Quasi-causal associations of physical activity and neighborhood walkability with body mass index: A twin study

Preventive Medicine

Volumn 70, Issue , 2015, Pages 90-95

  Duncan, Glen E ^a   Cash, Stephanie Whisnant ^a,b,d   Horn, Erin E ^c   Turkheimer, Eric ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Department of Psychology University of Virginia ^*  (United States)

Author keywords

Body mass index; Environment and public health; Heredity; Motor activity; Twins

Indexed keywords

ADULT; ARTICLE; BIOMETRY; BODY MASS; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEIGHBORHOOD; PHENOTYPE; PHYSICAL ACTIVITY; RACE; TWINS; WALKING; DEMOGRAPHY; DEVICES; DIZYGOTIC TWINS; ENVIRONMENTAL PLANNING; GENETICS; GEOGRAPHIC INFORMATION SYSTEM; MONOZYGOTIC TWINS; MOTOR ACTIVITY; MULTIVARIATE ANALYSIS; PHYSIOLOGIC MONITORING; PHYSIOLOGY; PROCEDURES; STATISTICS AND NUMERICAL DATA; WASHINGTON;

ADULT; BODY MASS INDEX; ENVIRONMENT DESIGN; FEMALE; GEOGRAPHIC INFORMATION SYSTEMS; HUMANS; MALE; MONITORING, PHYSIOLOGIC; MOTOR ACTIVITY; MULTIVARIATE ANALYSIS; PHENOTYPE; RESIDENCE CHARACTERISTICS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; WALKING; WASHINGTON;

EID: 84916910748     PISSN: 00917435     EISSN: 10960260     Source Type: Journal    
DOI: 10.1016/j.ypmed.2014.11.024     Document Type: Article

References (57)

