Characterization of mammary analogue secretory carcinoma of the salivary gland: Discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

Human Pathology

Volumn 46, Issue 1, 2015, Pages 94-103

  Urano, Makoto ^a   Nagao, Toshitaka ^b   Miyabe, Satoru ^c   Ishibashi, Kenichiro ^c   Higuchi, Kayoko ^d   Kuroda, Makoto ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c AICHI GAKUIN UNIVERSITY   (Japan)

^d Aizawa Hospital   (Japan)

Author keywords

Acinic cell carcinoma; Cystadenocarcinoma; ETV6 NTRK3; Immunohistochemistry; Mammary analogue secretory carcinoma; Salivary gland

Indexed keywords

ADIPOPHILIN; AMYLASE; CYTOKERATIN; CYTOKERATIN 19; MAMMAGLOBIN; MUCIN 1; NEUROTROPHIC TYROSINE KINASE RECEPTOR 3; PROTEIN P63; PROTEIN S 100; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR SOX10; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VIMENTIN; ZYMOGEN GRANULE; ETV6-NTRK3 FUSION PROTEIN, HUMAN; ONCOPROTEIN; TUMOR MARKER;

ACINAR CELL CARCINOMA; ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; DNA SEQUENCE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE TRANSLOCATION; GENETIC PROCEDURES; HUMAN; IMMUNOHISTOCHEMISTRY; LOW GRADE CRIBRIFORM CYSTADENOCARCINOMA; MALE; MAMMARY ANALOGUE SECRETORY CARCINOMA; MINOR SALIVA GLAND; MOLECULAR MIMICRY; MOLECULAR WEIGHT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND TUMOR; ADOLESCENT; BREAST TUMOR; CARCINOMA; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DIAGNOSTIC ERROR; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; PREVENTION AND CONTROL; PROGNOSIS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BREAST NEOPLASMS; CARCINOMA; CARCINOMA, ACINAR CELL; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALIVARY GLAND NEOPLASMS; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84916225030     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.09.012     Document Type: Article

References (34)

