Characterization of skin lesions induced by skin-tropic α- And β-papillomaviruses in a patient with epidermodysplasia verruciformis

British Journal of Dermatology

Volumn 171, Issue 6, 2014, Pages 1550-1554

  Borgogna, C ^a   Landini, M M ^a,b   Lanfredini, S ^a   Doorbar, J ^c   Bouwes Bavinck, J N ^d   Quint, K D ^d,e   De Koning, M N C ^e   Genders, R E ^d   Gariglio, M ^a  

^a Azienda Ospedaliero Universitaria Maggiore della Carità   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Manager Development and Diagnostic Services (DDS)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN L1; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN E4; VIRUS DNA;

ADULT; ALPHAPAPILLOMAVIRUS; ARTICLE; BETAPAPILLOMAVIRUS; BOWEN DISEASE; CASE REPORT; CELL PROLIFERATION; EPIDERMODYSPLASIA VERRUCIFORMIS; EVER1 GENE; EVER2 GENE; GENE; GENETIC ANALYSIS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 20; HUMAN PAPILLOMAVIRUS TYPE 27; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPHENOTYPING; LASER CAPTURE MICRODISSECTION; MALE; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SKIN BIOPSY; SKIN DEFECT; WART VIRUS; IMMUNOCOMPROMIZED PATIENT; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY;

ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; DNA, VIRAL; EPIDERMODYSPLASIA VERRUCIFORMIS; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED; VIRAL PROTEINS;

EID: 84917724676     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13156     Document Type: Article

References (18)

1. Patel T, Morrison LK, Rady P, et al,. Epidermodysplasia verruciformis and susceptibility to HPV. Dis Markers 2010; 29: 199-206.
2. Akgül B, Cooke JC, Storey A,. HPV-associated skin disease. J Pathol 2006; 208: 165-75.
3. Dell'Oste V, Azzimonti B, De Andrea M, et al,. High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis. J Invest Dermatol 2009; 129: 1026-34.
4. Borgogna C, Zavattaro E, De Andrea M, et al,. Characterization of beta papillomavirus E4 expression in tumours from epidermodysplasia verruciformis patients and in experimental models. Virology 2012; 423: 195-204.
5. Ramoz N, Rueda LA, Bouadjar B, et al,. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet 2002; 32: 579-81.
6. Azzimonti B, Mondini M, De Andrea M, et al,. CD8+ T-cell lymphocytopenia and lack of EVER mutations in a patient with clinically and virologically typical epidermodysplasia verruciformis. Arch Dermatol 2005; 141: 1323-5.
7. Zavattaro E, Azzimonti B, Mondini M, et al,. Identification of defective Fas function and variation of the perforin gene in an epidermodysplasia verruciformis patient lacking EVER1 and EVER2 mutations. J Invest Dermatol 2008; 128: 732-5.
8. Landini MM, Zavattaro E, Borgogna C, et al,. Lack of EVER2 protein in two epidermodysplasia verruciformis patients with skin cancer presenting previously unreported homozygous genetic deletions in the EVER2 gene. J Invest Dermatol 2012; 132: 1305-8.
9. Bernard H-U,. Taxonomy and phylogeny of papillomaviruses: An overview and recent developments. Infect Genet Evol 2013; 18: 357-61.
10. Pfister H,. Chapter 8: Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 2003; 31: 52-6.
11. Nindl I, Gottschling M, Stockfleth E,. Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations. Dis Markers 2006; 23: 247-59.
12. Arnold AW, Burger B, Kump E, et al,. Homozygosity for the c.917A→T (p. N306 l) polymorphism in the EVER2/TMC8 gene of two sisters with epidermodysplasia verruciformis Lewandowsky-Lutz originally described by Wilhelm Lutz. Dermatology 2011; 222: 81-6.
13. Kleter B, van Doorn LJ, Schrauwen L, et al,. Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogenital human papillomavirus. J Clin Microbiol 1999; 37: 2508-17.
14. De Koning M, Quint W, Struijk L, et al,. Evaluation of a novel highly sensitive, broad-spectrum PCR-reverse hybridization assay for detection and identification of beta-papillomavirus DNA. J Clin Microbiol 2006; 44: 1792-800.
15. Doorbar J, Quint W, Banks L, et al,. The biology and life-cycle of human papillomaviruses. Vaccine 2012; 30: F55-70.
16. Borgogna C, Lanfredini S, Peretti A, et al,. Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients. Mod Pathol 2014; 27: 1101-15.
17. Cubie HA,. Diseases associated with human papillomavirus infection. Virology 2013; 445: 21-34.
18. Landini M, Borgogna C, Peretti A, et al,. α- and β-papillomavirus infection in a young patient with an unclassified primary T-cell immunodeficiency and multiple mucosal and cutaneous lesions. J Am Acad Dermatol 2014; 71: 108-15 e1.