Atypical manifestations of visceral leishmaniasis in patients with HIV in north Ethiopia: A gap in guidelines for the management of opportunistic infections in resource poor settings

The Lancet Infectious Diseases

Volumn 15, Issue 1, 2015, Pages 122-129

  Diro, Ermias ^a   van Griensven, Johan ^b   Mohammed, Rezika ^a   Colebunders, Robert ^b   Asefa, Mesfin ^a   Hailu, Asrat ^c   Lynen, Lutgarde ^b  

^a UNIVERSITY OF GONDAR   (Ethiopia)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c ADDIS ABABA UNIVERSITY   (Ethiopia)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; CD4 ANTIGEN; CEFTRIAXONE; COTRIMOXAZOLE; HEMOGLOBIN; METRONIDAZOLE; STIBOGLUCONATE SODIUM;

ABDOMINAL MASS; ADULT; ANEMIA; ANOREXIA; BLEEDING; BODY MASS; BONE MARROW BIOPSY; CASE REPORT; CD4 LYMPHOCYTE COUNT; CERVICAL LYMPH NODE; CERVICAL LYMPHADENOPATHY; DIARRHEA; DYSPHAGIA; ETHIOPIA; FECES INCONTINENCE; FEMALE; FEVER; FINE NEEDLE ASPIRATION BIOPSY; GIEMSA STAIN; HEMORRHOID; HEPATOSPLENOMEGALY; HISTIOCYTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LYMPHOMA; MALE; MILIARY TUBERCULOSIS; MIXED INFECTION; MORBIDITY; MORTALITY; MOUTH LESION; NOTE; OPPORTUNISTIC INFECTION; PANCYTOPENIA; PARASITE LOAD; PARASITE TRANSMISSION; PRACTICE GUIDELINE; SCREENING; SEPTIC SHOCK; SPLENOMEGALY; THORAX RADIOGRAPHY; THROMBOCYTE COUNT; TREATMENT FAILURE; VISCERAL LEISHMANIASIS; VOMITING; WEIGHT REDUCTION; AIDS-RELATED OPPORTUNISTIC INFECTIONS; COINFECTION; COMPLICATION; DEVELOPING COUNTRY; LEISHMANIASIS, VISCERAL; PATHOLOGY;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; COINFECTION; DEVELOPING COUNTRIES; ETHIOPIA; FEMALE; HIV INFECTIONS; HUMANS; LEISHMANIASIS, VISCERAL; MALE; PRACTICE GUIDELINES AS TOPIC;

EID: 84917730574     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(14)70833-3     Document Type: Note

References (96)

1. Marlier S, Menard G, Gisserot O, Kologo K, De Jaureguiberry JP Leishmaniasis and human immunodeficiency virus: an emerging co-infection?. Med Trop (Mars) 1999, 59:193-200. (in French).
2. Control of the leishmaniases WHO, (accessed Feb 5, 2013). http://apps.who.int/iris/bitstream/10665/44412/1/WHO_TRS_949_eng.pdf.
3. Alvar J, Aparicio P, Aseffa A, et al. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 2008, 21:334-359.
4. van Griensven J, Diro E Visceral leishmaniasis. Infect Dis Clin North Am 2012, 26:309-322.
5. Gelanew T, Kuhls K, Hurissa Z, et al. Inference of population structure of Leishmania donovani strains isolated from different Ethiopian visceral leishmaniasis endemic areas. PLoS Negl Trop Dis 2010, 4:e889.
6. Hurissa Z, Gebre-Silassie S, Hailu W, et al. Clinical characteristics and treatment outcome of patients with visceral leishmaniasis and HIV co-infection in northwest Ethiopia. Trop Med Int Health 2010, 15:848-855.
7. Laguna F, Adrados M, Alvar J, et al. Visceral leishmaniasis in patients infected with the human immunodeficiency virus. Eur J Clin Microbiol Infect Dis 1997, 16:898-903.
8. Pintado V, Martin-Rabadan P, Rivera ML, Moreno S, Bouza E Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study. Medicine (Baltimore) 2001, 80:54-73.
