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Volumn 20, Issue 11, 2014, Pages O831-O839

In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae

Author keywords

Extended spectrum lactamase; Inoculum effect; Klebsiella pneumoniae; Meropenem; Piperacillin tazobactam; Pneumonia

Indexed keywords

BETA LACTAM; CARBAPENEM DERIVATIVE; CEFEPIME; CEFOTAXIME; CEFPODOXIME; CEFTAZIDIME; CILASTATIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; ANTIINFECTIVE AGENT; PENICILLANIC ACID; PIPERACILLIN; PIPERACILLIN, TAZOBACTAM DRUG COMBINATION; THIENAMYCIN DERIVATIVE;

EID: 84917735893     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/1469-0691.12677     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 3042706689 scopus 로고    scopus 로고
    • Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    • Paterson DL, Ko WC, Von Gottberg A et al. Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. Clin Infect Dis 2004; 39: 31-37.
    • (2004) Clin Infect Dis , vol.39 , pp. 31-37
    • Paterson, D.L.1    Ko, W.C.2    Von Gottberg, A.3
  • 2
    • 84870937083 scopus 로고    scopus 로고
    • Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. Bacteremia. A multicentric cohort study
    • Peralta G, Lamelo M, Alvarez-Garcia P et al. Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. Bacteremia. A multicentric cohort study. BMC Infect Dis 2012; 12: 245.
    • (2012) BMC Infect Dis , vol.12 , pp. 245
    • Peralta, G.1    Lamelo, M.2    Alvarez-Garcia, P.3
  • 3
    • 31944432354 scopus 로고    scopus 로고
    • Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome
    • Tumbarello M, Spanu T, Sanguinetti M et al. Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob Agents Chemother 2006; 50: 498-504.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 498-504
    • Tumbarello, M.1    Spanu, T.2    Sanguinetti, M.3
  • 5
    • 0031938022 scopus 로고    scopus 로고
    • Epidemiology of klebsiella bacteraemia: a case control study using Escherichia coli bacteraemia as control
    • Hansen DS, Gottschau A, Kolmos HJ. Epidemiology of klebsiella bacteraemia: a case control study using Escherichia coli bacteraemia as control. J Hosp Infect 1998; 38: 119-132.
    • (1998) J Hosp Infect , vol.38 , pp. 119-132
    • Hansen, D.S.1    Gottschau, A.2    Kolmos, H.J.3
  • 7
    • 0023194148 scopus 로고
    • Effect of inoculum size on results of macrotube broth dilution susceptibility tests with branhamella catarrhalis
    • Doern GV, Tubert T. Effect of inoculum size on results of macrotube broth dilution susceptibility tests with branhamella catarrhalis. J Clin Microbiol 1987; 25: 1576-1578.
    • (1987) J Clin Microbiol , vol.25 , pp. 1576-1578
    • Doern, G.V.1    Tubert, T.2
  • 8
    • 0018731845 scopus 로고
    • Effect of inoculum size on the susceptibility of haemophilus influenzae b to beta-lactam antibiotics
    • Syriopoulou VP, Scheifele DW, Sack CM, Smith AL. Effect of inoculum size on the susceptibility of haemophilus influenzae b to beta-lactam antibiotics. Antimicrob Agents Chemother 1979; 16: 510-513.
    • (1979) Antimicrob Agents Chemother , vol.16 , pp. 510-513
    • Syriopoulou, V.P.1    Scheifele, D.W.2    Sack, C.M.3    Smith, A.L.4
  • 9
    • 0024668922 scopus 로고
    • Inoculum effect
    • Brook I. Inoculum effect. Rev Infect Dis 1989; 11: 361-368.
