Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

eLife

Volumn 3, Issue , 2014, Pages e03671-

  Wang, Weiwei ^a   Whorton, Matthew R ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

G protein coupled receptor; G protein gated potassium channel; G proteins; PIP2; planar lipid bilayer; sodium activation

Indexed keywords

ARTIFICIAL MEMBRANE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GNA11 PROTEIN, HUMAN; GNB4 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; KCNJ6 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN BINDING; RECOMBINANT PROTEIN; SODIUM;

ANIMAL; ARTIFICIAL MEMBRANE; CHANNEL GATING; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MOUSE; PICHIA; SIGNAL TRANSDUCTION;

ANIMALS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MEMBRANES, ARTIFICIAL; MICE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PICHIA; PROTEIN BINDING; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SODIUM;

EID: 84916634632     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.03671     Document Type: Article

References (0)