9. Ejara ED, Lynen L, Boelaert M, van Griensven J Challenges in HIV and visceral leishmania co-infection: future research directions. Trop Med Int Health 2010, 15:1266-1267.
10. Ara M, Maillo C, Peon G, et al. Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus. Br J Dermatol 1998, 139:114-117.
11. Bosch RJ, Rodrigo AB, Sanchez P, de Galvez MV, Herrera E Presence of leishmania organisms in specific and non-specific skin lesions in HIV-infected individuals with visceral leishmaniasis. Int J Dermatol 2002, 41:670-675.
12. Gonzalez-Beato MJ, Moyano B, Sanchez C, et al. Kaposi's sarcoma-like lesions and other nodules as cutaneous involvement in AIDS-related visceral leishmaniasis. Br J Dermatol 2000, 143:1316-1318.
13. Postigo C, Llamas R, Zarco C, et al. Cutaneous lesions in patients with visceral leishmaniasis and HIV infection. J Infect 1997, 35:265-268.
14. Dereure J, Duong TH, Lavabre-Bertrand T, et al. Visceral leishmaniasis. Persistence of parasites in lymph nodes after clinical cure. J Infect 2003, 47:77-81.
15. Aliaga L, Cobo F, Mediavilla JD, et al. Localized mucosal leishmaniasis due to Leishmania (Leishmania) infantum: clinical and microbiologic findings in 31 patients. Medicine (Baltimore) 2003, 82:147-158.
16. Cortes P, Cardenosa N, Romani J, et al. Oral leishmaniasis in an HIV-positive patient caused by two different zymodemes of Leishmania infantum. Trans R Soc Trop Med Hyg 1997, 91:438-439.
17. Albrecht H, Stellbrink HJ, Gross G, Berg B, Helmchen U, Mensing H Treatment of atypical leishmaniasis with interferon gamma resulting in progression of Kaposi's sarcoma in an AIDS patient. Clin Investig 1994, 72:1041-1047.
18. Alguacil GF, Moreno J, Ortolano A, Hallal H A malabsorption syndrome, gastrointestinal leishmaniasis and HIV infection. Gastroenterol Hepatol 1997, 20:386. (in Spanish).
19. Alonso MJ, Munoz E, Picazo A, et al. Duodenal leishmaniasis diagnosed by biopsy in two HIV-positive patients. Pathol Res Pract 1997, 193:43-47.
20. Angarano G, Maggi P, Rollo MA, et al. Diffuse necrotic hepatic lesions due to visceral leishmaniasis in AIDS. J Infect 1998, 36:167-169.
21. Balkhair A, Ben AF Gastric and cutaneous dissemination of visceral leishmaniasis in a patient with advanced HIV. Int J Infect Dis 2008, 12:111-113.
22. Betz P, Elsing C, Purrmann J, Frenzel H Leishmaniasis of the upper gastrointestinal tract in an HIV positive patient. Pathologe 1990, 11:97-100. (in German).
23. Canovas DL, Carbonell J, Torres J, Altes J, Buades J Laryngeal leishmaniasis as initial opportunistic disease in HIV infection. J Laryngol Otol 1994, 108:1089-1092.
24. Heudier P, Taillan B, Garnier G, Marty P, Fuzibet JG, Dujardin P Pulmonary site of visceral leishmaniasis in HIV infection. Presse Med 1993, 22:1060. (in French).
25. Gelanew T, Hurissa Z, Diro E, et al. Disseminated cutaneous leishmaniasis resembling post-kala-azar dermal leishmaniasis caused by Leishmania donovani in three patients co-infected with visceral leishmaniasis and human immunodeficiency virus/acquired immunodeficiency syndrome in Ethiopia. Am J Trop Med Hyg 2011, 84:906-912.
26. Vyas DH, Shah PD Atypical presentation of visceral leishmaniasis in a HIV-positive patient from a nonendemic area. J Lab Physicians 2011, 3:119-121.