1. Afari N., Noonan C., Goldberg J., et al. University of Washington Twin Registry: construction and characteristics of a community-based twin registry. Twin Res. Human Genet. 2006, 9:1023-1029.
2. American Diabetes Association Economic costs of diabetes in the U.S. in 2007. Diabetes Care 2008, 31:596-615.
3. Anderson L.H., Martinson B.C., Crain A.L., et al. Health care charges associated with physical inactivity, overweight, and obesity. Prev. Chronic Dis. 2005, 2:A09.
4. Black J.L., Macinko J. Neighborhoods and obesity. Nutr. Rev. 2008, 66:2-20.
5. Carlsson S., Andersson T., Lichtenstein P., Michaelsson K., Ahlbom A. Genetic effects on physical activity: results from the Swedish Twin Registry. Med. Sci. Sports Exerc. 2006, 38:1396-1401.
6. Carr L.J., Dunsiger S.I., Marcus B.H. Walk Score(TM) as a global estimate of neighborhood walkability. Am. J. Prev. Med. 2010, 39:460-463.
7. Carr L.J., Dunsiger S.I., Marcus B.H. Validation of Walk Score for estimating access to walkable amenities. Br. J. Sports Med. 2011, 45:1144-1148.
8. Centers for Disease Control and Prevention About Healthy Places. Centers for Disease Control and Prevention 2007, National Center for Environmental Health, Atlanta, GA.
9. Diez Roux A.V., Jacobs D.R., Kiefe C.I. Neighborhood characteristics and components of the insulin resistance syndrome in young adults: the coronary artery risk development in young adults (CARDIA) study. Diabetes Care 2002, 25:1976-1982.
10. Duncan G.E., Goldberg J., Noonan C., Moudon A.V., Hurvitz P., Buchwald D. Unique environmental effects on physical activity participation: a twin study. PLoS One 2008, 3:e2019.
11. Duncan G.E., Dansie E.J., Strachan E., et al. Genetic and environmental influences on residential location in the US. Health Place 2012, 18:515-519.
12. Duncan G.E., Mills B., Strachan E., et al. Stepping towards causation in studies of neighborhood and environmental effects: how twin research can overcome problems of selection and reverse causation. Health Place 2014, 27C:106-111.
13. Eisen S., Neuman R., Goldberg J., Rice J., True W. Determining zygosity in the Vietnam Era Twin Registry: an approach using questionnaires. Clin. Genet. 1989, 35:423-432.
14. Elks C.E., den Hoed M., Zhao J.H., et al. Variability in the heritability of body mass index: a systematic review and meta-regression. Front. Endocrinol. 2012, 3:29.
15. Eriksson M., Rasmussen F., Tynelius P. Genetic factors in physical activity and the equal environment assumption-the Swedish young male twins study. Behav. Genet. 2006, 36:238-247.
16. Ewing R., Schmid T., Killingsworth R., Zlot A., Raudenbush S. Relationship between urban sprawl and physical activity, obesity, and morbidity. Am. J. Health Promot. 2003, 18:47-57.
17. Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002, 288:1723-1727.
18. Flegal K.M., Graubard B.I., Williamson D.F., Gail M.H. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005, 293:1861-1867.
19. Flegal K.M., Carroll M.D., Ogden C.L., Curtin L.R. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010, 303:235-241.
20. Frank L.D., Andresen M.A., Schmid T.L. Obesity relationships with community design, physical activity, and time spent in cars. Am. J. Prev. Med. 2004, 27:87-96.
21. Frank L.D., Schmid T.L., Sallis J.F., Chapman J., Saelens B.E. Linking objectively measured physical activity with objectively measured urban form: findings from SMARTRAQ. Am. J. Prev. Med. 2005, 28:117-125.
22. Frank L.D., Sallis J.F., Conway T.L., Chapman J.E., Saelens B.E., Bachman W. Many pathways from land use to health-associations between neighborhood walkability and active transportation, body mass index, and air quality. J. Am. Plann. Assoc. 2006, 72:75-87.
23. Frank L.D., Saelens B.E., Powell K.E., Chapman J.E. Stepping towards causation: do built environments or neighborhood and travel preferences explain physical activity, driving, and obesity?. Soc. Sci. Med. 2007, 65:1898-1914.
24. Frumkin H., Frank L., Jackson R. Urban Sprawl and Public Health. Designing, Planning, and Building for Healthy Communities 2004, Island Press, Washington, D.C.
25. Garber C.E., Blissmer B., Deschenes M.R., et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med. Sci. Sports Exerc. 2011, 43:1334-1359.
26. Hedley A.A., Ogden C.L., Johnson C.L., Carroll M.D., Curtin L.R., Flegal K.M. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 2004, 291:2847-2850.
27. Joosen A.M., Gielen M., Vlietinck R., Westerterp K.R. Genetic analysis of physical activity in twins. Am. J. Clin. Nutr. 2005, 82:1253-1259.
28. Lauderdale D.S., Fabsitz R., Meyer J.M., Sholinsky P., Ramakrishnan V., Goldberg J. Familial determinants of moderate and intense physical activity: a twin study. Med. Sci. Sports Exerc. 1997, 29:1062-1068.
