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Angewandte Chemie - International Edition

Volumn 53, Issue 44, 2014, Pages 11969-11973

Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site

(8) Dubiella, Christian a Cui, Haissi c Gersch, Malte a Brouwer, Arwin J d Sieber, Stephan A a Krüger, Achim c Liskamp, Rob M J b Groll, Michael a

a Munich Center for Integrated Protein Science (Germany)

b UNIVERSITY OF GLASGOW (United Kingdom)

c TECHNICAL UNIVERSITY OF MUNICH (Germany)

d UTRECHT UNIVERSITY (Netherlands)

Author keywords

Drug design; Immunoproteasome; Inhibitors; Peptido sulfonyl fluoride; Umpolung

Indexed keywords

CORROSION INHIBITORS; CYTOTOXICITY; DISEASES; FLUORINE COMPOUNDS;

AUTOIMMUNE DISEASE; AUTOIMMUNE DISORDER; DRUG DESIGN; IMMUNOPROTEASOME; MASS SPECTROMETRIC ANALYSIS; PEPTIDO SULFONYL FLUORIDE; SELECTIVE INHIBITION; UMPOLUNG;

CROSSLINKING;

LIGAND; PROTEASOME; PROTEASOME INHIBITOR;

CHEMISTRY; DRUG DESIGN;

DRUG DESIGN; LIGANDS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS;

EID: 84915750897 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201406964 Document Type: Article

Times cited : (65)

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