    • (1989) Rev Infect Dis , vol.11 , pp. 361-368
    • Brook, I.1
  • 10
    • 0025826523 scopus 로고
    • Comparison of the inoculum effect of cefoxitin and other cephalosporins and of beta-lactamase inhibitors and their penicillin-derived components on the bacteroides fragilis group
    • Goldstein EJ, Citron DM, Cherubin CE. Comparison of the inoculum effect of cefoxitin and other cephalosporins and of beta-lactamase inhibitors and their penicillin-derived components on the bacteroides fragilis group. Antimicrob Agents Chemother 1991; 35: 1868-1874.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1868-1874
    • Goldstein, E.J.1    Citron, D.M.2    Cherubin, C.E.3
  • 11
    • 0029805945 scopus 로고    scopus 로고
    • Inoculum effect and bactericidal activity of cefditoren and other antibiotics against Streptococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis
    • Soriano F, Coronel P, Gimeno M, Jimenez M, Garcia-Corbeira P, Fernandez-Roblas R. Inoculum effect and bactericidal activity of cefditoren and other antibiotics against Streptococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis. Eur J Clin Microbiol Infect Dis 1996; 15: 761-763.
    • (1996) Eur J Clin Microbiol Infect Dis , vol.15 , pp. 761-763
    • Soriano, F.1    Coronel, P.2    Gimeno, M.3    Jimenez, M.4    Garcia-Corbeira, P.5    Fernandez-Roblas, R.6
  • 12
    • 84869484115 scopus 로고    scopus 로고
    • Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to enterobacteriaceae producing extended-spectrum beta-lactamases: a systematic review and meta-analysis
    • Vardakas KZ, Tansarli GS, Rafailidis PI, Falagas ME. Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to enterobacteriaceae producing extended-spectrum beta-lactamases: a systematic review and meta-analysis. J Antimicrob Chemother 2012; 67: 2793-2803.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2793-2803
    • Vardakas, K.Z.1    Tansarli, G.S.2    Rafailidis, P.I.3    Falagas, M.E.4
  • 14
    • 84555209226 scopus 로고    scopus 로고
    • Can we really use ss-lactam/ss-lactam inhibitor combinations for the treatment of infections caused by extended-spectrum ss-lactamase-producing bacteria?
    • Perez F, Bonomo RA. Can we really use ss-lactam/ss-lactam inhibitor combinations for the treatment of infections caused by extended-spectrum ss-lactamase-producing bacteria? Clin Infect Dis 2012; 54: 175-177.
    • (2012) Clin Infect Dis , vol.54 , pp. 175-177
    • Perez, F.1    Bonomo, R.A.2
  • 15
    • 0028153854 scopus 로고
    • Different ratios of the piperacillin-tazobactam combination for treatment of experimental meningitis due to Klebsiella pneumoniae producing the tem-3 extended-spectrum beta-lactamase
    • Leleu G, Kitzis MD, Vallois JM, Gutmann L, Decazes JM. Different ratios of the piperacillin-tazobactam combination for treatment of experimental meningitis due to Klebsiella pneumoniae producing the tem-3 extended-spectrum beta-lactamase. Antimicrob Agents Chemother 1994; 38: 195-199.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 195-199
    • Leleu, G.1    Kitzis, M.D.2    Vallois, J.M.3    Gutmann, L.4    Decazes, J.M.5
  • 16
    • 0035189967 scopus 로고    scopus 로고
    • Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing enterobacteriaceae
    • Thomson KS, Moland ES. Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing enterobacteriaceae. Antimicrob Agents Chemother 2001; 45: 3548-3554.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 3548-3554
    • Thomson, K.S.1    Moland, E.S.2
  • 17
    • 2342646185 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of clinical isolates of enterobacteriaceae producing complex beta-lactamase patterns including extended-spectrum enzymes
    • Segatore B, Setacci D, Perilli M et al. Antimicrobial susceptibility of clinical isolates of enterobacteriaceae producing complex beta-lactamase patterns including extended-spectrum enzymes. Int J Antimicrob Agents 2004; 23: 480-486.
    • (2004) Int J Antimicrob Agents , vol.23 , pp. 480-486
    • Segatore, B.1    Setacci, D.2    Perilli, M.3
  • 18
    • 0347093260 scopus 로고    scopus 로고
    • Effects of inoculum and beta-lactamase activity in ampc- and extended-spectrum beta-lactamase (esbl)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using nccls esbl methodology
    • Queenan AM, Foleno B, Gownley C, Wira E, Bush K. Effects of inoculum and beta-lactamase activity in ampc- and extended-spectrum beta-lactamase (esbl)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using nccls esbl methodology. J Clin Microbiol 2004; 42: 269-275.