29. Lee C., Moudon A.V. Correlates of walking for transportation or recreation purposes. J. Phys. Act. Health 2006, 3:S77-S98.
30. Maia J.A., Thomis M., Beunen G. Genetic factors in physical activity levels: a twin study. Am. J. Prev. Med. 2002, 23:87-91.
31. Moudon A.V., Lee C., Cheadle A.D., et al. Operational definitions of walkable neighborhood: theoretical and empirical insights. J. Phys. Act. Health 2006, 3:S99-S117.
32. Moudon A.V., Lee C., Cheadle A.D., et al. Attributes of environments supporting walking. Am. J. Health Promot. 2007, 21:448-459.
33. Muthen L.K., Muthen B.O. Mplus. Statistical Analysis with Latent Variables. User's Guide 2012, Muthen & Muthen, Los Angeles, CA. 7th ed.
34. National Heart Lung and Blood Institute Predictors of obesity, weight gain, diet, and physical activity workshop 2004, National Institutes of Health, (Available at: http://www.nhlbi.nih.gov/research/reports/2004-obesity/index.htm. Accessed Sep 15, 2014).
35. National Institutes of Health Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults-The Evidence Report. Obes. Res. 1998, 6(Suppl. 2):51S-209S.
36. Novak D.A., Desai M., Ross M.G. Gestational programming of offspring obesity/hypertension. J. Matern. Fetal Neonatal Med. 2006, 19:591-599.
37. Oakes J.M. The (mis)estimation of neighborhood effects: causal inference for a practicable social epidemiology. Soc. Sci. Med. 2004, 58:1929-1952.
38. Oakes J.M. Commentary: advancing neighbourhood-effects research-selection, inferential support, and structural confounding. Int. J. Epidemiol. 2006, 35:643-647.
39. Ogden C.L., Carroll M.D., Curtin L.R., McDowell M.A., Tabak C.J., Flegal K.M. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555.
40. Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014, 311:806-814.
41. Papas M.A., Alberg A.J., Ewing R., Helzlsouer K.J., Gary T.L., Klassen A.C. The built environment and obesity. Epidemiol. Rev. 2007, 29:129-143.
42. Perusse L., Tremblay A., Leblanc C., Bouchard C. Genetic and environmental influences on level of habitual physical activity and exercise participation. Am. J. Epidemiol. 1989, 129:1012-1022.
43. Pronk N.P., Goodman M.J., O'Connor P.J., Martinson B.C. Relationship between modifiable health risks and short-term health care charges. JAMA 1999, 282:2235-2239.
44. Reynolds R.M., Labad J., Buss C., Ghaemmaghami P., Raikkonen K. Transmitting biological effects of stress in utero: implications for mother and offspring. Psychoneuroendocrinology 2013, 38:1843-1849.
45. Saelens B.E., Sallis J.F., Black J.B., Chen D. Neighborhood-based differences in physical activity: an environment scale evaluation. Am. J. Public Health 2003, 93:1552-1558.
46. Simonen R.L., Perusse L., Rankinen T., Rice T., Rao D.C., Bouchard C. Familial aggregation of physical activity levels in the Quebec Family Study. Med. Sci. Sports Exerc. 2002, 34:1137-1142.
47. Spitz E., Moutier R., Reed T., et al. Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis. Behav. Genet. 1996, 26:55-63.
48. Strachan E., Hunt C., Afari N., et al. University of Washington Twin Registry: poised for the next generation of twin research. Twin Res. Human Genet. 2013, 16:455-462.
49. Stubbe J.H., Boomsma D.I., Vink J.M., et al. Genetic influences on exercise participation in 37.051 twin pairs from seven countries. PLoS ONE 2006, 1:e22.
50. Torgersen S. The determination of twin zygosity by means of a mailed questionnaire. Acta Genet. Med. Gemellol. 1979, 28:225-236.
51. Turkheimer E., Harden K.P. Behavior genetic research methods: testing quasi-causal hypotheses using multivariate twin data. Handbook of Research Methods in Personality and Social Psychology 2014, 159-187. Cambridge University Press, Cambridge, U.K. 2nd ed. H.T. Reis, C.M. Judd (Eds.).
52. U.S.Department of Health and Human Services Physical Activity and Health: A Report of the Surgeon General 1996, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA.
53. Walk Score Walk Score Methodology Available at:, (Accessed Sep 15, 2014). http://www.walkscore.com/methodology.shtml.
54. Walk Score Get Your Walk Score-A Walkability Score For Any Address Available at:, (Accessed Sep 15, 2014). http://www.walkscore.com.
55. Wang Y.C., McPherson K., Marsh T., Gortmaker S.L., Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011, 378:815-825.
56. Whitfield J.B., Zhu G., Heath A.C., Martin N.G. Choice of residential location: chance, family influences, or genes?. Twin Res. Human Genet. 2005, 8:22-26.
57. Willemsen G., Posthuma D., Boomsma D.I. Environmental factors determine where the Dutch live: results from the Netherlands Twin Register. Twin Res. Human Genet. 2005, 8:312-317.