Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage

Journal of Biological Chemistry

Volumn 289, Issue 49, 2014, Pages 34024-34032

  Tang, Mengfan ^a   Li, Yujing ^a   Zhang, Xiya ^a   Deng, Tingting ^a   Zhou, Zhifen ^a   Ma, Wenbin ^a   Zhou, Songyang ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; DNA; JOINING;

CELL SURVIVAL; DNA DAMAGES; ELEVATED LEVEL; FLEXIBLE HINGES; GENE SILENCING; HOMOLOGOUS RECOMBINATION; NONHOMOLOGOUS END JOINING; STRUCTURAL MAINTENANCE;

REPAIR;

ADENOSINE TRIPHOSPHATASE; BRCA1 PROTEIN; HISTONE H2AX; STRUCTURAL MAINTENANCE OF CHROMOSOMES; STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN CONTAINING PROTEIN 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; BRCA1 PROTEIN, HUMAN; DNA; H2AFX PROTEIN, HUMAN; HISTONE; NONHISTONE PROTEIN; PHLEOMYCIN; SIGNAL PEPTIDE; SMALL INTERFERING RNA; SMCHD1 PROTEIN, HUMAN; TP53BP1 PROTEIN, HUMAN;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; GENE INACTIVATION; HUMAN; HUMAN CELL; PROTEIN DEPLETION; PROTEIN FUNCTION; RECOMBINATION REPAIR; ANTAGONISTS AND INHIBITORS; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; OSTEOBLAST; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; BRCA1 PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OSTEOBLASTS; RECOMBINATIONAL DNA REPAIR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84917735207     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.601179     Document Type: Article

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