    • (2004) J Clin Microbiol , vol.42 , pp. 269-275
    • Queenan, A.M.1    Foleno, B.2    Gownley, C.3    Wira, E.4    Bush, K.5
  • 19
    • 2342517246 scopus 로고    scopus 로고
    • In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-esbl producing Klebsiella pneumoniae
    • Burgess DS, Hall RG 2nd. In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-esbl producing Klebsiella pneumoniae. Diagn Microbiol Infect Dis 2004; 49: 41-46.
    • (2004) Diagn Microbiol Infect Dis , vol.49 , pp. 41-46
    • Burgess, D.S.1    Hall, R.G.2
  • 20
    • 84876224866 scopus 로고    scopus 로고
    • Inoculum effect on the efficacies of amoxicillin-clavulanate, piperacillin-tazobactam, and imipenem against extended-spectrum beta-lactamase (esbl)-producing and non-esbl-producing Escherichia coli in an experimental murine sepsis model
    • Docobo-Perez F, Lopez-Cerero L, Lopez-Rojas R et al. Inoculum effect on the efficacies of amoxicillin-clavulanate, piperacillin-tazobactam, and imipenem against extended-spectrum beta-lactamase (esbl)-producing and non-esbl-producing Escherichia coli in an experimental murine sepsis model. Antimicrob Agents Chemother 2013; 57: 2109-2113.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2109-2113
    • Docobo-Perez, F.1    Lopez-Cerero, L.2    Lopez-Rojas, R.3
  • 21
    • 34247142710 scopus 로고    scopus 로고
    • Bactericidal activities of meropenem and ertapenem against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model
    • DeRyke CA, Banevicius MA, Fan HW, Nicolau DP. Bactericidal activities of meropenem and ertapenem against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model. Antimicrob Agents Chemother 2007; 51: 1481-1486.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1481-1486
    • DeRyke, C.A.1    Banevicius, M.A.2    Fan, H.W.3    Nicolau, D.P.4
  • 22
    • 84917731180 scopus 로고    scopus 로고
    • Clinical and molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli in a Japanese tertiary hospital
    • Harada Y, Morinaga Y, Yamada K, Migiyama Y, Nagaoka K. Clinical and molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli in a Japanese tertiary hospital. J Med Microb Diagn 2013; 2: 3.
    • (2013) J Med Microb Diagn , vol.2 , pp. 3
    • Harada, Y.1    Morinaga, Y.2    Yamada, K.3    Migiyama, Y.4    Nagaoka, K.5
  • 23
    • 36448983199 scopus 로고    scopus 로고
    • Peritoneal penetration of doripenem after intravenous administration in abdominal-surgery patients
    • Ikawa K, Morikawa N, Urakawa N, Ikeda K, Ohge H, Sueda T. Peritoneal penetration of doripenem after intravenous administration in abdominal-surgery patients. J Antimicrob Chemother 2007; 60: 1395-1397.
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1395-1397
    • Ikawa, K.1    Morikawa, N.2    Urakawa, N.3    Ikeda, K.4    Ohge, H.5    Sueda, T.6
  • 24
    • 0028007490 scopus 로고
    • Pharmacokinetic study of tazobactam/piperacillin in experimental animals
    • Maeda TK, Matsushita K. Pharmacokinetic study of tazobactam/piperacillin in experimental animals. Chemotherapy 1994; 42: 206-216.
    • (1994) Chemotherapy , vol.42 , pp. 206-216
    • Maeda, T.K.1    Matsushita, K.2
  • 25
    • 33646742397 scopus 로고    scopus 로고
    • Clinical implications of hypermuco viscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia
    • Lee HC, Chuang YC, Yu WL et al. Clinical implications of hypermuco viscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia. J Intern Med 2006; 259: 606-614.
    • (2006) J Intern Med , vol.259 , pp. 606-614
    • Lee, H.C.1    Chuang, Y.C.2    Yu, W.L.3
  • 26
    • 1542313887 scopus 로고    scopus 로고
    • A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications
    • Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 2004; 199: 697-705.
