Calcium-mediated signaling and calmodulin-dependent kinase regulate hepatocyte-inducible nitric oxide synthase expression

Journal of Surgical Research

Volumn 193, Issue 2, 2015, Pages 795-801

  Zhang, Baochun ^a   Crankshaw, Will ^a   Nesemeier, Ryan ^a   Patel, Jay ^a   Nweze, Ikenna ^a   Lakshmanan, Jaganathan ^a   Harbrecht, Brian G ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Cytokines; Hepatocyte; Liver; Nitric oxide synthase; NOS2; Sepsis; Shock

Indexed keywords

CALCIMYCIN; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; CYTOKINE; EGTAZIC ACID; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NIFEDIPINE; NITRIC OXIDE; PROTEIN SERINE THREONINE KINASE INHIBITOR; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; CALCIUM; CALCIUM IONOPHORE; NOS2 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; LIVER CELL; LIVER CELL CULTURE; MACROPHAGE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; HUMAN; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CALCINEURIN; CALCIUM; CALCIUM IONOPHORES; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELLS, CULTURED; HEPATOCYTES; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS, SPRAGUE-DAWLEY;

EID: 84917674232     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.07.042     Document Type: Article

References (35)

1. J. Menezes, C. Hierholzer, and S.C. Watkins A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock Am J Physiol 277 1999 G144
2. F. Lhuillier, P. Parmantier, and J. Goudable Hepatic ischemia is associated with an increase in liver parenchyma nitric oxide that is in part enzyme-independent Anesthesiology 98 2003 373
3. J.M. Menezes, C. Hierholzer, S.C. Watkins, T.R. Billiar, A.B. Peitzman, and B.G. Harbrecht The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock Shock 17 2002 13
4. B.S. Taylor, M.E. deVera, and R.W. Ganster Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase (iNOS) gene J Biol Chem 273 1998 15148
5. V. Gavrilyuk, P. Horvath, G. Weinberg, and D.L. Feinstein A 27-bp region of the inducible nitric oxide synthase promoter regulates expression in glial cells J Neurochem 78 2001 129
6. B.G. Harbrecht, Y.-M. Kim, E.M. Wirant, and T.R. Billiar Glucagon inhibits hepatocyte nitric oxide synthesis Arch Surg 131 1996 1266
7. B.G. Harbrecht, B.S. Taylor, Z. Xu, S. Ramalakshmi, R.W. Ganster, and D.A. Geller cAMP inhibits inducible nitric oxide synthase expression and NF-κB binding activity in cultured rat hepatocytes J Surg Res 99 2001 258
8. B.G. Harbrecht, M. Perpetua, M. Fulmer, and B. Zhang Glucagon regulates hepatic inducible nitric oxide synthesis in vivo Shock 22 2004 157
9. G. Jiang, and B.B. Zhang Glucagon and regulation of glucose metabolism Am J Physiol Endocrinol Metab 284 2003 E671
10. Y. Jiang, A.M. Cypess, and E.D. Muse Glucagon receptor activates extracellular signal-related protein kinase 1/2 via cAMP-dependent protein kinase Proc Natl Acad Sci USA 98 2001 10102
11. K.A. Cullen, J. McCool, M.S. Aniver, and C.R.L. Webster Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis Am J Physiol Gastrointest Liver Physiol 287 2004 G334
12. 2+ inflow is an early action of glucagon and dibutyryl cyclic AMP in rat hepatocytes Biochem J 292 1993 19
13. G. Hong, B. Zhang, and B.G. Harbrecht Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism J Surg Res 159 2010 565
14. B. Zhang, S. Li, and B.G. Harbrecht Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK p44/42 Biochim Biophys Acta 1813 2011 73
15. B. Zhang, I. Nweze, J. Lakshmanan, and B.G. Harbrecht Activation of a cyclic AMP-guanine exchange factor in hepatocytes decreases nitric oxide synthase expression Shock 39 2013 70
16. T. Ueda, Y. Takeyama, Y. Hori, K. Takase, M. Goshima, and Y. Kuroda Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes Surg Res 93 2000 171
17. 2+/calmodulin-dependent protein kinase II J Biol Chem 276 2001 3719
18. L. Ozcan, C.C.L. Wong, and G. Li Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity Cell Metab 15 2012 739
19. R.M. Tribe, P. Moriarty, A. Dalrymple, A.A. Hassoni, and L. Poston Interleukin-1ß induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle Biol Reprod 68 2003 1842
20. 2+ stores Cell Signal 11 1999 101
21. M.L. Jordon, B. Rominski, A. Jaquins-Gerstl, D. Geller, and R.A. Hoffman Regulation of inducible nitric oxide production by intracellular calcium Surgery 118 1995 138
22. 2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability J Cell Biol 129 1995 1651
23. V. Trajkovic, V. Badovinac, V. Jankovic, and M.M. Stojkovic Cyclosporine A inhibits activation of inducible nitric oxide synthase in C6 glioma cell line Brain Res 816 1999 92
24. 2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium- dependent relaxation Am J Physiol Heart Circ Physiol 284 2003 H2311
25. B.G. Harbrecht, I. Nweze, J.W. Smith, and B. Zhang Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism Am J Physiol Gastrointest Liver Physiol 302 2012 G116
26. B.F. Trump, and I.K. Berezesky Calcium-mediated cell injury and death FASEB J 9 1995 219
27. 2+ influx channel Am J Physiol 273 1997 C1526
28. A. Tsung, J.R. Klune, and X. Zhang HMGB1 release induced by liver ischemia involves Toll-like receptor 4-dependent reactive oxygen species production and calcium-mediated signaling J Exp Med 204 2007 2913
29. B. Frantz, E.C. Nordby, and G. Bren Calcineurin acts in synergy with PMA to inactivate IκB/MAD3, an inhibitor of IκB EMBO J 13 1994 861
30. M. Kaibori, K. Sakitani, and M. Oda Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-κB activation in rat hepatocytes J Hepatol 30 1999 1138
31. Z. Sun, and R. Andersson NF-κB activation and inhibition: a review Shock 18 2002 99
32. M. Sasaki, M. Gonzalez-Zulueta, and H. Huang Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism Proc Natl Acad Sci USA 97 2000 8617
33. R. Somogyi, M. Zhao, and J.W. Stucki Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers Biochem J 286 1992 869
34. J.L. Collins, Y. Vodovotz, T. Yoneyama, K. Hatakeyama, A.M. Green, and T.R. Billiar Catecholamines decrease nitric oxide production by cytokine-stimulated hepatocytes Surgery 130 2001 256
35. 2+-dependent transcription Curr Opin Neurobiol 11 2001 312