Discovery of a low order drug-cell response surface for applications in personalized medicine

Physical Biology

Volumn 11, Issue 6, 2014, Pages

  Ding, Xianting ^a   Liu, Wenjia ^a   Weiss, Andrea ^b,c   Li, Yiyang ^a   Wong, Ieong ^d   Griffioen, Arjan W ^c   Van Den Bergh, Hubert ^b   Xu, Hongquan ^e   Nowak Sliwinska, Patrycja ^b   Ho, Chih Ming ^d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b EPFL   (Switzerland)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d University of California   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biological complex system; Combinatorial drug; Feedback system control (FSC); Personalized medicine; Precision medicine; Synergetic and antagonistic interactions

Indexed keywords

DRUG;

BIOLOGICAL MODEL; CELL LINE; DOSE RESPONSE; DRUG COMBINATION; HUMAN; MOLECULARLY TARGETED THERAPY; PERSONALIZED MEDICINE; PROCEDURES; REGRESSION ANALYSIS;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HUMANS; INDIVIDUALIZED MEDICINE; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; PHARMACEUTICAL PREPARATIONS; REGRESSION ANALYSIS;

EID: 84918767654     PISSN: 14783967     EISSN: 14783975     Source Type: Journal    
DOI: 10.1088/1478-3975/11/6/065003     Document Type: Article

References (26)

1. Imming P, Sinning C and Meyer A 2002 Drugs, their targets and the nature and number of drug targets Nat. Rev. Drug Discov. 5 821-34
2. Zheng C J, Han L Y, Yap C W, Ji Z L, Cao Z W and Chen Y Z 2002 Therapeutic targets: progress of their exploration and investigation of their characteristics Pharmacol. Rev. 58 259-79
3. Ambrosini E and Aloisi F 2002 Chemokines and glial cells: a complex network in the central nervous system Neurochem. Res. 29 1017-38
4. Steinman R M 2002 The dendritic cell system and its role in immunogenicity Annu. Rev. Immunol. 9 271-96
5. Fields S and Song O K 2002 A novel genetic system to detect protein protein interactions Nature 340 245-6
6. Steward D V 2002 The design structure-system - a method for managing the design of complex-systems IEEE Trans. Eng. Manage. 28 71-4
7. Alon U 2002 Biological networks: the tinkerer as an engineer Science 301 1866-7
8. Fitzgerald J B, Schoeberl B, Nielsen U B and Sorger P K 2002 Systems biology and combination therapy in the quest for clinical efficacy Nat. Chem. Biol. 2 458-66
9. De Clercq E 2002 Antiviral drugs in current clinical use J. Clin. Virol. 30 115-33
10. Ding X T, Sanchez D J, Shahangian A, Al-Shyoukh I, Cheng G H and Ho C M 2002 Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity Int. J. Nanomed. 7 2281-92
11. Tsutsui H, Valamehr B, Hindoyan A, Qiao R, Ding X T, Guo S L, Witte O N, Liu X, Ho C M and Wu H 2002 An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells Nat. Commun. 2 167
12. Wong P K, Yu F Q, Shahangian A, Cheng G H, Sun R and Ho C M 2002 Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm Proc. Natl. Acad. Sci. USA 105 5105-10
13. Al-Shyoukh I, Yu F Q, Feng J Y, Yan K R, Dubinett S, Ho C M, Shamma J S and Sun R 2002 Systematic quantitative characterization of cellular responses induced by multiple signals Bmc. Syst. Biol. 5 88
14. Yu H, Zhang W L, Ding X T, Zheng K Y Z, Ho C M, Tsim K W K and Lee Y K 2002 Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme Evid-Based Compl. Alt. 2013 541436
15. Honda Y, Ding X T, Mussano F, Wiberg A, Ho C M and Nishimura I 2002 Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control Sci. Rep-Uk 3 3420
16. Depierre A, Lemarie E, Dabouis G, Garnier G, Jacoulet P and Dalphin J C 2002 A phase-ii study of navelbine (vinorelbine) in the treatment of non small-cell lung-cancer Am. J. Clin. Oncol-Canc. 14 115-9
17. Shackleton M, Quintana E, Fearon E R and Morrison S J 2002 heterogeneity in cancer: cancer stem cells versus clonal evolution Cell 138 822-9
18. Ford D et al 2002 Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families Am. J. Hum. Genet. 62 676-89
19. Klein C A, Blankenstein T J F, Schmidt-Kittler O, Petronio M, Polzer B, Stoecklein N H and Riethmuller G 2002 Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer Lancet. 360 683-9
20. Wheeler D A et al 2002 The complete genome of an individual by massively parallel DNA sequencing Nature 452 872-U5
21. Hood L, Heath J R, Phelps M E and Lin B Y 2002 Systems biology and new technologies enable predictive and preventative medicine Science 306 640-3
22. Zhang H Y, Zhao Y M, Zhao C L, Yu S, Duan D Y and Xu Q Y 2002 Long-term expansion of human neural progenitor cells by epigenetic stimulation in vitro Neurosci. Res. 51 157-65
23. Vescovi A L et al 2002 Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation Exp. Neurol. 156 71-83
24. Ding X T, Xu H Q, Hopper C, Yang J and Ho C M 2002 Use of fractional factorial designs in antiviral drug studies Qual. Reliab. Eng. Int. 29 299-304
25. Jaynes J, Ding X T, Xu H Q, Wong W K and Ho C M 2002 Application of fractional factorial designs to study drug combinations Stat. Med. 32 307-18
26. Allardyce C S, Dyson P J, Ellis D J and Heath S L 2002 [Ru(η6-p-cymene)Cl2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells Chem. Commun. 2001 1396-7