1. G.L. Ellis, and R.L. Corio Acinic cell adenocarcinoma, a clinicopathologic analysis of 294 cases Cancer 52 1983 542 549
2. G.L. Ellis, and P. Auclair Malignant epithelial neoplasms acinic cell adenocarcinoma AFIP atlas of tumor pathology, Series 4, Fascicle 9. Tumors of the salivary glands 2008 American Registry of Pathology Washington D.C. 204 225
3. R. Delgado, D. Klimstra, R. Delgado, and J. Albores-Saavedra Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattern Cancer 78 1996 958 967
4. M.S. Brandwein-Gensler, and D.R. Gnepp Low-grade cribriform cystadenocarcinoma L. Barnes, J.W. Evenson, P. Reichart, D. Sidransky, World Health Organization classification of tumours pathology & genetics head and neck tumours 2005 IARC Press Lyon, France 233
5. A. Skalova, T. Vanecek, and R. Sima Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity Am J Surg Pathol 34 2010 599 608
6. C. Tognon, S.R. Knezevich, and D. Huntsman Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma Cancer Cell 2 2002 367 376
7. C. Griffith, R. Seethala, and S.I. Chiosea Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen poor acinic cell carcinoma Virchows Arch 459 2011 117 118
8. S.I. Chiosea, C. Griffith, A. Assaad, and R.R. Seethala The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma Am J Surg Pathol 36 2012 343 350
9. S. Tsuji, M. Hisaoka, and Y. Morimitsu Detection of SYT-SSX fusion transcript in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues Am J Pathol 153 1998 1807 1812
10. H. Xia, T. Nakayama, and K. Sakuma Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma Human Pathol 42 2011 1297 1304
11. M. Pia-Foschini, J.S. Reis-Filho, V. Eusebi, and S.R. Lakhani Salivary gland-like tumors of the breast: surgical and molecular pathology J Clin Pathol 56 2003 497 506
12. M. Lae, P. Freneaux, X. Sastre-Garau, O. Chouchane, B. Sigal-Zafani, and A. Vincent-Salomon Secretory breast carcinoma with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum Mod Pathol 22 2009 291 298
13. M. Hirokawa, K. Sugihara, and T. Sai Secretory carcinoma of the breast: a tumour analogous to salivary gland acinic cell carcinoma? Histopathol 40 2002 223 229
14. J.M. Bourgeois, S.R. Knezevich, J.A. Mathers, and P.H.B. Sorensen Molecular detection of the ETV6-NTRK3 gene fusion differences congenital fibrosarcoma from other childhood spindle cell tumors Am J Surg Pathol 24 2000 937 946
15. C.L. Lannon, and P.H. Sorensen ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages Semin Cancer Biol 15 2005 215 223
16. Z. Li, C.E. Tognon, and F.J. Godinho ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex Cancer Cell 12 2007 542 558
17. S.I. Chiosea, C. Griffith, A. Assaad, and R.R. Seethala Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands Histopathol 61 2012 387 394
18. M. Brandwein-Gensler, J. Hille, and B.Y. Wang Low-grade salivary duct carcinoma: description of 16 cases Am J Surg Pathol 28 2004 1040 1044
19. I. Weinreb, R. Tabanda-Lichauco, T. Van der Kwast, and B. Perez-Ordonez Low-grade intraductal carcinoma of salivary gland. Report of 3 cases with marked apocrine differentiation Am J Surg Pathol 30 2006 1014 1021
20. J.A. Bishop, R. Yonescu, D. Batista, S. Begum, D.W. Eisele, and W.H. Westra Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma Hum Pathol 44 2013 1982 1988
21. S. Schwarz, J. Zenk, and M. Muller The many faces of acinic cell carcinomas of the salivary glands: a study of 40 cases relating histological and immunohistological subtypes to clinical parameters and prognosis Histopathol 61 2012 395 408
22. J. Laco, M. Svajdler, and J. Andrejs Mammary analog secretory carcinoma of salivary glands: a report of 2 cases with expression of basal/myoepithelial markers (calponin, CD10 and p63 protein) Pathol Res Pract 209 2013 167 172
23. A. Connor, B. Perez-Ordoñez, and M. Shago Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity Am J Surg Pathol 36 2012 27 34
24. A. Skalova Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity Head Neck Pathol 7 2013 30 36 [Suppl]
25. F.V. Mariano, H.T. dos Santos, and W.D. Azanero Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification Histopathology 63 2013 558 567
26. M. Miettinen, Z.F. Wang, and J. Lasota DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors; a study of 1840 cases Am J Surg Pathol 33 2009 1401 1408
27. J. Chenevert, U. Duvvuri, and S. Chiosea DOG1: a novel marker of salivary acinar and intercalated duct differentiation Mod Pathol 25 2012 919 929
28. A. Pinto, V. Nose, C. Rojas, Y.S. Fan, and C. Gomez-Fernandez Searching for mammary analogue secretory carcinoma of salivary gland among its mimics Mod Pathol 27 2014 30 37
29. R. Ohtomo, T. Mori, and S. Shibata Sox 10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis Mod Pathol 26 2013 1041 1050
30. L.E. Schwartz, S. Begum, W.H. Westra, and J.A. Bishop GATA3 immunohistochemical expression in salivary gland neoplasms Head Neck Pathol 7 2013 311 315
31. A. Skalova, T. Vanecek, and H. Majewska Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes Am J Surg Pathol 38 2014 23 33
32. C.E. Tognon, A.M. Somasiri, and V.E. Evdokimova ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway Cancer Res 71 2011 1060 1070
33. H.T. Chi, B.T. Ly, Y. Kano, A. Tojo, T. Watanabe, and Y. Sato ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412 Biochem Biophys Res Commun 429 2012 87 92
34. S. Ito, E. Ishida, A. Skalova, K. Matsuura, H. Kumamoto, and I. Sato Case report of mammary analog secretory carcinoma of the parotid gland Pathol Int 62 2012 149 152