A modified prothrombin time to measure the anticoagulant activity of dabigatran

Thrombosis Research

Volumn 134, Issue 6, 2014, Pages 1368-1369

  Visino, Fabrizio ^a   Zaccaria, Federica ^a   Semeraro, Nicola ^a   Colucci, Mario ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; DABIGATRAN; ECARIN; REAGENT; RECOMBINANT THROMBOPLASTIN; THROMBIN INHIBITOR; THROMBOPLASTIN; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE;

ANTICOAGULATION; ASSAY; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; BLOOD DONOR; BLOOD SAMPLING; GOLD STANDARD; HEMATOLOGICAL PARAMETERS; HUMAN; INTERMETHOD COMPARISON; LABORATORY TEST; LETTER; MEASUREMENT; NORMAL HUMAN; PATIENT MONITORING; PROTHROMBIN TIME; THROMBIN TIME; VENOUS BLOOD; ANALOGS AND DERIVATIVES; BLOOD; BLOOD CLOTTING; DRUG EFFECTS; EVALUATION STUDY; PHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANTITHROMBINS; BENZIMIDAZOLES; BETA-ALANINE; BLOOD COAGULATION; HUMANS; PROTHROMBIN TIME; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84916229178     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.09.027     Document Type: Letter

References (7)

1. J. van Ryn, J. Stangier, S. Haertter, K.H. Liesenfeld, W. Wienen, and M. Feuring Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity Thromb Haemost 103 2010 1116 1127
2. A. Tripodi The laboratory and the direct oral anticoagulants Blood 121 2013 4032 4035
3. J. Stangier, and M. Feuring Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran Blood Coagul Fibrinolysis 23 2012 138 143
4. E.M. Hawes, A.M. Deal, D. Funk-Adcock, R. Gosselin, C. Jeanneret, and A.M. Cook Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels J Thromb Haemost 11 2013 1493 1502
5. C.T. Ammollo, F. Semeraro, F. Incampo, N. Semeraro, and M. Colucci Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor J Thromb Haemost 8 2010 790 798
6. D.M. Siegal, D.A. Garcia, and M.A. Crowther How I treat target-specific oral anticoagulant-associated bleeding Blood 123 2014 1152 1158
7. J. van Ryn, J. Schurer, M. Kink-Eiband, and A. Clemens Reversal of Dabigatran-induced Bleeding by Coagulation Factor Concentrates in a Rat-tail Bleeding Model and Lack of Effect on Assays of Coagulation Anesthesiology 120 2014 1429 1440