Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery

Biomaterials

Volumn 35, Issue 35, 2014, Pages 9546-9553

  He, Huacheng ^a   Cattran, Alexander W ^b   Nguyen, Tu ^a   Nieminen, Anna Liisa ^b   Xu, Peisheng ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Expandable; Nanoparticle; Photodynamic therapy; Stimuli responsive; Tumor targeted

Indexed keywords

NANOPARTICLES; NANOSTRUCTURED MATERIALS; PHOTOSENSITIZERS; REDOX REACTIONS; TUMORS;

BODY TEMPERATURE; EXPANDABLE; FUNCTIONALIZED; HEAD-AND-NECK TUMOR; RECEPTOR TARGETING; REDOX POTENTIALS; REDUCING ENVIRONMENT; STIMULI-RESPONSIVE;

PHOTODYNAMIC THERAPY;

FREE RADICAL; MACROGOL; NANOPARTICLE; PHOTOSENSITIZING AGENT; PHTHALOCYANINE DERIVATIVE; POLY(N ISOPROPYLACRYLAMIDE); SIGMA 2 OPIATE RECEPTOR; SILICON PHTHALOCYANINE; TRIS(2 CARBOXYETHYL)PHOSPHINE; UNCLASSIFIED DRUG; DRUG CARRIER; GEL; SIGMA OPIATE RECEPTOR; SIGMA-2 RECEPTOR;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY TEMPERATURE; CANCER CELL; CELL KILLING; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG TUMOR LEVEL; ENDOCYTOSIS; ENVIRONMENTAL TEMPERATURE; GEL; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HIGH TEMPERATURE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOCHONDRION; MOUSE; NANOFABRICATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PH; PHASE TRANSITION; PHOTODYNAMIC THERAPY; POLYMERIZATION; PRIORITY JOURNAL; TRANSITION TEMPERATURE; TRIPLE RESPONSIVE EXPANSILE NANOGEL SYSTEM; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; DRUG SCREENING; GENETICS; HEAD AND NECK NEOPLASMS; METABOLISM; PHARMACOKINETICS; PHOTOCHEMOTHERAPY; PROCEDURES; TEMPERATURE; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; HEAD AND NECK NEOPLASMS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NANOPARTICLES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RECEPTORS, SIGMA; TEMPERATURE; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84915806981     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.08.004     Document Type: Article

References (32)