27. Boumis E, Chinello P, Della RC, Paglia MG, Proietti MF, Petrosillo N Atypical disseminated leishmaniasis resembling post-kala-azar dermal leishmaniasis in an HIV-infected patient. Int J STD AIDS 2006, 17:351-353.
28. Calza L, D'Antuono A, Marinacci G, et al. Disseminated cutaneous leishmaniasis after visceral disease in a patient with AIDS. J Am Acad Dermatol 2004, 50:461-465.
29. Carnauba D, Konishi CT, Petri V, Martinez IC, Shimizu L, Pereira-Chioccola VL Atypical disseminated leishmaniasis similar to post-kala-azar dermal leishmaniasis in a Brazilian AIDS patient infected with Leishmania (Leishmania) infantum chagasi: a case report. Int J Infect Dis 2009, 13:e504-e507.
30. Catorze G, Alberto J, Afonso A, Vieira R, Cortes S, Campino L Leishmania infantum/HIV co-infection: cutaneous lesions following treatment of visceral leishmaniasis. Ann Dermatol Venereol 2006, 133:39-42. (in French).
31. Colebunders R, Depraetere K, Verstraeten T, et al. Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection. J Am Acad Dermatol 1999, 41:847-850.
32. Gobels K, Feldt T, Oette M, et al. Visceral leishmaniasis presenting as subcutaneous nodules in a HIV-positive patient. Eur J Clin Microbiol Infect Dis 2003, 22:329-331.
33. Gomez ME, Hiraldo GA, Sanz TA, Jimenez OF Cutaneous leishmaniasis associated with visceral leishmaniasis in a patient infected with human immunodeficiency virus. Med Clin (Barc) 2009, 133:648. (in Spanish).
34. Hamour AA, Skelly R, Jowitt SN, et al. Visceral leishmaniasis (Kala-azar) in two patients with HIV-1 infection: atypical features and response to therapy. J Infect 1998, 36:217-220.
35. Manfredi R, Passarini B, D'Antuono A, Misciali C, Marinacci G, Calza L Diffuse skin spread of HIV-associated visceral leishmaniasis: cumbersome diagnostic and therapeutic issues. G Ital Dermatol Venereol 2008, 143:339-346.
36. Manfredi R, Marinacci G, Calza L, Passarini B Diffuse cutaneous dissemination of visceral leishmaniasis during human immunodeficiency virus (HIV) infection, despite negligible immunodeficiency: repeated failure of liposomal amphotericin B administration, followed by successful long-term pentamidine and paromomycin administration. Int J Antimicrob Agents 2008, 31:590-592.
37. Perrin C, Taillan B, Hofman P, Mondain V, Lefichoux Y, Michiels JF Atypical cutaneous histological features of visceral leishmaniasis in acquired immunodeficiency syndrome. Am J Dermatopathol 1995, 17:145-150.
38. Pourahmad M, Hooshmand F, Rahiminejad M Cutaneous leishmaniasis associated with visceral leishmaniasis in a case of acquired immunodeficiency syndrome (AIDS). Int J Dermatol 2009, 48:59-61.
39. Santos-Oliveira JR, Da-Cruz AM, Pires LH, et al. Atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic leishmania species. Am J Trop Med Hyg 2011, 85:55-59.
40. Alsina-Gibert M, Lopez-Lerma I, Martinez-Chamorro E, Herrero-Mateu C Cutaneous manifestations of visceral leishmaniasis resistant to liposomal amphotericin B in an HIV-positive patient. Arch Dermatol 2006, 142:787-789.
41. Barrio J, Lecona M, Cosin J, Olalquiaga FJ, Hernanz JM, Soto J Leishmania infection occurring in herpes zoster lesions in an HIV-positive patient. Br J Dermatol 1996, 134:164-166.
42. Castellano VM, Rodriguez-Peralto JL, Alonso S, Gomez-De la Fuente E, Ibarrola C Dermatofibroma parasitized by leishmania in HIV infection: a new morphologic expression of dermal Kala Azar in an immunodepressed patient. J Cutan Pathol 1999, 26:516-519.
