Effect of empirical treatment on outcomes of clinical trials of diagnostic assays for tuberculosis

The Lancet Infectious Diseases

Volumn 15, Issue 1, 2015, Pages 17-18

  Lawn, Stephen D ^a,b   Nicol, Mark P ^c,d   Corbett, Elizabeth L ^a,e  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e MALAWI LIVERPOOL WELLCOME TRUST CLINICAL RESEARCH PROGRAMME   (Malawi)

Author keywords

[No Author keywords available]

Indexed keywords

HEALTH CARE PERSONNEL; HUMAN; LETTER; LUNG TUBERCULOSIS; MICROSCOPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SMEAR MICROSCOPY; THORAX RADIOGRAPHY; ISOLATION AND PURIFICATION; MYCOBACTERIUM TUBERCULOSIS; REAL TIME POLYMERASE CHAIN REACTION; STANDARDS; TUBERCULOSIS;

TUBERCULOSTATIC AGENT;

ANTITUBERCULAR AGENTS; HUMANS; MYCOBACTERIUM TUBERCULOSIS; REAL-TIME POLYMERASE CHAIN REACTION; TUBERCULOSIS;

EID: 84917706859     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(14)71049-7     Document Type: Letter

References (4)

1. Theron G, Zijenah L, Chanda D, et al. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. Lancet 2014, 383:424-435. for the TB-NEAT team.
2. Theron G, Peter J, Dowdy D, et al. Do high rates of empirical treatment undermine the potential effect of new diagnostic tests for tuberculosis in high-burden settings?. Lancet Infect Dis 2014, 14:527-532.
3. Braunholtz DA, Edwards SJ, Lilford RJ Are randomized clinical trials good for us (in the short term)? Evidence for a "trial effect". J Clin Epidemiol 2001, 54:217-224.
4. GeneXpert MTB/RIF progress report, December 2013. Johannesburg, South Africa: National Health Laboraotry Service National Health Laboratory Service, (accessed April 14, 2014). http://www.nhls.ac.za/assets/files/GeneXpert%20Progress%20Report%20December%202013_Final.pdf.