Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits

International Journal of Molecular Sciences

Volumn 15, Issue 12, 2014, Pages 23283-23293

  Bojic, Lazar A ^a   McLaren, David G ^a   Shah, Vinit ^a   Previs, Stephen F ^a   Johns, Douglas G ^a   Castro Perez, Jose M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Atherosclerosis; Lipidomics; Lipids; Mass spectrometry; Plaque

Indexed keywords

CERAMIDE; CHOLESTEROL ESTER; DIACYLGLYCEROL; FATTY ACID; LIPIDOME; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOMYELIN; TRIACYLGLYCEROL; GLYCEROPHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD ANALYSIS; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; LIPID COMPOSITION; MALE; MASS SPECTROMETRY; NONHUMAN; RABBIT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; COMPLICATION; LIPID METABOLISM; METABOLISM; PLAQUE, ATHEROSCLEROTIC;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CERAMIDES; CHOLESTEROL ESTERS; FATTY ACIDS; GLYCEROPHOSPHOLIPIDS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; MALE; PLAQUE, ATHEROSCLEROTIC; RABBITS; SPHINGOMYELINS; TRIGLYCERIDES;

EID: 84918591312     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151223283     Document Type: Article

References (28)

1. Go, A.S.; Mozaffarian, D.; Roger, V.L.; Benjamin, E.J.; Berry, J.D.; Borden, W.B.; Bravata, D.M.; Dai, S.; Ford, E.S.; Fox, C.S.; et al. Heart disease and stroke statistics—2013 update: A report from the American Heart Association. Circulation2013, 127, e6–e245.
2. Libby, P. The forgotten majority: Unfinished business in cardiovascular risk reduction. J. Am. Coll. Cardiol. 2005, 46, 1225–1228.
3. Moore, K.J.; Tabas, I. Macrophages in the pathogenesis of atherosclerosis. Cell2011, 145, 341–355.
4. Libby, P.; Ridker, P.M.; Hansson, G.K. Progress and challenges in translating the biology of atherosclerosis. Nature2011, 473, 317–325.
5. Laufs, U.; Weintraub, W.S.; Packard, C.J. Beyond statins: What to expect from add-on lipid regulating therapy? Eur. Heart J. 2013, 34, 2660–2665.
6. Lattermann, A.; Matthaus, C.; Bergner, N.; Beleites, C.; Romeike, B.F.; Krafft, C.; Brehm, B.R.; Popp, J. Characterization of atherosclerotic plaque depositions by raman and ftir imaging. J. Biophotonics2013, 6, 110–121.
7. Matthaus, C.; Dochow, S.; Bergner, G.; Lattermann, A.; Romeike, B.F.; Marple, E.T.; Krafft, C.; Dietzek, B.; Brehm, B.R.; Popp, J. In vivo characterization of atherosclerotic plaque depositions by Raman-probe spectroscopy and in vitro coherent anti-stokes Raman scattering microscopic imaging on a rabbit model. Anal. Chem. 2012, 84, 7845–7851.
8. Williams, K.J.; Feig, J.E.; Fisher, E.A. Rapid regression of atherosclerosis: Insights from the clinical and experimental literature. Nat. Clin. Pract. Cardiovasc. Med. 2008, 5, 91–102.
9. Yin, W.; Carballo-Jane, E.; McLaren, D.G.; Mendoza, V.H.; Gagen, K.; Geoghagen, N.S.; McNamara, L.A.; Gorski, J.N.; Eiermann, G.J.; Petrov, A.; et al. Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia. J. Lipid Res. 2012, 53, 51–65.
10. Quehenberger, O.; Armando, A.M.; Brown, A.H.; Milne, S.B.; Myers, D.S.; Merrill, A.H.; Bandyopadhyay, S.; Jones, K.N.; Kelly, S.; Shaner, R.L.; et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J. Lipid Res. 2010, 51, 3299–3305.
11. Libby, P.; Ridker, P.M.; Hansson, G.K. Inflammation in atherosclerosis: From pathophysiology to practice. J. Am. Coll. Cardiol. 2009, 54, 2129–2138.
12. Chang, S.; Borensztajn, J. Hepatic lipase function and the accumulation of β-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits. Biochem. J. 1993, 293, 745–750.
13. Rousset, X.; Vaisman, B.; Amar, M.; Sethi, A.A.; Remaley, A.T. Lecithin: Cholesterol acyltransferase—From biochemistry to role in cardiovascular disease. Curr. Opin. Endocrinol. Diabetes Obes. 2009, 16, 163–171.
14. Chang, T.Y.; Chang, C.C.; Lin, S.; Yu, C.; Li, B.L.; Miyazaki, A. Roles of acyl-coenzyme a: Cholesterol acyltransferase-1 and -2. Curr. Opin. Lipidol. 2001, 12, 289–296.
15. Lee, R.G.; Kelley, K.L.; Sawyer, J.K.; Farese, R.V., Jr.; Parks, J.S.; Rudel, L.L. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ. Res. 2004, 95, 998–1004.
16. Norris, P.C.; Dennis, E.A. A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Adv. Biol. Regul. 2014, 54, 99–110.
17. Vost, A. Uptake and metabolism of circulating chylomicron triglyceride by rabbit aorta. J. Lipid Res. 1972, 13, 695–704.
18. Howard, C.F., De novo synthesis and elongation of fatty acids by subcellar fractions of monkey aorta. J. Lipid Res. 1968, 9, 254–261.
19. Stein, Y.; Stein, O. Incorporation of fatty acids into lipids of aortic slices of rabbits, dogs, rats and baboons. J. Atheroscler. Res. 1962, 2, 400–412.
20. Vost, A. Lipid accretion in the perfused rabbit aorta. J. Atheroscler. Res. 1969, 9, 221–238.
21. Zhou, L.; Nilsson, A. Sources of eicosanoid precursor fatty acid pools in tissues. J. Lipid Res. 2001, 42, 1521–1542.
22. Buczynski, M.W.; Dumlao, D.S.; Dennis, E.A. Thematic review series: Proteomics. An integrated omics analysis of eicosanoid biology. J. Lipid Res. 2009, 50, 1015–1038.
23. Li, Z.; Fan, Y.; Liu, J.; Li, Y.; Huan, C.; Bui, H.H.; Kuo, M.S.; Park, T.S.; Cao, G.; Jiang, X.C. Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice. Arterioscler. Thromb. Vasc. Boil. 2012, 32, 1577–1584.
24. Lands, W.E. Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J. Boil. Chem. 1960, 235, 2233–2237.
25. Lands, W.E.; Merkl, I. Metabolism of glycerolipids. III. Reactivity of various acyl esters of coenzyme a with α'-acylglycerophosphorylcholine, and positional specificities in lecithin synthesis. J. Boil. Chem. 1963, 238, 898–904.
26. Merrill, A.H., Jr. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem. Rev. 2011, 111, 6387–6422.
27. Bligh, E.G.; Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37, 911–917.
28. Shah, V.; Castro-Perez, J.M.; McLaren, D.G.; Herath, K.B.; Previs, S.F.; Roddy, T.P. Enhanced data-independent analysis of lipids using ion mobility-tofmse to unravel quantitative and qualitative information in human plasma. Rapid Commun. Mass Spectrom. 2013, 27, 2195–2200.