43. Del Giudice P Leishmania infection occurring in herpes zoster lesions in an HIV positive patient. Br J Dermatol 1996, 135:1005-1006.
44. Forsyth SF, Lawn SD, Miller RF, Fernando JJ, Lockwood DN, Vega-Lopez F Multiple dermatofibroma-like lesions in a human immunodeficiency virus-positive patient coinfected with visceral leishmaniasis. Br J Dermatol 2003, 148:185-187.
45. Gallego MA, Aguilar A, Plaza S, et al. Kaposi's sarcoma with an intense parasitization by leishmania. Cutis 1996, 57:103-105.
46. Garcia-Rio I, Dauden E, Ballestero-Diez M, Fraga J, Garcia-Diez A Leishmaniasis and rheumatoid nodulosis in a patient with HIV infection. Actas Dermosifiliogr 2010, 101:164-167. (in Spanish).
47. Hinojosa MC, Gonzalez MI, Martinez G, Gines A Leishmanial parasitation of Kaposi's sarcoma in a HIV patient. Rev Esp Quimioter 2011, 24:54-55. (in Spanish).
48. Taillan B, Marty P, Schneider S, et al. Visceral leishmaniasis involving a cutaneous Kaposi's sarcoma lesion and free areas of skin. Eur J Med 1992, 1:255.
49. Ali A Leishmaniases and HIV/AIDS co-infections: review of common features and management experiences. Ethiop Med J 2002, 40(suppl 1):37-49.
50. Kumar P, Sharma PK, Jain RK, Gautam RK, Bhardwaj M, Kar HK Oral ulcer as an unusual feature of visceral leishmaniasis in an AIDS patient. Indian J Med Sci 2007, 61:97-101.
51. Gonzalez-Anglada MI, Pena JM, Barbado FJ, et al. Two cases of laryngeal leishmaniasis in patients infected with HIV. Eur J Clin Microbiol Infect Dis 1994, 13:509-511.
52. Grasa JM, Lorente J, Crego F, et al. Nasal leishmaniasis in an HIV-positive patient. Acta Otorrinolaringol Esp 2000, 51:169-173. (in Spanish).
53. Villanueva JL, Torre-Cisneros J, Jurado R, Villar A, et al. Leishmania esophagitis in an AIDS patient: an unusual form of visceral leishmaniasis. Am J Gastroenterol 1994, 89:273-275.
54. Bechade D, Seurat L, Discamps G, Taniere PH, Du Bourguet F Multiple digestive involvement in visceral leishmaniasis in a patient with HIV infection: favourable course with itraconazole. Rev Med Interne 1996, 17:234-237. (in French).
55. Bel Haj SM, Mekni A, Khanfir M, et al. Unusual presentation of visceral leishmaniasis in an immunocompetent patient. Med Mal Infect 2006, 36:167-169. (in French).
56. Garcia-Samaniego J, Laguna F Intestinal leishmaniasis in AIDS patients. Rev Esp Enferm Dig 1997, 89:145. (in Spanish).
57. Jablonowski H, Szelenyi H, Borchard F, Dohring-Schwerdtfeger E, Hengels KJ Visceral leishmaniasis with gastrointestinal involvement in a 30-year-old HIV infected patient. Z Gastroenterol 1994, 32:405-407. (in German).
58. Jawhar NM Visceral leishmaniasis with an unusual presentation in an HIV positive patient. Sultan Qaboos Univ Med J 2011, 11:269-272.
59. Laguna F, Garcia-Samaniego J, Moreno V, Gonzalez-Lahoz JM Prevalence of gastrointestinal leishmaniasis in Spanish HIV-positive patients with digestive symptoms. Am J Gastroenterol 1994, 89:1606.
60. Laguna F, Soriano V, Valencia E, Gonzalez-Lahoz JM Gastrointestinal leishmaniasis in patients infected with the human immunodeficiency virus. Rev Clin Esp 1994, 194:510-511. (in Spanish).
