Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice

Biomacromolecules

Volumn 15, Issue 12, 2014, Pages 4570-4578

  Yu, Guanping ^a,b   Wu, Xueming ^a,b   Ayat, Nadia ^a   Maeda, Akiko ^c   Gao, Song Qi ^c   Golczak, Marcin ^c   Palczewski, Krzysztof ^c   Lu, Zheng Rong ^c  

^a Civil Engineering Program   (United States)

^b Section of Neonatology   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; ENZYMES; MAMMALS; OPHTHALMOLOGY;

AGE-RELATED MACULAR DEGENERATION; CONTROLLED DELIVERY; GASTROINTESTINAL TRACT; IDENTICAL CONDITIONS; ORAL ADMINISTRATION; RETINAL DEGENERATIONS; RETINAL DEGENERATIVE DISEASE; SUSTAINED DRUG RELEASE;

EYE PROTECTION;

AGENTS ACTING ON THE EYE; GLYCINE; LEUCINE; MACROGOL; PHENYLALANINE; RETINYLAMINE; UNCLASSIFIED DRUG; DITERPENE; MACROGOL DERIVATIVE;

AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONJUGATE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ELECTRORETINOGRAM; FEMALE; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE BRUSH BORDER; LIGHT EXPOSURE; LIMIT OF DETECTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHOTORECEPTOR CELL; PROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE; RETINA DEGENERATION; SOLID PHASE SYNTHESIS; STARGARDT DISEASE; SUSTAINED DRUG RELEASE; SYSTEMIC CIRCULATION; WILD TYPE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHEMISTRY; LIGHT; MACULAR DEGENERATION; PATHOLOGY; RETINAL DEGENERATION; TRANSGENIC MOUSE;

MUS;

ANIMALS; DITERPENES; DRUG DELIVERY SYSTEMS; FEMALE; LIGHT; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYETHYLENE GLYCOLS; RETINAL DEGENERATION;

EID: 84916631735     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm501352s     Document Type: Article

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