    • (2004) J Exp Med , vol.199 , pp. 697-705
    • Fang, C.T.1    Chuang, Y.P.2    Shun, C.T.3    Chang, S.C.4    Wang, J.T.5
  • 27
    • 0026725416 scopus 로고
    • Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase i
    • Fukasawa M, Sumita Y, Harabe ET et al. Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase i. Antimicrob Agents Chemother 1992; 36: 1577-1579.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1577-1579
    • Fukasawa, M.1    Sumita, Y.2    Harabe, E.T.3
  • 28
    • 0035145798 scopus 로고    scopus 로고
    • Lipopolysaccharide induces mucus cell metaplasia in mouse lung
    • Yanagihara K, Seki M, Cheng PW. Lipopolysaccharide induces mucus cell metaplasia in mouse lung. Am J Respir Cell Mol Biol 2001; 24: 66-73.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 66-73
    • Yanagihara, K.1    Seki, M.2    Cheng, P.W.3
  • 29
    • 84904070751 scopus 로고    scopus 로고
    • European committee on antimicrobial susceptibility testing, Available from: (last accessed 30 May 2014).
    • EUCAST. Rationale for the eucast clinical breakpoints, version 1.0. Piperacillin-tazobactam. European committee on antimicrobial susceptibility testing, 2010. Available from: http://www.eucast.org/documents/rd/ (last accessed 30 May 2014).
    • (2010) Rationale for the eucast clinical breakpoints, version 1.0. Piperacillin-tazobactam
  • 30
    • 84917737685 scopus 로고    scopus 로고
    • European committee on antimicrobial susceptibility testing, Available from: (last accessed 30 May 2014).
    • EUCAST. Rationale for the eucast clinical breakpoints, version 1.5. Meropenem. European committee on antimicrobial susceptibility testing, 2009. Available from: http://www.eucast.org/documents/rd/ (last accessed 30 May 2014).
    • (2009) Rationale for the eucast clinical breakpoints, version 1.5. Meropenem
  • 31
    • 0029035979 scopus 로고
    • In vitro activities of various beta-lactam antimicrobial agents against clinical isolates of Escherichia coli and klebsiella spp. Resistant to oxyimino cephalosporins
    • Jett BD, Ritchie DJ, Reichley R, Bailey TC, Sahm DF. In vitro activities of various beta-lactam antimicrobial agents against clinical isolates of Escherichia coli and klebsiella spp. Resistant to oxyimino cephalosporins. Antimicrob Agents Chemother 1995; 39: 1187-1190.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1187-1190
    • Jett, B.D.1    Ritchie, D.J.2    Reichley, R.3    Bailey, T.C.4    Sahm, D.F.5
  • 32
    • 0035522334 scopus 로고    scopus 로고
    • Effect of inoculum size on the antibacterial activity of cefpirome and cefepime against Klebsiella pneumoniae strains producing shv extended-spectrum beta-lactamases
    • Bedenic B, Beader N, Zagar Z. Effect of inoculum size on the antibacterial activity of cefpirome and cefepime against Klebsiella pneumoniae strains producing shv extended-spectrum beta-lactamases. Clin Microbiol Infect 2001; 7: 626-635.
    • (2001) Clin Microbiol Infect , vol.7 , pp. 626-635
    • Bedenic, B.1    Beader, N.2    Zagar, Z.3
  • 33
    • 12344334529 scopus 로고    scopus 로고
    • Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated ampc-type beta-lactamase
    • Kang CI, Pai H, Kim SH et al. Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated ampc-type beta-lactamase. J Antimicrob Chemother 2004; 54: 1130-1133.
    • (2004) J Antimicrob Chemother , vol.54 , pp. 1130-1133
    • Kang, C.I.1    Pai, H.2    Kim, S.H.3
  • 34
    • 84873021014 scopus 로고    scopus 로고
    • Cefepime therapy for monomicrobial bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing enterobacteriaceae: mic matters
    • Lee NY, Lee CC, Huang WH, Tsui KC, Hsueh PR, Ko WC. Cefepime therapy for monomicrobial bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing enterobacteriaceae: mic matters. Clin Infect Dis 2013; 56: 488-495.
