 scopus 로고    scopus 로고
    • Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance
    • Mirsalis JC, Schindler-Horvat J, Hill JR et al (1999) Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance. Cancer Chemother Pharmacol 44(5):395-402
    • (1999) Cancer Chemother Pharmacol , vol.44 , Issue.5 , pp. 395-402
    • Mirsalis, J.C.1    Schindler-Horvat, J.2    Hill, J.R.3
  • 55
    • 78049515807 scopus 로고    scopus 로고
    • Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
    • Younes A, Bartlett NL, Leonard JP et al (2010) Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med 363(19):1812-1821
    • (2010) N Engl J Med , vol.363 , Issue.19 , pp. 1812-1821
    • Younes, A.1    Bartlett, N.L.2    Leonard, J.P.3
  • 56
    • 0038207068 scopus 로고    scopus 로고
    • Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas
    • Frierson HF, Jr et al (2003) Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Human Pathology 34:605-609
    • (2003) Human Pathology , vol.34 , pp. 605-609
    • Frierson, H.F.1
  • 57
    • 67349279575 scopus 로고    scopus 로고
    • Preclinical studies and clinical utilization of monoclonal antibodies in epithelial ovarian cancer
    • Frederick PJ, Straughn JM, Jr, Alvarez RD et al (2009) Preclinical studies and clinical utilization of monoclonal antibodies in epithelial ovarian cancer. Gynecologic Oncology 113:384-390
    • (2009) Gynecologic Oncology , vol.113 , pp. 384-390
    • Frederick, P.J.1    Straughn, J.M.2    Alvarez, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.