Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases: Pro-demyelinating and axon-preservative functions

Neural Regeneration Research

Volumn 9, Issue 22, 2014, Pages 1952-1954

  Kim, Jong Kuk ^a   Lee, Hye Jeong ^a   Park, Hwan Tae ^a  

^a Dong A University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DEDIFFERENTIATION; CELL INFILTRATION; CHEMOTAXIS; DEGENERATIVE DISEASE; DEMYELINATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; MACROPHAGE; NERVE FIBER REGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PROTEIN EXPRESSION; SCHWANN CELL; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL;

EID: 84918592200     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.145370     Document Type: Article

References (12)

1. Arthur-Farraj PJ, Latouche M, Wilton DK, Quintes S, Chabrol E, Banerjee A, Woodhoo A, Jenkins B, Rahman M, Turmaine M, Wicher GK, Mitter R, Greensmith L, Behrens A, Raivich G, Mirsky R, Jessen KR (2012) c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. Neuron 75: 633-647.
2. Fontana X, Hristova M, Da Costa C, Patodia S, Thei L, Makwana M, Spencer-Dene B, Latouche M, Mirsky R, Jessen KR, Klein R, Raivich G, Behrens A (2012) c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. J Cell Biol 198: 127-141.
3. Groh J, Heinl K, Kohl B, Wessig C, Greeske J, Fischer S, Martini R (2010) Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X. Hum Mol Genet 19: 3530-3543.
4. Hantke J, Carty L, Wagstaff LJ, Turmaine M, Wilton DK, Quintes S, Koltzenburg M, Baas F, Mirsky R, Jessen KR (2014) c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy. Brain 137: 2922-2937.
5. Hutton EJ, Carty L, Laura M, Houlden H, Lunn MP, Brandner S, Mirsky R, Jessen K, Reilly MM (2011) c-Jun expression in human neuropathies: a pilot study. J Peripher Nerv Syst 16: 295-303.
6. Jessen KR, Mirsky R (2008) Negative regulation of myelination: relevance for development, injury and demyelinating disease. Glia 56: 1552-1565.
7. Klein D, Groh J, Wettmarshausen J, Martini R (2014) Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation. Glia 62: 736-750.
8. Lee HJ, Shin YK, Park HT (2014) Mitogen activated protein kinase family proteins and c-jun signaling in injury-induced Schwann cell plasticity. Exp Neurobiol 23: 130-761.
9. Martini R, Fischer S, Lopez-Vales R, David S (2008) Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia 56: 1566-1577.
10. Pollard JD, Armati PJ (2011) CIDP-the relevance of recent advances in Schwann cell/axonal neurobiology. J Peripher Nerv Syst 16: 15-23.
11. Sherman DL, Brophy PJ (2005) Mechanisms of axon ensheathment and myelin growth. Nat Rev Neurosci 6: 683-690.
12. Shin YK, Jang SY, Park JY, Park SY, Lee HJ, Suh DJ, Park HT (2013) The Neuregulin-Rac-MKK7 pathway regulates antagonistic c-jun/Krox20 expression in Schwann cell dedifferentiation. Glia 61: 892-904.