61. Lemaistre AI, Chapel F, Cie P, Jeantils V, Guettier C Unusual vascular lesions in the course of a colonic leishmaniasis in an HIV positive patient. Ann Pathol 1997, 17:200-202. (in French).
62. McBride MO, Fisher M, Skinner CJ, Golden R, Main J An unusual gastrointestinal presentation of leishmaniasis. Scand J Infect Dis 1995, 27:297-298.
63. Mediavilla Garcia JD, Lopez-Gomez M, Corrales Torres AJ, Ortiz FF, Jimenez-Alonso J Esophago-gastric leishmaniasis in a patient with HIV infection. Rev Clin Esp 1992, 191:335-336. (in Spanish).
64. Pesce A, Saint-Paul MC, Vinti H, et al. Gastric leishmaniasis in a patient with acquired immunodeficiency syndrome. Presse Med 1990, 19:178. (in French).
65. Sanchez LA, Ferrero OL, Baraia-Etxaburu J, et al. Visceral leishmaniasis with duodenal involvement in an HIV patient. Rev Esp Enferm Dig 2001, 93:740-741. (in Spanish).
66. Santos GI, Fernandez BM Gastric leishmaniasis associated with human immunodeficiency virus infection. Rev Clin Esp 1999, 199:332. (in Spanish).
67. Sebastian JJ, Garcia S, Soria MT, Pac J, Vicente J, Uribarrena R Visceral leishmaniasis diagnosed by colonoscopy. J Clin Gastroenterol 1997, 25:691-692.
68. Zimmer G, Guillou L, Gauthier T, Iten A, Saraga EP Digestive leishmaniasis in acquired immunodeficiency syndrome: a light and electron microscopic study of two cases. Mod Pathol 1996, 9:966-969.
69. Alex S, Criado C, Fernandez-Guerrero ML, et al. Nephrotic syndrome complicating chronic visceral leishmaniasis: re-emergence in patients with AIDS. Clin Nephrol 2008, 70:65-68.
70. Clevenbergh P, Okome MN, Benoit S, et al. Acute renal failure as initial presentation of visceral leishmaniasis in an HIV-1-infected patient. Scand J Infect Dis 2002, 34:546-547.
71. de Valliere S, Mary C, Joneberg JE, et al. AA-amyloidosis caused by visceral leishmaniasis in a human immunodeficiency virus-infected patient. Am J Trop Med Hyg 2009, 81:209-212.
72. Navarro M, Bonet J, Bonal J, Romero R Secondary amyloidosis with irreversible acute renal failure caused by visceral leishmaniasis in a patient with AIDS. Nefrologia 2006, 26:745-746. (in Spanish).
73. Matheron S, Cabie A, Parquin F, et al. Visceral leishmaniasis and HIV infection: unusual presentation with pleuropulmonary involvement, and effect of secondary prophylaxis. AIDS 1992, 6:238-240.
74. Mofredj A, Guerin JM, Leibinger F, Masmoudi R Visceral leishmaniasis with pericarditis in an HIV-infected patient. Scand J Infect Dis 2002, 34:151-153.
75. Munoz-Rodriguez FJ, Padro S, Pastor P, et al. Pleural and peritoneal leishmaniasis in an AIDS patient. Eur J Clin Microbiol Infect Dis 1997, 16:246-248.
76. Canalias J, Falco J, Martin J, Jurado I Macronodular hepatic granulomas due to visceral leishmaniasis in an AIDS patient: imaging findings. J Comput Assist Tomogr 1997, 21:677-679.
77. Fernandez-Miranda C, Colina F, Delgado JM, Lopez-Carreira M Diffuse nodular regenerative hyperplasia of the liver associated with human immunodeficiency virus and visceral leishmaniasis. Am J Gastroenterol 1993, 88:433-435.
78. Mondain-Miton V, Toussaint-Gari M, Hofman P, et al. Atypical leishmaniasis in a patient infected with human immunodeficiency virus. Clin Infect Dis 1995, 21:663-665.