    • (2013) Clin Infect Dis , vol.56 , pp. 488-495
    • Lee, N.Y.1    Lee, C.C.2    Huang, W.H.3    Tsui, K.C.4    Hsueh, P.R.5    Ko, W.C.6
  • 35
    • 0025274003 scopus 로고
    • Activities of beta-lactam antibiotics against Escherichia coli strains producing extended-spectrum beta-lactamases
    • Jacoby GA, Carreras I. Activities of beta-lactam antibiotics against Escherichia coli strains producing extended-spectrum beta-lactamases. Antimicrob Agents Chemother 1990; 34: 858-862.
    • (1990) Antimicrob Agents Chemother , vol.34 , pp. 858-862
    • Jacoby, G.A.1    Carreras, I.2
  • 36
    • 0033835559 scopus 로고    scopus 로고
    • In vitro activities of parenteral beta-lactam antimicrobials against tem-10-, tem-26- and shv-5-derived extended-spectrum beta-lactamases expressed in an isogenic Escherichia coli host
    • Rebuck JA, Olsen KM, Fey PD, Bergman KL, Rupp ME. In vitro activities of parenteral beta-lactam antimicrobials against tem-10-, tem-26- and shv-5-derived extended-spectrum beta-lactamases expressed in an isogenic Escherichia coli host. J Antimicrob Chemother 2000; 46: 461-464.
    • (2000) J Antimicrob Chemother , vol.46 , pp. 461-464
    • Rebuck, J.A.1    Olsen, K.M.2    Fey, P.D.3    Bergman, K.L.4    Rupp, M.E.5
  • 37
    • 0347362476 scopus 로고    scopus 로고
    • Growing group of extended-spectrum beta-lactamases: the ctx-m enzymes
    • Bonnet R. Growing group of extended-spectrum beta-lactamases: the ctx-m enzymes. Antimicrob Agents Chemother 2004; 48: 1-14.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1-14
    • Bonnet, R.1
  • 38
    • 74549187084 scopus 로고    scopus 로고
    • Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates
    • Lopez-Cerero L, Picon E, Morillo C et al. Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates. Clin Microbiol Infect 2010; 16: 132-136.
    • (2010) Clin Microbiol Infect , vol.16 , pp. 132-136
    • Lopez-Cerero, L.1    Picon, E.2    Morillo, C.3
  • 39
    • 21244471489 scopus 로고    scopus 로고
    • Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection
    • del Mar Tomas M, Cartelle M, Pertega S et al. Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection. Clin Microbiol Infect 2005; 11: 540-546.
    • (2005) Clin Microbiol Infect , vol.11 , pp. 540-546
    • del Mar Tomas, M.1    Cartelle, M.2    Pertega, S.3
  • 40
    • 34250220334 scopus 로고    scopus 로고
    • Effects of carbapenem exposure on the risk for digestive tract carriage of intensive care unit-endemic carbapenem-resistant Pseudomonas aeruginosa strains in critically ill patients
    • Pena C, Guzman A, Suarez C et al. Effects of carbapenem exposure on the risk for digestive tract carriage of intensive care unit-endemic carbapenem-resistant Pseudomonas aeruginosa strains in critically ill patients. Antimicrob Agents Chemother 2007; 51: 1967-1971.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1967-1971
    • Pena, C.1    Guzman, A.2    Suarez, C.3
  • 41
    • 84876869277 scopus 로고    scopus 로고
    • An evidence-based review of risk-reductive strategies for osteonecrosis of the jaws among cancer patients
    • Kyrgidis A, Tzellos TG, Toulis K, Arora A, Kouvelas D, Triaridis S. An evidence-based review of risk-reductive strategies for osteonecrosis of the jaws among cancer patients. Curr Clin Pharmacol 2013; 8: 124-134.
    • (2013) Curr Clin Pharmacol , vol.8 , pp. 124-134
    • Kyrgidis, A.1    Tzellos, T.G.2    Toulis, K.3    Arora, A.4    Kouvelas, D.5    Triaridis, S.6


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