1. Oleinick N.L., Morris R.L., Belichenko T. The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photoch Photobio Sci 2002, 1:1-21.
2. Lam M., Oleinick N.L., Nieminen A.L. Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. Reactive oxygen species and mitochondrial inner membrane permeabilization. JBiol Chem 2001, 276:47379-47386.
3. Master A.M., Rodriguez M.E., Kenney M.E., Oleinick N.L., Gupta A.S. Delivery of the photosensitizer Pc 4 in PEG-PCL micelles for invitro PDT studies. JPharm Sci-Us 2010, 99:2386-2398.
4. 2 mesoporous nanoparticles. Biosens Bioelectron 2014, 53:340-345.
5. Master A.M., Livingston M., Oleinick N.L., Sen Gupta A. Optimization of a nanomedicine-based silicon phthalocyanine 4 photodynamic therapy (Pc 4-PDT) strategy for targeted treatment of EGFR-overexpressing cancers. Mol Pharm 2012, 9:2331-2338.
6. Cheng Y., Meyers J.D., Broome A.-M., Kenney M.E., Basilion J.P., Burda C. Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates. JAm Chem Soc 2011, 133:2583-2591.
7. Master A.M., Qi Y., Oleinick N.L., Gupta A.S. EGFR-mediated intracellular delivery of Pc 4 nanoformulation for targeted photodynamic therapy of cancer: invitro studies. Nanomedicine 2012, 8:655-664.
8. Griset A.P., Walpole J., Liu R., Gaffey A., Colson Y.L., Grinstaff M.W. Expansile nanoparticles: synthesis, characterization, and invivo efficacy of an acid-responsive polymeric drug delivery system. JAm Chem Soc 2009, 131:2469-2471.
9. Liu R., Gilmore D.M., Zubris K.A., Xu X., Catalano P.J., Padera R.F., et al. Prevention of nodal metastases in breast cancer following the lymphatic migration of paclitaxel-loaded expansile nanoparticles. Biomaterials 2013, 34:1810-1819.
10. Liu R., Khullar O.V., Griset A.P., Wade J.E., Zubris K.A., Grinstaff M.W., et al. Paclitaxel-loaded expansile nanoparticles delay local recurrence in a heterotopic murine non-small cell lung cancer model. Ann Thorac Surg 2011, 91:1077-1083.
11. Zubris K.A., Liu R., Colby A., Schulz M.D., Colson Y.L., Grinstaff M.W. Invitro activity of paclitaxel-loaded polymeric expansile nanoparticles in breast cancer cells. Biomacromolecules 2013, 14:2074-2082.
12. Ryu J.-H., Jiwpanich S., Chacko R., Bickerton S., Thayumanavan S. Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities. JAm Chem Soc 2010, 132:8246-8247.
13. Gonzalez-Toro D.C., Ryu J.H., Chacko R.T., Zhuang J., Thayumanavan S. Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels. JAm Chem Soc 2012, 134:6964-6967.
14. Bahadur K.C.R., Xu P. Multicompartment intracellular self-expanding nanogel for targeted delivery of drug cocktail. Adv Mater 2012, 24:6479-6483.
15. Xu P., Gullotti E., Tong L., Highley C.B., Errabelli D.R., Hasan T., et al. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm 2009, 6:190-201.
16. Nieminen A.L., Gores G.J., Bond J.M., Imberti R., Herman B., Lemasters J.J. Anovel cytotoxicity screening assay using a multiwell fluorescence scanner. Toxicol Appl Pharmacol 1992, 115:147-155.
17. von Nessen K., Karg M., Hellweg T. Thermoresponsive poly-(N-isopropylmethacrylamide) microgels: tailoring particle size by interfacial tension control. Polymer 2013, 54:5499-5510.
18. Rahman M.M., Chehimi M.M., Fessi H., Elaissari A. Highly temperature responsive core-shell magnetic particles: synthesis, characterization and colloidal properties. JColloid Interface Sci 2011, 360:556-564.
19. Matsumura Y., Iwai K. Synthesis and thermo-responsive behavior of fluorescent labeled microgel particles based on poly(n-isopropylacrylamide) and its related polymers. Polymer 2005, 46:10027-10034.
20. Schafer F.Q., Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001, 30:1191-1212.
21. Biel M. Photodynamic therapy of head and neck cancers. Photodynamic therapy 2010, 281-293. Humana Press. C.J. Gomer (Ed.).
22. Kashiwagi H., McDunn J., Simon P., Goedegebuure P., Xu J., Jones L., et al. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer 2007, 6:48.
23. Mach R., Smith C., al-Nabulsi I., Whirrett B., Childers S., Wheeler K. Sigma 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 1997, 57:156-161.
24. Yang Y., Hu Y.X., Wang Y.H., Li J., Liu F., Huang L. Nanoparticle delivery of pooled siRNA for effective treatment of non-small cell lung cancer. Mol Pharm 2012, 9:2280-2289.
25. Yang Y., Li J., Liu F., Huang L. Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol Ther 2012, 20:609-615.
26. Chono S., Li S.D., Conwell C.C., Huang L. An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. JControl Release 2008, 131:64-69.
27. Halig L.V., Wang D., Wang A.Y., Chen Z.G., Fei B. Biodistribution study of nanoparticle encapsulated photodynamic therapy drugs using multispectral imaging. Proc SPIE 2013, 8672.
28. Cheng Y., CS A., Meyers J.D., Panagopoulos I., Fei B., Burda C. Highly efficient drug delivery with gold nanoparticle vectors for invivo photodynamic therapy of cancer. JAm Chem Soc 2008, 130:10643-10647.
29. Wang D., Fei B., Halig L.V., Qin X., Hu Z., Xu H., et al. Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer. ACS Nano 2014, 8:6620-6632.
30. Master A., Malamas A., Solanki R., Clausen D.M., Eiseman J.L., Sen Gupta A. Acell-targeted photodynamic nanomedicine strategy for head and neck cancers. Mol Pharm 2013, 10:1988-1997.
31. Ding H., Mora R., Gao J., Sumer B.D. Characterization and optimization of mTHPP nanoparticles for photodynamic therapy of head and neck cancer. Otolaryngol Head Neck Surg 2011, 145:612-617.
32. Cohen E.M., Ding H., Kessinger C.W., Khemtong C., Gao J., Sumer B.D. Polymeric micelle nanoparticles for photodynamic treatment of head and neck cancer cells. Otolaryngol Head Neck Surg 2010, 143:109-115.