Apicidin sensitizes pancreatic cancer cells to gemcitabine by epigenetically regulating MUC4 expression

Anticancer Research

Volumn 34, Issue 10, 2014, Pages 5269-5276

  Ansari, Daniel ^a   Urey, Carlos ^a   Hilmersson, Katarzyna Said ^a   Bauden, Monika P ^a   Ek, Fredrik ^b   Olsson, Roger ^b   Andersson, Roland ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Apicidin; Capan 1; Epigenetics; Histone deacetylase inhibitor; HNF4 ; MUC4; Pancreatic cancer; Phosphatase inhibitor; Small molecule inhibitor library; Targeted treatment

Indexed keywords

APICIDIN; GEMCITABINE; HEPATOCYTE NUCLEAR FACTOR 4; MUCIN 4; ANTINEOPLASTIC ANTIMETABOLITE; CYCLOPEPTIDE; DEOXYCYTIDINE; HISTONE DEACETYLASE INHIBITOR; MOLECULAR LIBRARY;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER SCREENING; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SENSITIZATION; EPIGENETICS; HUMAN; HUMAN CELL; LD 50; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PROTEIN EXPRESSION; TREATMENT OUTCOME; ANALOGS AND DERIVATIVES; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; MOLECULAR LIBRARY; PANCREATIC NEOPLASMS; TUMOR CELL LINE;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE INHIBITORS; HUMANS; MUCIN-4; PANCREATIC NEOPLASMS; PEPTIDES, CYCLIC; SMALL MOLECULE LIBRARIES;

EID: 84917743981     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin 64: 9-29, 2014.
2. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74: 2913-2921, 2014.
3. Vincent A, Herman J, Schulick R, Hruban RH and Goggins M: Pancreatic cancer. Lancet 378: 607-620, 2011.
4. Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardiere C, Bennouna J, Bachet JB, Khemissa-Akouz F, Pere-Verge D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M, for the Groupe Tumeurs Digestives of Unicancer and the PRODIGE Intergroup: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364: 1817-1825, 2011.
5. Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J and Renschler MF: Increased survival in pancreatic cancer with nabpaclitaxel plus gemcitabine. N Engl J Med 369: 1691-1703, 2013.
6. Bafna S, Kaur S, Momi N and Batra SK: Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br J Cancer 101: 1155-1161, 2009.
7. Kaur S, Kumar S, Momi N, Sasson AR and Batra SK: Mucins in pancreatic cancer and its microenvironment. Nat Rev Gastroenterol Hepatol 10: 607-620, 2013.
8. Vincent A, Ducourouble MP and Van Seuningen I: Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J 22: 3035-3045, 2008.
9. Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M and Yonezawa S: Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer 100: 344-351, 2009.
10. Chaturvedi P, Singh AP, Moniaux N, Senapati S, Chakraborty S, Meza JL and Batra SK: MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res 5: 309-320, 2007.
11. Saitou M, Goto M, Horinouchi M, Tamada S, Nagata K, Hamada T, Osako M, Takao S, Batra SK, Aikou T, Imai K and Yonezawa S: MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol 58: 845-852, 2005.
12. Skrypek N, Duchene B, Hebbar M, Leteurtre E, van Seuningen I and Jonckheere N: The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the concentrative nucleoside transporter family. Oncogene 32: 1714-1723, 2013.
13. Wissniowski TT, Meister S, Hahn EG, Kalden JR, Voll R and Ocker M: Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells. Int J Oncol 40: 1581-1589, 2012.
14. Jonckheere N, Skrypek N and Van Seuningen I: Mucins and pancreatic cancer. Cancers (Basel) 2: 1794-1812, 2010.
15. Algamas-Dimantov A, Yehuda-Shnaidman E, Peri I and Schwartz B: Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. Cell Oncol 36: 155-167, 2013.
16. Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW and Lee HW: Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21 WAF1/ CIP1 and gelsolin. Cancer Res 60: 6068-6074, 2000.
17. Hong J, Ishihara K, Yamaki K, Hiraizumi K, Ohno T, Ahn JW, Zee O and Ohuchi K: Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells. Cancer Lett 189: 197-206, 2003.
18. Ishihara K, Hong J, Zee O and Ohuchi K: Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. Br J Pharmacol 142: 1020-1030, 2004.
19. Ueda T, Takai N, Nishida M, Nasu K and Narahara H: Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells. Int J Mol Med 19: 301-308, 2007.
20. Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB and Van Seuningen I: The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 282: 22638-22650, 2007.
21. Kim S, Kang JK, Kim YK, Seo DW, Ahn SH, Lee JC, Lee CH, You JS, Cho EJ, Lee HW and Han JW: Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. Biochem Biophys Res Commun 342: 1168-1173, 2006.
22. Donadelli M, Costanzo C, Beghelli S, Scupoli MT, Dandrea M, Bonora A, Piacentini P, Budillon A, Caraglia M, Scarpa A and Palmieri M: Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. Biochim Biophys Acta 1773: 1095-1106, 2007.