The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair

Genes and Development

Volumn 28, Issue 24, 2014, Pages 2736-2738

  Henriksson, Sofia ^a   Rassoolzadeh, Hanif ^a   Hedström, Elisabeth ^a   Coucoravas, Christos ^a   Julner, Alexander ^a   Goldstein, Michael ^b   Imreh, Gabriela ^a   Zhivotovsky, Boris ^a   Kastan, Michael B ^b   Helleday, Thomas ^a   Farnebo, Marianne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; MDC1; RNF8 E3 ligase; Ubiquitin; WD40 scaffold; WRAP53

Indexed keywords

DOUBLE STRANDED DNA; HISTONE H2AX; PROTEIN WRAP53BETA; SCAFFOLD PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ATM PROTEIN; DNA BINDING PROTEIN; H2AFX PROTEIN, HUMAN; HISTONE; MDC1 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN BINDING; RNF8 PROTEIN, HUMAN; TELOMERASE; TELOMERASE CAJAL BODY PROTEIN 1, HUMAN; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL CLONE; CELL CYCLE ARREST; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; COMET ASSAY; COMPLEX FORMATION; DELETION MUTANT; DEPLETION; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; FIBROBLAST; HELA CELL LINE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MISSENSE MUTATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULSED FIELD GEL ELECTROPHORESIS; U2OS CELL LINE; UBIQUITINATION; WESTERN BLOTTING; CELL CULTURE; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HELA CELLS; HISTONES; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TELOMERASE; TRANS-ACTIVATORS; UBIQUITIN;

EID: 84918567080     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.246546.114     Document Type: Article

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