79. Guidelines for management of opportunistic infections and antiretroviral treatment in adolescents and adults in Ethiopia Federal HIV/AIDS Prevention and Control Office, Federal Ministry of HealthFederal Ministry of Health, (accessed Feb 5, 2013). http://www.who.int/hiv/pub/guidelines/ethiopia_art.pdf.
80. de Faria FB, Barroca H Fine needle aspiration of a lymph node in an HIV patient with chronic infection by leishmania: a case report. Acta Cytol 2010, 54(5 suppl):946-948.
81. Harms G, Zenk J, Martin S, et al. Localized lymphadenopathy due to leishmanial infection. Infection 2001, 29:355-356.
82. Ignatius R, Loddenkemper C, Woitzik J, Schneider T, Harms G Localized leishmanial lymphadenopathy: an unusual manifestation of leishmaniasis in a traveler in southern Europe. Vector Borne Zoonotic Dis 2011, 11:1213-1215.
83. Sharma SK, Das ML, Rijal S, Sah SP, Koirala S Lymphatic leishmaniasis-first case report from Nepal. Southeast Asian J Trop Med Public Health 2001, 32:749-750.
84. Tallada N, Raventos A, Martinez S, Compano C, Almirante B Leishmania lymphadenitis diagnosed by fine-needle aspiration biopsy. Diagn Cytopathol 1993, 9:673-676.
85. de Beer P, el Harith A, Deng LL, Semiao-Santos SJ, Chantal B, van Grootheest M A killing disease epidemic among displaced Sudanese population identified as visceral leishmaniasis. Am J Trop Med Hyg 1991, 44:283-289.
86. Bielory BP, Lari HB, Mirani N, Kapila R, Fitzhugh VA, Turbin RE Conjunctival squamous cell carcinoma harboring leishmania amastigotes in a human immunodeficiency virus-positive patient. Arch Ophthalmol 2011, 129:1230-1231.
87. Canet JJ, Julia J, Martinez-Lacasa J, Garau J Clinical microbiological case: esophageal lesion in an AIDS patient. Clin Microbiol Infect 2003, 9:421. 463-66.
88. Diego MJ, Omar M, Jimenez-Alonso J, Miranda C, Aliaga L Visceral leishmaniasis with small intestine and colon involvement in a patient with HIV infection. Enferm Infecc Microbiol Clin 1995, 13:377-378. (in Spanish).
89. Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, el-Hassan AM Post-kala-azar dermal leishmaniasis. Lancet Infect Dis 2003, 3:87-98.
90. Lynen L Clinical HIV/AIDS care guidelines for resource-poor settings. Médecins Sans Frontières (accessed Feb 5, 2013). http://telemedicine.itg.be/telemedicine/Uploads/MSFGuidelines2006JuneMSF.pdf.
91. IMAI acute care: interim guidelines for first-level facility health workers at health centre and district outpatient clinic WHO, (accessed Feb 5, 2013). http://www.who.int/hiv/pub/imai/acute_care.pdf.
92. IMAI/IMCI chronic care with ARV therapy and prevention: interim guidelines for first-level facility health workers at health centers and district outpatient clinic WHO, (accessed Feb 5, 2013). http://www.who.int/hiv/pub/imai/Chronic_HIV_Care7.05.07.pdf.
93. IMAI district clinician manual: hospital care for adolescents and adults - guidelines for the management of illnesses with limited resources WHO, (accessed Feb 5, 2013). http://www.who.int/hiv/topics/capacity/en/.
94. Tackling the HIV challenge in Sudan: the way forward Sudan HIV/AIDS working group, (accessed Feb 5, 2013). http://www.shawg.org/Documents/the%20way%20forward%202008.pdf.
95. National manual for the management of HIV related opportunistic infection and conditions. A healthcare workers' manual Ministry of Health, (accessed Feb 5, 2013). http://nascop.or.ke/library/ARTguidelines/NationalManualforthemanagementofHIVrelatedOIs.pdf.
96. Antiretroviral therapy for HIV Infection in adults and adolescents: recommendations for a public health approach WHO, (accessed Feb 5, 2013). http://www.who.int/hiv/pub/guidelines/adult/en/index.html.